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The map label for this gene is phoR [H]

Identifier: 152974826

GI number: 152974826

Start: 1139153

End: 1140532

Strand: Direct

Name: phoR [H]

Synonym: Bcer98_1022

Alternate gene names: 152974826

Gene position: 1139153-1140532 (Clockwise)

Preceding gene: 152974825

Following gene: 152974827

Centisome position: 27.87

GC content: 35.58

Gene sequence:

>1380_bases
ATGTTTACAATGGTACAGAAGCTATGGCTTACAGTTGTATGTGCAGTATGTATAACAGTTTCTTTTCTTTACTTTGTGTC
ATTGTACTCGTATGAAAAATTATACGTTCAAAATATTAAAGACACATTAATTGTAGAAGGAAAAAAACTTGTTTCACAAT
ACAATAAGCGTGAAGGGATTTCTGCATTTGAGGAAAAGGTAAGAATGTTTGATAGAGTCTCTCATGCAGATATACTATTT
GTAAATAACCCGCGTGATTTAAGTGCGTGCTTACCTTTTGATGTGCATTATGATTCACTTATTAGTGAACAGGATCGACA
AATATTATTAGACGGTAAAACAGTGACAAAGGTTGGATATGAGGAACACTTTAATCGGAATATTATGGGAGTAGTTATTC
CTGTTTTAGAAGAAAAGAAATTAGTGGGAATTGTATATTCTTACATCCCTTTAAAAAGTATTAAAGATTTAATATTTGAT
ATGGGCATCATTTTAGCACCGTTAGCGCTTATTATAGTAATACTTACTGTATGGATTGGCCGGAAAATTATTATTGCGAT
TACAAAGCCGCTTTCACAAATGGAACAGATTGCAAACCATATGGCAACGGGGGACTTTTCAGAGCGTATTACCATTTCAT
CTGAGGATGAAATAGGTCGCCTTGGAAGAGCATTTAATAAAATGGCTACTTCATTGGAGAATGAAGATATAAAGCGAAAG
GAATTTTTAGCGAATGTTTCACATGAACTTCGGACGCCTCTTAGCTATATTAAAGGATATAGTGAAGCGATTTTAGATGG
TGTGGCAAAGGGGAAACAAGAGAAATTTATGCAACTTATTCATAAAGAAGCAGGACGGATGCAGCGACTTGTGCATGATT
TATTAGATTTAGCTCAATTAGAAGGGGAGCATTTTCCACTTCAAAAACAGCCAATCGTCTTTGCGCAGCTTATTGAAGAT
GTGGTGGAAACGTATGAATGGAAATGTATCGAAAAACAAGTGGAAATTTCAATGGAACTAGATCCGGATATTATTGTAAT
GATTGATGAAGATCGAATGCAACAGGTGCTCCATAACATATTGGATAATGCTATCCGCTATACAAATGAAAAGGGAAAGA
TTACAGTGCAGCTACAGAAGCTGAAGAAAGATTGTCAGTTGAAAATCATGGATACAGGAATTGGAATTGAACGAGAACAT
GTAGAACAACTTGGCGAAAGATTTTATCGAGTTGATAAAGCAAGAAGTCGTCAGCATGGTGGGACTGGACTCGGACTTGC
GATTGTAAAACAAATTGTGCACATTCATGATGGGAAATGGAAAATTGAGAGCGAAAAAGGAAAAGGAACAACTGTTATGA
TCCAATTACAAATGGAGTAA

Upstream 100 bases:

>100_bases
ACGGTGGATACACATGTGAAAACAATGCGTTTGAAACTAGGAGAAAGCGGAAACTGCATCCAAACAGTTTGGGGTGTAGG
ATATAAATTTGAGGTGTAAT

Downstream 100 bases:

>100_bases
CGCAGAGAGGGGGGCATGGTAGAACGATAGGATTTTTATGGAAATGAAGGGTGAAAATAATATAGTATGCAGAGAAAAGG
AAGATAAATAGAAAAATTAT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MFTMVQKLWLTVVCAVCITVSFLYFVSLYSYEKLYVQNIKDTLIVEGKKLVSQYNKREGISAFEEKVRMFDRVSHADILF
VNNPRDLSACLPFDVHYDSLISEQDRQILLDGKTVTKVGYEEHFNRNIMGVVIPVLEEKKLVGIVYSYIPLKSIKDLIFD
MGIILAPLALIIVILTVWIGRKIIIAITKPLSQMEQIANHMATGDFSERITISSEDEIGRLGRAFNKMATSLENEDIKRK
EFLANVSHELRTPLSYIKGYSEAILDGVAKGKQEKFMQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLQKQPIVFAQLIED
VVETYEWKCIEKQVEISMELDPDIIVMIDEDRMQQVLHNILDNAIRYTNEKGKITVQLQKLKKDCQLKIMDTGIGIEREH
VEQLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHDGKWKIESEKGKGTTVMIQLQME

Sequences:

>Translated_459_residues
MFTMVQKLWLTVVCAVCITVSFLYFVSLYSYEKLYVQNIKDTLIVEGKKLVSQYNKREGISAFEEKVRMFDRVSHADILF
VNNPRDLSACLPFDVHYDSLISEQDRQILLDGKTVTKVGYEEHFNRNIMGVVIPVLEEKKLVGIVYSYIPLKSIKDLIFD
MGIILAPLALIIVILTVWIGRKIIIAITKPLSQMEQIANHMATGDFSERITISSEDEIGRLGRAFNKMATSLENEDIKRK
EFLANVSHELRTPLSYIKGYSEAILDGVAKGKQEKFMQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLQKQPIVFAQLIED
VVETYEWKCIEKQVEISMELDPDIIVMIDEDRMQQVLHNILDNAIRYTNEKGKITVQLQKLKKDCQLKIMDTGIGIEREH
VEQLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHDGKWKIESEKGKGTTVMIQLQME
>Mature_459_residues
MFTMVQKLWLTVVCAVCITVSFLYFVSLYSYEKLYVQNIKDTLIVEGKKLVSQYNKREGISAFEEKVRMFDRVSHADILF
VNNPRDLSACLPFDVHYDSLISEQDRQILLDGKTVTKVGYEEHFNRNIMGVVIPVLEEKKLVGIVYSYIPLKSIKDLIFD
MGIILAPLALIIVILTVWIGRKIIIAITKPLSQMEQIANHMATGDFSERITISSEDEIGRLGRAFNKMATSLENEDIKRK
EFLANVSHELRTPLSYIKGYSEAILDGVAKGKQEKFMQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLQKQPIVFAQLIED
VVETYEWKCIEKQVEISMELDPDIIVMIDEDRMQQVLHNILDNAIRYTNEKGKITVQLQKLKKDCQLKIMDTGIGIEREH
VEQLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHDGKWKIESEKGKGTTVMIQLQME

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=33.5766423357664, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1786600, Length=213, Percent_Identity=39.906103286385, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789149, Length=367, Percent_Identity=24.7956403269755, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1786783, Length=369, Percent_Identity=28.4552845528455, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=26.9709543568465, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=28.8793103448276, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=29.0441176470588, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=30, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790861, Length=339, Percent_Identity=25.9587020648968, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=30.9322033898305, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=24.1071428571429, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1787894, Length=262, Percent_Identity=26.7175572519084, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=27.8969957081545, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=26.605504587156, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790551, Length=295, Percent_Identity=26.7796610169492, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788279, Length=274, Percent_Identity=25.1824817518248, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082128, Length=293, Percent_Identity=22.5255972696246, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789808, Length=458, Percent_Identity=24.6724890829694, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789403, Length=276, Percent_Identity=24.6376811594203, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787374, Length=287, Percent_Identity=24.7386759581882, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=225, Percent_Identity=23.1111111111111, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52724; Mature: 52724

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTMVQKLWLTVVCAVCITVSFLYFVSLYSYEKLYVQNIKDTLIVEGKKLVSQYNKREGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCH
SAFEEKVRMFDRVSHADILFVNNPRDLSACLPFDVHYDSLISEQDRQILLDGKTVTKVGY
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCHHHHHCCCCCEEEECCCHHHHCCH
EEHFNRNIMGVVIPVLEEKKLVGIVYSYIPLKSIKDLIFDMGIILAPLALIIVILTVWIG
HHHHCCCCCEEEEHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RKIIIAITKPLSQMEQIANHMATGDFSERITISSEDEIGRLGRAFNKMATSLENEDIKRK
CEEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCHHHH
EFLANVSHELRTPLSYIKGYSEAILDGVAKGKQEKFMQLIHKEAGRMQRLVHDLLDLAQL
HHHHHHHHHHHCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGEHFPLQKQPIVFAQLIEDVVETYEWKCIEKQVEISMELDPDIIVMIDEDRMQQVLHNI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCHHHHHHHHHH
LDNAIRYTNEKGKITVQLQKLKKDCQLKIMDTGIGIEREHVEQLGERFYRVDKARSRQHG
HHHHHHHCCCCCCEEEEHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GTGLGLAIVKQIVHIHDGKWKIESEKGKGTTVMIQLQME
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEC
>Mature Secondary Structure
MFTMVQKLWLTVVCAVCITVSFLYFVSLYSYEKLYVQNIKDTLIVEGKKLVSQYNKREGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCH
SAFEEKVRMFDRVSHADILFVNNPRDLSACLPFDVHYDSLISEQDRQILLDGKTVTKVGY
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCHHHHHCCCCCEEEECCCHHHHCCH
EEHFNRNIMGVVIPVLEEKKLVGIVYSYIPLKSIKDLIFDMGIILAPLALIIVILTVWIG
HHHHCCCCCEEEEHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RKIIIAITKPLSQMEQIANHMATGDFSERITISSEDEIGRLGRAFNKMATSLENEDIKRK
CEEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCHHHH
EFLANVSHELRTPLSYIKGYSEAILDGVAKGKQEKFMQLIHKEAGRMQRLVHDLLDLAQL
HHHHHHHHHHHCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGEHFPLQKQPIVFAQLIEDVVETYEWKCIEKQVEISMELDPDIIVMIDEDRMQQVLHNI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCHHHHHHHHHH
LDNAIRYTNEKGKITVQLQKLKKDCQLKIMDTGIGIEREHVEQLGERFYRVDKARSRQHG
HHHHHHHCCCCCCEEEEHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GTGLGLAIVKQIVHIHDGKWKIESEKGKGTTVMIQLQME
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]