BacMap

Definition	Bacillus cereus subsp. cytotoxis NVH 391-98, complete genome.
Accession	NC_009674
Length	4,087,024

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The map label for this gene is ppiB [H]

Identifier: 152976471

GI number: 152976471

Start: 2843815

End: 2844252

Strand: Reverse

Name: ppiB [H]

Synonym: Bcer98_2760

Alternate gene names: 152976471

Gene position: 2844252-2843815 (Counterclockwise)

Preceding gene: 152976473

Following gene: 152976470

Centisome position: 69.59

GC content: 41.55

Gene sequence:

>438_bases
ATGAAAACTTTAGGATACATATTAATGGAAAATGGGGAGAAAATTGAACTAGAGTTTTTTCCAGAAGAAGCACCAACAAC
AGTTGAAAACTTTAAAAAACTAGCGATGCAAGGATTTTACGATGGTGTTACATTCCACCGCGTTATCCCTGGGTTTGTAA
GTCAGGGTGGAGATCCAACAGGAACAGGTGCAGGCGGCCCAGGTTATACAATTCCATGTGAAACAGATGGTAATCCTCAC
CGTCACGTTGTAGGATCGCTTTCTATGGCACACGCTGGCCGTAATACAGGTGGTAGCCAGTTCTTTATCGTTCATGAGCC
ACAACCACATTTAGATGGCGTTCATACTGTATTTGGTAAAGTAACAAGCGGTATGGAAACGGTACTTAATATGCGTCAAG
GCGATGTAATGAAAGAAGTTAAAGTTTGGGAAGAATAA

Upstream 100 bases:

>100_bases
TTAATTGAAGAAAGATGTATCTATATTGTCGGATTCTTTTTGTTTCTGGTCGTGAATATGGTAATATAGTGCTGAGATAC
TTGAAAGGAGATATATACGT

Downstream 100 bases:

>100_bases
GTGAGAGGCTGTGCCAAAAGGTCGTGAACAGCGACCTTTTGGAGACAGCCTTTTTTTTGCTTTATTATTGAAAGTGTAAA
TCTAAAAAGATGATATTCAA

Product: peptidyl-prolyl cis-trans isomerase cyclophilin type

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MKTLGYILMENGEKIELEFFPEEAPTTVENFKKLAMQGFYDGVTFHRVIPGFVSQGGDPTGTGAGGPGYTIPCETDGNPH
RHVVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGKVTSGMETVLNMRQGDVMKEVKVWEE

Sequences:

>Translated_145_residues
MKTLGYILMENGEKIELEFFPEEAPTTVENFKKLAMQGFYDGVTFHRVIPGFVSQGGDPTGTGAGGPGYTIPCETDGNPH
RHVVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGKVTSGMETVLNMRQGDVMKEVKVWEE
>Mature_145_residues
MKTLGYILMENGEKIELEFFPEEAPTTVENFKKLAMQGFYDGVTFHRVIPGFVSQGGDPTGTGAGGPGYTIPCETDGNPH
RHVVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGKVTSGMETVLNMRQGDVMKEVKVWEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=117, Percent_Identity=52.1367521367521, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI19557636, Length=117, Percent_Identity=49.5726495726496, Blast_Score=106, Evalue=7e-24,
Organism=Homo sapiens, GI7706339, Length=117, Percent_Identity=47.008547008547, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI64276486, Length=128, Percent_Identity=41.40625, Blast_Score=99, Evalue=9e-22,
Organism=Homo sapiens, GI10863927, Length=142, Percent_Identity=42.9577464788732, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI4826932, Length=126, Percent_Identity=43.6507936507937, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI256017253, Length=122, Percent_Identity=43.4426229508197, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI221139811, Length=122, Percent_Identity=43.4426229508197, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI256017251, Length=122, Percent_Identity=43.4426229508197, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI310127646, Length=142, Percent_Identity=40.8450704225352, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI310114371, Length=142, Percent_Identity=40.8450704225352, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI310119221, Length=142, Percent_Identity=40.8450704225352, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI178057341, Length=125, Percent_Identity=43.2, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI6631100, Length=130, Percent_Identity=40.7692307692308, Blast_Score=83, Evalue=8e-17,
Organism=Homo sapiens, GI5031987, Length=121, Percent_Identity=47.1074380165289, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI209417936, Length=124, Percent_Identity=43.5483870967742, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI30102944, Length=124, Percent_Identity=43.5483870967742, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI219842199, Length=124, Percent_Identity=43.5483870967742, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI150418007, Length=143, Percent_Identity=40.5594405594406, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4505991, Length=122, Percent_Identity=47.5409836065574, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310129267, Length=138, Percent_Identity=39.8550724637681, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI310120620, Length=138, Percent_Identity=39.8550724637681, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI4758950, Length=117, Percent_Identity=47.8632478632479, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI303305009, Length=135, Percent_Identity=39.2592592592593, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI42560244, Length=130, Percent_Identity=40.7692307692308, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI45439316, Length=138, Percent_Identity=38.4057971014493, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310110104, Length=121, Percent_Identity=42.9752066115703, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI169164185, Length=139, Percent_Identity=40.2877697841727, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI169163623, Length=139, Percent_Identity=40.2877697841727, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI5174637, Length=124, Percent_Identity=39.5161290322581, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI169163387, Length=139, Percent_Identity=40.2877697841727, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI5454154, Length=131, Percent_Identity=39.6946564885496, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI169214050, Length=142, Percent_Identity=38.7323943661972, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI310127745, Length=124, Percent_Identity=42.741935483871, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI310119290, Length=124, Percent_Identity=42.741935483871, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI239751853, Length=141, Percent_Identity=37.5886524822695, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI113428306, Length=141, Percent_Identity=37.5886524822695, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310114540, Length=124, Percent_Identity=42.741935483871, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI310132444, Length=142, Percent_Identity=37.3239436619718, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI310113152, Length=142, Percent_Identity=37.3239436619718, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI20911035, Length=142, Percent_Identity=33.0985915492958, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI22547212, Length=135, Percent_Identity=42.2222222222222, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI7657473, Length=135, Percent_Identity=42.2222222222222, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI22547215, Length=135, Percent_Identity=42.2222222222222, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1789763, Length=134, Percent_Identity=38.0597014925373, Blast_Score=74, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=134, Percent_Identity=47.0149253731343, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17506311, Length=123, Percent_Identity=46.3414634146341, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17532641, Length=130, Percent_Identity=40.7692307692308, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71997782, Length=138, Percent_Identity=42.0289855072464, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17539498, Length=126, Percent_Identity=44.4444444444444, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=117, Percent_Identity=39.3162393162393, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=117, Percent_Identity=39.3162393162393, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17551282, Length=118, Percent_Identity=47.4576271186441, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551284, Length=118, Percent_Identity=47.4576271186441, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565860, Length=133, Percent_Identity=41.3533834586466, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=121, Percent_Identity=46.2809917355372, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17506307, Length=138, Percent_Identity=43.4782608695652, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17552782, Length=132, Percent_Identity=40.1515151515151, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17566266, Length=129, Percent_Identity=41.0852713178295, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI32563659, Length=133, Percent_Identity=37.593984962406, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559074, Length=129, Percent_Identity=40.3100775193798, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17552784, Length=130, Percent_Identity=36.1538461538462, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=125, Percent_Identity=39.2, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=121, Percent_Identity=47.9338842975207, Blast_Score=91, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320359, Length=122, Percent_Identity=46.7213114754098, Blast_Score=85, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321848, Length=134, Percent_Identity=45.5223880597015, Blast_Score=84, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320510, Length=114, Percent_Identity=47.3684210526316, Blast_Score=81, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323246, Length=130, Percent_Identity=40.7692307692308, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922376, Length=140, Percent_Identity=42.8571428571429, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17986117, Length=118, Percent_Identity=47.4576271186441, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24650807, Length=130, Percent_Identity=44.6153846153846, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20130249, Length=124, Percent_Identity=47.5806451612903, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357249, Length=120, Percent_Identity=37.5, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922912, Length=125, Percent_Identity=47.2, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17647301, Length=126, Percent_Identity=42.8571428571429, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45549139, Length=122, Percent_Identity=45.0819672131148, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24652460, Length=117, Percent_Identity=37.6068376068376, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24664125, Length=122, Percent_Identity=45.9016393442623, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357783, Length=122, Percent_Identity=45.9016393442623, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136360, Length=124, Percent_Identity=39.5161290322581, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355677, Length=144, Percent_Identity=31.9444444444444, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586038, Length=132, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15809; Mature: 15809

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLGYILMENGEKIELEFFPEEAPTTVENFKKLAMQGFYDGVTFHRVIPGFVSQGGDPT
CCCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
GTGAGGPGYTIPCETDGNPHRHVVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGK
CCCCCCCCCEEECCCCCCCCHHHEHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHH
VTSGMETVLNMRQGDVMKEVKVWEE
HHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MKTLGYILMENGEKIELEFFPEEAPTTVENFKKLAMQGFYDGVTFHRVIPGFVSQGGDPT
CCCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
GTGAGGPGYTIPCETDGNPHRHVVGSLSMAHAGRNTGGSQFFIVHEPQPHLDGVHTVFGK
CCCCCCCCCEEECCCCCCCCHHHEHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHH
VTSGMETVLNMRQGDVMKEVKVWEE
HHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934829; 8022278; 9384377; 8755892 [H]