| Definition | Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome. |
|---|---|
| Accession | NC_009648 |
| Length | 5,315,120 |
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The map label for this gene is ilvI [H]
Identifier: 152968663
GI number: 152968663
Start: 97328
End: 99052
Strand: Direct
Name: ilvI [H]
Synonym: KPN_00082
Alternate gene names: 152968663
Gene position: 97328-99052 (Clockwise)
Preceding gene: 152968662
Following gene: 152968664
Centisome position: 1.83
GC content: 59.54
Gene sequence:
>1725_bases ATGGAGATGTTGTCAGGAGCCGAGATGGTCGTCCAATCGCTTGTCGATCAGGGCGTCAAGCAAGTATTCGGCTATCCCGG AGGCGCAGTCCTCGATATCTATGATGCGTTACATACCCTTGGCGGTATCGATCATGTGCTGGTTCGTCACGAGCAGGCGG CGGTGCATATGGCGGATGGCCTGGCGCGGGCGACCGGGGAGGTCGGCGTGGTGCTGGTGACCTCTGGGCCTGGGGCGACG AACGCCATCACTGGCATTGCGACAGCCTATATGGACTCTATTCCGTTGGTGATCCTCTCGGGGCAGGTAGCCACCTCGCT TATCGGCTACGATGCCTTCCAGGAGTGCGACATGGTGGGGATTTCCCGTCCGGTGGTGAAGCACAGTTTCCTGGTGAAGC AGACCGAAGATATTCCCGGCGTGCTGAAGAAAGCCTTCTGGCTGGCGGCCAGCGGTCGCCCCGGTCCGGTAGTGGTCGAT CTGCCGAAGGATATTCTCAATCCGGCGAAGAAGCTGCCTTACGTCTGGCCGGACGCGGTGAGCATGCGCTCGTATAACCC AACCACCAGTGGCCATAAAGGGCAGATTAAACGCGCCCTGCAGACCCTTGTGGCCGCAAGTAAGCCGGTCGTCTACGTCG GCGGCGGGGCGATCAATGCGCATTGCGAACCTCAGCTGCGCGAGCTGGTGGAAAAACTGAAGCTGCCGGTGGCCTCATCC TTGATGGGACTTGGCGCTTTCCCGGCGACACACTCGCAGGCGCTGGGGATGCTGGGGATGCACGGCACCTATGAAGCCAA CATGACCATGCACCACTCGGACGTGATTTTTGCCGTCGGCGTTCGCTTTGACGACCGGACCACCAATAACCTGGCCAAGT ATTGTCCGAACGCGACGGTACTGCATATTGATATCGATCCGACTTCAATCTCGAAAACCGTGCCGGCAGATGTGCCGATC GTCGGCGATGCCCGGCTGGTGCTGGAGCAGATGCTGGAGCTGCTGGAGCAGGAGGAAGCGCAGCAGCCGCTGGACGACAT TCGCGACTGGTGGCAACAGATCGAGCAGTGGCGTGCCCGTCATTGTCTGCGCTACGACGACCAGAGCGATAAAATCAAAC CGCAGGCGGTAATTGAAACTATCTGGCGGCTGACCCAGGGCGATGCCTACGTCACTTCCGATGTGGGTCAGCATCAGATG TTCGCCGCCCTGTATTACCCCTTCGATAAACCGCGGCGCTGGATTAACTCCGGTGGTCTCGGCACCATGGGCTTTGGCCT ACCGGCTGCGCTGGGGGTCAAAATGGCTCTGCCGGACGAAATGGTGGTCTGCGTGACCGGTGACGGCAGTATCCAGATGA ACATTCAGGAACTCTCCACTGCGCTGCAGTATGAGCTGCCGGTCCTGGTGCTTAACCTCAACAACCGCTATCTCGGGATG GTGAAGCAGTGGCAGGATATGCTCTATTCCGGGCGTCACTCGCAGTCCTATATGGAATCGCTACCGGACTTTGTCCGTCT GGCGGAAGCCTATGGCCACGTCGGGATCCGCATCAGCGAGCCGCAGGAGCTGGAGACGAAGCTTGCTGAAGCTCTGGAGC AGGTGCGCCAGCGTCGGCTGGTGTTTGTCGATGTGACCGTCGACGGCAGTGAGCATGTGTACCCCATGCAGATCCGCGGC GGCGGCATGGATGAAATGTGGTTGAGCAAAACGGAGAGGACCTGA
Upstream 100 bases:
>100_bases CAGTACATTCACCTCAATGCGGAGGACCACTCCTTCGCATCGTGCGAGCGCGCGGAAATTGAGTTCCGCTGTCGTAAAAC AATAAGCCTGGAGGCAAACC
Downstream 100 bases:
>100_bases TTATGCGCCGGATATTATCGGTATTACTGGAAAACGAATCGGGTGCACTGTCCCGCGTTATCGGCCTCTTCTCCCAGCGT GGCTATAATATAGAAAGCCT
Product: acetolactate synthase 3 catalytic subunit
Products: NA
Alternate protein names: AHAS-III; ALS-III; Acetohydroxy-acid synthase III large subunit [H]
Number of amino acids: Translated: 574; Mature: 574
Protein sequence:
>574_residues MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGAT NAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVD LPKDILNPAKKLPYVWPDAVSMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATVLHIDIDPTSISKTVPADVPI VGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRARHCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQM FAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRLVFVDVTVDGSEHVYPMQIRG GGMDEMWLSKTERT
Sequences:
>Translated_574_residues MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGAT NAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVD LPKDILNPAKKLPYVWPDAVSMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATVLHIDIDPTSISKTVPADVPI VGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRARHCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQM FAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRLVFVDVTVDGSEHVYPMQIRG GGMDEMWLSKTERT >Mature_574_residues MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGAT NAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVD LPKDILNPAKKLPYVWPDAVSMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATVLHIDIDPTSISKTVPADVPI VGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRARHCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQM FAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRLVFVDVTVDGSEHVYPMQIRG GGMDEMWLSKTERT
Specific function: Valine and isoleucine biosynthesis; first step. [C]
COG id: COG0028
COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family [H]
Homologues:
Organism=Homo sapiens, GI93004078, Length=562, Percent_Identity=28.2918149466192, Blast_Score=203, Evalue=3e-52, Organism=Homo sapiens, GI21361361, Length=581, Percent_Identity=25.9896729776248, Blast_Score=160, Evalue=3e-39, Organism=Escherichia coli, GI87081685, Length=574, Percent_Identity=91.4634146341463, Blast_Score=1097, Evalue=0.0, Organism=Escherichia coli, GI1790104, Length=564, Percent_Identity=39.7163120567376, Blast_Score=416, Evalue=1e-117, Organism=Escherichia coli, GI1786717, Length=562, Percent_Identity=34.5195729537367, Blast_Score=317, Evalue=9e-88, Organism=Escherichia coli, GI1787096, Length=562, Percent_Identity=29.8932384341637, Blast_Score=205, Evalue=7e-54, Organism=Escherichia coli, GI1788716, Length=556, Percent_Identity=25.1798561151079, Blast_Score=177, Evalue=1e-45, Organism=Caenorhabditis elegans, GI17531299, Length=548, Percent_Identity=27.3722627737226, Blast_Score=169, Evalue=4e-42, Organism=Caenorhabditis elegans, GI17531301, Length=548, Percent_Identity=27.3722627737226, Blast_Score=169, Evalue=5e-42, Organism=Caenorhabditis elegans, GI17542570, Length=503, Percent_Identity=26.0437375745527, Blast_Score=144, Evalue=1e-34, Organism=Saccharomyces cerevisiae, GI6323755, Length=583, Percent_Identity=41.852487135506, Blast_Score=448, Evalue=1e-126, Organism=Saccharomyces cerevisiae, GI6320816, Length=489, Percent_Identity=24.5398773006135, Blast_Score=120, Evalue=5e-28, Organism=Drosophila melanogaster, GI19922626, Length=494, Percent_Identity=27.9352226720648, Blast_Score=189, Evalue=6e-48,
Paralogues:
None
Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012846 - InterPro: IPR012000 - InterPro: IPR012001 - InterPro: IPR000399 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.6 [H]
Molecular weight: Translated: 63072; Mature: 63072
Theoretical pI: Translated: 5.56; Mature: 5.56
Prosite motif: PS00187 TPP_ENZYMES
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 4.2 %Met (Translated Protein) 5.1 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 4.2 %Met (Mature Protein) 5.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADG CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH LARATGEVGVVLVTSGPGATNAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVG HHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCC ISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVDLPKDILNPAKKLPYVWPDAV CCCHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCEEEECCHHHCCHHHHCCCCCCCCC SMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS CCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCCHHHHHHHHHHCCCHHHH LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATV HHHCCCCCCCHHHHHHCCCCCCEEECCEEEEECCEEEEEEEEECCCCHHHHHHHCCCCEE LHIDIDPTSISKTVPADVPIVGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRAR EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH HCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQMFAALYYPFDKPRRWINSGGL HHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHEECCCHHHHHHHCCCCC GTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM CCCCCCCHHHHCEEEECCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEECCCCHHHH VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRL HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCE VFVDVTVDGSEHVYPMQIRGGGMDEMWLSKTERT EEEEEEECCCCCEEEEEECCCCCCHHHHHHCCCC >Mature Secondary Structure MEMLSGAEMVVQSLVDQGVKQVFGYPGGAVLDIYDALHTLGGIDHVLVRHEQAAVHMADG CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH LARATGEVGVVLVTSGPGATNAITGIATAYMDSIPLVILSGQVATSLIGYDAFQECDMVG HHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCC ISRPVVKHSFLVKQTEDIPGVLKKAFWLAASGRPGPVVVDLPKDILNPAKKLPYVWPDAV CCCHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCEEEECCHHHCCHHHHCCCCCCCCC SMRSYNPTTSGHKGQIKRALQTLVAASKPVVYVGGGAINAHCEPQLRELVEKLKLPVASS CCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCCCCHHHHHHHHHHCCCHHHH LMGLGAFPATHSQALGMLGMHGTYEANMTMHHSDVIFAVGVRFDDRTTNNLAKYCPNATV HHHCCCCCCCHHHHHHCCCCCCEEECCEEEEECCEEEEEEEEECCCCHHHHHHHCCCCEE LHIDIDPTSISKTVPADVPIVGDARLVLEQMLELLEQEEAQQPLDDIRDWWQQIEQWRAR EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH HCLRYDDQSDKIKPQAVIETIWRLTQGDAYVTSDVGQHQMFAALYYPFDKPRRWINSGGL HHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHEECCCHHHHHHHCCCCC GTMGFGLPAALGVKMALPDEMVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYLGM CCCCCCCHHHHCEEEECCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEECCCCHHHH VKQWQDMLYSGRHSQSYMESLPDFVRLAEAYGHVGIRISEPQELETKLAEALEQVRQRRL HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCE VFVDVTVDGSEHVYPMQIRGGGMDEMWLSKTERT EEEEEEECCCCCEEEEEECCCCCCHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 6308579; 1630901; 9278503; 3891724; 9298646 [H]