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The map label for this gene is fes [H]

Identifier: 152969174

GI number: 152969174

Start: 681713

End: 682861

Strand: Direct

Name: fes [H]

Synonym: KPN_00603

Alternate gene names: 152969174

Gene position: 681713-682861 (Clockwise)

Preceding gene: 152969166

Following gene: 152969175

Centisome position: 12.83

GC content: 67.54

Gene sequence:

>1149_bases
GTGGATGACGCCATCGAGGTAACGTTCTGGTGGCGGGACCCGGCGGGGGATGAAACCCGCTCTCCCCATCGTCGGGTATG
GCTCTATATCACCGGCGTGACCGACCACCATCAGAATGCGCGTCCGCAATCGCTGCAACGTCTCCCCGGGACCGACGCCT
GGTTCTGGCGCACTACGCTGTCGCCGACCTGGCGCGGCAGCTACTGTTTTATTCCCTCCGACCGTGACGATGATTTTTCC
CCTGAGGTGTTCAGCGCTAATGCGCCCGACCGCGCGCTGCTACGCGAAGGCTGGCGCAAACTGCTGCCGCGGGCGATAGC
CGATCCGCTGAACCCGCACAGCTGGCGGGGCGGACGCGGCCATGGCGTGTCCGCCCTGGAGATGCCGCAGGCCCCCGCGC
AGCCTGGCTGGGACCCGCTTAATGAGGCGCATCCTGCCGCCCGTTGCCTTGAGTGGCGCAGCGCGCGTCTGGGCAACCAT
CGCCGGGTCTGGATCTACACCACCGGCGAGGCTGTCGACCCGCAAACGCGGCCGCTGGCGATCCTGCTCGACGGCCAATT
CTGGGCCGAGAGCATGCCGGTGTGGTCGCCGCTGGCCGCCCTGACCCGCGAGGGGAGACTGCCGCCGGCGGTCTACCTGC
TGATCGACGCGATCGACAACCAGCGCCGCGGGGTTGAGCTGCCCTGTCACCGCGATTTCTGGCTTGCGGTGCAGGAGGAG
CTCCTGCCGCTGGTCCACGGCTATGCCCCGTTCAGCGACCGCCCGGATCGGACGGTGGTGGCCGGGCAAAGCTTCGGCGG
TCTGGCGGCGATGTTCGCCGCTCTCAACTGGCCGCAGCGCTTTGGCTGCGTGCTCAGCCAGTCAGGCTCCTACTGGTGGC
CGCACCGTGATGGCCGCGGGACGGGCTTTATCGGCGAACAGCTTCGCCAGGGTGAGGTGTCCGCGGCCGGGCTGCGCGTC
TGGCTGGAAGCGGGCCAACGCGAACCGATCATTTTTCGCGCGAACCAGGCGCTACTGGCGCAACTCACCACAACACAGCA
GACGATTTTCTGGCGTCAGGTTGACGGCGGGCATGATGCGCTTTGCTGGCGCGGCGGGCTGACGGCAGGGCTTATCCAGC
TCTGGCAGCCTCTGCTGTCGCACCCTTAG

Upstream 100 bases:

>100_bases
TAATTAAAAAAGTCACGCTATACATAGGGTTAATGACAGAATGTTAAGGACAGGAAGCGAGGAGTGGTGGCAAACCCTGC
GGGGGCCGCAGTGCCGCGCA

Downstream 100 bases:

>100_bases
CATCGCGTTTTACGACAGGAGTTTGATATGCAATTCAGTAACCCCTTCGACAATCCGCAAGGGCAGTTTTACATTCTGCG
CAATGATCAACAGCAGTACA

Product: enterobactin/ferric enterobactin esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDDAIEVTFWWRDPAGDETRSPHRRVWLYITGVTDHHQNARPQSLQRLPGTDAWFWRTTLSPTWRGSYCFIPSDRDDDFS
PEVFSANAPDRALLREGWRKLLPRAIADPLNPHSWRGGRGHGVSALEMPQAPAQPGWDPLNEAHPAARCLEWRSARLGNH
RRVWIYTTGEAVDPQTRPLAILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDNQRRGVELPCHRDFWLAVQEE
LLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQRFGCVLSQSGSYWWPHRDGRGTGFIGEQLRQGEVSAAGLRV
WLEAGQREPIIFRANQALLAQLTTTQQTIFWRQVDGGHDALCWRGGLTAGLIQLWQPLLSHP

Sequences:

>Translated_382_residues
MDDAIEVTFWWRDPAGDETRSPHRRVWLYITGVTDHHQNARPQSLQRLPGTDAWFWRTTLSPTWRGSYCFIPSDRDDDFS
PEVFSANAPDRALLREGWRKLLPRAIADPLNPHSWRGGRGHGVSALEMPQAPAQPGWDPLNEAHPAARCLEWRSARLGNH
RRVWIYTTGEAVDPQTRPLAILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDNQRRGVELPCHRDFWLAVQEE
LLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQRFGCVLSQSGSYWWPHRDGRGTGFIGEQLRQGEVSAAGLRV
WLEAGQREPIIFRANQALLAQLTTTQQTIFWRQVDGGHDALCWRGGLTAGLIQLWQPLLSHP
>Mature_382_residues
MDDAIEVTFWWRDPAGDETRSPHRRVWLYITGVTDHHQNARPQSLQRLPGTDAWFWRTTLSPTWRGSYCFIPSDRDDDFS
PEVFSANAPDRALLREGWRKLLPRAIADPLNPHSWRGGRGHGVSALEMPQAPAQPGWDPLNEAHPAARCLEWRSARLGNH
RRVWIYTTGEAVDPQTRPLAILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDNQRRGVELPCHRDFWLAVQEE
LLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQRFGCVLSQSGSYWWPHRDGRGTGFIGEQLRQGEVSAAGLRV
WLEAGQREPIIFRANQALLAQLTTTQQTIFWRQVDGGHDALCWRGGLTAGLIQLWQPLLSHP

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=375, Percent_Identity=67.4666666666667, Blast_Score=515, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 43200; Mature: 43200

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDAIEVTFWWRDPAGDETRSPHRRVWLYITGVTDHHQNARPQSLQRLPGTDAWFWRTTL
CCCCEEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHCCCCCCEEEEEEC
SPTWRGSYCFIPSDRDDDFSPEVFSANAPDRALLREGWRKLLPRAIADPLNPHSWRGGRG
CCCCCCCEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HGVSALEMPQAPAQPGWDPLNEAHPAARCLEWRSARLGNHRRVWIYTTGEAVDPQTRPLA
CCCCCEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEE
ILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDNQRRGVELPCHRDFWLAVQEE
EEECCCHHHCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
LLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQRFGCVLSQSGSYWWPHRDGRG
HHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHEECCCCEECCCCCCCC
TGFIGEQLRQGEVSAAGLRVWLEAGQREPIIFRANQALLAQLTTTQQTIFWRQVDGGHDA
CCHHHHHHHCCCCCHHHHHEEEECCCCCCEEEECCHHHHHHHHHCCEEEEEEECCCCCCE
LCWRGGLTAGLIQLWQPLLSHP
EEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDDAIEVTFWWRDPAGDETRSPHRRVWLYITGVTDHHQNARPQSLQRLPGTDAWFWRTTL
CCCCEEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHCCCCCCEEEEEEC
SPTWRGSYCFIPSDRDDDFSPEVFSANAPDRALLREGWRKLLPRAIADPLNPHSWRGGRG
CCCCCCCEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HGVSALEMPQAPAQPGWDPLNEAHPAARCLEWRSARLGNHRRVWIYTTGEAVDPQTRPLA
CCCCCEECCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEE
ILLDGQFWAESMPVWSPLAALTREGRLPPAVYLLIDAIDNQRRGVELPCHRDFWLAVQEE
EEECCCHHHCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
LLPLVHGYAPFSDRPDRTVVAGQSFGGLAAMFAALNWPQRFGCVLSQSGSYWWPHRDGRG
HHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHEECCCCEECCCCCCCC
TGFIGEQLRQGEVSAAGLRVWLEAGQREPIIFRANQALLAQLTTTQQTIFWRQVDGGHDA
CCHHHHHHHCCCCCHHHHHEEEECCCCCCEEEECCHHHHHHHHHCCEEEEEEECCCCCCE
LCWRGGLTAGLIQLWQPLLSHP
EEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]