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The map label for this gene is top6B [H]

Identifier: 150400870

GI number: 150400870

Start: 457628

End: 459616

Strand: Reverse

Name: top6B [H]

Synonym: Maeo_0438

Alternate gene names: 150400870

Gene position: 459616-457628 (Counterclockwise)

Preceding gene: 150400871

Following gene: 150400869

Centisome position: 29.28

GC content: 33.28

Gene sequence:

>1989_bases
ATGGCAACGGAAAGCGATGGAATATTTGACGAATTTAAAGAACATTCAATATCTGAATTTTTTAGGAAAAATAGGCATAT
GTTGGGATACAGTGGAAAATTAAGAAGTATGACAACAATAATTCACGAGCTTATTACAAACTCCCTTGATGCCTGTGAAG
AAGCTGAAATTTTACCGGATATAGACATAACAATTAAAAAACTGGGTTCTGACCATTATCATATTTCTGTTGAGGACAAT
GGTCCAGGGATTCCTCCTGAATTTGTTCCAAAAGTATTTGGAAAAATGCTCGCAGGTTCAAAGATGCATAGGCTGGTACA
ATCAAGAGGTCAGCAAGGTATTGGAGCAGCTGGTGTATTATTATTTGCCCAAATAACCACAGGAAAACCTTTAAGAATTA
CTACCTCCACAGGAGATGGTAAAATCCACACATTGGATATAAAAATGAGTGTTGAAAAAAACGAAGGAGATGTAGTAAAT
CATGAAATAAGAGACGGAGTTTGGAGGGGAATTAAAGTAGAAGGTGAATTTAAAGAAATAACATACAGTAGAAGAGAACA
AGGTCCTTTTGAATATTTAAGAAGGATTAGTTTATCCACGCCCCATGCTAAAATAGTATTAACAGACCCAGAGGAGACCA
TAACATTTGATAGGACTGTGGAAATTATACCGGATAGACCAGAGGAAATGAAACCACACCCCTATGGATTAACACCAGAT
GAATTATTATATACTTCAAGAAGAACAGAATTTACAAAAATTTCTAGTATGCTAACCGGGGAATTATCAAGAATGACTTC
AAAAAGATTGAAGGAGCTCCAAGATTATATGCTAAGAGATAAACTTCTTGAAAATTATAGGGGTAGCACATTCTGGGATA
TTGTAGTAAATTGTTATTTAAATGTTAATATTAATCAATATGTTGGTAAAGATGGCAAATATAACAAATATGTTGATAAA
AATGAAATATCTGACATAGAGGAGATAATAAATACGCTACCTGACAGTTTGCCTGATTTAAAAATACATTATTTAAAATA
TATAATAATGGACTATTTAATTGGAAAACTTGACGAAGAAACCATTAAAGAGATTAAAAAACACTTTAAAAAGAAACCTG
AAAACTTTATAGAATTTGCGGAAAAGAATTATTTAAATGCTTCTTTAATGGATGAATTTAAAAAGAAATCAAGGGACATA
ACTAAAAGCCCTTCCGAATTTGTAAATACGCTAATAGATATGGCAATGGTTTCAAACGAAGAAAAAGACAGATTTAAAAA
TGAAATAAAAAATGTAATGAAAATGAACCCATCTAAAATGGATTGGAAGAATGCCGAGTTAATAGTAAGAGTAATTCAAG
ATATGGACTTTATGGCACCATCTACAATAGGGTTAAGACCGATTGGGGACGAAAATATAAAAAAGTCATTATCTACACTA
AATCCTGAGTTTGCAACCACGCTAACAAGAAAACCTAAAACATACAAAGGAGGAGTTCCTTTTGCTGTGGAAGTTGGATT
GGCATATGGTGGAGATGCTGGAAAAATGGGGGATACCGGAAGAAAGATGGAAATAATGAGATTTTCCAACCATGTCCCAT
TGTTATTTGATACCTCTGGCTGTGGATTAACCAGTGGTGTAAAAAGTGTAAATTGGAGAAGATACGGACTTAGGAGTGAA
GAAGATGTCCCATTAACTGTATTTGTAAATTTAATATCTACCCATATACCATATACTTCCGCAGGAAAACAGGCAATAGC
ATGTAGTGCAGAGGAAAATGAAGAGATATTTAACGAAATAAGACAGGCTTTAATGATTTGTGCAAGGGGCATGGAAAAAC
ATATTTCAAAAATTAGGAAAGAAAAAGAGGAAGAGCAGAAAAGAAAATATGTAATGAAATATGCCGTTATATTCGCAGAA
GGACTTGCAAGTATCACAGGCAAACCAAAAGAAGATATAGAGGAAAGAATTATTGAATTATTAAGATGA

Upstream 100 bases:

>100_bases
AATTAAATAATTGGATTTAATATTGAGCGAAAAAGTTCGAAGATTGGCTATCGTAATATTTTTTTAACATTTTTTAATTT
TAATAATTAATGGTGAAATC

Downstream 100 bases:

>100_bases
TAAATAATTAAATAAAATAATAAAAAATATAAATCATTTTTTAACACATATTTTTATAATAATATATTTTTATATTTTTA
TTAATATTTGGAGCTCCAAA

Product: DNA topoisomerase VI subunit B

Products: NA

Alternate protein names: Type II DNA topoisomerase VI subunit B; TopoVI-B [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MATESDGIFDEFKEHSISEFFRKNRHMLGYSGKLRSMTTIIHELITNSLDACEEAEILPDIDITIKKLGSDHYHISVEDN
GPGIPPEFVPKVFGKMLAGSKMHRLVQSRGQQGIGAAGVLLFAQITTGKPLRITTSTGDGKIHTLDIKMSVEKNEGDVVN
HEIRDGVWRGIKVEGEFKEITYSRREQGPFEYLRRISLSTPHAKIVLTDPEETITFDRTVEIIPDRPEEMKPHPYGLTPD
ELLYTSRRTEFTKISSMLTGELSRMTSKRLKELQDYMLRDKLLENYRGSTFWDIVVNCYLNVNINQYVGKDGKYNKYVDK
NEISDIEEIINTLPDSLPDLKIHYLKYIIMDYLIGKLDEETIKEIKKHFKKKPENFIEFAEKNYLNASLMDEFKKKSRDI
TKSPSEFVNTLIDMAMVSNEEKDRFKNEIKNVMKMNPSKMDWKNAELIVRVIQDMDFMAPSTIGLRPIGDENIKKSLSTL
NPEFATTLTRKPKTYKGGVPFAVEVGLAYGGDAGKMGDTGRKMEIMRFSNHVPLLFDTSGCGLTSGVKSVNWRRYGLRSE
EDVPLTVFVNLISTHIPYTSAGKQAIACSAEENEEIFNEIRQALMICARGMEKHISKIRKEKEEEQKRKYVMKYAVIFAE
GLASITGKPKEDIEERIIELLR

Sequences:

>Translated_662_residues
MATESDGIFDEFKEHSISEFFRKNRHMLGYSGKLRSMTTIIHELITNSLDACEEAEILPDIDITIKKLGSDHYHISVEDN
GPGIPPEFVPKVFGKMLAGSKMHRLVQSRGQQGIGAAGVLLFAQITTGKPLRITTSTGDGKIHTLDIKMSVEKNEGDVVN
HEIRDGVWRGIKVEGEFKEITYSRREQGPFEYLRRISLSTPHAKIVLTDPEETITFDRTVEIIPDRPEEMKPHPYGLTPD
ELLYTSRRTEFTKISSMLTGELSRMTSKRLKELQDYMLRDKLLENYRGSTFWDIVVNCYLNVNINQYVGKDGKYNKYVDK
NEISDIEEIINTLPDSLPDLKIHYLKYIIMDYLIGKLDEETIKEIKKHFKKKPENFIEFAEKNYLNASLMDEFKKKSRDI
TKSPSEFVNTLIDMAMVSNEEKDRFKNEIKNVMKMNPSKMDWKNAELIVRVIQDMDFMAPSTIGLRPIGDENIKKSLSTL
NPEFATTLTRKPKTYKGGVPFAVEVGLAYGGDAGKMGDTGRKMEIMRFSNHVPLLFDTSGCGLTSGVKSVNWRRYGLRSE
EDVPLTVFVNLISTHIPYTSAGKQAIACSAEENEEIFNEIRQALMICARGMEKHISKIRKEKEEEQKRKYVMKYAVIFAE
GLASITGKPKEDIEERIIELLR
>Mature_661_residues
ATESDGIFDEFKEHSISEFFRKNRHMLGYSGKLRSMTTIIHELITNSLDACEEAEILPDIDITIKKLGSDHYHISVEDNG
PGIPPEFVPKVFGKMLAGSKMHRLVQSRGQQGIGAAGVLLFAQITTGKPLRITTSTGDGKIHTLDIKMSVEKNEGDVVNH
EIRDGVWRGIKVEGEFKEITYSRREQGPFEYLRRISLSTPHAKIVLTDPEETITFDRTVEIIPDRPEEMKPHPYGLTPDE
LLYTSRRTEFTKISSMLTGELSRMTSKRLKELQDYMLRDKLLENYRGSTFWDIVVNCYLNVNINQYVGKDGKYNKYVDKN
EISDIEEIINTLPDSLPDLKIHYLKYIIMDYLIGKLDEETIKEIKKHFKKKPENFIEFAEKNYLNASLMDEFKKKSRDIT
KSPSEFVNTLIDMAMVSNEEKDRFKNEIKNVMKMNPSKMDWKNAELIVRVIQDMDFMAPSTIGLRPIGDENIKKSLSTLN
PEFATTLTRKPKTYKGGVPFAVEVGLAYGGDAGKMGDTGRKMEIMRFSNHVPLLFDTSGCGLTSGVKSVNWRRYGLRSEE
DVPLTVFVNLISTHIPYTSAGKQAIACSAEENEEIFNEIRQALMICARGMEKHISKIRKEKEEEQKRKYVMKYAVIFAEG
LASITGKPKEDIEERIIELLR

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP [H]

COG id: COG1389

COG function: function code L; DNA topoisomerase VI, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005734
- InterPro:   IPR015320
- ProDom:   PD013790 [H]

Pfam domain/function: PF02518 HATPase_c; PF09239 Topo-VIb_trans [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 75670; Mature: 75539

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATESDGIFDEFKEHSISEFFRKNRHMLGYSGKLRSMTTIIHELITNSLDACEEAEILPD
CCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IDITIKKLGSDHYHISVEDNGPGIPPEFVPKVFGKMLAGSKMHRLVQSRGQQGIGAAGVL
CCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHH
LFAQITTGKPLRITTSTGDGKIHTLDIKMSVEKNEGDVVNHEIRDGVWRGIKVEGEFKEI
HEEEECCCCCEEEEECCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHCCCEECCHHHHH
TYSRREQGPFEYLRRISLSTPHAKIVLTDPEETITFDRTVEIIPDRPEEMKPHPYGLTPD
HHHHHCCCHHHHHHHHCCCCCCEEEEEECCHHHEEECCEEEECCCCCHHCCCCCCCCCHH
ELLYTSRRTEFTKISSMLTGELSRMTSKRLKELQDYMLRDKLLENYRGSTFWDIVVNCYL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEE
NVNINQYVGKDGKYNKYVDKNEISDIEEIINTLPDSLPDLKIHYLKYIIMDYLIGKLDEE
ECCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHH
TIKEIKKHFKKKPENFIEFAEKNYLNASLMDEFKKKSRDITKSPSEFVNTLIDMAMVSNE
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
EKDRFKNEIKNVMKMNPSKMDWKNAELIVRVIQDMDFMAPSTIGLRPIGDENIKKSLSTL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC
NPEFATTLTRKPKTYKGGVPFAVEVGLAYGGDAGKMGDTGRKMEIMRFSNHVPLLFDTSG
CCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEECCC
CGLTSGVKSVNWRRYGLRSEEDVPLTVFVNLISTHIPYTSAGKQAIACSAEENEEIFNEI
CCHHHCHHHCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHH
RQALMICARGMEKHISKIRKEKEEEQKRKYVMKYAVIFAEGLASITGKPKEDIEERIIEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LR
HC
>Mature Secondary Structure 
ATESDGIFDEFKEHSISEFFRKNRHMLGYSGKLRSMTTIIHELITNSLDACEEAEILPD
CCCCCCHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IDITIKKLGSDHYHISVEDNGPGIPPEFVPKVFGKMLAGSKMHRLVQSRGQQGIGAAGVL
CCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHH
LFAQITTGKPLRITTSTGDGKIHTLDIKMSVEKNEGDVVNHEIRDGVWRGIKVEGEFKEI
HEEEECCCCCEEEEECCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHCCCEECCHHHHH
TYSRREQGPFEYLRRISLSTPHAKIVLTDPEETITFDRTVEIIPDRPEEMKPHPYGLTPD
HHHHHCCCHHHHHHHHCCCCCCEEEEEECCHHHEEECCEEEECCCCCHHCCCCCCCCCHH
ELLYTSRRTEFTKISSMLTGELSRMTSKRLKELQDYMLRDKLLENYRGSTFWDIVVNCYL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEE
NVNINQYVGKDGKYNKYVDKNEISDIEEIINTLPDSLPDLKIHYLKYIIMDYLIGKLDEE
ECCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHH
TIKEIKKHFKKKPENFIEFAEKNYLNASLMDEFKKKSRDITKSPSEFVNTLIDMAMVSNE
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
EKDRFKNEIKNVMKMNPSKMDWKNAELIVRVIQDMDFMAPSTIGLRPIGDENIKKSLSTL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC
NPEFATTLTRKPKTYKGGVPFAVEVGLAYGGDAGKMGDTGRKMEIMRFSNHVPLLFDTSG
CCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEECCC
CGLTSGVKSVNWRRYGLRSEEDVPLTVFVNLISTHIPYTSAGKQAIACSAEENEEIFNEI
CCHHHCHHHCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHH
RQALMICARGMEKHISKIRKEKEEEQKRKYVMKYAVIFAEGLASITGKPKEDIEERIIEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LR
HC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]