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The map label for this gene is umuC [H]

Identifier: 152969738

GI number: 152969738

Start: 1333284

End: 1334549

Strand: Direct

Name: umuC [H]

Synonym: KPN_01184

Alternate gene names: 152969738

Gene position: 1333284-1334549 (Clockwise)

Preceding gene: 152969737

Following gene: 152969740

Centisome position: 25.08

GC content: 61.61

Gene sequence:

>1266_bases
ATGTTCGCGCATTGTGATGTGAACGCCTTCTATGCCAGCTGTCAGACCGCCTTCCGGCCAGACCTGAAGGGGCGGCCGGT
GGTGGTGCTGTCGAACAACGACGGCTGCGTGATCGCCCGCTCGGCGGAGGCGAAGCCGTTTGTGAAAATGGGCGAACCCT
ACTTTAAGCAGAAGGCTGCGTTTCTTCGCCACGGCGTCGTGGCGTTTAGCAGTAATTATGAGCTGTATGCCGACATGTCC
AGCCGGGTGATGGCCACCCTGGAAGAGCTCACCCCGCGCTGCGAAATTTACAGTATCGATGAGGCCTTTTGCGATGTCAG
CGGTGTGCGTCATTGCAGAGATCTGACCGATTTTGGCCGCGAAATCCGCGCCACGGTGCTGCAGCGTACCCATCTGACGC
TGGGCGTTGGCATCGCCCAGACCAAAACCCTGGCGAAGCTGGCCAACCACGCGGCGAAGCAGTGGCCGCGGCAGACGGGC
GGGGTAGTGGACTTGTCCTGCCCGCAGCGGCAGCGAAAGCTGATGGCGCTGCTGCCGGTGAGCGAGGTCTGGGGCATCGG
GCGGCGGATCGGCAAAAAGCTTGAAGCGATGGGGATCGGCACGGTACTCCAGCTGGCGGAGAGCGATATCCGCTTTATCC
GCAAGCACTTCACGGTAGTGCTCGAACGAACGGTACGGGAGCTGCGCGGCGAGCCTTGCCTGGCGCTGGAGGAGTTTGCC
CCCGCTAAGCAGGAAATTATCTGCAGCCGCTCGTTCGGGGATCGGATTACGGCCTATGAGGATATGCGCCAGGCGATCTG
CAGCTATGCCGCGCGGGCAGCAGAAAAGCTGCGCGGTGAGCATCAGTACTGCCGGTTCGTCTCCGCCTTTGTCAAAACCA
GCCCCTTCGCGCTGAATGAACCCTATTACGGCAACAGCGCCTCGCTAAAGCTGCTGACGCCGACCCAGGACTCCCGGGAT
ATTATCGCCGCGGCGACGAGCTGTCTGGATGCCATCTGGAAAGCGGGGCATCGCTATCAGAAGGCCGGCGTGATGCTCGG
CGATTTCTACAGCCAGGGCGTCGCCCAGCTGAATCTGTTCGACGAGCTTGCTCCGCGGCACAACAGCGCCAGACTGATGC
AGGTTCTCGACCAGCTGAATGCGAAAAACGGCAGGGGGGCGCTCTATTTTGCCGGCCAGGGGATCCAGCAGCAGTGGCAG
ATGAAGCGGGAGATGCTCTCGCCGCGCTACACCACGCGATACGGCGACCTGCTCCGCGTCAGATAA

Upstream 100 bases:

>100_bases
ACCCGATGAACCCGGCCTATTCGCCCATCGTGGTCGGCCGCGAGGAGACGCTCGATATTTTCGGCGTCGTAACCTACATC
ATCAAGGCGGCGGGCTGATC

Downstream 100 bases:

>100_bases
CGCGCGCTATCCCTGCACCGCGGCCGGAAAAACCGCCACCAGCCAGTCAATAAAGACGCGGAGCCGGGGCGGGACGTGCC
GGTGCCGGGCATAGACAACG

Product: DNA polymerase V subunit UmuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MFAHCDVNAFYASCQTAFRPDLKGRPVVVLSNNDGCVIARSAEAKPFVKMGEPYFKQKAAFLRHGVVAFSSNYELYADMS
SRVMATLEELTPRCEIYSIDEAFCDVSGVRHCRDLTDFGREIRATVLQRTHLTLGVGIAQTKTLAKLANHAAKQWPRQTG
GVVDLSCPQRQRKLMALLPVSEVWGIGRRIGKKLEAMGIGTVLQLAESDIRFIRKHFTVVLERTVRELRGEPCLALEEFA
PAKQEIICSRSFGDRITAYEDMRQAICSYAARAAEKLRGEHQYCRFVSAFVKTSPFALNEPYYGNSASLKLLTPTQDSRD
IIAAATSCLDAIWKAGHRYQKAGVMLGDFYSQGVAQLNLFDELAPRHNSARLMQVLDQLNAKNGRGALYFAGQGIQQQWQ
MKREMLSPRYTTRYGDLLRVR

Sequences:

>Translated_421_residues
MFAHCDVNAFYASCQTAFRPDLKGRPVVVLSNNDGCVIARSAEAKPFVKMGEPYFKQKAAFLRHGVVAFSSNYELYADMS
SRVMATLEELTPRCEIYSIDEAFCDVSGVRHCRDLTDFGREIRATVLQRTHLTLGVGIAQTKTLAKLANHAAKQWPRQTG
GVVDLSCPQRQRKLMALLPVSEVWGIGRRIGKKLEAMGIGTVLQLAESDIRFIRKHFTVVLERTVRELRGEPCLALEEFA
PAKQEIICSRSFGDRITAYEDMRQAICSYAARAAEKLRGEHQYCRFVSAFVKTSPFALNEPYYGNSASLKLLTPTQDSRD
IIAAATSCLDAIWKAGHRYQKAGVMLGDFYSQGVAQLNLFDELAPRHNSARLMQVLDQLNAKNGRGALYFAGQGIQQQWQ
MKREMLSPRYTTRYGDLLRVR
>Mature_421_residues
MFAHCDVNAFYASCQTAFRPDLKGRPVVVLSNNDGCVIARSAEAKPFVKMGEPYFKQKAAFLRHGVVAFSSNYELYADMS
SRVMATLEELTPRCEIYSIDEAFCDVSGVRHCRDLTDFGREIRATVLQRTHLTLGVGIAQTKTLAKLANHAAKQWPRQTG
GVVDLSCPQRQRKLMALLPVSEVWGIGRRIGKKLEAMGIGTVLQLAESDIRFIRKHFTVVLERTVRELRGEPCLALEEFA
PAKQEIICSRSFGDRITAYEDMRQAICSYAARAAEKLRGEHQYCRFVSAFVKTSPFALNEPYYGNSASLKLLTPTQDSRD
IIAAATSCLDAIWKAGHRYQKAGVMLGDFYSQGVAQLNLFDELAPRHNSARLMQVLDQLNAKNGRGALYFAGQGIQQQWQ
MKREMLSPRYTTRYGDLLRVR

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=422, Percent_Identity=83.175355450237, Blast_Score=732, Evalue=0.0,
Organism=Escherichia coli, GI1786425, Length=218, Percent_Identity=27.0642201834862, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47299; Mature: 47299

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAHCDVNAFYASCQTAFRPDLKGRPVVVLSNNDGCVIARSAEAKPFVKMGEPYFKQKAA
CCEECCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHCCCHHHHHHHH
FLRHGVVAFSSNYELYADMSSRVMATLEELTPRCEIYSIDEAFCDVSGVRHCRDLTDFGR
HHHHCCEEEECCCEEEECHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
EIRATVLQRTHLTLGVGIAQTKTLAKLANHAAKQWPRQTGGVVDLSCPQRQRKLMALLPV
HHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHCHHHCCCEEECCCCHHHHHHHHHCCH
SEVWGIGRRIGKKLEAMGIGTVLQLAESDIRFIRKHFTVVLERTVRELRGEPCLALEEFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHC
PAKQEIICSRSFGDRITAYEDMRQAICSYAARAAEKLRGEHQYCRFVSAFVKTSPFALNE
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCC
PYYGNSASLKLLTPTQDSRDIIAAATSCLDAIWKAGHRYQKAGVMLGDFYSQGVAQLNLF
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
DELAPRHNSARLMQVLDQLNAKNGRGALYFAGQGIQQQWQMKREMLSPRYTTRYGDLLRV
HHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHCCCCCEEEC
R
C
>Mature Secondary Structure
MFAHCDVNAFYASCQTAFRPDLKGRPVVVLSNNDGCVIARSAEAKPFVKMGEPYFKQKAA
CCEECCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHCCCHHHHHHHH
FLRHGVVAFSSNYELYADMSSRVMATLEELTPRCEIYSIDEAFCDVSGVRHCRDLTDFGR
HHHHCCEEEECCCEEEECHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
EIRATVLQRTHLTLGVGIAQTKTLAKLANHAAKQWPRQTGGVVDLSCPQRQRKLMALLPV
HHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHCHHHCCCEEECCCCHHHHHHHHHCCH
SEVWGIGRRIGKKLEAMGIGTVLQLAESDIRFIRKHFTVVLERTVRELRGEPCLALEEFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHC
PAKQEIICSRSFGDRITAYEDMRQAICSYAARAAEKLRGEHQYCRFVSAFVKTSPFALNE
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCC
PYYGNSASLKLLTPTQDSRDIIAAATSCLDAIWKAGHRYQKAGVMLGDFYSQGVAQLNLF
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
DELAPRHNSARLMQVLDQLNAKNGRGALYFAGQGIQQQWQMKREMLSPRYTTRYGDLLRV
HHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHCCCCCEEEC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]