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The map label for this gene is comEC [H]

Identifier: 152976466

GI number: 152976466

Start: 2839304

End: 2840206

Strand: Reverse

Name: comEC [H]

Synonym: Bcer98_2755

Alternate gene names: 152976466

Gene position: 2840206-2839304 (Counterclockwise)

Preceding gene: 152976467

Following gene: 152976465

Centisome position: 69.49

GC content: 35.55

Gene sequence:

>903_bases
ATGAAAGGGGTACGGAGTATTCTTTTGCTAGTTTCTGTTTTATTATGTTTTTCATTAAACAGCACATCGGCGAAACGATA
TATGATGTCTATTCATGCGGCATCCTTTTTTTCTATGCAACGTCCGCATCTTGGGAAAATGAAAGTAAGTTTTTTTAAAG
TTGGGCAAGGGGATGCAACATTGATTACATTGCCAAATGGTCAAACGGTATTAATTGATGGAGGACCTTATGAAGCAGGA
GAAGTCCTTATTCAAAAGTTACTTGAAAAAGGAATTAATCATTTAGATGTTATAGTAGGAACTCATCCGGATATGGATCA
TATAGGTGGGCTAATTCCAATTATAGAACAAATGCCTGTAGCACTTGTATTAGATAGTGGAAAAACGTATAGTTCTCTTA
CATATCATACGTATAGAAATCATATTAAAAAGAGAGGAATTCCATTTGTTCGTGTTAAACAAGGGCAATATCTCCCGTTA
GATCCTCATGTGTCCATTCAAGTGTTGAATAATGGAAAATCAAAAGATGAGAATAATGAATCTTCAATTGTATTAAAGGT
TCGTTATGGGAAAGCGGATTTTTTATTAATGGGGGATGCAGATATACGGACGGAAAATAAAATAGTAAAGCGATATGATG
TCCATGCAGATGTGTTAAAAGTAGGACATCATGGCTCCTATACATCAACAGGCGAAGCCTTTTTAAAAAGGGTAAATCCT
CAATTTGCTATTCTTTCTTATGGGAGTAAGAATCCATATGGTCATCCGCATCAAAGTGTAGTCAAAAGATTAAAACGGCA
TGGTGTGATGATGTATGGGACAAATAAAAGAACAGTGGAGATTGAAACGGATGGAGAGCATATTAAAATGTGGTCCAATG
CTCCACTCCCATTATTAAAGTAA

Upstream 100 bases:

>100_bases
GTTGCAAGAATTATCAAAATGAAAGCTTAGCACTTCGCTAAGCTTTTTTTGTATATGAAATACATAGCGTGTCATACTAA
ATGAAAAAAGGAGGCAAGTT

Downstream 100 bases:

>100_bases
CAAAGAGCAATTTCCTTTTTGGAAAAAAGAATAAGATATATTATAATGAAAATAAAGAGTAATTTCCTTTTTTAACAATA
GAAAAGGAAATTTCACTTAA

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKGVRSILLLVSVLLCFSLNSTSAKRYMMSIHAASFFSMQRPHLGKMKVSFFKVGQGDATLITLPNGQTVLIDGGPYEAG
EVLIQKLLEKGINHLDVIVGTHPDMDHIGGLIPIIEQMPVALVLDSGKTYSSLTYHTYRNHIKKRGIPFVRVKQGQYLPL
DPHVSIQVLNNGKSKDENNESSIVLKVRYGKADFLLMGDADIRTENKIVKRYDVHADVLKVGHHGSYTSTGEAFLKRVNP
QFAILSYGSKNPYGHPHQSVVKRLKRHGVMMYGTNKRTVEIETDGEHIKMWSNAPLPLLK

Sequences:

>Translated_300_residues
MKGVRSILLLVSVLLCFSLNSTSAKRYMMSIHAASFFSMQRPHLGKMKVSFFKVGQGDATLITLPNGQTVLIDGGPYEAG
EVLIQKLLEKGINHLDVIVGTHPDMDHIGGLIPIIEQMPVALVLDSGKTYSSLTYHTYRNHIKKRGIPFVRVKQGQYLPL
DPHVSIQVLNNGKSKDENNESSIVLKVRYGKADFLLMGDADIRTENKIVKRYDVHADVLKVGHHGSYTSTGEAFLKRVNP
QFAILSYGSKNPYGHPHQSVVKRLKRHGVMMYGTNKRTVEIETDGEHIKMWSNAPLPLLK
>Mature_300_residues
MKGVRSILLLVSVLLCFSLNSTSAKRYMMSIHAASFFSMQRPHLGKMKVSFFKVGQGDATLITLPNGQTVLIDGGPYEAG
EVLIQKLLEKGINHLDVIVGTHPDMDHIGGLIPIIEQMPVALVLDSGKTYSSLTYHTYRNHIKKRGIPFVRVKQGQYLPL
DPHVSIQVLNNGKSKDENNESSIVLKVRYGKADFLLMGDADIRTENKIVKRYDVHADVLKVGHHGSYTSTGEAFLKRVNP
QFAILSYGSKNPYGHPHQSVVKRLKRHGVMMYGTNKRTVEIETDGEHIKMWSNAPLPLLK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=260, Percent_Identity=28.0769230769231, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 33498; Mature: 33498

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVRSILLLVSVLLCFSLNSTSAKRYMMSIHAASFFSMQRPHLGKMKVSFFKVGQGDAT
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEE
LITLPNGQTVLIDGGPYEAGEVLIQKLLEKGINHLDVIVGTHPDMDHIGGLIPIIEQMPV
EEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCHHHHHHCCCE
ALVLDSGKTYSSLTYHTYRNHIKKRGIPFVRVKQGQYLPLDPHVSIQVLNNGKSKDENNE
EEEEECCCCCHHEEHHHHHHHHHHCCCCEEEECCCCEECCCCCEEEEEEECCCCCCCCCC
SSIVLKVRYGKADFLLMGDADIRTENKIVKRYDVHADVLKVGHHGSYTSTGEAFLKRVNP
CEEEEEEEECCEEEEEECCCCCCCCCHHHHHHCCCHHHHEECCCCCCCCHHHHHHHHCCC
QFAILSYGSKNPYGHPHQSVVKRLKRHGVMMYGTNKRTVEIETDGEHIKMWSNAPLPLLK
CEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MKGVRSILLLVSVLLCFSLNSTSAKRYMMSIHAASFFSMQRPHLGKMKVSFFKVGQGDAT
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEE
LITLPNGQTVLIDGGPYEAGEVLIQKLLEKGINHLDVIVGTHPDMDHIGGLIPIIEQMPV
EEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCHHHHHHCCCE
ALVLDSGKTYSSLTYHTYRNHIKKRGIPFVRVKQGQYLPLDPHVSIQVLNNGKSKDENNE
EEEEECCCCCHHEEHHHHHHHHHHCCCCEEEECCCCEECCCCCEEEEEEECCCCCCCCCC
SSIVLKVRYGKADFLLMGDADIRTENKIVKRYDVHADVLKVGHHGSYTSTGEAFLKRVNP
CEEEEEEEECCEEEEEECCCCCCCCCHHHHHHCCCHHHHEECCCCCCCCHHHHHHHHCCC
QFAILSYGSKNPYGHPHQSVVKRLKRHGVMMYGTNKRTVEIETDGEHIKMWSNAPLPLLK
CEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]