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The map label for this gene is fdhA [H]

Identifier: 150401009

GI number: 150401009

Start: 596870

End: 598903

Strand: Reverse

Name: fdhA [H]

Synonym: Maeo_0578

Alternate gene names: 150401009

Gene position: 598903-596870 (Counterclockwise)

Preceding gene: 150401010

Following gene: 150401008

Centisome position: 38.16

GC content: 36.58

Gene sequence:

>2034_bases
ATGACCGAATTTAAAATGGTCCATACAGTATGTCCATACTGCGGATGCGGATGCGGAATAGATTTGACCGTAAAAGATGA
TAAAATCGTCGGGACTCATCCGTTTAAAAGACATCCAGTAAATGAAGGAAAAACATGTATTAAAGGAAATTACTGCCATG
AATTTGTTCATAGTGACGAGCGACTAAAAAAACCATTAATTAAAAAAGATGGTCAATTTGTTGAATCCAGCTGGGAAGAG
GTTTTGGATTTAATTGCAAGTAAATTAAAGAAATATACTCCTGATGAAGTGGGTTTTTTCTCATCTGCAAGATGTACGAA
TGAGGATAATTATATATTCCAAAAATTTTCAAGAGCAGTGATGAAAACAAATAATATAGATCATTGTGCGAGAATTTGAC
ACTCTGCAACTGTTGCAGGTCTTGGGGAAGCTTTTGGGTCTGGTGCCATGACAAACTCAATTGAAGATATTGAAGAAGCA
AATTGTATATTTATTATAGGTTCAAACACATTTGAACAGCATCCGATAATTGCGAGAAGAATAATTAGGGCAAAAGAAAA
CGGAACTAAGGTCATAGTTGTTGACCCGAGAAAAACGATGACTGCCCAGCAGGCCGACATATTTCTCCAAATAACTCCTG
GAACAAATGCTGCCATATTAAATGGTTTGATAAATGTAATAATAAAGAATAATTTAATCGATAATGAATTCATAAAAAAT
AGGACAAAAGGATTCGCAGAGTTAAAAAAGTCTGTGGAAAAATACACTCCCGAATATGTTTCAAAGATTTGTGGGGTTTC
ACCTGAATTAATAGTGGAAGCGGCAAAAATATATGCAACTTCTGAAAAGTCATCGATATTATATTGTATGGGCGTGACTC
AGTTCATACATGGTGTAGATAATGTTAAATGTTGCTGTAATTTATCATCTATAACGGGAAATATTGGAAAAAGAGGAACC
GGAGTTAATCCATTGAGGGGACAAAACAATGTTCAGGGGGCCTGTGATATGGGAGCTCTACCTAATGTATATCCTGGATA
CCAAAAGGTAAATGTCCCCGAAATATATGGTAAATTCGAAGAACTTTGGAACACCGAATTAAGTCATGATGTGGGACTCA
CAATTTCAGAAATGATTGAAAAATGCGGAGATGAATTAAAATGTCTGTATATAATGGGGGAAAACCCAATGGTTTCTGAC
CCAGATATAAACCATTTAGAGCATGCATTTGAATCCCTAGATTTCCTCATTGTTCAGGATATATTCCTAACCGAAACAGC
CCAAATGGCAGATGTTGTTTTACCCTCTGCGTGTTGGGCTGAAAAGGACGGAACATTTGCAAATACTGAAAGAAGAGTTC
AGAAAATAAGAAAAGCAGTAAATCCACCAGGGGAGGCCCTTGAAGACTGGATTATAATTAAAAAACTTGCTGAAAAGATG
GGATATGGCGAAATGTTTAACTATACTTCGCATGAGGACATATTTAATGAGATTAGAAAAGCTACGCCACAGTATGCAGG
AATTACCTACGGAAGATTAGGCACAGATGGCATTCACTGGCCATGTAAAACAGAAGATAGTAAAGGAACTCCAATACTAC
ATACTGAAAAATTCCTTACGCCAGATGGAATAGGTAAATTATTTGCCATCGAATATGGGGAAGCCGCAGAGCTTCCAGAT
GAAGAATATCCGATGATTTTGACCACTGGAAGGATTGTATTCCACTACCATACAGGAACAATGACGAGAAAATGTAAGCA
CATTACCTCAGAGATAAACGAGGGATTCGTAGAAATACACCCCGAAGATGCTGAAAAATTAAACATTAAAAATAATGAAC
TTGTCAAGGTTTCATCTAGGAGGGGCGAAGTAAAAGTTAAGGTAAGAGTCACTAAAAATATCAAAAAGGGAGTGGTATTT
ATGCCGTTCCACTTTGCAGAAAGTGCCGCAAACCTATTAACTAACACCGCAGTAGATCCAAACTGTAAGATACCAGAATT
TAAAGTATGTGCAGTTAAAATTGATAAACAATAA

Upstream 100 bases:

>100_bases
GGAGTAGATAATAGAAAAAAAAATACCAAAAGTTTCCCAAAAACTAAAATATAATATAATAAATTAAATAATCCAATAAG
TTAAAAGAAAGGTGGATATA

Downstream 100 bases:

>100_bases
TCATATAAATTTTTTTATTTTTTTATATATTCGAAATGGTGATGACCATGAAATACTTAATCCAATCAACAGATGAAAAC
ATATTAAAACATGCTGAATG

Product: formate dehydrogenase, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MTEFKMVHTVCPYCGCGCGIDLTVKDDKIVGTHPFKRHPVNEGKTCIKGNYCHEFVHSDERLKKPLIKKDGQFVESSWEE
VLDLIASKLKKYTPDEVGFFSSARCTNEDNYIFQKFSRAVMKTNNIDHCARIUHSATVAGLGEAFGSGAMTNSIEDIEEA
NCIFIIGSNTFEQHPIIARRIIRAKENGTKVIVVDPRKTMTAQQADIFLQITPGTNAAILNGLINVIIKNNLIDNEFIKN
RTKGFAELKKSVEKYTPEYVSKICGVSPELIVEAAKIYATSEKSSILYCMGVTQFIHGVDNVKCCCNLSSITGNIGKRGT
GVNPLRGQNNVQGACDMGALPNVYPGYQKVNVPEIYGKFEELWNTELSHDVGLTISEMIEKCGDELKCLYIMGENPMVSD
PDINHLEHAFESLDFLIVQDIFLTETAQMADVVLPSACWAEKDGTFANTERRVQKIRKAVNPPGEALEDWIIIKKLAEKM
GYGEMFNYTSHEDIFNEIRKATPQYAGITYGRLGTDGIHWPCKTEDSKGTPILHTEKFLTPDGIGKLFAIEYGEAAELPD
EEYPMILTTGRIVFHYHTGTMTRKCKHITSEINEGFVEIHPEDAEKLNIKNNELVKVSSRRGEVKVKVRVTKNIKKGVVF
MPFHFAESAANLLTNTAVDPNCKIPEFKVCAVKIDKQ

Sequences:

>Translated_677_residues
MTEFKMVHTVCPYCGCGCGIDLTVKDDKIVGTHPFKRHPVNEGKTCIKGNYCHEFVHSDERLKKPLIKKDGQFVESSWEE
VLDLIASKLKKYTPDEVGFFSSARCTNEDNYIFQKFSRAVMKTNNIDHCARI*HSATVAGLGEAFGSGAMTNSIEDIEEA
NCIFIIGSNTFEQHPIIARRIIRAKENGTKVIVVDPRKTMTAQQADIFLQITPGTNAAILNGLINVIIKNNLIDNEFIKN
RTKGFAELKKSVEKYTPEYVSKICGVSPELIVEAAKIYATSEKSSILYCMGVTQFIHGVDNVKCCCNLSSITGNIGKRGT
GVNPLRGQNNVQGACDMGALPNVYPGYQKVNVPEIYGKFEELWNTELSHDVGLTISEMIEKCGDELKCLYIMGENPMVSD
PDINHLEHAFESLDFLIVQDIFLTETAQMADVVLPSACWAEKDGTFANTERRVQKIRKAVNPPGEALEDWIIIKKLAEKM
GYGEMFNYTSHEDIFNEIRKATPQYAGITYGRLGTDGIHWPCKTEDSKGTPILHTEKFLTPDGIGKLFAIEYGEAAELPD
EEYPMILTTGRIVFHYHTGTMTRKCKHITSEINEGFVEIHPEDAEKLNIKNNELVKVSSRRGEVKVKVRVTKNIKKGVVF
MPFHFAESAANLLTNTAVDPNCKIPEFKVCAVKIDKQ
>Mature_676_residues
TEFKMVHTVCPYCGCGCGIDLTVKDDKIVGTHPFKRHPVNEGKTCIKGNYCHEFVHSDERLKKPLIKKDGQFVESSWEEV
LDLIASKLKKYTPDEVGFFSSARCTNEDNYIFQKFSRAVMKTNNIDHCARI*HSATVAGLGEAFGSGAMTNSIEDIEEAN
CIFIIGSNTFEQHPIIARRIIRAKENGTKVIVVDPRKTMTAQQADIFLQITPGTNAAILNGLINVIIKNNLIDNEFIKNR
TKGFAELKKSVEKYTPEYVSKICGVSPELIVEAAKIYATSEKSSILYCMGVTQFIHGVDNVKCCCNLSSITGNIGKRGTG
VNPLRGQNNVQGACDMGALPNVYPGYQKVNVPEIYGKFEELWNTELSHDVGLTISEMIEKCGDELKCLYIMGENPMVSDP
DINHLEHAFESLDFLIVQDIFLTETAQMADVVLPSACWAEKDGTFANTERRVQKIRKAVNPPGEALEDWIIIKKLAEKMG
YGEMFNYTSHEDIFNEIRKATPQYAGITYGRLGTDGIHWPCKTEDSKGTPILHTEKFLTPDGIGKLFAIEYGEAAELPDE
EYPMILTTGRIVFHYHTGTMTRKCKHITSEINEGFVEIHPEDAEKLNIKNNELVKVSSRRGEVKVKVRVTKNIKKGVVFM
PFHFAESAANLLTNTAVDPNCKIPEFKVCAVKIDKQ

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=689, Percent_Identity=42.5253991291727, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1788534, Length=788, Percent_Identity=29.0609137055838, Blast_Score=301, Evalue=9e-83,
Organism=Escherichia coli, GI3868720, Length=615, Percent_Identity=29.2682926829268, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI3868719, Length=611, Percent_Identity=28.3142389525368, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1787778, Length=675, Percent_Identity=25.1851851851852, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87081797, Length=736, Percent_Identity=22.1467391304348, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1787870, Length=736, Percent_Identity=23.2336956521739, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI171474008, Length=734, Percent_Identity=23.0245231607629, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI145693196, Length=677, Percent_Identity=20.384047267356, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17565758, Length=89, Percent_Identity=39.3258426966292, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 75507; Mature: 75376

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFKMVHTVCPYCGCGCGIDLTVKDDKIVGTHPFKRHPVNEGKTCIKGNYCHEFVHSDE
CCCHHHHHHHCCCCCCCCCCEEEECCCEEECCCCCCCCCCCCCCEEECCCHHHHHHCCHH
RLKKPLIKKDGQFVESSWEEVLDLIASKLKKYTPDEVGFFSSARCTNEDNYIFQKFSRAV
HHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHH
MKTNNIDHCARIHSATVAGLGEAFGSGAMTNSIEDIEEANCIFIIGSNTFEQHPIIARRI
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCCCCHHHHHH
IRAKENGTKVIVVDPRKTMTAQQADIFLQITPGTNAAILNGLINVIIKNNLIDNEFIKNR
HHHCCCCCEEEEECCCHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
TKGFAELKKSVEKYTPEYVSKICGVSPELIVEAAKIYATSEKSSILYCMGVTQFIHGVDN
HHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHEEECCCCCEEEEEEHHHHHCCCCC
VKCCCNLSSITGNIGKRGTGVNPLRGQNNVQGACDMGALPNVYPGYQKVNVPEIYGKFEE
CEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LWNTELSHDVGLTISEMIEKCGDELKCLYIMGENPMVSDPDINHLEHAFESLDFLIVQDI
HHCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FLTETAQMADVVLPSACWAEKDGTFANTERRVQKIRKAVNPPGEALEDWIIIKKLAEKMG
HHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
YGEMFNYTSHEDIFNEIRKATPQYAGITYGRLGTDGIHWPCKTEDSKGTPILHTEKFLTP
CCHHCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
DGIGKLFAIEYGEAAELPDEEYPMILTTGRIVFHYHTGTMTRKCKHITSEINEGFVEIHP
CCCCCEEEEECCCCCCCCCCCCCEEEEECEEEEEEECCCHHHHHHHHHHHHCCCEEEECC
EDAEKLNIKNNELVKVSSRRGEVKVKVRVTKNIKKGVVFMPFHFAESAANLLTNTAVDPN
CCCCEECCCCCCEEEEECCCCEEEEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCC
CKIPEFKVCAVKIDKQ
CCCCCEEEEEEEECCC
>Mature Secondary Structure 
TEFKMVHTVCPYCGCGCGIDLTVKDDKIVGTHPFKRHPVNEGKTCIKGNYCHEFVHSDE
CCHHHHHHHCCCCCCCCCCEEEECCCEEECCCCCCCCCCCCCCEEECCCHHHHHHCCHH
RLKKPLIKKDGQFVESSWEEVLDLIASKLKKYTPDEVGFFSSARCTNEDNYIFQKFSRAV
HHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHH
MKTNNIDHCARIHSATVAGLGEAFGSGAMTNSIEDIEEANCIFIIGSNTFEQHPIIARRI
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCCCCHHHHHH
IRAKENGTKVIVVDPRKTMTAQQADIFLQITPGTNAAILNGLINVIIKNNLIDNEFIKNR
HHHCCCCCEEEEECCCHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
TKGFAELKKSVEKYTPEYVSKICGVSPELIVEAAKIYATSEKSSILYCMGVTQFIHGVDN
HHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHEEECCCCCEEEEEEHHHHHCCCCC
VKCCCNLSSITGNIGKRGTGVNPLRGQNNVQGACDMGALPNVYPGYQKVNVPEIYGKFEE
CEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LWNTELSHDVGLTISEMIEKCGDELKCLYIMGENPMVSDPDINHLEHAFESLDFLIVQDI
HHCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FLTETAQMADVVLPSACWAEKDGTFANTERRVQKIRKAVNPPGEALEDWIIIKKLAEKMG
HHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
YGEMFNYTSHEDIFNEIRKATPQYAGITYGRLGTDGIHWPCKTEDSKGTPILHTEKFLTP
CCHHCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
DGIGKLFAIEYGEAAELPDEEYPMILTTGRIVFHYHTGTMTRKCKHITSEINEGFVEIHP
CCCCCEEEEECCCCCCCCCCCCCEEEEECEEEEEEECCCHHHHHHHHHHHHCCCEEEECC
EDAEKLNIKNNELVKVSSRRGEVKVKVRVTKNIKKGVVFMPFHFAESAANLLTNTAVDPN
CCCCEECCCCCCEEEEECCCCEEEEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCC
CKIPEFKVCAVKIDKQ
CCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]