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The map label for this gene is neuA [H]

Identifier: 150400849

GI number: 150400849

Start: 437048

End: 437737

Strand: Direct

Name: neuA [H]

Synonym: Maeo_0417

Alternate gene names: 150400849

Gene position: 437048-437737 (Clockwise)

Preceding gene: 150400848

Following gene: 150400850

Centisome position: 27.85

GC content: 30.29

Gene sequence:

>690_bases
ATGAAAAATAAAATCCTTGCATTAATCCCCGCAAGAGGGGGAAGTAAAGGACTTCCAAGAAAAAATATAAAACCACTGTT
GGGAAAGCCTTTAATTGCTTGGACAATTGAGCAAGCAAAGAATAGCAAGTATGTAGATAAGGTTGTTGTATCTACTGATG
ATGAAGAAATTGCAGAAATTTCAAGAAAATATGGAGCAGAAGTTCCATTTTTAAGGCCGAAAGAATTGGCAAGAGATGAT
TCCCCTACAATTGATACAATTATGCATGCAACAAACTGGTTTGAAGAAAGAGGGGAAATTTTTGATATTATTGTATTACT
TCAGCCAACATCACCATTAAAAACTACTGAGGATATTGATAATGCAATTGAACTATTTTTAAATAATAAAAATGCTCTAT
CATTAGTTAGTGTTAAAGAAAATGAACATCCGCCATTTTGGAGTTTTAAAATTGAAAACGACTATATAAAACCACTATTT
GGAAATGAATATATTAATAAAAGGAGACAAGAACTCCCAAAATGCCATATACCAAATGGTGCAATATTTATATCCTATAT
TAAGGTATTAAAAGAATATAGGACATTTTACACTCCAAAAACAATATCCTACATAATGCCACCAGAAAGAAGTGTTGATA
TTGATAATGAATTTGATTTTCTATTGGCTGAATTTATCTTAAAAAAATAA

Upstream 100 bases:

>100_bases
TTATTTTGGAATATATATGTTGGGAATATTTGGACTAAAAATAATAAATATAAATGAGATTAATGATATTATTGGCAAAA
TTATAAAGAGGTAAGCAATC

Downstream 100 bases:

>100_bases
AAAGTGATACAATGAAAAATTCTGTATATTCCCATCAACTTGTTATATATAAGATCATAAAAAATTTATGTACAAATAAA
ATATTATATGGCATATTTAG

Product: acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKNKILALIPARGGSKGLPRKNIKPLLGKPLIAWTIEQAKNSKYVDKVVVSTDDEEIAEISRKYGAEVPFLRPKELARDD
SPTIDTIMHATNWFEERGEIFDIIVLLQPTSPLKTTEDIDNAIELFLNNKNALSLVSVKENEHPPFWSFKIENDYIKPLF
GNEYINKRRQELPKCHIPNGAIFISYIKVLKEYRTFYTPKTISYIMPPERSVDIDNEFDFLLAEFILKK

Sequences:

>Translated_229_residues
MKNKILALIPARGGSKGLPRKNIKPLLGKPLIAWTIEQAKNSKYVDKVVVSTDDEEIAEISRKYGAEVPFLRPKELARDD
SPTIDTIMHATNWFEERGEIFDIIVLLQPTSPLKTTEDIDNAIELFLNNKNALSLVSVKENEHPPFWSFKIENDYIKPLF
GNEYINKRRQELPKCHIPNGAIFISYIKVLKEYRTFYTPKTISYIMPPERSVDIDNEFDFLLAEFILKK
>Mature_229_residues
MKNKILALIPARGGSKGLPRKNIKPLLGKPLIAWTIEQAKNSKYVDKVVVSTDDEEIAEISRKYGAEVPFLRPKELARDD
SPTIDTIMHATNWFEERGEIFDIIVLLQPTSPLKTTEDIDNAIELFLNNKNALSLVSVKENEHPPFWSFKIENDYIKPLF
GNEYINKRRQELPKCHIPNGAIFISYIKVLKEYRTFYTPKTISYIMPPERSVDIDNEFDFLLAEFILKK

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=222, Percent_Identity=35.1351351351351, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 26441; Mature: 26441

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKILALIPARGGSKGLPRKNIKPLLGKPLIAWTIEQAKNSKYVDKVVVSTDDEEIAEI
CCCCEEEEEECCCCCCCCCCCCCCHHHCCCEEEEEHHHHCCCCCHHEEEEECCHHHHHHH
SRKYGAEVPFLRPKELARDDSPTIDTIMHATNWFEERGEIFDIIVLLQPTSPLKTTEDID
HHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHH
NAIELFLNNKNALSLVSVKENEHPPFWSFKIENDYIKPLFGNEYINKRRQELPKCHIPNG
HHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCEEECCCC
AIFISYIKVLKEYRTFYTPKTISYIMPPERSVDIDNEFDFLLAEFILKK
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKNKILALIPARGGSKGLPRKNIKPLLGKPLIAWTIEQAKNSKYVDKVVVSTDDEEIAEI
CCCCEEEEEECCCCCCCCCCCCCCHHHCCCEEEEEHHHHCCCCCHHEEEEECCHHHHHHH
SRKYGAEVPFLRPKELARDDSPTIDTIMHATNWFEERGEIFDIIVLLQPTSPLKTTEDID
HHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHH
NAIELFLNNKNALSLVSVKENEHPPFWSFKIENDYIKPLFGNEYINKRRQELPKCHIPNG
HHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCEEECCCC
AIFISYIKVLKEYRTFYTPKTISYIMPPERSVDIDNEFDFLLAEFILKK
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]