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The map label for this gene is pyrD [H]

Identifier: 150401339

GI number: 150401339

Start: 936192

End: 937109

Strand: Reverse

Name: pyrD [H]

Synonym: Maeo_0912

Alternate gene names: 150401339

Gene position: 937109-936192 (Counterclockwise)

Preceding gene: 150401340

Following gene: 150401338

Centisome position: 59.71

GC content: 35.95

Gene sequence:

>918_bases
ATGTTAAAAACAAATTTATTTGGTATTGATTTTAAAAATCCCGTATTCCTTGCCGCGGGAATTATGGGGGAGACAGGAAG
TGCCTTAAAGAGAATGGGAAAAAATGGGGCTGGTGCTGTATGCACGAAATCCATAGGGTTAGAAAAGAAAATGGGGCATA
ACAATCCTACAATGGTAGAAGTAGAAGGTGGATTTTTAAATGCCATGGGGTTGCCAAATCCCGGAATAAATGAATATGTT
GGAGAAATTGAAGAAATAAGGGACGATTTAAAAAAGATGGGCGTAAAAATAATAGGTTCCATATATGGAAAAGACAGTAA
TGAATTTTCAAAAGTTGCAGAAACAATAAGTCCATTTGTAGATGTTATCGAATTAAATATATCTTGCCCACATGCGGGAG
GTTTTTATGGGGCTCAAATTGGACAAAATCCAGATTTATCTCATTCGGTTGTATCTGCTGTAAAGGACTGTGTAAATAAA
CAACCTGTTATGGCTAAATTAACTCCAAATGTAGCGGATATAAAAGAAATAGCTAAATCCGTTGAAGATGCTGGGGCCGA
TGGTATTGTGGCAATAAATACACTTGGTCCGGGCATGGTAATAGATATAGAAACCAAAAAACCAATATTGGGCAACAAAT
TTGGTGGAATGTCTGGAAAGGCAATAAAACCAATTGCCATAAAAAATGTTTATGATATTTATTCTGCGGTGGAGCTCCCA
ATAATTGGAGTTGGCGGAATTACCATGGGATTAGATGCAATAGAGTTTATGTTGGCTGGTGCCTCTGCTGTTCAGGTTGG
AACTGGTGTATATTATAGGGGATACGATATATTTGATAAAATATGTGAGGAAATGGAACAATTTTTAATTGAAAAAAATA
TTAAATTAAAAGATATTGTTGGGGGAGCTCATGAATAA

Upstream 100 bases:

>100_bases
ATGAAAAATATTATAAAGTGATTCAAAGAAGAAAAAAAGAAAATAGTTATAAAAATAGATTAAGGAAATAATTATAATAA
AAATAAATTATGGTGATATA

Downstream 100 bases:

>100_bases
TATTAATGAAATAGAAGCGAAGCTTCTATACCCAAATCAAAGATTTGAGGATTTCCTATCGGAAATGGTGGAATTTCTAA
ATTCAAAAAATCCACAAGAT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MLKTNLFGIDFKNPVFLAAGIMGETGSALKRMGKNGAGAVCTKSIGLEKKMGHNNPTMVEVEGGFLNAMGLPNPGINEYV
GEIEEIRDDLKKMGVKIIGSIYGKDSNEFSKVAETISPFVDVIELNISCPHAGGFYGAQIGQNPDLSHSVVSAVKDCVNK
QPVMAKLTPNVADIKEIAKSVEDAGADGIVAINTLGPGMVIDIETKKPILGNKFGGMSGKAIKPIAIKNVYDIYSAVELP
IIGVGGITMGLDAIEFMLAGASAVQVGTGVYYRGYDIFDKICEEMEQFLIEKNIKLKDIVGGAHE

Sequences:

>Translated_305_residues
MLKTNLFGIDFKNPVFLAAGIMGETGSALKRMGKNGAGAVCTKSIGLEKKMGHNNPTMVEVEGGFLNAMGLPNPGINEYV
GEIEEIRDDLKKMGVKIIGSIYGKDSNEFSKVAETISPFVDVIELNISCPHAGGFYGAQIGQNPDLSHSVVSAVKDCVNK
QPVMAKLTPNVADIKEIAKSVEDAGADGIVAINTLGPGMVIDIETKKPILGNKFGGMSGKAIKPIAIKNVYDIYSAVELP
IIGVGGITMGLDAIEFMLAGASAVQVGTGVYYRGYDIFDKICEEMEQFLIEKNIKLKDIVGGAHE
>Mature_305_residues
MLKTNLFGIDFKNPVFLAAGIMGETGSALKRMGKNGAGAVCTKSIGLEKKMGHNNPTMVEVEGGFLNAMGLPNPGINEYV
GEIEEIRDDLKKMGVKIIGSIYGKDSNEFSKVAETISPFVDVIELNISCPHAGGFYGAQIGQNPDLSHSVVSAVKDCVNK
QPVMAKLTPNVADIKEIAKSVEDAGADGIVAINTLGPGMVIDIETKKPILGNKFGGMSGKAIKPIAIKNVYDIYSAVELP
IIGVGGITMGLDAIEFMLAGASAVQVGTGVYYRGYDIFDKICEEMEQFLIEKNIKLKDIVGGAHE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=322, Percent_Identity=29.8136645962733, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI45006951, Length=325, Percent_Identity=25.5384615384615, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI87082059, Length=318, Percent_Identity=31.1320754716981, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787177, Length=305, Percent_Identity=26.8852459016393, Blast_Score=84, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71984108, Length=309, Percent_Identity=31.3915857605178, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17509475, Length=311, Percent_Identity=30.2250803858521, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322633, Length=297, Percent_Identity=30.976430976431, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24640763, Length=312, Percent_Identity=32.0512820512821, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI18858217, Length=312, Percent_Identity=32.0512820512821, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI281361352, Length=318, Percent_Identity=24.8427672955975, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137316, Length=318, Percent_Identity=24.8427672955975, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32345; Mature: 32345

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTNLFGIDFKNPVFLAAGIMGETGSALKRMGKNGAGAVCTKSIGLEKKMGHNNPTMVE
CCCCCEEEECCCCCEEEEECCCCCCHHHHHHHCCCCCCCEEEHHCCCHHHCCCCCCEEEE
VEGGFLNAMGLPNPGINEYVGEIEEIRDDLKKMGVKIIGSIYGKDSNEFSKVAETISPFV
ECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
DVIELNISCPHAGGFYGAQIGQNPDLSHSVVSAVKDCVNKQPVMAKLTPNVADIKEIAKS
EEHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
VEDAGADGIVAINTLGPGMVIDIETKKPILGNKFGGMSGKAIKPIAIKNVYDIYSAVELP
HHHCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
IIGVGGITMGLDAIEFMLAGASAVQVGTGVYYRGYDIFDKICEEMEQFLIEKNIKLKDIV
EEEECHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHCCCCCEECC
GGAHE
CCCCC
>Mature Secondary Structure
MLKTNLFGIDFKNPVFLAAGIMGETGSALKRMGKNGAGAVCTKSIGLEKKMGHNNPTMVE
CCCCCEEEECCCCCEEEEECCCCCCHHHHHHHCCCCCCCEEEHHCCCHHHCCCCCCEEEE
VEGGFLNAMGLPNPGINEYVGEIEEIRDDLKKMGVKIIGSIYGKDSNEFSKVAETISPFV
ECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
DVIELNISCPHAGGFYGAQIGQNPDLSHSVVSAVKDCVNKQPVMAKLTPNVADIKEIAKS
EEHEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
VEDAGADGIVAINTLGPGMVIDIETKKPILGNKFGGMSGKAIKPIAIKNVYDIYSAVELP
HHHCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
IIGVGGITMGLDAIEFMLAGASAVQVGTGVYYRGYDIFDKICEEMEQFLIEKNIKLKDIV
EEEECHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHCCCCCEECC
GGAHE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]