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The map label for this gene is pdhA [H]

Identifier: 152976386

GI number: 152976386

Start: 2758746

End: 2759861

Strand: Reverse

Name: pdhA [H]

Synonym: Bcer98_2674

Alternate gene names: 152976386

Gene position: 2759861-2758746 (Counterclockwise)

Preceding gene: 152976389

Following gene: 152976385

Centisome position: 67.53

GC content: 38.8

Gene sequence:

>1116_bases
ATGGGTACTAAAACAAAAAAGACCCTATTTAATGTTGATGAGCAAATGAAAGCTATCGCAGCTCAATTTGAAACATTACA
AATTTTAAATGAAAAAGGCGAAGTTGTGAATGAAGCAGCAATGCCTAATTTAACTGATGATCAATTAAAAGAATTAATGC
GCCGCATGGTGTATACTCGCGTACTAGATCAACGTTCTATTTCTTTAAACCGTCAAGGACGTTTAGGTTTCTATGCACCA
ACAGCTGGACAAGAAGCTTCTCAATTAGCGAGTCATTTTGCACTTGAAGCAGAAGACTTTATTTTACCGGGATATCGTGA
CGTTCCACAATTAGTATGGCACGGTCTACCATTATACCAAGCATTCTTATTCTCTCGTGGACATTTCATGGGTAACCAAA
TGCCAGAGAATGTAAATGCACTTCCTCCACAAATTATTATCGGTGCGCAAATTATCCAAACTGCTGGTGTTGCGTTAGGT
ATGAAATTACGTGGTAAAAAATCTGTTGCAATTACTTACACTGGTGATGGCGGTGCATCTCAAGGTGACTTCTATGAAGG
TATGAACTTTGCAGGTGCGTTCAAAGCTCCAGCAATCTTTGTTGTTCAAAACAACCGTTATGCAATCTCTACTCCAGTAG
AAAAACAATCTGCAGCAAAAACTGTAGCTCAAAAAGCAGTAGCAGCAGGTATTTATGGAATTCAAGTAGACGGTATGGAC
CCATTAGCTGTATACGCAGCAACTGCTTTTGCTCGTGAGCGCGCAGTAAATGGTGAAGGTCCTACTTTAATCGAGACTTT
AACATTCCGTTATGGTCCACATACAATGGCTGGTGATGACCCAACTCGTTACCGCACAAAAGATATTGAAAATGAATGGG
AACAAAAAGACCCAATCGTACGCTTCCGTGCATTCTTAGAAAATAAAGGCCTATGGTCTCAAGAAGAAGAAGAAAAAGTA
ATCGAAGAAGCAAAAGAAGATATCAAACAAGCTATTGCTAAGGCTGACCAAGCTCCAAAACAAAAAGTAACTGATTTAAT
GGAAATCATGTACGAAGAAATGCCTTACAACTTAGCTGAACAATATGAAATTTACAAAGAAAAGGAGTCGAAGTAA

Upstream 100 bases:

>100_bases
ATAAGGATTCCTATCGGTTTACATGATTGCGTTTTCTTTCTAGATGTATGCTAGTGAAAGCGTTTCAGAATATGGTTCAA
GAGAGGAAGAGGTGAACGGA

Downstream 100 bases:

>100_bases
GCCATGGCTCAAATGACAATGATTCAAGCAATCACTGATGCTTTACGCGTTGAAATGAAAAATGATCCTAACGTACTTGT
TTTTGGTGAAGACGTTGGTG

Product: pyruvate dehydrogenase (acetyl-transferring)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MGTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPNLTDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAP
TAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQAFLFSRGHFMGNQMPENVNALPPQIIIGAQIIQTAGVALG
MKLRGKKSVAITYTGDGGASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMD
PLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIVRFRAFLENKGLWSQEEEEKV
IEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEEMPYNLAEQYEIYKEKESK

Sequences:

>Translated_371_residues
MGTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPNLTDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAP
TAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQAFLFSRGHFMGNQMPENVNALPPQIIIGAQIIQTAGVALG
MKLRGKKSVAITYTGDGGASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMD
PLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIVRFRAFLENKGLWSQEEEEKV
IEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEEMPYNLAEQYEIYKEKESK
>Mature_370_residues
GTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPNLTDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAPT
AGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQAFLFSRGHFMGNQMPENVNALPPQIIIGAQIIQTAGVALGM
KLRGKKSVAITYTGDGGASQGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMDP
LAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIVRFRAFLENKGLWSQEEEEKVI
EEAKEDIKQAIAKADQAPKQKVTDLMEIMYEEMPYNLAEQYEIYKEKESK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=347, Percent_Identity=33.1412103746398, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI258645172, Length=347, Percent_Identity=33.1412103746398, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4505685, Length=333, Percent_Identity=30.6306306306306, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI291084742, Length=333, Percent_Identity=30.6306306306306, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI291084744, Length=211, Percent_Identity=36.9668246445498, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4885543, Length=307, Percent_Identity=29.6416938110749, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI291084757, Length=315, Percent_Identity=28.8888888888889, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI86563355, Length=346, Percent_Identity=33.8150289017341, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI86563357, Length=346, Percent_Identity=33.8150289017341, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17536047, Length=304, Percent_Identity=32.2368421052632, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=304, Percent_Identity=32.2368421052632, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321026, Length=378, Percent_Identity=28.042328042328, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21355903, Length=347, Percent_Identity=31.4121037463977, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24639744, Length=321, Percent_Identity=31.7757009345794, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI28571106, Length=321, Percent_Identity=31.7757009345794, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24639740, Length=321, Percent_Identity=31.7757009345794, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24639746, Length=288, Percent_Identity=32.6388888888889, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24639748, Length=285, Percent_Identity=30.5263157894737, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41498; Mature: 41367

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00037 MYB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPNLTDDQLKELMRRMVYTR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
VLDQRSISLNRQGRLGFYAPTAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQ
HHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHH
AFLFSRGHFMGNQMPENVNALPPQIIIGAQIIQTAGVALGMKLRGKKSVAITYTGDGGAS
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCCCEEEEEEECCCCCC
QGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMD
CCCHHHCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCEEEEEECCCC
PLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHH
RFRAFLENKGLWSQEEEEKVIEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEEMPYNLAE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHH
QYEIYKEKESK
HHHHHHHHCCC
>Mature Secondary Structure 
GTKTKKTLFNVDEQMKAIAAQFETLQILNEKGEVVNEAAMPNLTDDQLKELMRRMVYTR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
VLDQRSISLNRQGRLGFYAPTAGQEASQLASHFALEAEDFILPGYRDVPQLVWHGLPLYQ
HHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHH
AFLFSRGHFMGNQMPENVNALPPQIIIGAQIIQTAGVALGMKLRGKKSVAITYTGDGGAS
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCCCEEEEEEECCCCCC
QGDFYEGMNFAGAFKAPAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMD
CCCHHHCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCEEEEEECCCC
PLAVYAATAFARERAVNGEGPTLIETLTFRYGPHTMAGDDPTRYRTKDIENEWEQKDPIV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHH
RFRAFLENKGLWSQEEEEKVIEEAKEDIKQAIAKADQAPKQKVTDLMEIMYEEMPYNLAE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHH
QYEIYKEKESK
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA