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The map label for this gene is parE [H]

Identifier: 152975974

GI number: 152975974

Start: 2348980

End: 2350944

Strand: Reverse

Name: parE [H]

Synonym: Bcer98_2247

Alternate gene names: 152975974

Gene position: 2350944-2348980 (Counterclockwise)

Preceding gene: 152975975

Following gene: 152975973

Centisome position: 57.52

GC content: 38.37

Gene sequence:

>1965_bases
TTGGCAAAGCATCAATTTCAATATAATGAAGATGCAATTCAAGTGTTAGAAGGCCTTGAAGCCGTTCGAAAACGCCCGGG
TATGTATATCGGGAGCACGGACAGCCGTGGATTGCATCATTTAGTATACGAAATAGTAGATAACTCTGTTGATGAAGCAT
TAGCAGGGTTTGGCGATGAAATTTCTGTCATCATACATAAAGATAATAGTATTAGTGTTATTGATAAAGGGCGAGGAATG
CCGACGGGAATGCATAAACTTGGGAAACCAACACCTGAAGTTATTTTAACTATACTTCATGCAGGTGGTAAGTTTGGACA
AGGTGGCTATAAAACAAGCGGTGGTTTACACGGTGTTGGAGCATCGGTTGTAAATGCACTATCAGAATGGCTAGTCGTAA
CAATTAAGCGCGATGGAAACATTTATGAGCAACGCTTTGAAAATGGCGGTATTCCTGTAACAACGTTAGAGAAAATTGGA
AAAACGAAAGAATCTGGTACAACGATGCATTTTAAACCGGATTCATCTATTTTTAGTACAACAAATTATAATTATGAGAC
GTTATGTGAAAGATTACGTGAATCGGCATTCTTATTAAAAGGGATGAAAATTTCAATCAAAGATGAGCGAAATGATTTAG
AAGATGTTTTCCATTATGAAACAGGTATTGAGGCTTTTGTTTCATATTTAAATGAGGAGAAAGATGCGATTCATCCCGTT
GTTTATTTCTCCGGAGAACAAAATGGAATTGAAGCAGAGTTAGCATTTCAGTTTAACGATGGCTATTCAGAGAACATTCT
TTCATTTGTAAATAATGTACGTACGAAAGATGGCGGGACGCATGAAGCTGGATTTAAAACAGCAATGACTCGTGTCTTCA
ATGAATATGCTCGCAAAGTTTCTTTATTAAAAGAAAAAGATAAGAATTTAGAAGGTACAGATATTCGTGAAGGGTTAGCA
GCGGTTGTTTCTGTTCGTGTACCAGAAGAGTTACTTCAATTTGAAGGACAAACGAAAGGAAAACTCGGCACAAGTGAGGC
TCGTTCTTCTATTGATGCGATTGTATCGGAGCACTTAGCTTACTTTTTAGAAGAAACTCCTGATGTAGCTACACTTCTTG
TGAAAAAAGCGATTAAAGCAGCACAGGCACGAGAAGCTGCTCGTAAAGCGAGAGAAGAAGCGCGTACTGGCAAGAAGAAA
AAGCGTTCAGAAGGGACTTTAAGCGGAAAGTTAACACCTGCACAATCACGTAACCCACAGAAAAATGAATTGTATTTAGT
AGAGGGTGATTCTGCTGGTGGATCTGCGAAACAAGGACGTGATCGTCGTTTTCAAGCAGTATTACCTCTTCGTGGTAAAG
TAATCAATACGGAAAAGGCAAAACTTGCTGATATTTTCAAAAATGAAGAGATTAATACAATCATTTATGCAATCGGTGGC
GGTGTTGGCAATGAGTTTTCTATTGAAGATATCAACTATGATAAAGTGGTGATCATGACCGATGCCGATACAGATGGAGC
TCATATTCAAGTGCTGTTACTTACATTTTTCTATCGCTATATGAAGTCGTTAATTGAAGCTGGAAAAGTATTTATTGCCC
TTCCACCTTTATATAAAGTAAGTAAAGGAAAAGGAAAAAACGAAGTGATTGAATATGCATGGTCAGATGAAGAGTTGGCT
AGCGTAACGAAAAAAGTTGGGAAAGGTTATATCTTACAGCGTTATAAAGGACTTGGTGAAATGAACGCCGATCAATTATG
GGAAACAACGATGAATCCAGAGACGCGTACATTAATTCGTGTGAAAATTGATGATGCGGCAAGAGCAGAACGTCGCGTTA
CAACGTTGATGGGAGATAAAGTAGAACCTCGTCGTAAATGGATTGAGCGCAATGTACAGTTCGGTATGCAAGAAGAAGGC
AATATTTTAGAAAATGAAATGATTATGGAGACGGAGGTGGAATAA

Upstream 100 bases:

>100_bases
GTATATAAAAGGATAACATACCTTGCCAAACACATGGTTAAGGCGTTATTCTATAATAGAAACATATGTTCTGATTTTGA
CTAGGAAAGGGGCAAGGAGT

Downstream 100 bases:

>100_bases
CATGCAAGCAGAGAAGTTTCATGACCTCCCGCTTGAAGATGTGTTAGGTGATCGCTTTGCACGTTACAGTAAATATATTA
TTCAAGATCGTGCGCTTCCA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MAKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVIIHKDNSISVIDKGRGM
PTGMHKLGKPTPEVILTILHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIKRDGNIYEQRFENGGIPVTTLEKIG
KTKESGTTMHFKPDSSIFSTTNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDAIHPV
VYFSGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVSLLKEKDKNLEGTDIREGLA
AVVSVRVPEELLQFEGQTKGKLGTSEARSSIDAIVSEHLAYFLEETPDVATLLVKKAIKAAQAREAARKAREEARTGKKK
KRSEGTLSGKLTPAQSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGG
GVGNEFSIEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKSLIEAGKVFIALPPLYKVSKGKGKNEVIEYAWSDEELA
SVTKKVGKGYILQRYKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEG
NILENEMIMETEVE

Sequences:

>Translated_654_residues
MAKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVIIHKDNSISVIDKGRGM
PTGMHKLGKPTPEVILTILHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIKRDGNIYEQRFENGGIPVTTLEKIG
KTKESGTTMHFKPDSSIFSTTNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDAIHPV
VYFSGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVSLLKEKDKNLEGTDIREGLA
AVVSVRVPEELLQFEGQTKGKLGTSEARSSIDAIVSEHLAYFLEETPDVATLLVKKAIKAAQAREAARKAREEARTGKKK
KRSEGTLSGKLTPAQSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGG
GVGNEFSIEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKSLIEAGKVFIALPPLYKVSKGKGKNEVIEYAWSDEELA
SVTKKVGKGYILQRYKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEG
NILENEMIMETEVE
>Mature_653_residues
AKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVIIHKDNSISVIDKGRGMP
TGMHKLGKPTPEVILTILHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIKRDGNIYEQRFENGGIPVTTLEKIGK
TKESGTTMHFKPDSSIFSTTNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDAIHPVV
YFSGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVSLLKEKDKNLEGTDIREGLAA
VVSVRVPEELLQFEGQTKGKLGTSEARSSIDAIVSEHLAYFLEETPDVATLLVKKAIKAAQAREAARKAREEARTGKKKK
RSEGTLSGKLTPAQSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGGG
VGNEFSIEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKSLIEAGKVFIALPPLYKVSKGKGKNEVIEYAWSDEELAS
VTKKVGKGYILQRYKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEGN
ILENEMIMETEVE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=638, Percent_Identity=26.0188087774295, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI19913408, Length=658, Percent_Identity=24.468085106383, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI48994957, Length=542, Percent_Identity=53.1365313653137, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1789408, Length=656, Percent_Identity=38.719512195122, Blast_Score=424, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17535065, Length=679, Percent_Identity=25.1840942562592, Blast_Score=145, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI212645845, Length=600, Percent_Identity=25.6666666666667, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI212645657, Length=248, Percent_Identity=27.4193548387097, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=649, Percent_Identity=26.8104776579353, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI17136538, Length=674, Percent_Identity=24.7774480712166, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72910; Mature: 72778

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDE
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCC
ISVIIHKDNSISVIDKGRGMPTGMHKLGKPTPEVILTILHAGGKFGQGGYKTSGGLHGVG
EEEEEECCCCEEEEECCCCCCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
ASVVNALSEWLVVTIKRDGNIYEQRFENGGIPVTTLEKIGKTKESGTTMHFKPDSSIFST
HHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEECCCCCEEEC
TNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDAIHPV
CCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VYFSGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKV
EEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
SLLKEKDKNLEGTDIREGLAAVVSVRVPEELLQFEGQTKGKLGTSEARSSIDAIVSEHLA
HHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
YFLEETPDVATLLVKKAIKAAQAREAARKAREEARTGKKKKRSEGTLSGKLTPAQSRNPQ
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCC
KNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGG
CCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCCCCEEEEEECC
GVGNEFSIEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKSLIEAGKVFIALPPLYKV
CCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
SKGKGKNEVIEYAWSDEELASVTKKVGKGYILQRYKGLGEMNADQLWETTMNPETRTLIR
CCCCCCCHHEEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEE
VKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEGNILENEMIMETEVE
EEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHCCEEEEECCC
>Mature Secondary Structure 
AKHQFQYNEDAIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDE
CCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCC
ISVIIHKDNSISVIDKGRGMPTGMHKLGKPTPEVILTILHAGGKFGQGGYKTSGGLHGVG
EEEEEECCCCEEEEECCCCCCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
ASVVNALSEWLVVTIKRDGNIYEQRFENGGIPVTTLEKIGKTKESGTTMHFKPDSSIFST
HHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEECCCCCEEEC
TNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDAIHPV
CCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VYFSGEQNGIEAELAFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKV
EEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
SLLKEKDKNLEGTDIREGLAAVVSVRVPEELLQFEGQTKGKLGTSEARSSIDAIVSEHLA
HHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
YFLEETPDVATLLVKKAIKAAQAREAARKAREEARTGKKKKRSEGTLSGKLTPAQSRNPQ
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCC
KNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGG
CCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCCCCEEEEEECC
GVGNEFSIEDINYDKVVIMTDADTDGAHIQVLLLTFFYRYMKSLIEAGKVFIALPPLYKV
CCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
SKGKGKNEVIEYAWSDEELASVTKKVGKGYILQRYKGLGEMNADQLWETTMNPETRTLIR
CCCCCCCHHEEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEE
VKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEGNILENEMIMETEVE
EEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]