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The map label for this gene is dcp [H]

Identifier: 152970143

GI number: 152970143

Start: 1767060

End: 1769105

Strand: Direct

Name: dcp [H]

Synonym: KPN_01591

Alternate gene names: 152970143

Gene position: 1767060-1769105 (Clockwise)

Preceding gene: 152970140

Following gene: 152970145

Centisome position: 33.25

GC content: 61.09

Gene sequence:

>2046_bases
ATGTCCGAACGAAACCCCTTTTTTAGCGTCAGTACGTTGCCTTACCAGGCGCCGCCGTTCGATGTGATTGACGACAGCCA
CTATCGCCCGGCGTTTGATGAGGGCGTCCGGCAGCAGCGGGCCGAAATTCGCGCTATTATCGACAATCCGCAGCCGGCCA
GTTTCGCCAACACGCTCGAGGCGCTGGAGCAGAGTGGTCAGCTGCTGGCGCGGGTGACGCGGGTCTTTTTCGCCATGGCT
GGCGCCCATACCAATCCTTATATTCAATCACTGGATGAACAATTTTCCGCCGAACTCGCCGAGCTGGGGAATGACATCTG
GCTTAATGCGGCCTTGTTTCAGCGCGTGAACAGCGTCTACGAGCAGCGCGACGCGCTGGCGCTGGACAGCGAGTCCTATC
GTCTCCTGACCCTGACGTGGCAACGTTTTGTTCACGCCGGGGCGACGCTGGCTCCCGAGCAGCAGGCGGCGCTGCGCACA
CTGAACACCGAAGCGGCTACGCTGCAAAGTCAGTTCCAGCAGCGACTGCTGGGAGCGGCAAAAAGCGGCGGCCTGGTGGT
TGATTACCGGCATCAACTGGCTGGCCTGAGCGATGAGGAGATAGCGGCGGCGGCTGACGCAGCGCGTGAAAGAGGGCTTA
GCGACCGCTGGTTGCTGACGCTGACCAATACCACCCAGCAGCCACAGCTGCTTGCGCTGCGCGACCGGCAAACGCGGGAG
AATCTCTTCGCCGCCGGCTGGACCCGCAATCAGCAGGGCGATGAGCATGATACGCGTGACCTGGTACTGCGGCTGGCGGC
GATCCGTGCGCAGCAGGCTGAGCTGTTGGGAGCCGCTGATTACGCCAGCTGGGCGCTGACCGATCAAATGGCGGCTTCCC
CGGCGGAGGCATTGGGCTTTATGCGTCAGATCGCGCCGGCTGCGCGGGCGCGGGCGGAACGAGAGCTGGCGGACATCCAG
CAGGTGATCGACAACGAAGGCGGGGGTTTTCGCGCGACGGCATGGGACTGGCTTTACTACAGCGAGCAGGTGCGGCGGGC
TGCCTACGCCATTGATGACGCGCAGCTCAAACCCTATTTTGCCCTCGAGCGGGTGCTGCACGACGGCGTCTTCTGGACGG
CAACGCAGCTCTTTGGGCTGCGCTTTGTTGAGCGCTTTGATATACCGGTCTATCACCCGGATGTGCGGGTCTGGGAGATC
TTCGATCACAACGGCGAAGGGATGGCGCTGTTTTACGGTGACTACTACGCTCGTGACTCAAAGAGCGGCGGCGCATGGAT
GGATGTGTTTGTCGAACAGTCGACTCTGCGCGCGCAGCGCCCGGTTATCTACAATGTCTGCAACTACCTCCGTCCGCAGG
CAGGGCAGAGCGCGCTGCTGTCGTGGGATGAGGTGATCACCCTGTTTCATGAGTTCGGCCATACCCTGCATGGGCTGTTC
GCCAGCCAGCGCTACGCCAGTCTCTCGGGGACCAATACGCCGCGCGATTTTGTCGAATTTCCTTCGCAGATCTTCGAACA
CTGGGCCAGCCAGCCGCAGGTGTTTGCCCACTACGCGAAGCACTACCAGTCCGGGGAGCCGATGCCGCAGGCGCTACGCG
ACAATATGTTGCGTGCGGCAACCTTCAATAAAGGGTACGACATGAGCGAGCTGTTGGCTGCTGCGTTACTCGATATGCGG
TGGCATAGCCTGTCGACCTCGGCATTACCGGAGGAGGTGGACGCGTTTGAGCAGCTGGTGCTTCGGGAAGAGAACCTGGA
TCTGGCGGCGGTCCCCCCGCGCTATCGCAGCAGCTATTTCTCCCATATCTTCGGCGGCGGCTATGCGGCAGGCTATTACG
CCTATCTGTGGACCCAGATGCTGGCCGACGACGGCTATCAATGGTTCGTGGAGCAGGGCGGTTTGACCCGTGAGAACGGT
CAGCGTTTCCGTGAGGCGATTTTATCACGCGGGAACAGCACTGATTTAGCTGAACTGTATCGCCAGTGGCGCGGACACGA
TCCGCAGATTGAGCCGATGCTGAAAAATCGCGGGTTGAGTGCGTAG

Upstream 100 bases:

>100_bases
CATACCATAGCACGCACAGGCGGCGACCGGTAACGGAAATCATTGCGACCCCTTAAGGAGAGGCCTAATCTTACAGCATT
AGCCTGTACAGGAGAGAAAG

Downstream 100 bases:

>100_bases
GGCAATTTTAGTCTGACAAGATAACCGGGCGCGCTGCCCGGTTTTTTGTCTGATCTAGTCGTAACCTTATATTTCTTTTA
CCTCACGCTGCCTAAATCTT

Product: dipeptidyl carboxypeptidase II

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MSERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLEALEQSGQLLARVTRVFFAMA
GAHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVYEQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRT
LNTEAATLQSQFQQRLLGAAKSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTRE
NLFAAGWTRNQQGDEHDTRDLVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGFMRQIAPAARARAERELADIQ
QVIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYFALERVLHDGVFWTATQLFGLRFVERFDIPVYHPDVRVWEI
FDHNGEGMALFYGDYYARDSKSGGAWMDVFVEQSTLRAQRPVIYNVCNYLRPQAGQSALLSWDEVITLFHEFGHTLHGLF
ASQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAATFNKGYDMSELLAAALLDMR
WHSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYFSHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENG
QRFREAILSRGNSTDLAELYRQWRGHDPQIEPMLKNRGLSA

Sequences:

>Translated_681_residues
MSERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLEALEQSGQLLARVTRVFFAMA
GAHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVYEQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRT
LNTEAATLQSQFQQRLLGAAKSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTRE
NLFAAGWTRNQQGDEHDTRDLVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGFMRQIAPAARARAERELADIQ
QVIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYFALERVLHDGVFWTATQLFGLRFVERFDIPVYHPDVRVWEI
FDHNGEGMALFYGDYYARDSKSGGAWMDVFVEQSTLRAQRPVIYNVCNYLRPQAGQSALLSWDEVITLFHEFGHTLHGLF
ASQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAATFNKGYDMSELLAAALLDMR
WHSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYFSHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENG
QRFREAILSRGNSTDLAELYRQWRGHDPQIEPMLKNRGLSA
>Mature_680_residues
SERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLEALEQSGQLLARVTRVFFAMAG
AHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVYEQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRTL
NTEAATLQSQFQQRLLGAAKSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTREN
LFAAGWTRNQQGDEHDTRDLVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGFMRQIAPAARARAERELADIQQ
VIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYFALERVLHDGVFWTATQLFGLRFVERFDIPVYHPDVRVWEIF
DHNGEGMALFYGDYYARDSKSGGAWMDVFVEQSTLRAQRPVIYNVCNYLRPQAGQSALLSWDEVITLFHEFGHTLHGLFA
SQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAATFNKGYDMSELLAAALLDMRW
HSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYFSHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQ
RFREAILSRGNSTDLAELYRQWRGHDPQIEPMLKNRGLSA

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=623, Percent_Identity=28.2504012841091, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI14149738, Length=597, Percent_Identity=26.8006700167504, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI156105687, Length=630, Percent_Identity=23.4920634920635, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI1787819, Length=680, Percent_Identity=69.1176470588235, Blast_Score=942, Evalue=0.0,
Organism=Escherichia coli, GI1789913, Length=692, Percent_Identity=32.514450867052, Blast_Score=353, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6319793, Length=609, Percent_Identity=25.1231527093596, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6322715, Length=381, Percent_Identity=24.9343832020997, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356111, Length=551, Percent_Identity=25.4083484573503, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI20129717, Length=392, Percent_Identity=26.7857142857143, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 77138; Mature: 77007

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLE
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALEQSGQLLARVTRVFFAMAGAHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHH
EQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRTLNTEAATLQSQFQQRLLGAA
HHHHHHEECCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHC
KSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTRE
CCCCEEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHHHHHHHH
NLFAAGWTRNQQGDEHDTRDLVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGF
HHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MRQIAPAARARAERELADIQQVIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHH
ALERVLHDGVFWTATQLFGLRFVERFDIPVYHPDVRVWEIFDHNGEGMALFYGDYYARDS
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCEEEEEECCCCCCCC
KSGGAWMDVFVEQSTLRAQRPVIYNVCNYLRPQAGQSALLSWDEVITLFHEFGHTLHGLF
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ASQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TFNKGYDMSELLAAALLDMRWHSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYF
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHH
SHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQRFREAILSRGNSTDLAELY
HHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
RQWRGHDPQIEPMLKNRGLSA
HHHCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
SERNPFFSVSTLPYQAPPFDVIDDSHYRPAFDEGVRQQRAEIRAIIDNPQPASFANTLE
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALEQSGQLLARVTRVFFAMAGAHTNPYIQSLDEQFSAELAELGNDIWLNAALFQRVNSVY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHH
EQRDALALDSESYRLLTLTWQRFVHAGATLAPEQQAALRTLNTEAATLQSQFQQRLLGAA
HHHHHHEECCCCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHC
KSGGLVVDYRHQLAGLSDEEIAAAADAARERGLSDRWLLTLTNTTQQPQLLALRDRQTRE
CCCCEEEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHHHHHHHH
NLFAAGWTRNQQGDEHDTRDLVLRLAAIRAQQAELLGAADYASWALTDQMAASPAEALGF
HHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MRQIAPAARARAERELADIQQVIDNEGGGFRATAWDWLYYSEQVRRAAYAIDDAQLKPYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHH
ALERVLHDGVFWTATQLFGLRFVERFDIPVYHPDVRVWEIFDHNGEGMALFYGDYYARDS
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEECCCCEEEEEECCCCCCCC
KSGGAWMDVFVEQSTLRAQRPVIYNVCNYLRPQAGQSALLSWDEVITLFHEFGHTLHGLF
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ASQRYASLSGTNTPRDFVEFPSQIFEHWASQPQVFAHYAKHYQSGEPMPQALRDNMLRAA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TFNKGYDMSELLAAALLDMRWHSLSTSALPEEVDAFEQLVLREENLDLAAVPPRYRSSYF
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHH
SHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQRFREAILSRGNSTDLAELY
HHHHCCCHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
RQWRGHDPQIEPMLKNRGLSA
HHHCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]