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The map label for this gene is glmS [H]

Identifier: 150401462

GI number: 150401462

Start: 1067334

End: 1069193

Strand: Direct

Name: glmS [H]

Synonym: Maeo_1038

Alternate gene names: 150401462

Gene position: 1067334-1069193 (Clockwise)

Preceding gene: 150401460

Following gene: 150401464

Centisome position: 68.0

GC content: 32.47

Gene sequence:

>1860_bases
ATGTGTGGCATAATAGGATATATCGGAAACCAGCAGGCATCACCTATACTTTTAAACGGATTGAAAAGACTAGAATATAG
GGGATATGATAGTTGCGGTATTGGAATTATCGATAATACCAATCCAAATGACATAAATATCATAATAAAAAAAAATATTG
GTAAAGTTAATGAAGTGTCTGCAAAAGAGGACTTTTCAAATATGAATGGGTATGTGGGAATAAGCCACGATAGGTGGGGC
ACCCATGGAAAGATAACTAAGGAAAATGCCCACCCCCATACAGATTGTAATAATAATTTATGTGTTGTCCATAATGGAAT
AATTTCTAACTATGCGGAATTAAAAACCATATTAATGGATAAAGGACATAAATTTAAATCAGAAACCGATACAGAGATAA
TACCCCACCTAATCGAAGAAGAATTAAAAAAATATGACGGTCCTTCTGAGAACGATTATATATATGCAATAAAAGAGGCT
CTTAAAAAAATTGACGGAACTTATGCTATTCTTATATTAAACAAAAACTTTCCGAATATGTTGGTGGGAGTTAAAAATGA
GAGCCCACTTATTGTGGGATTAAAGGAAAATGAATATTTTTTAGGGAGTGATATATCTGCATTTTTAGAATGGACAAAAG
ATATTATTCCATTAGAAGATGGAGATATTGTAATTTTAAAAAAAGATGATAACAATTCAGATGCCAATGGTACCGGCGCT
AATTTATCATATAAAATATACAACAACGATATAGATGCCACCAATAAAAGAGAAAAAATAACTATTGAATGGGATATAGA
AAGTGCTGAAAAGGGAGGATACGAGCACTTTATGTTAAAGGAAATTATGGAAGAACCTGAAATTATAAAAGATTCCTCCA
AAATATCCACTTCTGAGATAAAAGAATTGGCAAAGGAAATGAAAAATTATGATAAAATATATATTGTTGCAATGGGGACT
TCATTAAATGCATCAATGGTGGCAGAATATTGGTTTTCAAATCATAATAAATTAATTATACCATGTGATTCCTCGGAATT
TTTAGTAAAAGGCATAATAGACGAAAATACGCTTGTTATAGGAATTACTCAAAGTGGGGAAACATATGACACCATAAAAG
CCCTAAAATATGCCAAAAAACAGGGGGCAAAAACTGCCACAATTGTAAATGTTCTTGGGAGCTCCGCAACTCGTGAGGCC
GATATTACAATTATGATGGGTTCTGGTATTGAAATATCAGTATGTGCCACAAAAACATATATGTCCCAATTAATGATATT
ATATAGATTATTCATAGAATATGGGTTGGTTATTGGAAAAGATATGAGTAAATACCAGCAAGAAATGGAAAACATACCAA
ATTACATTAAAGAAGTAATTGGGGAGAAAGAACGGGAAAATATAAAACGAATAGCAAAAAATTTAACTGCGTCGAACTAT
CTATTTATATCAAAGGGAGTAAATTTGCCTAATTCATTGGAGGGGGCTCTGAAATTTAAAGAGATTACTTACCTACATGC
CGAAGGTATGAGTAGCGGGTTTTTAAAACACGGTACAATATCTCTTATTGACGAAAATATGGATACAGTTGTATTAATTC
CGCCTACAAAATCGGAATTGTTTAAATCCGTGTTGGCAAATATTGAAGAAATAAAAGCTCGAAATGGAAAAATAATTGGA
GTTAGTCCTGTGGAATCTCAAAATATTGAAAATATAATAAAAGTTCCTGATGTGATGGAAGAAGTAAGTCCTTTTGTTTA
TGCCCCTGCCTGTCAATTGTTGGCATATTATAAAGCTGTTGAAATGGGAAGAGATGTAGATAAACCCAGAGGATTGGCTA
AAAGTGTTACGGTCGAATAA

Upstream 100 bases:

>100_bases
ATCTATATATTATGATATAATATATAATAATAAATAAGAAGTAATATTAATAATATTTAATTAATAATATCTAATTAATA
TAATAAAATATGGTGTAAAT

Downstream 100 bases:

>100_bases
TTTTAATAAATAATATTATATTAAATTTCTTCATATATTCTTTTTAAAAAGATTGTATCATACTCCATTTTTGGACTTTC
ACAAATTACAGTCCCTGAAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MCGIIGYIGNQQASPILLNGLKRLEYRGYDSCGIGIIDNTNPNDINIIIKKNIGKVNEVSAKEDFSNMNGYVGISHDRWG
THGKITKENAHPHTDCNNNLCVVHNGIISNYAELKTILMDKGHKFKSETDTEIIPHLIEEELKKYDGPSENDYIYAIKEA
LKKIDGTYAILILNKNFPNMLVGVKNESPLIVGLKENEYFLGSDISAFLEWTKDIIPLEDGDIVILKKDDNNSDANGTGA
NLSYKIYNNDIDATNKREKITIEWDIESAEKGGYEHFMLKEIMEEPEIIKDSSKISTSEIKELAKEMKNYDKIYIVAMGT
SLNASMVAEYWFSNHNKLIIPCDSSEFLVKGIIDENTLVIGITQSGETYDTIKALKYAKKQGAKTATIVNVLGSSATREA
DITIMMGSGIEISVCATKTYMSQLMILYRLFIEYGLVIGKDMSKYQQEMENIPNYIKEVIGEKERENIKRIAKNLTASNY
LFISKGVNLPNSLEGALKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVVLIPPTKSELFKSVLANIEEIKARNGKIIG
VSPVESQNIENIIKVPDVMEEVSPFVYAPACQLLAYYKAVEMGRDVDKPRGLAKSVTVE

Sequences:

>Translated_619_residues
MCGIIGYIGNQQASPILLNGLKRLEYRGYDSCGIGIIDNTNPNDINIIIKKNIGKVNEVSAKEDFSNMNGYVGISHDRWG
THGKITKENAHPHTDCNNNLCVVHNGIISNYAELKTILMDKGHKFKSETDTEIIPHLIEEELKKYDGPSENDYIYAIKEA
LKKIDGTYAILILNKNFPNMLVGVKNESPLIVGLKENEYFLGSDISAFLEWTKDIIPLEDGDIVILKKDDNNSDANGTGA
NLSYKIYNNDIDATNKREKITIEWDIESAEKGGYEHFMLKEIMEEPEIIKDSSKISTSEIKELAKEMKNYDKIYIVAMGT
SLNASMVAEYWFSNHNKLIIPCDSSEFLVKGIIDENTLVIGITQSGETYDTIKALKYAKKQGAKTATIVNVLGSSATREA
DITIMMGSGIEISVCATKTYMSQLMILYRLFIEYGLVIGKDMSKYQQEMENIPNYIKEVIGEKERENIKRIAKNLTASNY
LFISKGVNLPNSLEGALKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVVLIPPTKSELFKSVLANIEEIKARNGKIIG
VSPVESQNIENIIKVPDVMEEVSPFVYAPACQLLAYYKAVEMGRDVDKPRGLAKSVTVE
>Mature_619_residues
MCGIIGYIGNQQASPILLNGLKRLEYRGYDSCGIGIIDNTNPNDINIIIKKNIGKVNEVSAKEDFSNMNGYVGISHDRWG
THGKITKENAHPHTDCNNNLCVVHNGIISNYAELKTILMDKGHKFKSETDTEIIPHLIEEELKKYDGPSENDYIYAIKEA
LKKIDGTYAILILNKNFPNMLVGVKNESPLIVGLKENEYFLGSDISAFLEWTKDIIPLEDGDIVILKKDDNNSDANGTGA
NLSYKIYNNDIDATNKREKITIEWDIESAEKGGYEHFMLKEIMEEPEIIKDSSKISTSEIKELAKEMKNYDKIYIVAMGT
SLNASMVAEYWFSNHNKLIIPCDSSEFLVKGIIDENTLVIGITQSGETYDTIKALKYAKKQGAKTATIVNVLGSSATREA
DITIMMGSGIEISVCATKTYMSQLMILYRLFIEYGLVIGKDMSKYQQEMENIPNYIKEVIGEKERENIKRIAKNLTASNY
LFISKGVNLPNSLEGALKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVVLIPPTKSELFKSVLANIEEIKARNGKIIG
VSPVESQNIENIIKVPDVMEEVSPFVYAPACQLLAYYKAVEMGRDVDKPRGLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=711, Percent_Identity=31.0829817158931, Blast_Score=314, Evalue=2e-85,
Organism=Homo sapiens, GI4826742, Length=709, Percent_Identity=31.4527503526093, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI29570798, Length=207, Percent_Identity=28.0193236714976, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790167, Length=642, Percent_Identity=37.5389408099688, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1788651, Length=235, Percent_Identity=26.8085106382979, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI87082251, Length=348, Percent_Identity=21.264367816092, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=725, Percent_Identity=30.6206896551724, Blast_Score=301, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17532899, Length=725, Percent_Identity=30.4827586206897, Blast_Score=296, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17532897, Length=447, Percent_Identity=31.5436241610738, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322745, Length=450, Percent_Identity=31.3333333333333, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=212, Percent_Identity=37.7358490566038, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323731, Length=442, Percent_Identity=24.8868778280543, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323958, Length=248, Percent_Identity=27.0161290322581, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357745, Length=709, Percent_Identity=32.2990126939351, Blast_Score=347, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 69139; Mature: 69139

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGYIGNQQASPILLNGLKRLEYRGYDSCGIGIIDNTNPNDINIIIKKNIGKVNEVS
CCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEECCCCCCHHCC
AKEDFSNMNGYVGISHDRWGTHGKITKENAHPHTDCNNNLCVVHNGIISNYAELKTILMD
CHHHHHCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHC
KGHKFKSETDTEIIPHLIEEELKKYDGPSENDYIYAIKEALKKIDGTYAILILNKNFPNM
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCCCE
LVGVKNESPLIVGLKENEYFLGSDISAFLEWTKDIIPLEDGDIVILKKDDNNSDANGTGA
EEEECCCCCEEEEEECCCEEECCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCC
NLSYKIYNNDIDATNKREKITIEWDIESAEKGGYEHFMLKEIMEEPEIIKDSSKISTSEI
EEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCHHHH
KELAKEMKNYDKIYIVAMGTSLNASMVAEYWFSNHNKLIIPCDSSEFLVKGIIDENTLVI
HHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCEEEE
GITQSGETYDTIKALKYAKKQGAKTATIVNVLGSSATREADITIMMGSGIEISVCATKTY
EEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEHHHH
MSQLMILYRLFIEYGLVIGKDMSKYQQEMENIPNYIKEVIGEKERENIKRIAKNLTASNY
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCE
LFISKGVNLPNSLEGALKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVVLIPPTKSEL
EEEECCCCCCCCHHHHEEEEEEEEEEECCCCCCCCCCCEEEEEECCCCEEEEECCCHHHH
FKSVLANIEEIKARNGKIIGVSPVESQNIENIIKVPDVMEEVSPFVYAPACQLLAYYKAV
HHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHH
EMGRDVDKPRGLAKSVTVE
HHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MCGIIGYIGNQQASPILLNGLKRLEYRGYDSCGIGIIDNTNPNDINIIIKKNIGKVNEVS
CCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEEECCCCCCHHCC
AKEDFSNMNGYVGISHDRWGTHGKITKENAHPHTDCNNNLCVVHNGIISNYAELKTILMD
CHHHHHCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHC
KGHKFKSETDTEIIPHLIEEELKKYDGPSENDYIYAIKEALKKIDGTYAILILNKNFPNM
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCCCE
LVGVKNESPLIVGLKENEYFLGSDISAFLEWTKDIIPLEDGDIVILKKDDNNSDANGTGA
EEEECCCCCEEEEEECCCEEECCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCC
NLSYKIYNNDIDATNKREKITIEWDIESAEKGGYEHFMLKEIMEEPEIIKDSSKISTSEI
EEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCHHHH
KELAKEMKNYDKIYIVAMGTSLNASMVAEYWFSNHNKLIIPCDSSEFLVKGIIDENTLVI
HHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCEEEE
GITQSGETYDTIKALKYAKKQGAKTATIVNVLGSSATREADITIMMGSGIEISVCATKTY
EEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEHHHH
MSQLMILYRLFIEYGLVIGKDMSKYQQEMENIPNYIKEVIGEKERENIKRIAKNLTASNY
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCE
LFISKGVNLPNSLEGALKFKEITYLHAEGMSSGFLKHGTISLIDENMDTVVLIPPTKSEL
EEEECCCCCCCCHHHHEEEEEEEEEEECCCCCCCCCCCEEEEEECCCCEEEEECCCHHHH
FKSVLANIEEIKARNGKIIGVSPVESQNIENIIKVPDVMEEVSPFVYAPACQLLAYYKAV
HHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHH
EMGRDVDKPRGLAKSVTVE
HHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA