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The map label for this gene is pdhR [H]

Identifier: 152968698

GI number: 152968698

Start: 136761

End: 137540

Strand: Direct

Name: pdhR [H]

Synonym: KPN_00117

Alternate gene names: 152968698

Gene position: 136761-137540 (Clockwise)

Preceding gene: 152968694

Following gene: 152968699

Centisome position: 2.57

GC content: 57.18

Gene sequence:

>780_bases
ATGGCCTACAGCAAAATCCGCCAACCAAAATTATCCGATGTGATAGAGCAGCAGCTGGAGTTTCTGATTCTTGAGGGGAC
CTTGCGCCCCGGTGAAAAACTCCCGCCAGAACGCGAACTGGCTAAACAGTTCGACGTTTCCCGCCCCTCGCTGCGTGAGG
CGATTCAACGCCTCGAAGCCAAGGGCTTGTTGCTTCGTCGTCAGGGAGGTGGAACGTTTGTTCAGAGCCGCCTGTGGCAG
AGCTTCAGCGATCCGCTGGTTGAGCTGCTGTCCGATCACCCTGAATCCCAATTCGATCTGCTTGAGACCCGTCACGCGCT
GGAAGGCATTGCGGCCTATTACGCGGCGCTGCGCAGCAATGATGAGGATCGCGACCGTATCCGTGAGCTGCATCAGGCTA
TTGAACGCGCTCAGCAGTCGGGCGATTTGGACGCTGAGTCCGGCGCCGTCGTCCAGTATCAAATCGCCGTCACCGAGGCG
GCACACAATGTGGTGTTGCTTCATCTGCTAAGGTGTATGGAGCCGATGTTGGCGCAAAACGTGCGTCAGAACTTTGAATT
GCTGTATGCCCGGCGGGAAATGCTCCCGTTGGTCAGCAACCATCGCACTCGCATTTTCGAGGCGATAATGGCCGGGGAGC
CGGAGCAGGCGCGTGAAGCGTCGCACCGTCACCTGGCGTTCATTGAGGAAATTTTGCTGGATCGTAGTCGTGAGCAGAGC
CGTCGAGAGCGCTCACTGCGTCGTTTACAGCAACGAAAGGACGAGAACTCCGGTTCTTAA

Upstream 100 bases:

>100_bases
AACCTGTATGGACAGAAGGTGAATACTTTGTTACTTTAGCGCTACGAACTTTAAATTGGTAAGACCAATTGACTCCGGGC
TAATGGCAGAGACAGGGAAT

Downstream 100 bases:

>100_bases
GCGCCATTTTTAGAGCGCGGCAACTAAACGCAGAACCTGTCTTATTGAATTTTTGGTTGTTCCAGCGTGAAGAACGAAGA
GTTCAATGGGACAGGTTCCA

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSRLWQ
SFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRSNDEDRDRIRELHQAIERAQQSGDLDAESGAVVQYQIAVTEA
AHNVVLLHLLRCMEPMLAQNVRQNFELLYARREMLPLVSNHRTRIFEAIMAGEPEQAREASHRHLAFIEEILLDRSREQS
RRERSLRRLQQRKDENSGS

Sequences:

>Translated_259_residues
MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSRLWQ
SFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRSNDEDRDRIRELHQAIERAQQSGDLDAESGAVVQYQIAVTEA
AHNVVLLHLLRCMEPMLAQNVRQNFELLYARREMLPLVSNHRTRIFEAIMAGEPEQAREASHRHLAFIEEILLDRSREQS
RRERSLRRLQQRKDENSGS
>Mature_258_residues
AYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSRLWQS
FSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRSNDEDRDRIRELHQAIERAQQSGDLDAESGAVVQYQIAVTEAA
HNVVLLHLLRCMEPMLAQNVRQNFELLYARREMLPLVSNHRTRIFEAIMAGEPEQAREASHRHLAFIEEILLDRSREQSR
RERSLRRLQQRKDENSGS

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=254, Percent_Identity=93.7007874015748, Blast_Score=450, Evalue=1e-128,
Organism=Escherichia coli, GI1790032, Length=252, Percent_Identity=36.5079365079365, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790780, Length=222, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789353, Length=231, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29953; Mature: 29822

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA
CCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLLRRQGGGTFVQSRLWQSFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRSN
HCHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DEDRDRIRELHQAIERAQQSGDLDAESGAVVQYQIAVTEAAHNVVLLHLLRCMEPMLAQN
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQNFELLYARREMLPLVSNHRTRIFEAIMAGEPEQAREASHRHLAFIEEILLDRSREQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHH
RRERSLRRLQQRKDENSGS
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA
CCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLLRRQGGGTFVQSRLWQSFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRSN
HCHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DEDRDRIRELHQAIERAQQSGDLDAESGAVVQYQIAVTEAAHNVVLLHLLRCMEPMLAQN
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQNFELLYARREMLPLVSNHRTRIFEAIMAGEPEQAREASHRHLAFIEEILLDRSREQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHH
RRERSLRRLQQRKDENSGS
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]