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The map label for this gene is tyrR [H]

Identifier: 152969859

GI number: 152969859

Start: 1464595

End: 1466136

Strand: Direct

Name: tyrR [H]

Synonym: KPN_01305

Alternate gene names: 152969859

Gene position: 1464595-1466136 (Clockwise)

Preceding gene: 152969858

Following gene: 152969860

Centisome position: 27.56

GC content: 61.67

Gene sequence:

>1542_bases
ATGCGTCTTGAAGTCTTTTGTGAAGACCGTCTCGGTCTGACTCGTGAATTGCTCGATTTGCTGGTGCTGCGTGGTATTGA
CCTGCGCGGTATCGATATTGACCCTATTGGCCGAATTTACCTCAATTTCGCCGAACTGGAATTCGCCACGTTCAGCAGCC
TGATGGCTGAGATCCGCCGTATCGCCGGCGTGACGGACGTGCGCACCGTGCCCTGGATGCCGTCTGAACGTGAACACCTG
GCGCTCAGCGCGCTGCTGGTAGCGATGCCGGAGCCGGTGCTGTCGCTGGATACCAAAGGTCGGGTGGAACTGGCGAACCC
CGCCAGCTGCCTGCTGTTTGGCCAAAGCCAGGCGAAGCTGCGTAACCACCCGGTGGCCCAGCTGATCGCCGATTTTAACG
TTCAGCGCTGGCTGGAGAGCAGCCCGCAGGAGACGCATGCGGAGCATGTGGTGGTGAATGGGCAGAACTACCTGCTGGAA
GTGACTCCGGTCTATCTGGAAGGAGAGCATAACGAGCGAGTGCTGACCGGCGCCGTGGCGATGTTGCGCTCAACCGTGCG
CATGGGACGCCAGCTGCAGACCATGACCAGCCAGGATACCAGCGCTTTCAGTCAGATCCTCGCGGTGGGGCCGAAAATGC
GCCACGTGGTGGAGCAAGCGCGCAAGCTGGCGATGCTCAGCGCGCCGCTGCTGATTGTCGGCGACACCGGCACCGGTAAA
GATCTGCTGGCCCATGCCTGCCATCTGGCCAGTCCGCGGGCGGGCAAACCCTATCTGGCGCTCAACTGTGGCTCCATTCC
CGAGGACGCGGTCGAGAGCGAGCTGTTTGGCGACGCGCTGCAGGGCAAGAAGGGCTTCTTCGAGCAAGCCAACGGCGGCT
CGGTGCTGCTGGATGAAATTGGCGAGATGTCGCCGCGCATGCAGACCAAGCTGCTGCGCTTTCTCAACGACGGCACCTTC
CGCCGCGTTGGCGAGGATCATGAAGTGCACGTCGATGTGCGGGTGATCTGCGCGACGCAGAAAAACCTGATCGAGCTGGT
GCAGAAAGGGCTTTTCCGCGAAGATCTCTACTATCGCCTCAACGTCCTGACGCTGTATCTGCCGCCGCTGCGCGATTGCC
CGCAGGACATCATGCCGCTGACGGAGCTGTTCGTGGCCCGCTTTGCCGACGAGCAGGGGATCCCGCGGCCGAAGCTCTCT
GCCGATCTCAGTACGGTGCTTACCCGCTACAGCTGGCCCGGCAACGTCCGCCAGCTGAAGAATGCCGTCTATCGCGCACT
GACCCAGCTGGAAGGATTTGAGCTGCGTCCACAGGACATTCTGCTGCCGGACCATGACGTCGCCTCGCTGCCGGTGGGCG
AGGAGGCCATGGAAGGGTCGCTGGACGACATCACCCGCCGCTTTGAGCGCTCGGTGCTGACCCAGCTCTATCGCAGCTAC
CCCAGCACACGTAAGCTGGCGAAGCGGCTGGGGGTGTCGCATACCGCCATCGCCAATAAGCTGCGTGAATATGGTCTGAG
TCAGAAAAAGGGCGACGAATAA

Upstream 100 bases:

>100_bases
TTCCGCCACACTGTCAATAATTGTTGACAGTTAGCTTCCCGAAAACCCATTCCTGGCCTATTATTCTCCCGTCATTGGCA
CTTTTAGGGTGAACACTCCC

Downstream 100 bases:

>100_bases
TCCCGCCAGGCCGGCGACTCACGTCGCCGGCATCCCGGCCTGCAAAGCGGGCCAAACCTGTATATACTGGTTTTTTAATC
CTTTTTCCGGGGTGGTGCAT

Product: DNA-binding transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MRLEVFCEDRLGLTRELLDLLVLRGIDLRGIDIDPIGRIYLNFAELEFATFSSLMAEIRRIAGVTDVRTVPWMPSEREHL
ALSALLVAMPEPVLSLDTKGRVELANPASCLLFGQSQAKLRNHPVAQLIADFNVQRWLESSPQETHAEHVVVNGQNYLLE
VTPVYLEGEHNERVLTGAVAMLRSTVRMGRQLQTMTSQDTSAFSQILAVGPKMRHVVEQARKLAMLSAPLLIVGDTGTGK
DLLAHACHLASPRAGKPYLALNCGSIPEDAVESELFGDALQGKKGFFEQANGGSVLLDEIGEMSPRMQTKLLRFLNDGTF
RRVGEDHEVHVDVRVICATQKNLIELVQKGLFREDLYYRLNVLTLYLPPLRDCPQDIMPLTELFVARFADEQGIPRPKLS
ADLSTVLTRYSWPGNVRQLKNAVYRALTQLEGFELRPQDILLPDHDVASLPVGEEAMEGSLDDITRRFERSVLTQLYRSY
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGDE

Sequences:

>Translated_513_residues
MRLEVFCEDRLGLTRELLDLLVLRGIDLRGIDIDPIGRIYLNFAELEFATFSSLMAEIRRIAGVTDVRTVPWMPSEREHL
ALSALLVAMPEPVLSLDTKGRVELANPASCLLFGQSQAKLRNHPVAQLIADFNVQRWLESSPQETHAEHVVVNGQNYLLE
VTPVYLEGEHNERVLTGAVAMLRSTVRMGRQLQTMTSQDTSAFSQILAVGPKMRHVVEQARKLAMLSAPLLIVGDTGTGK
DLLAHACHLASPRAGKPYLALNCGSIPEDAVESELFGDALQGKKGFFEQANGGSVLLDEIGEMSPRMQTKLLRFLNDGTF
RRVGEDHEVHVDVRVICATQKNLIELVQKGLFREDLYYRLNVLTLYLPPLRDCPQDIMPLTELFVARFADEQGIPRPKLS
ADLSTVLTRYSWPGNVRQLKNAVYRALTQLEGFELRPQDILLPDHDVASLPVGEEAMEGSLDDITRRFERSVLTQLYRSY
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGDE
>Mature_513_residues
MRLEVFCEDRLGLTRELLDLLVLRGIDLRGIDIDPIGRIYLNFAELEFATFSSLMAEIRRIAGVTDVRTVPWMPSEREHL
ALSALLVAMPEPVLSLDTKGRVELANPASCLLFGQSQAKLRNHPVAQLIADFNVQRWLESSPQETHAEHVVVNGQNYLLE
VTPVYLEGEHNERVLTGAVAMLRSTVRMGRQLQTMTSQDTSAFSQILAVGPKMRHVVEQARKLAMLSAPLLIVGDTGTGK
DLLAHACHLASPRAGKPYLALNCGSIPEDAVESELFGDALQGKKGFFEQANGGSVLLDEIGEMSPRMQTKLLRFLNDGTF
RRVGEDHEVHVDVRVICATQKNLIELVQKGLFREDLYYRLNVLTLYLPPLRDCPQDIMPLTELFVARFADEQGIPRPKLS
ADLSTVLTRYSWPGNVRQLKNAVYRALTQLEGFELRPQDILLPDHDVASLPVGEEAMEGSLDDITRRFERSVLTQLYRSY
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGDE

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=513, Percent_Identity=84.990253411306, Blast_Score=901, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=345, Percent_Identity=36.8115942028986, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1790299, Length=358, Percent_Identity=38.268156424581, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI87082152, Length=334, Percent_Identity=36.8263473053892, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1790437, Length=309, Percent_Identity=37.2168284789644, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1789233, Length=450, Percent_Identity=27.1111111111111, Blast_Score=185, Evalue=8e-48,
Organism=Escherichia coli, GI1788905, Length=239, Percent_Identity=41.8410041841004, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789087, Length=319, Percent_Identity=35.423197492163, Blast_Score=178, Evalue=9e-46,
Organism=Escherichia coli, GI87082117, Length=366, Percent_Identity=32.7868852459016, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786524, Length=275, Percent_Identity=41.4545454545455, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87081872, Length=257, Percent_Identity=36.9649805447471, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1789828, Length=244, Percent_Identity=34.8360655737705, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI87081858, Length=436, Percent_Identity=23.6238532110092, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57400; Mature: 57400

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVFCEDRLGLTRELLDLLVLRGIDLRGIDIDPIGRIYLNFAELEFATFSSLMAEIRR
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHH
IAGVTDVRTVPWMPSEREHLALSALLVAMPEPVLSLDTKGRVELANPASCLLFGQSQAKL
HCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCEEECCCCEEEEECCCHHHH
RNHPVAQLIADFNVQRWLESSPQETHAEHVVVNGQNYLLEVTPVYLEGEHNERVLTGAVA
HCCHHHHHHHHHHHHHHHHCCCCHHCCCEEEECCCCEEEEEEEEEEECCCCCHHHHHHHH
MLRSTVRMGRQLQTMTSQDTSAFSQILAVGPKMRHVVEQARKLAMLSAPLLIVGDTGTGK
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
DLLAHACHLASPRAGKPYLALNCGSIPEDAVESELFGDALQGKKGFFEQANGGSVLLDEI
HHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHH
GEMSPRMQTKLLRFLNDGTFRRVGEDHEVHVDVRVICATQKNLIELVQKGLFREDLYYRL
HCCCHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHE
NVLTLYLPPLRDCPQDIMPLTELFVARFADEQGIPRPKLSADLSTVLTRYSWPGNVRQLK
EEEEEECCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
NAVYRALTQLEGFELRPQDILLPDHDVASLPVGEEAMEGSLDDITRRFERSVLTQLYRSY
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHC
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGDE
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRLEVFCEDRLGLTRELLDLLVLRGIDLRGIDIDPIGRIYLNFAELEFATFSSLMAEIRR
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHH
IAGVTDVRTVPWMPSEREHLALSALLVAMPEPVLSLDTKGRVELANPASCLLFGQSQAKL
HCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCEEECCCCEEEEECCCHHHH
RNHPVAQLIADFNVQRWLESSPQETHAEHVVVNGQNYLLEVTPVYLEGEHNERVLTGAVA
HCCHHHHHHHHHHHHHHHHCCCCHHCCCEEEECCCCEEEEEEEEEEECCCCCHHHHHHHH
MLRSTVRMGRQLQTMTSQDTSAFSQILAVGPKMRHVVEQARKLAMLSAPLLIVGDTGTGK
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
DLLAHACHLASPRAGKPYLALNCGSIPEDAVESELFGDALQGKKGFFEQANGGSVLLDEI
HHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHH
GEMSPRMQTKLLRFLNDGTFRRVGEDHEVHVDVRVICATQKNLIELVQKGLFREDLYYRL
HCCCHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHE
NVLTLYLPPLRDCPQDIMPLTELFVARFADEQGIPRPKLSADLSTVLTRYSWPGNVRQLK
EEEEEECCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
NAVYRALTQLEGFELRPQDILLPDHDVASLPVGEEAMEGSLDDITRRFERSVLTQLYRSY
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHC
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGDE
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA