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The map label for this gene is degP [H]

Identifier: 152968757

GI number: 152968757

Start: 207659

End: 209092

Strand: Direct

Name: degP [H]

Synonym: KPN_00176

Alternate gene names: 152968757

Gene position: 207659-209092 (Clockwise)

Preceding gene: 152968756

Following gene: 152968758

Centisome position: 3.91

GC content: 57.6

Gene sequence:

>1434_bases
ATGAAAAAAACCACGTTAGCAATGAGTGCACTGGCTCTGAGTTTAGGTCTGGCGTTGTCCCCGCTCTCTGCGAGCGCGGC
AGAAACGGCATCTTCGGCCACTAATGCACAGCAGATGCCAAGCCTGGCCCCGATGCTGGAGAAGGTGATGCCGTCGGTGG
TGAGCATTAACGTTGAAGGTAGCACCACCGTTAATACTCCACGGATGCCACGCAACTTCCAGCAGTTCTTTGGCGATAAT
TCGCCGTTCTGCCAGGATGGTTCTCCTTTCCAGAGTTCACCGTTTTGCCAGGGCGGCGGACAGGGCGGTCAGCCTGACGG
CGGCCAGCAGCAGAAATTTATGGCGCTGGGCTCCGGCGTCATCATTGATGCCGCCAAAGGGTATGTGGTGACCAACAACC
ACGTCGTGGACAACGCCACCACGATTAAGGTTCAGCTGAGCGATGGCCGTAGGTTTGATGCTAAAGTCGTCGGCAAAGAT
CCGCGCTCTGATATCGCGCTGATTCAGATTCAGGAGCCAAAAAACCTGACGGCGATTAAGCTTGCCGACTCCGATGCGCT
GCGCGTCGGTGATTACACCGTGGCTATCGGCAACCCGTTCGGTCTGGGCGAAACCGTGACCTCCGGGATTGTCTCCGCGC
TGGGCCGTAGCGGCCTCAACGTAGAAAACTACGAAAACTTTATCCAGACCGATGCGGCGATTAACCGCGGGAACTCCGGC
GGTGCGCTGGTGAACCTCAACGGCGAGCTGATCGGTATCAACACCGCCATTCTGGCGCCGGACGGCGGCAACATCGGTAT
CGGTTTTGCTATCCCGAGCAACATGGTGAAAAACCTGACCGAGCAGATGGTGAAATATGGCCAGGTGAAACGCGGTGAGC
TCGGCATTATGGGCACCGAACTGAACTCTGAGCTGGCGAAAGCGATGAAAGTCGATGCCCAGCGCGGGGCCTTCGTCAGC
CAGGTAATGCCAGGTTCGGCGGCCGCGAAAGCGGGCATTAAAGCCGGCGATGTCATCACCTCCCTCAACGGGAAAGCGAT
CAGCAGCTTCGCCGCGTTGCGTGCCCAGGTCGGCACCATGCCTATCGGCAGCAAAGTTGAGCTTGGTCTGCTGCGCGACG
GCAAACCGGTGACCGTGACCGTCGAACTGCAGCAGAGCAACCAGACCCAGGTTGACTCCAGCACTATCTTCAACGGGATT
GAAGGGGCGGAAATGAGCAATAAGGGTCAGGATAAGGGCGTGGTGGTCAATAATGTGAAAGCCGGTACCCCGGCGGCACA
GATTGGCCTCAAGAAAGGCGACGTCATCGTCGGGGCGAATCAGCAGCCGGTGAAAAACATCGCCGATCTGCGGAAAATCT
TCGACGCCAAACCGTCCGTACTGGCGCTGAACATTCAGCGCGGCGACGCCTCTATCTATCTGCTGTTGCAGTAA

Upstream 100 bases:

>100_bases
ACTTTTTCCAGAAACTTAATTCCGGAACTTAGCGTTATAAAATGACTCTGATAGTCACGTACACAGCAACTTTCGTTACC
TGATATTGAGATTGAAACTG

Downstream 100 bases:

>100_bases
CCGCCAGCGCTCGCTTCCCAAGCCCCTTCCCTCGCCGAGGGCAGGGGCTTTTTTCGTTCTGTGACCGCCCCCACAACTCC
ACATATCTCACCCCGGCTTA

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MKKTTLAMSALALSLGLALSPLSASAAETASSATNAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDN
SPFCQDGSPFQSSPFCQGGGQGGQPDGGQQQKFMALGSGVIIDAAKGYVVTNNHVVDNATTIKVQLSDGRRFDAKVVGKD
PRSDIALIQIQEPKNLTAIKLADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSG
GALVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTEQMVKYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVS
QVMPGSAAAKAGIKAGDVITSLNGKAISSFAALRAQVGTMPIGSKVELGLLRDGKPVTVTVELQQSNQTQVDSSTIFNGI
EGAEMSNKGQDKGVVVNNVKAGTPAAQIGLKKGDVIVGANQQPVKNIADLRKIFDAKPSVLALNIQRGDASIYLLLQ

Sequences:

>Translated_477_residues
MKKTTLAMSALALSLGLALSPLSASAAETASSATNAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDN
SPFCQDGSPFQSSPFCQGGGQGGQPDGGQQQKFMALGSGVIIDAAKGYVVTNNHVVDNATTIKVQLSDGRRFDAKVVGKD
PRSDIALIQIQEPKNLTAIKLADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSG
GALVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTEQMVKYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVS
QVMPGSAAAKAGIKAGDVITSLNGKAISSFAALRAQVGTMPIGSKVELGLLRDGKPVTVTVELQQSNQTQVDSSTIFNGI
EGAEMSNKGQDKGVVVNNVKAGTPAAQIGLKKGDVIVGANQQPVKNIADLRKIFDAKPSVLALNIQRGDASIYLLLQ
>Mature_477_residues
MKKTTLAMSALALSLGLALSPLSASAAETASSATNAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDN
SPFCQDGSPFQSSPFCQGGGQGGQPDGGQQQKFMALGSGVIIDAAKGYVVTNNHVVDNATTIKVQLSDGRRFDAKVVGKD
PRSDIALIQIQEPKNLTAIKLADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSG
GALVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTEQMVKYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVS
QVMPGSAAAKAGIKAGDVITSLNGKAISSFAALRAQVGTMPIGSKVELGLLRDGKPVTVTVELQQSNQTQVDSSTIFNGI
EGAEMSNKGQDKGVVVNNVKAGTPAAQIGLKKGDVIVGANQQPVKNIADLRKIFDAKPSVLALNIQRGDASIYLLLQ

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=251, Percent_Identity=43.0278884462151, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI22129776, Length=263, Percent_Identity=38.4030418250951, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI24308541, Length=248, Percent_Identity=37.0967741935484, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI7019477, Length=260, Percent_Identity=37.3076923076923, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786356, Length=477, Percent_Identity=90.146750524109, Blast_Score=808, Evalue=0.0,
Organism=Escherichia coli, GI1789629, Length=480, Percent_Identity=56.0416666666667, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1789630, Length=353, Percent_Identity=38.2436260623229, Blast_Score=203, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24646839, Length=252, Percent_Identity=38.4920634920635, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49530; Mature: 49530

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTTLAMSALALSLGLALSPLSASAAETASSATNAQQMPSLAPMLEKVMPSVVSINVEG
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHCCCEEEEEECC
STTVNTPRMPRNFQQFFGDNSPFCQDGSPFQSSPFCQGGGQGGQPDGGQQQKFMALGSGV
CCEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCE
IIDAAKGYVVTNNHVVDNATTIKVQLSDGRRFDAKVVGKDPRSDIALIQIQEPKNLTAIK
EEECCCCEEEECCEEECCEEEEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEE
LADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSG
EECCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
GALVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTEQMVKYGQVKRGELGIMGTE
CEEEEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECC
LNSELAKAMKVDAQRGAFVSQVMPGSAAAKAGIKAGDVITSLNGKAISSFAALRAQVGTM
HHHHHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
PIGSKVELGLLRDGKPVTVTVELQQSNQTQVDSSTIFNGIEGAEMSNKGQDKGVVVNNVK
CCCCCEEEEEECCCCEEEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCC
AGTPAAQIGLKKGDVIVGANQQPVKNIADLRKIFDAKPSVLALNIQRGDASIYLLLQ
CCCCHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEEC
>Mature Secondary Structure
MKKTTLAMSALALSLGLALSPLSASAAETASSATNAQQMPSLAPMLEKVMPSVVSINVEG
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHCCCEEEEEECC
STTVNTPRMPRNFQQFFGDNSPFCQDGSPFQSSPFCQGGGQGGQPDGGQQQKFMALGSGV
CCEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCE
IIDAAKGYVVTNNHVVDNATTIKVQLSDGRRFDAKVVGKDPRSDIALIQIQEPKNLTAIK
EEECCCCEEEECCEEECCEEEEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEE
LADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSG
EECCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
GALVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTEQMVKYGQVKRGELGIMGTE
CEEEEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECC
LNSELAKAMKVDAQRGAFVSQVMPGSAAAKAGIKAGDVITSLNGKAISSFAALRAQVGTM
HHHHHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
PIGSKVELGLLRDGKPVTVTVELQQSNQTQVDSSTIFNGIEGAEMSNKGQDKGVVVNNVK
CCCCCEEEEEECCCCEEEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCC
AGTPAAQIGLKKGDVIVGANQQPVKNIADLRKIFDAKPSVLALNIQRGDASIYLLLQ
CCCCHHHHCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]