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The map label for this gene is arnA [H]

Identifier: 152974263

GI number: 152974263

Start: 485215

End: 486180

Strand: Direct

Name: arnA [H]

Synonym: Bcer98_0430

Alternate gene names: 152974263

Gene position: 485215-486180 (Clockwise)

Preceding gene: 152974262

Following gene: 152974264

Centisome position: 11.87

GC content: 35.71

Gene sequence:

>966_bases
ATGAAGAAACGTTGTTTGATTACAGGTGGAGCAGGATTTATTGGATCACATTTAGCGGAAGAACTCGTGAAACGAGGTCA
TCCAGTTACGATTGTTGATAATTTTTATAAAGGAAAAAGTAAATATCATGAAGAGTTAACAGGAAATATTCCGATTATTC
CAATTAGTATTCTTGATAAAAATTCAATGCATGAATTGGTAAATCAGCATGATGTTGTCTTTCATTTAGCTGCTATTTTA
GGTGTAAAGACTACAATGGAAAAAAGCATTGAATTAATTGAAACGAATTTTGATGGAACAAGAAATATTTTACAAGCAGC
ATTAAAGGGGAAGAAGAAAGTGATTTTTGCCTCCACTTCTGAAGTGTATGGAAAAGGAACGCCACCCTTTTCGGAAGATG
ATGATCGGTTATATGGGGCAACATCTAAAATTCGTTGGAGTTATGCAATTTGTAAAACATTAGAAGAGACATTGTGTTTA
GGATATGCGCTACAAGGATTACCAGTAACAATTGTCCGTTATTTTAATATTTATGGCCCTAGAGCAAAAGATGGTCCATA
TGCTGGGGTGATTCCGCGATTTATTCGTGCAGCACTTCAAGGTGATGATCTTCTTGTATATGGAGATGGAAAGCAAACGC
GTTGTTTTACGTATGTAAGTGATGCGGTAGAAGCGACAATTGCCGCAATGGATGAAAAAGTAAATGGAGAAATTATTAAT
ATAGGATCTGAAGACGAAAAAAGCATTCAAGAAGTAGCGCAAGATATTCATCAATTGACGCATTCATCTTCCAAAATTGT
TCATGTGCCATTTGAAAAGGTGTATCCACATGGGTTTGAAGAAATTCCGAATCGAAAGCCTGATGTTACAAAGCTAAAAG
AAATGTGCCAATTCCATCCTAATGTTTCATGGGAGCAAGGATTAAAAGAGACGATTCAGTGGTTTCGTGAAATAGAGAAT
GATTAA

Upstream 100 bases:

>100_bases
GCATACTAATTGTAACAGATCATTCCAATATAGATTGGAATATATGTAAAGGAATGAAGCATGTAATAGATACACGAGGT
GTACTAAAGAAGGTGAGTGC

Downstream 100 bases:

>100_bases
AAGATGATTCGTGATGATATCTGTTTGTCATCAGACCTAAAGTTTAAAATTATAAACAAGAAGTGTACCGATTTGGTACA
CTTCGTCTATTCTGTCATAA

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKKRCLITGGAGFIGSHLAEELVKRGHPVTIVDNFYKGKSKYHEELTGNIPIIPISILDKNSMHELVNQHDVVFHLAAIL
GVKTTMEKSIELIETNFDGTRNILQAALKGKKKVIFASTSEVYGKGTPPFSEDDDRLYGATSKIRWSYAICKTLEETLCL
GYALQGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGDDLLVYGDGKQTRCFTYVSDAVEATIAAMDEKVNGEIIN
IGSEDEKSIQEVAQDIHQLTHSSSKIVHVPFEKVYPHGFEEIPNRKPDVTKLKEMCQFHPNVSWEQGLKETIQWFREIEN
D

Sequences:

>Translated_321_residues
MKKRCLITGGAGFIGSHLAEELVKRGHPVTIVDNFYKGKSKYHEELTGNIPIIPISILDKNSMHELVNQHDVVFHLAAIL
GVKTTMEKSIELIETNFDGTRNILQAALKGKKKVIFASTSEVYGKGTPPFSEDDDRLYGATSKIRWSYAICKTLEETLCL
GYALQGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGDDLLVYGDGKQTRCFTYVSDAVEATIAAMDEKVNGEIIN
IGSEDEKSIQEVAQDIHQLTHSSSKIVHVPFEKVYPHGFEEIPNRKPDVTKLKEMCQFHPNVSWEQGLKETIQWFREIEN
D
>Mature_321_residues
MKKRCLITGGAGFIGSHLAEELVKRGHPVTIVDNFYKGKSKYHEELTGNIPIIPISILDKNSMHELVNQHDVVFHLAAIL
GVKTTMEKSIELIETNFDGTRNILQAALKGKKKVIFASTSEVYGKGTPPFSEDDDRLYGATSKIRWSYAICKTLEETLCL
GYALQGLPVTIVRYFNIYGPRAKDGPYAGVIPRFIRAALQGDDLLVYGDGKQTRCFTYVSDAVEATIAAMDEKVNGEIIN
IGSEDEKSIQEVAQDIHQLTHSSSKIVHVPFEKVYPHGFEEIPNRKPDVTKLKEMCQFHPNVSWEQGLKETIQWFREIEN
D

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=321, Percent_Identity=37.6947040498442, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI7657641, Length=329, Percent_Identity=31.6109422492401, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI56237023, Length=292, Percent_Identity=26.3698630136986, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI56118217, Length=292, Percent_Identity=26.3698630136986, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI189083684, Length=292, Percent_Identity=26.3698630136986, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI193211614, Length=233, Percent_Identity=26.6094420600858, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI8393516, Length=233, Percent_Identity=26.6094420600858, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788589, Length=340, Percent_Identity=29.1176470588235, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI48994969, Length=350, Percent_Identity=28.8571428571429, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1788353, Length=341, Percent_Identity=29.3255131964809, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788365, Length=336, Percent_Identity=27.3809523809524, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786974, Length=338, Percent_Identity=25.7396449704142, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790049, Length=326, Percent_Identity=25.4601226993865, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539532, Length=327, Percent_Identity=34.5565749235474, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17568069, Length=335, Percent_Identity=29.5522388059701, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982035, Length=290, Percent_Identity=26.2068965517241, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=336, Percent_Identity=26.1904761904762, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982038, Length=292, Percent_Identity=26.027397260274, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319493, Length=258, Percent_Identity=24.8062015503876, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI21356223, Length=327, Percent_Identity=37.6146788990826, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19923002, Length=260, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 36031; Mature: 36031

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRCLITGGAGFIGSHLAEELVKRGHPVTIVDNFYKGKSKYHEELTGNIPIIPISILDK
CCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECHHCCHHHHHHHHCCCCCEEEEEECCC
NSMHELVNQHDVVFHLAAILGVKTTMEKSIELIETNFDGTRNILQAALKGKKKVIFASTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECH
EVYGKGTPPFSEDDDRLYGATSKIRWSYAICKTLEETLCLGYALQGLPVTIVRYFNIYGP
HHCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
RAKDGPYAGVIPRFIRAALQGDDLLVYGDGKQTRCFTYVSDAVEATIAAMDEKVNGEIIN
CCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
IGSEDEKSIQEVAQDIHQLTHSSSKIVHVPFEKVYPHGFEEIPNRKPDVTKLKEMCQFHP
CCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCHHHCCCCCCCHHHHHHHHHHCC
NVSWEQGLKETIQWFREIEND
CCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKRCLITGGAGFIGSHLAEELVKRGHPVTIVDNFYKGKSKYHEELTGNIPIIPISILDK
CCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECHHCCHHHHHHHHCCCCCEEEEEECCC
NSMHELVNQHDVVFHLAAILGVKTTMEKSIELIETNFDGTRNILQAALKGKKKVIFASTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECH
EVYGKGTPPFSEDDDRLYGATSKIRWSYAICKTLEETLCLGYALQGLPVTIVRYFNIYGP
HHCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
RAKDGPYAGVIPRFIRAALQGDDLLVYGDGKQTRCFTYVSDAVEATIAAMDEKVNGEIIN
CCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
IGSEDEKSIQEVAQDIHQLTHSSSKIVHVPFEKVYPHGFEEIPNRKPDVTKLKEMCQFHP
CCCCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCHHHCCCCCCCHHHHHHHHHHCC
NVSWEQGLKETIQWFREIEND
CCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA