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The map label for this gene is parC [H]

Identifier: 152975973

GI number: 152975973

Start: 2346555

End: 2348978

Strand: Reverse

Name: parC [H]

Synonym: Bcer98_2246

Alternate gene names: 152975973

Gene position: 2348978-2346555 (Counterclockwise)

Preceding gene: 152975974

Following gene: 152975972

Centisome position: 57.47

GC content: 37.42

Gene sequence:

>2424_bases
ATGCAAGCAGAGAAGTTTCATGACCTCCCGCTTGAAGATGTGTTAGGTGATCGCTTTGCACGTTACAGTAAATATATTAT
TCAAGATCGTGCGCTTCCAGATGCGCGTGACGGTTTAAAACCAGTACAAAGACGTATTTTATATTCCATGTATGTAGAAG
GAAATGTGAATGATAAGCCATTTCGTAAATCAGCTAAAACAGTTGGTAATGTTATCGGTAACTATCATCCGCATGGTGAT
TCTTCTGTATATGAAGCCATGGTTCGTTTAAGTCAAGATTGGAAAGTTCGAAATGTTTTAGTTGAAATGCATGGGAATAA
TGGTAGTGTAGATGGCGACCCAGCAGCGGCTATGCGTTATACAGAAGCGCGCTTATCGCCAATCGCTTCTGAACTTCTCC
GTGATATTGATAAAGAAACGGTGGAGTTTGTTCCAAACTTTGATGATACAAGTGAAGAACCGGTTGTCTTACCTGCGATG
TTTCCAAACTTATTAGTAAATGGATCAACGGGGATTTCGGCTGGATATGCAACAGAAATTCCTCCGCATCATCTTGGTGA
AGTAATCGATGCGACAATGATGCGCATTGATAAGCCGAATTGTACGGTAGATGATTTACTAGCAATTATAAAAGGACCGG
ATTTTCCAACGGGCGGTATCATTCAAGGAATTGATGGAATAAAAAAAGCATATGAAACTGGAAAAGGAAAAATAATTATT
CGCGGAAAAGCAGAGGTAGAAACGATTCGTGGTGGAAAACAACAAATCGTTATTACAGAAATCCCTTACGAAGTAAACAA
GGCGAATCTCGTAAAAAAAATGGATGAACTACGTCTTGATAAAAAGTTAGATGGAATTGCAGAAGTTCGTGATGAAACGG
ATCGTACAGGTCTTCGTATCGTTATAGAGTTGAAAAAAGAAGCAAATGCGGAAGGGATTTTAAATTACTTATATAAAAAC
ACAGATTTACAAATCACATACAACTTTAATATGGTAGCGATTAATAATCGACGTCCAACGCTTATGACATTGCCAAATAT
TTTAGATGCCTATATCGGACATCAAAAGGAAGTTGTGACAAGGCGTTCGCAGTATGAATTAAGAAAAGCAGAAAATCGTC
AACATATTGTAGAAGGCTTAATGAAAGCTTTATCAATTTTAGATCAAGTAATTGAAACCATTCGAGCATCTAAAGATAAA
CGAAATGCGAAAGATAATTTAATTGCAAAATTTAGCTTTACAGAAGCGCAGGCAGAAGCAATTGTTTCCTTACAGTTATA
TCGTTTAACAAATACAGATATTACAGCACTAGAGAATGAAGCGGAAGAATTGAATCAAAAAATCACAACGTTACAAGCTA
TTTTAAACAGTGAAAAGAAACTTCTTCAAGTCATTAAAGCGGATTTAAAACGAGTGAAGAAAACATATAGTGACGAACGC
CGTTCTGTAATTGAAGAAGAAATTGAAGAAATTAAAATTGATGTAGAAGTGATGATTCCGCAAGAAGATGTTATCGTTAC
AGTAACGAAAGAAGGGTATGTGAAGCGAACGGGCTGGCGTTCGCATAATGCATCAAATGGGAAAGACTTCGGTATGAAAG
AGGGCGACGTCTTACTCGAACGATTTGATACAAATACGACAGAAACGGTTCTCTTGTTTACGAATAAAGGAAATTACATT
TATTTACCTGTATATGAAATGCCGGATATTCGTTGGAAAGATTTAGGACAGCACGTTGCAAATATCGTTTCACTGGATCG
CGATGAGACGTTAATATGGGCTACGGTTGTACCGAATTTTGAGGAAGAAAAGCGATTTGTCGTATTTGTTACACGAAATG
GTATGATTAAGAAAACAGAACTGAACCAATATAAAGTCCAGCGTTACTCTCGAGCATTTGTGGCGATAAATTTGAAAAAA
GATGATGAAGTTGTCGATATCTTTGCGACAGATGGAACAAGTGATATTGTTCTTGCGACACACGGTGCATATGCACTTAT
TTTTGATGAGGAAGAAGTGAGTCCGGTTGGCGTAAGGGCAGCTGGTGTTAAGGCAATTAATTTAAAAGAAGATGATTATG
TTGCTGCTGGTAAACCGTTAAATAGTGAAAAAGATCAATTCATGCTTGTTACACAGCGCGGTGCAGTGAAACGATTAAAA
GCTTCTGAAATTGAAAAATCAACAAGGGCGAAACGAGGCCTTGTCATTTTTAAAGAATTAAAACGGAATCCGTACCGTAT
TGTTGGCATTGAGGTTATTCGAGATGACGAATTAGTATATATGAAAACAGAAAAACAAATTGTAGAAGAAATTGATCCAA
AAACTTTCCGGAATAAAGACCGCTACAGTAATGGAAGTCTCGTACTAGATGTGAATGAGACAGGCGAAGTGGTTGAAACG
TGGACGCAGAAACGAACTGAATAA

Upstream 100 bases:

>100_bases
CCTCGTCGTAAATGGATTGAGCGCAATGTACAGTTCGGTATGCAAGAAGAAGGCAATATTTTAGAAAATGAAATGATTAT
GGAGACGGAGGTGGAATAAC

Downstream 100 bases:

>100_bases
ATAGAAGAAATCCTTGCTAGTTTCCATATAGCAAGGATTTTTTGGCCATGAAGCAAAGTATTAGGCAGATAACAATACCC
TTGCTATAATGAAAAATGAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 807; Mature: 807

Protein sequence:

>807_residues
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVNDKPFRKSAKTVGNVIGNYHPHGD
SSVYEAMVRLSQDWKVRNVLVEMHGNNGSVDGDPAAAMRYTEARLSPIASELLRDIDKETVEFVPNFDDTSEEPVVLPAM
FPNLLVNGSTGISAGYATEIPPHHLGEVIDATMMRIDKPNCTVDDLLAIIKGPDFPTGGIIQGIDGIKKAYETGKGKIII
RGKAEVETIRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRIVIELKKEANAEGILNYLYKN
TDLQITYNFNMVAINNRRPTLMTLPNILDAYIGHQKEVVTRRSQYELRKAENRQHIVEGLMKALSILDQVIETIRASKDK
RNAKDNLIAKFSFTEAQAEAIVSLQLYRLTNTDITALENEAEELNQKITTLQAILNSEKKLLQVIKADLKRVKKTYSDER
RSVIEEEIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDVLLERFDTNTTETVLLFTNKGNYI
YLPVYEMPDIRWKDLGQHVANIVSLDRDETLIWATVVPNFEEEKRFVVFVTRNGMIKKTELNQYKVQRYSRAFVAINLKK
DDEVVDIFATDGTSDIVLATHGAYALIFDEEEVSPVGVRAAGVKAINLKEDDYVAAGKPLNSEKDQFMLVTQRGAVKRLK
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEVIRDDELVYMKTEKQIVEEIDPKTFRNKDRYSNGSLVLDVNETGEVVET
WTQKRTE

Sequences:

>Translated_807_residues
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVNDKPFRKSAKTVGNVIGNYHPHGD
SSVYEAMVRLSQDWKVRNVLVEMHGNNGSVDGDPAAAMRYTEARLSPIASELLRDIDKETVEFVPNFDDTSEEPVVLPAM
FPNLLVNGSTGISAGYATEIPPHHLGEVIDATMMRIDKPNCTVDDLLAIIKGPDFPTGGIIQGIDGIKKAYETGKGKIII
RGKAEVETIRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRIVIELKKEANAEGILNYLYKN
TDLQITYNFNMVAINNRRPTLMTLPNILDAYIGHQKEVVTRRSQYELRKAENRQHIVEGLMKALSILDQVIETIRASKDK
RNAKDNLIAKFSFTEAQAEAIVSLQLYRLTNTDITALENEAEELNQKITTLQAILNSEKKLLQVIKADLKRVKKTYSDER
RSVIEEEIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDVLLERFDTNTTETVLLFTNKGNYI
YLPVYEMPDIRWKDLGQHVANIVSLDRDETLIWATVVPNFEEEKRFVVFVTRNGMIKKTELNQYKVQRYSRAFVAINLKK
DDEVVDIFATDGTSDIVLATHGAYALIFDEEEVSPVGVRAAGVKAINLKEDDYVAAGKPLNSEKDQFMLVTQRGAVKRLK
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEVIRDDELVYMKTEKQIVEEIDPKTFRNKDRYSNGSLVLDVNETGEVVET
WTQKRTE
>Mature_807_residues
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVNDKPFRKSAKTVGNVIGNYHPHGD
SSVYEAMVRLSQDWKVRNVLVEMHGNNGSVDGDPAAAMRYTEARLSPIASELLRDIDKETVEFVPNFDDTSEEPVVLPAM
FPNLLVNGSTGISAGYATEIPPHHLGEVIDATMMRIDKPNCTVDDLLAIIKGPDFPTGGIIQGIDGIKKAYETGKGKIII
RGKAEVETIRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRIVIELKKEANAEGILNYLYKN
TDLQITYNFNMVAINNRRPTLMTLPNILDAYIGHQKEVVTRRSQYELRKAENRQHIVEGLMKALSILDQVIETIRASKDK
RNAKDNLIAKFSFTEAQAEAIVSLQLYRLTNTDITALENEAEELNQKITTLQAILNSEKKLLQVIKADLKRVKKTYSDER
RSVIEEEIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDVLLERFDTNTTETVLLFTNKGNYI
YLPVYEMPDIRWKDLGQHVANIVSLDRDETLIWATVVPNFEEEKRFVVFVTRNGMIKKTELNQYKVQRYSRAFVAINLKK
DDEVVDIFATDGTSDIVLATHGAYALIFDEEEVSPVGVRAAGVKAINLKEDDYVAAGKPLNSEKDQFMLVTQRGAVKRLK
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEVIRDDELVYMKTEKQIVEEIDPKTFRNKDRYSNGSLVLDVNETGEVVET
WTQKRTE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=355, Percent_Identity=25.3521126760563, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI19913406, Length=175, Percent_Identity=30.2857142857143, Blast_Score=76, Evalue=2e-13,
Organism=Escherichia coli, GI1788562, Length=794, Percent_Identity=39.5465994962217, Blast_Score=549, Evalue=1e-157,
Organism=Escherichia coli, GI1789396, Length=749, Percent_Identity=33.5113484646195, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17535065, Length=168, Percent_Identity=31.547619047619, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=494, Percent_Identity=22.2672064777328, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=188, Percent_Identity=27.1276595744681, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136538, Length=168, Percent_Identity=30.3571428571429, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 91640; Mature: 91640

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVNDKP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHEEEECCCCCCC
FRKSAKTVGNVIGNYHPHGDSSVYEAMVRLSQDWKVRNVLVEMHGNNGSVDGDPAAAMRY
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHHH
TEARLSPIASELLRDIDKETVEFVPNFDDTSEEPVVLPAMFPNLLVNGSTGISAGYATEI
HHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEHHHCCHHEECCCCCCCCCCCCCC
PPHHLGEVIDATMMRIDKPNCTVDDLLAIIKGPDFPTGGIIQGIDGIKKAYETGKGKIII
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
RGKAEVETIRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRI
ECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VIELKKEANAEGILNYLYKNTDLQITYNFNMVAINNRRPTLMTLPNILDAYIGHQKEVVT
EEEECCCCCHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCEEEHHHHHHHHHCCHHHHHH
RRSQYELRKAENRQHIVEGLMKALSILDQVIETIRASKDKRNAKDNLIAKFSFTEAQAEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHH
IVSLQLYRLTNTDITALENEAEELNQKITTLQAILNSEKKLLQVIKADLKRVKKTYSDER
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RSVIEEEIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDVLLE
HHHHHHHHHHEEEEEEEEECCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCHHHH
RFDTNTTETVLLFTNKGNYIYLPVYEMPDIRWKDLGQHVANIVSLDRDETLIWATVVPNF
HCCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
EEEKRFVVFVTRNGMIKKTELNQYKVQRYSRAFVAINLKKDDEVVDIFATDGTSDIVLAT
CCCCEEEEEEECCCEEEECCCHHHHHHHHCEEEEEEEECCCCCEEEEEECCCCCCEEEEE
HGAYALIFDEEEVSPVGVRAAGVKAINLKEDDYVAAGKPLNSEKDQFMLVTQRGAVKRLK
CCEEEEEECCCCCCCCCEEECCEEEEECCCCCEEECCCCCCCCCCCEEEEECCCHHHHHH
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEVIRDDELVYMKTEKQIVEEIDPKTFRNKD
HHHHHHHHHHHCCEEEEHHHCCCCEEEEEEEEEECCCEEEEEHHHHHHHHCCCHHHCCCC
RYSNGSLVLDVNETGEVVETWTQKRTE
CCCCCCEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVNDKP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHEEEECCCCCCC
FRKSAKTVGNVIGNYHPHGDSSVYEAMVRLSQDWKVRNVLVEMHGNNGSVDGDPAAAMRY
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHHH
TEARLSPIASELLRDIDKETVEFVPNFDDTSEEPVVLPAMFPNLLVNGSTGISAGYATEI
HHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEHHHCCHHEECCCCCCCCCCCCCC
PPHHLGEVIDATMMRIDKPNCTVDDLLAIIKGPDFPTGGIIQGIDGIKKAYETGKGKIII
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
RGKAEVETIRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRI
ECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VIELKKEANAEGILNYLYKNTDLQITYNFNMVAINNRRPTLMTLPNILDAYIGHQKEVVT
EEEECCCCCHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCEEEHHHHHHHHHCCHHHHHH
RRSQYELRKAENRQHIVEGLMKALSILDQVIETIRASKDKRNAKDNLIAKFSFTEAQAEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHH
IVSLQLYRLTNTDITALENEAEELNQKITTLQAILNSEKKLLQVIKADLKRVKKTYSDER
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RSVIEEEIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDVLLE
HHHHHHHHHHEEEEEEEEECCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCHHHH
RFDTNTTETVLLFTNKGNYIYLPVYEMPDIRWKDLGQHVANIVSLDRDETLIWATVVPNF
HCCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
EEEKRFVVFVTRNGMIKKTELNQYKVQRYSRAFVAINLKKDDEVVDIFATDGTSDIVLAT
CCCCEEEEEEECCCEEEECCCHHHHHHHHCEEEEEEEECCCCCEEEEEECCCCCCEEEEE
HGAYALIFDEEEVSPVGVRAAGVKAINLKEDDYVAAGKPLNSEKDQFMLVTQRGAVKRLK
CCEEEEEECCCCCCCCCEEECCEEEEECCCCCEEECCCCCCCCCCCEEEEECCCHHHHHH
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEVIRDDELVYMKTEKQIVEEIDPKTFRNKD
HHHHHHHHHHHCCEEEEHHHCCCCEEEEEEEEEECCCEEEEEHHHHHHHHCCCHHHCCCC
RYSNGSLVLDVNETGEVVETWTQKRTE
CCCCCCEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]