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The map label for this gene is hisB

Identifier: 152971017

GI number: 152971017

Start: 2703037

End: 2704104

Strand: Direct

Name: hisB

Synonym: KPN_02478

Alternate gene names: 152971017

Gene position: 2703037-2704104 (Clockwise)

Preceding gene: 152971016

Following gene: 152971018

Centisome position: 50.86

GC content: 60.39

Gene sequence:

>1068_bases
ATGACCCAGAAGTATCTCTTTATTGACCGTGACGGCACACTGATTTCCGAACCGCCGGAGGATTTCCAGGTGGACCGGTT
CGACAAGCTGGCGTTTGAGCCGCAGGTGATCCCGGCGCTGCTGAAGCTGCAGCAGGAAGGCTATAAGCTGGTGATGATCA
CCAATCAGGATGGCCTGGGAACCGACAGTCTGCCGCAGGAAGCGTTTGATGGCCCGCACAACCTGATGATGCAGATCTTC
GCCTCGCAGGGCGTTAACTTTGAAGAGGTGCTGATTTGTCCGCACTTCCCGGGCGACAACTGCGCCTGCCGCAAGCCAAA
AACGCAGCTGGTGCTGCCGTGGCTGGAAGAGGGCGTGCTGGATAAATCCCACAGCTATGTGATTGGCGACCGGGCCACCG
ACCTTGAGCTGGCGGATAACATGGGAATTACCGGTCTGCGCTATGACCGCGAGACGCTCGACTGGCCGACCATCTGCGAG
CAGCTGACCCGCAGCGACCGCTATGCCCACGTCGAGCGCATCACCAAAGAGACCCAGGTGGATGTGAAAGTGTGGCTGGA
CCGCGAAGGCGGCAGCAAGATCCATACCGGCGTCGGCTTTTTTGACCATATGCTCGACCAAATCGCCACCCACGGCGGCT
TCCGCATGGAGGTTAACGTCGGCGGCGATCTGTACATCGACGATCACCACACGGTGGAAGATACCGGCCTGGCCCTCGGC
GAAGCCCTGAAGCTGGCCCTTGGCGACAAGCGCGGCATCAATCGCTTCGGCTTCGTGCTGCCGATGGACGAGTGTCTTGC
CCGCTGCGCGCTGGATATCTCCGGCCGTCCGCACCTGGAGTATAAGGCGGACTTCACCTATCAGCGCGTCGGCGATCTGA
GCACCGAGATGGTGGAACACTTCTTCCGCTCGCTCTCCTACACCATGGCGGTGACCCTGCACCTGAAAACCAAGGGCAAG
AACGATCACCACCGCGTGGAGAGCCTGTTCAAAGCCTTTGGCCGTACGCTGCGCCAGGCGATCCGCGTCCAGGGCGATGC
CCTGCCGTCTTCCAAAGGGGTGCTGTAA

Upstream 100 bases:

>100_bases
ACCAGAATAAACAACCTTCATTAAGCGGCTGTTTGCGTATCACTATCGGTACCCGTGCCGAGAGCCAGCGCGTGATTGAC
GCCTTGACTGCGGAGAATGT

Downstream 100 bases:

>100_bases
TGAATGTGGTGATCCTTGATACCGGCTGCGCCAACCTCAATTCGGTGAAATCGGCGATTGGCCGCCACGGCTATGAGCCA
GTGGTCAGCCGCGATCCGGA

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTQKYLFIDRDGTLISEPPEDFQVDRFDKLAFEPQVIPALLKLQQEGYKLVMITNQDGLGTDSLPQEAFDGPHNLMMQIF
ASQGVNFEEVLICPHFPGDNCACRKPKTQLVLPWLEEGVLDKSHSYVIGDRATDLELADNMGITGLRYDRETLDWPTICE
QLTRSDRYAHVERITKETQVDVKVWLDREGGSKIHTGVGFFDHMLDQIATHGGFRMEVNVGGDLYIDDHHTVEDTGLALG
EALKLALGDKRGINRFGFVLPMDECLARCALDISGRPHLEYKADFTYQRVGDLSTEMVEHFFRSLSYTMAVTLHLKTKGK
NDHHRVESLFKAFGRTLRQAIRVQGDALPSSKGVL

Sequences:

>Translated_355_residues
MTQKYLFIDRDGTLISEPPEDFQVDRFDKLAFEPQVIPALLKLQQEGYKLVMITNQDGLGTDSLPQEAFDGPHNLMMQIF
ASQGVNFEEVLICPHFPGDNCACRKPKTQLVLPWLEEGVLDKSHSYVIGDRATDLELADNMGITGLRYDRETLDWPTICE
QLTRSDRYAHVERITKETQVDVKVWLDREGGSKIHTGVGFFDHMLDQIATHGGFRMEVNVGGDLYIDDHHTVEDTGLALG
EALKLALGDKRGINRFGFVLPMDECLARCALDISGRPHLEYKADFTYQRVGDLSTEMVEHFFRSLSYTMAVTLHLKTKGK
NDHHRVESLFKAFGRTLRQAIRVQGDALPSSKGVL
>Mature_354_residues
TQKYLFIDRDGTLISEPPEDFQVDRFDKLAFEPQVIPALLKLQQEGYKLVMITNQDGLGTDSLPQEAFDGPHNLMMQIFA
SQGVNFEEVLICPHFPGDNCACRKPKTQLVLPWLEEGVLDKSHSYVIGDRATDLELADNMGITGLRYDRETLDWPTICEQ
LTRSDRYAHVERITKETQVDVKVWLDREGGSKIHTGVGFFDHMLDQIATHGGFRMEVNVGGDLYIDDHHTVEDTGLALGE
ALKLALGDKRGINRFGFVLPMDECLARCALDISGRPHLEYKADFTYQRVGDLSTEMVEHFFRSLSYTMAVTLHLKTKGKN
DHHRVESLFKAFGRTLRQAIRVQGDALPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=85.9154929577465, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1786399, Length=150, Percent_Identity=29.3333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=40.8256880733945, Blast_Score=164, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_KLEP7 (A6TBC5)

Other databases:

- EMBL:   CP000647
- RefSeq:   YP_001336126.1
- ProteinModelPortal:   A6TBC5
- STRING:   A6TBC5
- GeneID:   5341307
- GenomeReviews:   CP000647_GR
- KEGG:   kpn:KPN_02478
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   QDGLGTP
- ProtClustDB:   PRK05446
- GO:   GO:0005737
- HAMAP:   MF_01022
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01261
- TIGRFAMs:   TIGR01656

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P; SSF54211 Ribosomal_S5_D2-typ_fold; SSF56784 SSF56784

EC number: =3.1.3.15; =4.2.1.19

Molecular weight: Translated: 40115; Mature: 39984

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKYLFIDRDGTLISEPPEDFQVDRFDKLAFEPQVIPALLKLQQEGYKLVMITNQDGLG
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
TDSLPQEAFDGPHNLMMQIFASQGVNFEEVLICPHFPGDNCACRKPKTQLVLPWLEEGVL
CCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEECCHHHCCCC
DKSHSYVIGDRATDLELADNMGITGLRYDRETLDWPTICEQLTRSDRYAHVERITKETQV
CCCCCEEECCCCCCCCHHCCCCCCEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCEE
DVKVWLDREGGSKIHTGVGFFDHMLDQIATHGGFRMEVNVGGDLYIDDHHTVEDTGLALG
EEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCHHHHHHHH
EALKLALGDKRGINRFGFVLPMDECLARCALDISGRPHLEYKADFTYQRVGDLSTEMVEH
HHHHHHHCCCCCCCHHCEEECHHHHHHHHHHCCCCCCCEEEECCCCHHHHHCHHHHHHHH
FFRSLSYTMAVTLHLKTKGKNDHHRVESLFKAFGRTLRQAIRVQGDALPSSKGVL
HHHHCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TQKYLFIDRDGTLISEPPEDFQVDRFDKLAFEPQVIPALLKLQQEGYKLVMITNQDGLG
CCEEEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
TDSLPQEAFDGPHNLMMQIFASQGVNFEEVLICPHFPGDNCACRKPKTQLVLPWLEEGVL
CCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEECCHHHCCCC
DKSHSYVIGDRATDLELADNMGITGLRYDRETLDWPTICEQLTRSDRYAHVERITKETQV
CCCCCEEECCCCCCCCHHCCCCCCEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCEE
DVKVWLDREGGSKIHTGVGFFDHMLDQIATHGGFRMEVNVGGDLYIDDHHTVEDTGLALG
EEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCHHHHHHHH
EALKLALGDKRGINRFGFVLPMDECLARCALDISGRPHLEYKADFTYQRVGDLSTEMVEH
HHHHHHHCCCCCCCHHCEEECHHHHHHHHHHCCCCCCCEEEECCCCHHHHHCHHHHHHHH
FFRSLSYTMAVTLHLKTKGKNDHHRVESLFKAFGRTLRQAIRVQGDALPSSKGVL
HHHHCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA