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The map label for this gene is catF [H]

Identifier: 152970092

GI number: 152970092

Start: 1710900

End: 1712105

Strand: Direct

Name: catF [H]

Synonym: KPN_01540

Alternate gene names: 152970092

Gene position: 1710900-1712105 (Clockwise)

Preceding gene: 152970091

Following gene: 152970093

Centisome position: 32.19

GC content: 66.67

Gene sequence:

>1206_bases
ATGATGAATCAGGCATTTATCTGTGATGCGGTGCGTACACCCTTTGGCCGTTTCGGCGGTGCCCTGGCGACGATGCGCGC
TGACGACCTGGCGGCGCTGCCGCTGAAAGCGCTGCTGGCGCGGAACCCGGGACTGGATCCCTCGCGCATTGACGATGTGA
TCTTTGGCTGCGCCAACCAGGCCGGGGAAGACAACCGCAACGTGGCGCGAATGGCGCTGCTGCTGGCCGGCCTACCGGAG
AGCGTGCCCGGGAGCACCATCAACCGCCTGTGCGGTTCCAGCCTTGACGCGATCGGCGTCGCGGCGCGGGCGATTAAAAG
CGGGGAGACGCAGCTGATGATCGCCGGCGGGGTGGAGAGCATGTCCCGCGCGCCGTTTGTGATGGGGAAAGCGGAGAGCG
CCTTTAGCCGCAGCATGCAGATGGAGGATACCACCATCGGCTGGCGCTTTATTAACCCGCAGATGAAAGCCCTGTACGGC
GTGCATTCCATGCCGGAGACGGCGGAAAACGTCGCCGATGAGTTTGCCATCTCCCGTGCCGATCAGGACGCGTTCGCCTT
ACGCAGTCAGTTGCGCACCGCCGCGGCGCAAGAGGCGGGGCGTTTCGCCGATGAGCTGATCGCCGTCCAGGTGCCGCAGC
GCAAAGGCGAGCCGCTGCTGTTTAGCCGCGATGAGCACCCGCGCAGCACCTCGCTGGAGGCGCTGGCTAAACTGCGCGGC
GTGGTGCGCGCCGACGGCAGCGTTACCGCCGGTAACGCCTCCGGGGTTAACGACGGTGCCTGCGCGCTGTTGCTGGCCAG
CGAGACGGCGCTGTCGGCTAACGATCTTCAGCCGCTGGCCCGGGTGGTCGGCGTGGCGACAGCGGGCGTTGCGCCGCGGA
TCATGGGCTTTGGCCCGGCGCCGGCGGTGCGCAAGGTGCTGGCGCAGACCGGCCTGACATTAGGCCAGATGGATGTCATT
GAGCTGAATGAAGCCTTCGCCGCGCAGGCGCTGGCGGTGACCCGCGATTTGGGCTTACCGGACGATGCCGCCCACGTGAA
CCCTAACGGCGGGGCGATTGCGCTGGGCCACCCGCTCGGCGCCTCCGGCGGCCGGCTGGCGATGACCGCGGCTTATCAGC
TGAAACGGACCGGCGGCCGCTATGCCCTGTGCACCATGTGCATCGGCGTCGGACAGGGGATCGCCCTGATTATTGAACGC
GTTTAA

Upstream 100 bases:

>100_bases
GTGCGGGAAATCTTTAACGGCCTCTCTTTTGAAGAGCTGCAGCGCATCACTCCGGTGGCGCTGACCTTTCAACAACTGGC
GGAAAGCGCGTAAGGAACCT

Downstream 100 bases:

>100_bases
GGAGCCAGAATGAGTTTGTTGACCCCGATGCTGCGCAGCAGTCCGCTAACCGACTGGTTCAGCGACGCGCAGCGGGTGCA
GGGCATGCTGGATTTTGAAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MMNQAFICDAVRTPFGRFGGALATMRADDLAALPLKALLARNPGLDPSRIDDVIFGCANQAGEDNRNVARMALLLAGLPE
SVPGSTINRLCGSSLDAIGVAARAIKSGETQLMIAGGVESMSRAPFVMGKAESAFSRSMQMEDTTIGWRFINPQMKALYG
VHSMPETAENVADEFAISRADQDAFALRSQLRTAAAQEAGRFADELIAVQVPQRKGEPLLFSRDEHPRSTSLEALAKLRG
VVRADGSVTAGNASGVNDGACALLLASETALSANDLQPLARVVGVATAGVAPRIMGFGPAPAVRKVLAQTGLTLGQMDVI
ELNEAFAAQALAVTRDLGLPDDAAHVNPNGGAIALGHPLGASGGRLAMTAAYQLKRTGGRYALCTMCIGVGQGIALIIER
V

Sequences:

>Translated_401_residues
MMNQAFICDAVRTPFGRFGGALATMRADDLAALPLKALLARNPGLDPSRIDDVIFGCANQAGEDNRNVARMALLLAGLPE
SVPGSTINRLCGSSLDAIGVAARAIKSGETQLMIAGGVESMSRAPFVMGKAESAFSRSMQMEDTTIGWRFINPQMKALYG
VHSMPETAENVADEFAISRADQDAFALRSQLRTAAAQEAGRFADELIAVQVPQRKGEPLLFSRDEHPRSTSLEALAKLRG
VVRADGSVTAGNASGVNDGACALLLASETALSANDLQPLARVVGVATAGVAPRIMGFGPAPAVRKVLAQTGLTLGQMDVI
ELNEAFAAQALAVTRDLGLPDDAAHVNPNGGAIALGHPLGASGGRLAMTAAYQLKRTGGRYALCTMCIGVGQGIALIIER
V
>Mature_401_residues
MMNQAFICDAVRTPFGRFGGALATMRADDLAALPLKALLARNPGLDPSRIDDVIFGCANQAGEDNRNVARMALLLAGLPE
SVPGSTINRLCGSSLDAIGVAARAIKSGETQLMIAGGVESMSRAPFVMGKAESAFSRSMQMEDTTIGWRFINPQMKALYG
VHSMPETAENVADEFAISRADQDAFALRSQLRTAAAQEAGRFADELIAVQVPQRKGEPLLFSRDEHPRSTSLEALAKLRG
VVRADGSVTAGNASGVNDGACALLLASETALSANDLQPLARVVGVATAGVAPRIMGFGPAPAVRKVLAQTGLTLGQMDVI
ELNEAFAAQALAVTRDLGLPDDAAHVNPNGGAIALGHPLGASGGRLAMTAAYQLKRTGGRYALCTMCIGVGQGIALIIER
V

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=43.5323383084577, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=40.2010050251256, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=35.3233830845771, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=40.7594936708861, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=32.8605200945626, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=30, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=68.0798004987531, Blast_Score=547, Evalue=1e-157,
Organism=Escherichia coli, GI1788554, Length=403, Percent_Identity=46.8982630272953, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI87082165, Length=400, Percent_Identity=43.75, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=43.4567901234568, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1788683, Length=428, Percent_Identity=31.0747663551402, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=44.3609022556391, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI25147385, Length=406, Percent_Identity=35.2216748768473, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=33.9152119700748, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=31.7016317016317, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=408, Percent_Identity=29.9019607843137, Blast_Score=148, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=35.7843137254902, Blast_Score=230, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=36.8550368550369, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24655093, Length=402, Percent_Identity=45.0248756218905, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI17648125, Length=400, Percent_Identity=40.75, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=32.3308270676692, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=33.1775700934579, Blast_Score=181, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 41735; Mature: 41735

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNQAFICDAVRTPFGRFGGALATMRADDLAALPLKALLARNPGLDPSRIDDVIFGCANQ
CCCCHHHHHHHHCCHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
AGEDNRNVARMALLLAGLPESVPGSTINRLCGSSLDAIGVAARAIKSGETQLMIAGGVES
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHH
MSRAPFVMGKAESAFSRSMQMEDTTIGWRFINPQMKALYGVHSMPETAENVADEFAISRA
HCCCCEEECCCHHHHHHCCCCCCCEEEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHCC
DQDAFALRSQLRTAAAQEAGRFADELIAVQVPQRKGEPLLFSRDEHPRSTSLEALAKLRG
CHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHH
VVRADGSVTAGNASGVNDGACALLLASETALSANDLQPLARVVGVATAGVAPRIMGFGPA
HHCCCCCEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCC
PAVRKVLAQTGLTLGQMDVIELNEAFAAQALAVTRDLGLPDDAAHVNPNGGAIALGHPLG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCCC
ASGGRLAMTAAYQLKRTGGRYALCTMCIGVGQGIALIIERV
CCCCCEEEHHHHHHHHCCCCHHHHHHHHHCCCCHHHHEECC
>Mature Secondary Structure
MMNQAFICDAVRTPFGRFGGALATMRADDLAALPLKALLARNPGLDPSRIDDVIFGCANQ
CCCCHHHHHHHHCCHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
AGEDNRNVARMALLLAGLPESVPGSTINRLCGSSLDAIGVAARAIKSGETQLMIAGGVES
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHH
MSRAPFVMGKAESAFSRSMQMEDTTIGWRFINPQMKALYGVHSMPETAENVADEFAISRA
HCCCCEEECCCHHHHHHCCCCCCCEEEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHCC
DQDAFALRSQLRTAAAQEAGRFADELIAVQVPQRKGEPLLFSRDEHPRSTSLEALAKLRG
CHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHH
VVRADGSVTAGNASGVNDGACALLLASETALSANDLQPLARVVGVATAGVAPRIMGFGPA
HHCCCCCEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCC
PAVRKVLAQTGLTLGQMDVIELNEAFAAQALAVTRDLGLPDDAAHVNPNGGAIALGHPLG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCCC
ASGGRLAMTAAYQLKRTGGRYALCTMCIGVGQGIALIIERV
CCCCCEEEHHHHHHHHCCCCHHHHHHHHHCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]