BacMap

Definition	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome.
Accession	NC_009648
Length	5,315,120

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The map label for this gene is yeaE [H]

Identifier: 152969749

GI number: 152969749

Start: 1345116

End: 1346000

Strand: Direct

Name: yeaE [H]

Synonym: KPN_01195

Alternate gene names: 152969749

Gene position: 1345116-1346000 (Clockwise)

Preceding gene: 152969748

Following gene: 152969752

Centisome position: 25.31

GC content: 61.92

Gene sequence:

>885_bases
ATGGTGGTGCATACGGTTAAGGAGGAGAAGATGGTGAAAAAAACAGTACGCTTCGGCGAGCAGGCGGCAGTGCCGGCCAT
CGGGCTGGGCACCTGGTATATGGGCGAACATGCGGCGCAGCGTCAGCAGGAAGTGGCTGCACTGCGGGCGGGCATCGACC
ATGGACTGACGGTGATCGATACGGCGGAAATGTACGCCGACGGCGGGGCGGAGGAAGTGGTGGGCCAGGCGATCCGCGGT
CTGCGCGACCGGGTAGTGCTGGTCTCCAAAGTCTATCCCTGGCATGCCGGCAAAGCGGCGATGCACCGCGCCTGTGAAAA
CAGCCTGCGCCGGCTGCAGACCGACTATCTGGACATGTATCTCCTGCACTGGCGCGGGGATATCCCGCTGCAGGAGACGG
TTGAGGCGATGGAGAAGCTGGTGGCCGAGGGCAAGATCCGCCGCTGGGGCGTCTCTAATCTGGACACCGAGGATATGCAG
GCGCTGTGGCGGACGGCGGATGGCGAGCACTGTGCAACCAACCAGGTGCTCTACCATCTCGCATCGCGGGGCATTGAATA
CGATCTCCTGCCCTGGTGCCAGCAGCACAGTCTGCCGGTGATGGCCTACTGCCCGCTGGCGCAGGCTGGGCGCTTACGCG
ATGGACTTTTTCAGCATAGCGATATCATTAATATGGCTAACGCGCGGGGGATTACGGTAGCGCAACTGCTGCTCGCTTGG
GTGATTCGTCATCCGGGAGTGCTGGCGATCCCGAAAGCGGCCAGTATTGAGCATGTGGTGCAGAATGCCGCAGCGCTCGA
CATCGTCCTTAGTGGGGAAGAGCTCGCGCAGCTGGACCGCCTCTATCCGCCGCCGCAGCGAAAAACCCGGCTGGATATGG
TTTAA

Upstream 100 bases:

>100_bases
AGCGGTCTGATCTCCACCGGGATCACCTACACCTTCTGATTGTGCATTCTTACAGTGCGCTTCATGCAGCAAAACAGGGC
CTTGCGCCCTGTTTTGCTTT

Downstream 100 bases:

>100_bases
CCCATCGTTCACGGCAAAGAAAAACAAAAGCCCCGTTACCAACGGGGCTTTTGCTATTAGCGTTTTTTCACGCTGATGGT
TTGCGCCAGGCGAGAGGGCG

Product: putative an aldehyde reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MVVHTVKEEKMVKKTVRFGEQAAVPAIGLGTWYMGEHAAQRQQEVAALRAGIDHGLTVIDTAEMYADGGAEEVVGQAIRG
LRDRVVLVSKVYPWHAGKAAMHRACENSLRRLQTDYLDMYLLHWRGDIPLQETVEAMEKLVAEGKIRRWGVSNLDTEDMQ
ALWRTADGEHCATNQVLYHLASRGIEYDLLPWCQQHSLPVMAYCPLAQAGRLRDGLFQHSDIINMANARGITVAQLLLAW
VIRHPGVLAIPKAASIEHVVQNAAALDIVLSGEELAQLDRLYPPPQRKTRLDMV

Sequences:

>Translated_294_residues
MVVHTVKEEKMVKKTVRFGEQAAVPAIGLGTWYMGEHAAQRQQEVAALRAGIDHGLTVIDTAEMYADGGAEEVVGQAIRG
LRDRVVLVSKVYPWHAGKAAMHRACENSLRRLQTDYLDMYLLHWRGDIPLQETVEAMEKLVAEGKIRRWGVSNLDTEDMQ
ALWRTADGEHCATNQVLYHLASRGIEYDLLPWCQQHSLPVMAYCPLAQAGRLRDGLFQHSDIINMANARGITVAQLLLAW
VIRHPGVLAIPKAASIEHVVQNAAALDIVLSGEELAQLDRLYPPPQRKTRLDMV
>Mature_294_residues
MVVHTVKEEKMVKKTVRFGEQAAVPAIGLGTWYMGEHAAQRQQEVAALRAGIDHGLTVIDTAEMYADGGAEEVVGQAIRG
LRDRVVLVSKVYPWHAGKAAMHRACENSLRRLQTDYLDMYLLHWRGDIPLQETVEAMEKLVAEGKIRRWGVSNLDTEDMQ
ALWRTADGEHCATNQVLYHLASRGIEYDLLPWCQQHSLPVMAYCPLAQAGRLRDGLFQHSDIINMANARGITVAQLLLAW
VIRHPGVLAIPKAASIEHVVQNAAALDIVLSGEELAQLDRLYPPPQRKTRLDMV

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=296, Percent_Identity=28.7162162162162, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=29.553264604811, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=29.553264604811, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI291291012, Length=265, Percent_Identity=28.6792452830189, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI5174695, Length=305, Percent_Identity=26.2295081967213, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4504825, Length=311, Percent_Identity=25.7234726688103, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI27436969, Length=311, Percent_Identity=25.7234726688103, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI223718702, Length=217, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI27436964, Length=296, Percent_Identity=26.0135135135135, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI27436966, Length=296, Percent_Identity=26.0135135135135, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI27436962, Length=297, Percent_Identity=26.5993265993266, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4502049, Length=290, Percent_Identity=28.9655172413793, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310109922, Length=285, Percent_Identity=25.6140350877193, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI24497583, Length=306, Percent_Identity=25.4901960784314, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI41327764, Length=187, Percent_Identity=32.620320855615, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI24497585, Length=300, Percent_Identity=25.6666666666667, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI310109920, Length=305, Percent_Identity=24.2622950819672, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI45446745, Length=305, Percent_Identity=24.2622950819672, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4503285, Length=305, Percent_Identity=24.2622950819672, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI5453543, Length=305, Percent_Identity=23.9344262295082, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI41152114, Length=215, Percent_Identity=30.2325581395349, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1788081, Length=284, Percent_Identity=66.5492957746479, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI87081735, Length=305, Percent_Identity=30.1639344262295, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87082198, Length=285, Percent_Identity=29.4736842105263, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788070, Length=298, Percent_Identity=28.1879194630872, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1786400, Length=276, Percent_Identity=27.8985507246377, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789375, Length=311, Percent_Identity=27.0096463022508, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789199, Length=335, Percent_Identity=26.865671641791, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787674, Length=301, Percent_Identity=25.5813953488372, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI48994888, Length=254, Percent_Identity=28.740157480315, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564128, Length=318, Percent_Identity=28.6163522012579, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17561298, Length=278, Percent_Identity=29.136690647482, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17552492, Length=272, Percent_Identity=28.3088235294118, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71998625, Length=284, Percent_Identity=30.2816901408451, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537077, Length=299, Percent_Identity=26.4214046822742, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537075, Length=313, Percent_Identity=26.517571884984, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17538386, Length=280, Percent_Identity=28.9285714285714, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17550248, Length=300, Percent_Identity=23.3333333333333, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17566692, Length=290, Percent_Identity=25.1724137931034, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324694, Length=300, Percent_Identity=26, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322556, Length=289, Percent_Identity=26.643598615917, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=28.1138790035587, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644950, Length=308, Percent_Identity=29.8701298701299, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221378297, Length=328, Percent_Identity=28.0487804878049, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45553081, Length=298, Percent_Identity=27.5167785234899, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24663317, Length=296, Percent_Identity=27.027027027027, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI20129731, Length=297, Percent_Identity=29.2929292929293, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=28.2945736434109, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24657054, Length=299, Percent_Identity=27.0903010033445, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=26.962457337884, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356425, Length=296, Percent_Identity=26.3513513513513, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24662781, Length=293, Percent_Identity=25.5972696245734, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 32823; Mature: 32823

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVHTVKEEKMVKKTVRFGEQAAVPAIGLGTWYMGEHAAQRQQEVAALRAGIDHGLTVID
CCCCCHHHHHHHHHHHHCCCHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
TAEMYADGGAEEVVGQAIRGLRDRVVLVSKVYPWHAGKAAMHRACENSLRRLQTDYLDMY
HHHHHHCCCHHHHHHHHHHHHHHHEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLHWRGDIPLQETVEAMEKLVAEGKIRRWGVSNLDTEDMQALWRTADGEHCATNQVLYHL
HEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
ASRGIEYDLLPWCQQHSLPVMAYCPLAQAGRLRDGLFQHSDIINMANARGITVAQLLLAW
HHCCCCCCCCCHHHHCCCCEEEECCCHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VIRHPGVLAIPKAASIEHVVQNAAALDIVLSGEELAQLDRLYPPPQRKTRLDMV
HHHCCCEEEECCHHHHHHHHHHHHHHEEEECCHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MVVHTVKEEKMVKKTVRFGEQAAVPAIGLGTWYMGEHAAQRQQEVAALRAGIDHGLTVID
CCCCCHHHHHHHHHHHHCCCHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
TAEMYADGGAEEVVGQAIRGLRDRVVLVSKVYPWHAGKAAMHRACENSLRRLQTDYLDMY
HHHHHHCCCHHHHHHHHHHHHHHHEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLHWRGDIPLQETVEAMEKLVAEGKIRRWGVSNLDTEDMQALWRTADGEHCATNQVLYHL
HEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
ASRGIEYDLLPWCQQHSLPVMAYCPLAQAGRLRDGLFQHSDIINMANARGITVAQLLLAW
HHCCCCCCCCCHHHHCCCCEEEECCCHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VIRHPGVLAIPKAASIEHVVQNAAALDIVLSGEELAQLDRLYPPPQRKTRLDMV
HHHCCCEEEECCHHHHHHHHHHHHHHEEEECCHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]