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The map label for this gene is capL [H]

Identifier: 152974262

GI number: 152974262

Start: 483947

End: 485218

Strand: Direct

Name: capL [H]

Synonym: Bcer98_0429

Alternate gene names: 152974262

Gene position: 483947-485218 (Clockwise)

Preceding gene: 152974261

Following gene: 152974263

Centisome position: 11.84

GC content: 35.38

Gene sequence:

>1272_bases
ATGGAAAAAGAGAAAGGAGAAGAAAAAATGAATGATAGTAGGAAGATAACTGTCATTGGATTGGGCTATGTTGGTCTTCC
TTTAGCGATACATTTTGCGGAAAGAGGATATAACGTAGTCGGATTAGATAAAGATAAACGAAAAATAGAACGAATTGAAA
AAGGAGATAGCTATATACCAGATGTTTCCTCGAATGTTTTAAAAGATTTGGTTCAAAACAAACAGTTGGTAGTTTATACG
CCTCATACAGGGATAGAAGAATTTCAAAATAGTGAGTATGTGATTGTTACGGTACCAACGCCAATTAATAAACAAAAAGA
ACCTGATTTAAGTGCTCTTATTGCAGCCTCTCATTATATAAAACAAAACCTTCAAGCAGGACAAACCTTCATTTTTGAAA
GTTCCACATATCCGGGTACATTGGAAGAGGTCATCATTCCGATTATTGCTCAATCAGGTAAAGAAGTTGGAAAAGATTAT
TATATTGGATACTCACCAGAGCGAATTGATCCAGCGAATCAGCAATATACAGTACAAACCATTCCAAAAGTCATTAGTGG
TCAAACAGAAAGATGTAAGCAACAAGTCCAAAAATTGTATAGCACGATATTTGACACAGTCGTTCCAGTTAGTTCCCCAA
AAGTAGCAGAGATGTGTAAGTTATTTGAAAATATTCAGCGTTTAGTTAATATTTCCTTAGTAAATGAGTTAAATATACTT
TGTGAAAAGTTGGGGATTGATTTTCGGGAGGCTCTTGAAGCTGCGGCGACAAAACCATTTGGTTTTACACCATATTGGCC
GGGACCAGGAATAGGAGGACATTGTATTCCAGTTGATCCTTTATATTTTCAGTGGAAAGCAAGACAGCTAGGGCAATCAA
GTCAATTAATCGAAGTAGCTCATATGATTAATGAAAAGATGCCGCAACAAATTGTAACGCAGGTGAAAGAATTAAGTGCT
CCCCCAGGAACTGTCTTTCTGATTGGTATTGCGTATAAGAAAGATGTAAATGATTTACGAGAATCTCCAGCATTACCAAT
TATCGAGCTGTTAGTAAACGAGGGATATAAAGTACAATATCACGATCCATATATTTCATCTGCGAAAATTGGAGATAAAA
TATATGATTCTATCCCACTTAAGAAGAAAACATTAGAAAAAGCAGATTGCATACTAATTGTAACAGATCATTCCAATATA
GATTGGAATATATGTAAAGGAATGAAGCATGTAATAGATACACGAGGTGTACTAAAGAAGGTGAGTGCATGA

Upstream 100 bases:

>100_bases
GAAGAAAACTAGTAAACAGTTTGAATAGACCATTAAATTATTTTTTAAATAATATTTTTAAAAACTTCGCGACGCTCATT
TCATAAATGGCGAGGTAAAT

Downstream 100 bases:

>100_bases
AGAAACGTTGTTTGATTACAGGTGGAGCAGGATTTATTGGATCACATTTAGCGGAAGAACTCGTGAAACGAGGTCATCCA
GTTACGATTGTTGATAATTT

Product: UDP-glucose 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MEKEKGEEKMNDSRKITVIGLGYVGLPLAIHFAERGYNVVGLDKDKRKIERIEKGDSYIPDVSSNVLKDLVQNKQLVVYT
PHTGIEEFQNSEYVIVTVPTPINKQKEPDLSALIAASHYIKQNLQAGQTFIFESSTYPGTLEEVIIPIIAQSGKEVGKDY
YIGYSPERIDPANQQYTVQTIPKVISGQTERCKQQVQKLYSTIFDTVVPVSSPKVAEMCKLFENIQRLVNISLVNELNIL
CEKLGIDFREALEAAATKPFGFTPYWPGPGIGGHCIPVDPLYFQWKARQLGQSSQLIEVAHMINEKMPQQIVTQVKELSA
PPGTVFLIGIAYKKDVNDLRESPALPIIELLVNEGYKVQYHDPYISSAKIGDKIYDSIPLKKKTLEKADCILIVTDHSNI
DWNICKGMKHVIDTRGVLKKVSA

Sequences:

>Translated_423_residues
MEKEKGEEKMNDSRKITVIGLGYVGLPLAIHFAERGYNVVGLDKDKRKIERIEKGDSYIPDVSSNVLKDLVQNKQLVVYT
PHTGIEEFQNSEYVIVTVPTPINKQKEPDLSALIAASHYIKQNLQAGQTFIFESSTYPGTLEEVIIPIIAQSGKEVGKDY
YIGYSPERIDPANQQYTVQTIPKVISGQTERCKQQVQKLYSTIFDTVVPVSSPKVAEMCKLFENIQRLVNISLVNELNIL
CEKLGIDFREALEAAATKPFGFTPYWPGPGIGGHCIPVDPLYFQWKARQLGQSSQLIEVAHMINEKMPQQIVTQVKELSA
PPGTVFLIGIAYKKDVNDLRESPALPIIELLVNEGYKVQYHDPYISSAKIGDKIYDSIPLKKKTLEKADCILIVTDHSNI
DWNICKGMKHVIDTRGVLKKVSA
>Mature_423_residues
MEKEKGEEKMNDSRKITVIGLGYVGLPLAIHFAERGYNVVGLDKDKRKIERIEKGDSYIPDVSSNVLKDLVQNKQLVVYT
PHTGIEEFQNSEYVIVTVPTPINKQKEPDLSALIAASHYIKQNLQAGQTFIFESSTYPGTLEEVIIPIIAQSGKEVGKDY
YIGYSPERIDPANQQYTVQTIPKVISGQTERCKQQVQKLYSTIFDTVVPVSSPKVAEMCKLFENIQRLVNISLVNELNIL
CEKLGIDFREALEAAATKPFGFTPYWPGPGIGGHCIPVDPLYFQWKARQLGQSSQLIEVAHMINEKMPQQIVTQVKELSA
PPGTVFLIGIAYKKDVNDLRESPALPIIELLVNEGYKVQYHDPYISSAKIGDKIYDSIPLKKKTLEKADCILIVTDHSNI
DWNICKGMKHVIDTRGVLKKVSA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=385, Percent_Identity=24.1558441558442, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994968, Length=438, Percent_Identity=31.2785388127854, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17136908, Length=380, Percent_Identity=24.7368421052632, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47407; Mature: 47407

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEKGEEKMNDSRKITVIGLGYVGLPLAIHFAERGYNVVGLDKDKRKIERIEKGDSYIP
CCCCCCHHHCCCCCEEEEEEECHHHHHHHEEEHHCCCEEEECCCHHHHHHHHHCCCCCCC
DVSSNVLKDLVQNKQLVVYTPHTGIEEFQNSEYVIVTVPTPINKQKEPDLSALIAASHYI
CCHHHHHHHHHCCCEEEEECCCCCHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
KQNLQAGQTFIFESSTYPGTLEEVIIPIIAQSGKEVGKDYYIGYSPERIDPANQQYTVQT
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHCCCCEEECCCCCCCCCCCCCEEHHH
IPKVISGQTERCKQQVQKLYSTIFDTVVPVSSPKVAEMCKLFENIQRLVNISLVNELNIL
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CEKLGIDFREALEAAATKPFGFTPYWPGPGIGGHCIPVDPLYFQWKARQLGQSSQLIEVA
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCHHEEHHHHHCCCCHHHHHHH
HMINEKMPQQIVTQVKELSAPPGTVFLIGIAYKKDVNDLRESPALPIIELLVNEGYKVQY
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHCCCCHHHHHHHCCCCEEEE
HDPYISSAKIGDKIYDSIPLKKKTLEKADCILIVTDHSNIDWNICKGMKHVIDTRGVLKK
CCCCCCCHHHCHHHHHCCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
VSA
HCC
>Mature Secondary Structure
MEKEKGEEKMNDSRKITVIGLGYVGLPLAIHFAERGYNVVGLDKDKRKIERIEKGDSYIP
CCCCCCHHHCCCCCEEEEEEECHHHHHHHEEEHHCCCEEEECCCHHHHHHHHHCCCCCCC
DVSSNVLKDLVQNKQLVVYTPHTGIEEFQNSEYVIVTVPTPINKQKEPDLSALIAASHYI
CCHHHHHHHHHCCCEEEEECCCCCHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
KQNLQAGQTFIFESSTYPGTLEEVIIPIIAQSGKEVGKDYYIGYSPERIDPANQQYTVQT
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHCCCCEEECCCCCCCCCCCCCEEHHH
IPKVISGQTERCKQQVQKLYSTIFDTVVPVSSPKVAEMCKLFENIQRLVNISLVNELNIL
HHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CEKLGIDFREALEAAATKPFGFTPYWPGPGIGGHCIPVDPLYFQWKARQLGQSSQLIEVA
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCHHEEHHHHHCCCCHHHHHHH
HMINEKMPQQIVTQVKELSAPPGTVFLIGIAYKKDVNDLRESPALPIIELLVNEGYKVQY
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHCCCCHHHHHHHCCCCEEEE
HDPYISSAKIGDKIYDSIPLKKKTLEKADCILIVTDHSNIDWNICKGMKHVIDTRGVLKK
CCCCCCCHHHCHHHHHCCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
VSA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]