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The map label for this gene is serA [H]

Identifier: 150400998

GI number: 150400998

Start: 584837

End: 586408

Strand: Direct

Name: serA [H]

Synonym: Maeo_0567

Alternate gene names: 150400998

Gene position: 584837-586408 (Clockwise)

Preceding gene: 150400995

Following gene: 150400999

Centisome position: 37.26

GC content: 34.41

Gene sequence:

>1572_bases
ATGCCAAAAATACTTATAACCGATTCAATTCATGATGATGCCGTGGAATTATTAAAACAGGCAGGAACTGTGGAAGTGGC
GACAGACCTCACTGTTGAAGAATTAAAAGAAAAAATAAAGGATGCTGATGCACTTGTAATAAGAAGTGGAACAAAAGCAA
CAAAAGAAATAATTGATGCTGCGGATAATTTAAAAGTAATTGCTAGGGCTGGTGTTGGCGTTGATAATGTTGATTTAACA
GCAGCAACAGAAAAAGGAATTATTGTTGTTAATTCACCAGATGCTTCTTCAATTTCAGTTGCAGAATTGGCCTTGGGTTT
AATGCTTTCTTCGGCAAGAAATATACCTCAGGCTACGGCATCATTAAAAAGAGGAGAATGGGACAGAAAATCATTCAAAG
GTATGGAGCTCTACGGAAAAACTCTCGGTATTATTGGATTAGGTAGAATTGGACAGCAAATAGCAAAAAGAGCGGAAGCT
TTTGGAATGACTGTTGTAGCTTATGACCCATATATACCTGTGGAAGTTGCTAAAAATATGGGCATCGAACTTATGGAAGT
AAATGATTTATGTAAAGTTAGTGATTTTATAACTCTTCATGTTCCATTAACTCCAAAAACAAAACATATGATCGGAAAAG
AACAAATTTCATTAATGAAACCAAATACAATTATTGTAAATTGTGCAAGAGGCGGACTTATTGATGAAGAAGCCCTATAT
GATGCCATAAACAATAAAAAAATAGGAGGAGCCGGACTAGATGTATTTGAGGAAGAACCACCAAAAGATAATCCATTATT
AACACTTGATAAATTTATAGGGACTCCTCACCAAGGAGCTTCAACGGTAGAAGCTCAAAAAAGTGCTGGAACTGTGGTAG
CTGAACAGGTTGTAAAAATATTGGCTGGAAAACCTGCGGATAATATAGTAAATCTCCCAAGAATGCCAACAGATAAAATG
AACAAATTAAATCCATATATGGCACTTGCTGAAAAAATGGGGAATATGATTATACAGCTTCTCGATAAATCCGTTGAAAA
AGTAGAATTAACATATAGTGGCGAATTAGCATCAGAGGATACAGAAATGGTAAAAAGGTCATTCTTAATGGGCTTATTAT
CTCCAATATTACTTGCAGGTGTTAATTTGGTAAATGCTCCAACCATAGCCAAAAATAGAAATATAAAAATCGTAGAGGGA
ACACTTTCAGAGTGCGAATATGGAAGTAGCATAAAAATAAAAGCAGAAGGAAAAGAAGAATGTATATCATTGGTGGGCTC
ACTTGTTGAAGGAGCTCCTGTGCTCAAAGAAATAAACAACTATAAAATAGATATAAAACCAGAAGGTATTGTTTGTGTAA
TTAAACATATGGATAAACCAGGAATAATAGGAAAAGCGAGCACACTATTGGGAGATTATGGAGTAAATATTGCAGGAATG
CAAGTTGGAAGACAAGAACCAGGAGGAGAAAGTGTTATGGTTCTTAATTTAGACCATGTTATCACAGAGGAAGTGATAAG
TAAATTAAAAAATATTGATAATATAATAGATGCTAAAATAATTAAGTTATAA

Upstream 100 bases:

>100_bases
ATGGTAAATCGACAAATACCATATATATTATTATATATTTTATTATATTATGTTAATTAATATGTCTAATCTAAAACAAT
TAAATTTATTAGGTGATTTT

Downstream 100 bases:

>100_bases
TTAACAATTATTTTTAATTTTTTTATGAATATATGGGGGAGCTCCGAAATTAATTATTTAATTATATTATTTTATTTATA
GTCTATCTTCGGTCTTTTTC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MPKILITDSIHDDAVELLKQAGTVEVATDLTVEELKEKIKDADALVIRSGTKATKEIIDAADNLKVIARAGVGVDNVDLT
AATEKGIIVVNSPDASSISVAELALGLMLSSARNIPQATASLKRGEWDRKSFKGMELYGKTLGIIGLGRIGQQIAKRAEA
FGMTVVAYDPYIPVEVAKNMGIELMEVNDLCKVSDFITLHVPLTPKTKHMIGKEQISLMKPNTIIVNCARGGLIDEEALY
DAINNKKIGGAGLDVFEEEPPKDNPLLTLDKFIGTPHQGASTVEAQKSAGTVVAEQVVKILAGKPADNIVNLPRMPTDKM
NKLNPYMALAEKMGNMIIQLLDKSVEKVELTYSGELASEDTEMVKRSFLMGLLSPILLAGVNLVNAPTIAKNRNIKIVEG
TLSECEYGSSIKIKAEGKEECISLVGSLVEGAPVLKEINNYKIDIKPEGIVCVIKHMDKPGIIGKASTLLGDYGVNIAGM
QVGRQEPGGESVMVLNLDHVITEEVISKLKNIDNIIDAKIIKL

Sequences:

>Translated_523_residues
MPKILITDSIHDDAVELLKQAGTVEVATDLTVEELKEKIKDADALVIRSGTKATKEIIDAADNLKVIARAGVGVDNVDLT
AATEKGIIVVNSPDASSISVAELALGLMLSSARNIPQATASLKRGEWDRKSFKGMELYGKTLGIIGLGRIGQQIAKRAEA
FGMTVVAYDPYIPVEVAKNMGIELMEVNDLCKVSDFITLHVPLTPKTKHMIGKEQISLMKPNTIIVNCARGGLIDEEALY
DAINNKKIGGAGLDVFEEEPPKDNPLLTLDKFIGTPHQGASTVEAQKSAGTVVAEQVVKILAGKPADNIVNLPRMPTDKM
NKLNPYMALAEKMGNMIIQLLDKSVEKVELTYSGELASEDTEMVKRSFLMGLLSPILLAGVNLVNAPTIAKNRNIKIVEG
TLSECEYGSSIKIKAEGKEECISLVGSLVEGAPVLKEINNYKIDIKPEGIVCVIKHMDKPGIIGKASTLLGDYGVNIAGM
QVGRQEPGGESVMVLNLDHVITEEVISKLKNIDNIIDAKIIKL
>Mature_522_residues
PKILITDSIHDDAVELLKQAGTVEVATDLTVEELKEKIKDADALVIRSGTKATKEIIDAADNLKVIARAGVGVDNVDLTA
ATEKGIIVVNSPDASSISVAELALGLMLSSARNIPQATASLKRGEWDRKSFKGMELYGKTLGIIGLGRIGQQIAKRAEAF
GMTVVAYDPYIPVEVAKNMGIELMEVNDLCKVSDFITLHVPLTPKTKHMIGKEQISLMKPNTIIVNCARGGLIDEEALYD
AINNKKIGGAGLDVFEEEPPKDNPLLTLDKFIGTPHQGASTVEAQKSAGTVVAEQVVKILAGKPADNIVNLPRMPTDKMN
KLNPYMALAEKMGNMIIQLLDKSVEKVELTYSGELASEDTEMVKRSFLMGLLSPILLAGVNLVNAPTIAKNRNIKIVEGT
LSECEYGSSIKIKAEGKEECISLVGSLVEGAPVLKEINNYKIDIKPEGIVCVIKHMDKPGIIGKASTLLGDYGVNIAGMQ
VGRQEPGGESVMVLNLDHVITEEVISKLKNIDNIIDAKIIKL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=450, Percent_Identity=39.1111111111111, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI6912396, Length=316, Percent_Identity=34.1772151898734, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI4557497, Length=306, Percent_Identity=33.6601307189542, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI61743967, Length=306, Percent_Identity=33.6601307189542, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI145580578, Length=306, Percent_Identity=33.0065359477124, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI4557499, Length=306, Percent_Identity=33.0065359477124, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI145580575, Length=308, Percent_Identity=32.7922077922078, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1789279, Length=321, Percent_Identity=38.9408099688474, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI87082289, Length=318, Percent_Identity=31.4465408805031, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=35.1351351351351, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788660, Length=269, Percent_Identity=29.7397769516729, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=299, Percent_Identity=44.1471571906354, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI25147481, Length=321, Percent_Identity=30.8411214953271, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=328, Percent_Identity=37.8048780487805, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=38.2262996941896, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6324055, Length=317, Percent_Identity=32.807570977918, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324964, Length=303, Percent_Identity=29.7029702970297, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321253, Length=284, Percent_Identity=26.4084507042254, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=201, Percent_Identity=27.8606965174129, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=302, Percent_Identity=25.1655629139073, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921140, Length=308, Percent_Identity=43.8311688311688, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24646446, Length=306, Percent_Identity=34.640522875817, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24646448, Length=306, Percent_Identity=34.640522875817, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24646452, Length=306, Percent_Identity=34.640522875817, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24646450, Length=306, Percent_Identity=34.640522875817, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=35.031847133758, Blast_Score=155, Evalue=9e-38,
Organism=Drosophila melanogaster, GI62472511, Length=306, Percent_Identity=34.640522875817, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=29.1666666666667, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI28574286, Length=279, Percent_Identity=30.4659498207885, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45552429, Length=314, Percent_Identity=30.8917197452229, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45551003, Length=314, Percent_Identity=30.8917197452229, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574284, Length=314, Percent_Identity=30.8917197452229, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24585514, Length=314, Percent_Identity=30.8917197452229, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28574282, Length=314, Percent_Identity=30.8917197452229, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56233; Mature: 56102

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKILITDSIHDDAVELLKQAGTVEVATDLTVEELKEKIKDADALVIRSGTKATKEIIDA
CCCEEEECCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCC
ADNLKVIARAGVGVDNVDLTAATEKGIIVVNSPDASSISVAELALGLMLSSARNIPQATA
CCCCEEEEECCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHH
SLKRGEWDRKSFKGMELYGKTLGIIGLGRIGQQIAKRAEAFGMTVVAYDPYIPVEVAKNM
HHHCCCCCHHHCCCHHHHCCHHCEEEHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHCC
GIELMEVNDLCKVSDFITLHVPLTPKTKHMIGKEQISLMKPNTIIVNCARGGLIDEEALY
CEEEEECCCHHHHCCEEEEEEECCCCHHHHHCHHHHHEECCCEEEEECCCCCCCCHHHHH
DAINNKKIGGAGLDVFEEEPPKDNPLLTLDKFIGTPHQGASTVEAQKSAGTVVAEQVVKI
HHHCCCCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHH
LAGKPADNIVNLPRMPTDKMNKLNPYMALAEKMGNMIIQLLDKSVEKVELTYSGELASED
HCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCH
TEMVKRSFLMGLLSPILLAGVNLVNAPTIAKNRNIKIVEGTLSECEYGSSIKIKAEGKEE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEEEECCHHHCCCCCEEEEEECCHHH
CISLVGSLVEGAPVLKEINNYKIDIKPEGIVCVIKHMDKPGIIGKASTLLGDYGVNIAGM
HHHHHHHHHCCCHHHHHCCCCEEEECCCCEEEEEEECCCCCCCCCHHHHHHHCCCEEEEE
QVGRQEPGGESVMVLNLDHVITEEVISKLKNIDNIIDAKIIKL
ECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
PKILITDSIHDDAVELLKQAGTVEVATDLTVEELKEKIKDADALVIRSGTKATKEIIDA
CCEEEECCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCC
ADNLKVIARAGVGVDNVDLTAATEKGIIVVNSPDASSISVAELALGLMLSSARNIPQATA
CCCCEEEEECCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHH
SLKRGEWDRKSFKGMELYGKTLGIIGLGRIGQQIAKRAEAFGMTVVAYDPYIPVEVAKNM
HHHCCCCCHHHCCCHHHHCCHHCEEEHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHCC
GIELMEVNDLCKVSDFITLHVPLTPKTKHMIGKEQISLMKPNTIIVNCARGGLIDEEALY
CEEEEECCCHHHHCCEEEEEEECCCCHHHHHCHHHHHEECCCEEEEECCCCCCCCHHHHH
DAINNKKIGGAGLDVFEEEPPKDNPLLTLDKFIGTPHQGASTVEAQKSAGTVVAEQVVKI
HHHCCCCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHH
LAGKPADNIVNLPRMPTDKMNKLNPYMALAEKMGNMIIQLLDKSVEKVELTYSGELASED
HCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCH
TEMVKRSFLMGLLSPILLAGVNLVNAPTIAKNRNIKIVEGTLSECEYGSSIKIKAEGKEE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEEEECCHHHCCCCCEEEEEECCHHH
CISLVGSLVEGAPVLKEINNYKIDIKPEGIVCVIKHMDKPGIIGKASTLLGDYGVNIAGM
HHHHHHHHHCCCHHHHHCCCCEEEECCCCEEEEEEECCCCCCCCCHHHHHHHCCCEEEEE
QVGRQEPGGESVMVLNLDHVITEEVISKLKNIDNIIDAKIIKL
ECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]