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The map label for this gene is ybiC [H]

Identifier: 152970638

GI number: 152970638

Start: 2289097

End: 2290176

Strand: Direct

Name: ybiC [H]

Synonym: KPN_02089

Alternate gene names: 152970638

Gene position: 2289097-2290176 (Clockwise)

Preceding gene: 152970634

Following gene: 152970639

Centisome position: 43.07

GC content: 66.94

Gene sequence:

>1080_bases
GTGCCTACAGGACACCGCTTTCTGGCGACGGATCTGCATCAGTTTGTCGTCTCACTGTTTACCCATCTCGGCAGTACCCC
AGGGGAAGCCACCCTCGTCGCGGACCATCTGATCGCCGCCAATCTTGCCGGGCATGACTCCCACGGCGTCGGGATGATCC
CCAGCTACGTCAAATCCCACGCCGGTGGTTTTCTGCAGCTCAACCGCCACGCCACGGTGACCAAAGACGCCGGCGCCGTG
GTCACCCTCGACGGCAACGCCGGCTTCGGCCAGGTGGTCGCCCACGAAGCGATGCAGTTAGGCATTGAAAAGGCGAAGCA
GCATGGTATGGCGGCTATCGCCCTGCGCAATGCGCATCACGTCGGTCGCATCGGCTACTGGGCCGAACAGTGCGCCGCCG
CCGGGCTGATCTCCATTCACTTCGTCAGCGTCATCGGCGACCCGATGGTCGCCCCGTTCCGCGGGAAGGACAGCCGCTTC
GGCACCAACCCGCTGTGCGTGGTGTTTCCCCGCGCGGGCCATCCGCCGCTGCTGCTGGACTACGCCACCAGCGCCATCGC
CTTTGGTAAAACCCGCGTCGCCTGGCATAAAGGCGAAGCCGTGGCCCCCGGCTGCCTGATTGACGCCGAGGGTCGACCCA
CTACCGACCCGGCGGTGATGCAGACCTCGCCGCTGGGCGCCCTGCTCACCTTCGCCCAGCACAAAGGCTATGCCCTGGCG
ACGCTGTGCGAAGTGCTCGGCGGCGCGCTCTCCGGCGGGCAAACCACCCATCAGGAGAGCCTGCAGACCAGCGTCGACGC
CATCTTTAACTGCATGACCACGGTGATCCTGCGCCCGGACGCGTTCGATGCCCCGGACAGCCAGGCGCAGACGGAGGCCT
TTATCGCATGGTGTAAGCAGTCGCCGCACGATGCCGATGCCCCGGTACTGGCGCCCGGCGAATGGGAGGCCGCCAACCGC
GAAGCGCGGCTGGCGCAGGGGATCCCGCTGGATGCCGGCAGCTGGCAGGCTATCTGCGCCGCCGCGCGCGACGTCGGCCT
GAGCGAATCGCACTTCGACCGCTGCCGCCCTCTCGCCTAG

Upstream 100 bases:

>100_bases
GCATGTCGCCGGGAGACGCCGCCCTTGACCTTCTGCGCCGGGCGGCGCAGCATAAAACGGCAAACATAACAAAATAACAA
CAGACTACAGGAGAGAATCA

Downstream 100 bases:

>100_bases
CCGCGTTTTACTCCCGCAGAGCGTCTGACGTCGGCGCTCTGCGTCATCGTCATTAGTGACGAGGTCATGCTCCCGTCATC
AATCTCTTTTCATTTTTCAA

Product: hypothetical protein

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MPTGHRFLATDLHQFVVSLFTHLGSTPGEATLVADHLIAANLAGHDSHGVGMIPSYVKSHAGGFLQLNRHATVTKDAGAV
VTLDGNAGFGQVVAHEAMQLGIEKAKQHGMAAIALRNAHHVGRIGYWAEQCAAAGLISIHFVSVIGDPMVAPFRGKDSRF
GTNPLCVVFPRAGHPPLLLDYATSAIAFGKTRVAWHKGEAVAPGCLIDAEGRPTTDPAVMQTSPLGALLTFAQHKGYALA
TLCEVLGGALSGGQTTHQESLQTSVDAIFNCMTTVILRPDAFDAPDSQAQTEAFIAWCKQSPHDADAPVLAPGEWEAANR
EARLAQGIPLDAGSWQAICAAARDVGLSESHFDRCRPLA

Sequences:

>Translated_359_residues
MPTGHRFLATDLHQFVVSLFTHLGSTPGEATLVADHLIAANLAGHDSHGVGMIPSYVKSHAGGFLQLNRHATVTKDAGAV
VTLDGNAGFGQVVAHEAMQLGIEKAKQHGMAAIALRNAHHVGRIGYWAEQCAAAGLISIHFVSVIGDPMVAPFRGKDSRF
GTNPLCVVFPRAGHPPLLLDYATSAIAFGKTRVAWHKGEAVAPGCLIDAEGRPTTDPAVMQTSPLGALLTFAQHKGYALA
TLCEVLGGALSGGQTTHQESLQTSVDAIFNCMTTVILRPDAFDAPDSQAQTEAFIAWCKQSPHDADAPVLAPGEWEAANR
EARLAQGIPLDAGSWQAICAAARDVGLSESHFDRCRPLA
>Mature_358_residues
PTGHRFLATDLHQFVVSLFTHLGSTPGEATLVADHLIAANLAGHDSHGVGMIPSYVKSHAGGFLQLNRHATVTKDAGAVV
TLDGNAGFGQVVAHEAMQLGIEKAKQHGMAAIALRNAHHVGRIGYWAEQCAAAGLISIHFVSVIGDPMVAPFRGKDSRFG
TNPLCVVFPRAGHPPLLLDYATSAIAFGKTRVAWHKGEAVAPGCLIDAEGRPTTDPAVMQTSPLGALLTFAQHKGYALAT
LCEVLGGALSGGQTTHQESLQTSVDAIFNCMTTVILRPDAFDAPDSQAQTEAFIAWCKQSPHDADAPVLAPGEWEAANRE
ARLAQGIPLDAGSWQAICAAARDVGLSESHFDRCRPLA

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=360, Percent_Identity=70.8333333333333, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1786727, Length=304, Percent_Identity=29.9342105263158, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790000, Length=304, Percent_Identity=26.3157894736842, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17507179, Length=316, Percent_Identity=28.7974683544304, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17536633, Length=246, Percent_Identity=27.6422764227642, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45553211, Length=312, Percent_Identity=28.525641025641, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24667912, Length=312, Percent_Identity=28.525641025641, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24667908, Length=312, Percent_Identity=28.525641025641, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24667904, Length=312, Percent_Identity=28.525641025641, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24658010, Length=315, Percent_Identity=24.1269841269841, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648360, Length=249, Percent_Identity=22.8915662650602, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 37778; Mature: 37647

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTGHRFLATDLHQFVVSLFTHLGSTPGEATLVADHLIAANLAGHDSHGVGMIPSYVKSH
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHC
AGGFLQLNRHATVTKDAGAVVTLDGNAGFGQVVAHEAMQLGIEKAKQHGMAAIALRNAHH
CCCEEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
VGRIGYWAEQCAAAGLISIHFVSVIGDPMVAPFRGKDSRFGTNPLCVVFPRAGHPPLLLD
CCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEH
YATSAIAFGKTRVAWHKGEAVAPGCLIDAEGRPTTDPAVMQTSPLGALLTFAQHKGYALA
HHHHHHHCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCEECCCHHHHHHHHHCCCCHHH
TLCEVLGGALSGGQTTHQESLQTSVDAIFNCMTTVILRPDAFDAPDSQAQTEAFIAWCKQ
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
SPHDADAPVLAPGEWEAANREARLAQGIPLDAGSWQAICAAARDVGLSESHFDRCRPLA
CCCCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure 
PTGHRFLATDLHQFVVSLFTHLGSTPGEATLVADHLIAANLAGHDSHGVGMIPSYVKSH
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHC
AGGFLQLNRHATVTKDAGAVVTLDGNAGFGQVVAHEAMQLGIEKAKQHGMAAIALRNAHH
CCCEEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
VGRIGYWAEQCAAAGLISIHFVSVIGDPMVAPFRGKDSRFGTNPLCVVFPRAGHPPLLLD
CCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEH
YATSAIAFGKTRVAWHKGEAVAPGCLIDAEGRPTTDPAVMQTSPLGALLTFAQHKGYALA
HHHHHHHCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCEECCCHHHHHHHHHCCCCHHH
TLCEVLGGALSGGQTTHQESLQTSVDAIFNCMTTVILRPDAFDAPDSQAQTEAFIAWCKQ
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
SPHDADAPVLAPGEWEAANREARLAQGIPLDAGSWQAICAAARDVGLSESHFDRCRPLA
CCCCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]