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The map label for this gene is galE [C]

Identifier: 150400811

GI number: 150400811

Start: 391018

End: 391926

Strand: Direct

Name: galE [C]

Synonym: Maeo_0378

Alternate gene names: 150400811

Gene position: 391018-391926 (Clockwise)

Preceding gene: 150400810

Following gene: 150400812

Centisome position: 24.91

GC content: 30.14

Gene sequence:

>909_bases
TTGAAAGTTCTCATAACTGGTGGAGCAGGATTTATTGGAAGTCATATAGTAGATAAATTTTTAGAAAATAACCACGAGGT
TGTAGTTTTAGACAATTTAACCACGGGCAATTTAGATAATATTAAACGAAATAATGATAATATTGAATTTATAAATAAAA
GCATACGAGATAATGATTTAAATTTTGAAGATATTGATGTGGTAATACATCATGCTGCACAAATAAATGTTAGAACCTCT
GTTGAAAATCCTGTTTTAGATGGAGATATAAATATTTTAGGATTAATAAATATTTTAGAGAAGATAAAAAAATATGGGGT
TAAAAAAATAATATTTGCATCTTCGGGAGGGGCTGTTTATGGGGAACCAGAATATATGCCCGTTGATGAAAATCATGTCG
GAGCTCCAATGAGTCCTTATGGAGTAAGTAAATTTTGTGGGGAAGAATATATAAAATTATACAATAGATTGTATGGCATT
GATTATACTATTTTGCGATATTCAAATGTATTTGGGGAACGGCAAGACCCATTGGGTGAAGCCGGAGTAATCTCTATATT
TATCGATAAAATGGTTAAAAACGAAAAAGCCACAATATTTGGAGATGGTGGCCAGACAAGAGATTTTGTTTATGTTGGTG
ATGTGGCAGAGGCAAATTTAAAGGCCTTGGATTGGAAAAATGAAATTGTAAATATTGGAACAGGAATAGAAACCTCTGTA
AATGAATTATATTCAGTAATTGCAAATGAATTAAATTATAATGATAAACCAATATATGATAAACCAAGAGAAGGAGAGGT
TTATAGAATTTCATTGGAGATAAATAAGGCTAAAAAATTAGGTTGGAAACCTATTGTTGATTTAAAAGAAGGCATAAAAA
GAACTGTTGAATGGACGAAAAATAAATAA

Upstream 100 bases:

>100_bases
AAAAGAAGTTGTTAATAAATAATATTCATTTGGGCAGTGTTATGGGAGCTCCCGTGATGCCATAACAAATAATATAATTA
TTTTTAAAAAAGGTGAAATA

Downstream 100 bases:

>100_bases
TATAAAAAAATATCGATAATATAAAATTCCCAAAAAAGAGGAATAAATTTCTACGAGGTGCAAAATGAAAGGTATAGTTT
TAGCAGGAGGTTCTGGGACT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKVLITGGAGFIGSHIVDKFLENNHEVVVLDNLTTGNLDNIKRNNDNIEFINKSIRDNDLNFEDIDVVIHHAAQINVRTS
VENPVLDGDINILGLINILEKIKKYGVKKIIFASSGGAVYGEPEYMPVDENHVGAPMSPYGVSKFCGEEYIKLYNRLYGI
DYTILRYSNVFGERQDPLGEAGVISIFIDKMVKNEKATIFGDGGQTRDFVYVGDVAEANLKALDWKNEIVNIGTGIETSV
NELYSVIANELNYNDKPIYDKPREGEVYRISLEINKAKKLGWKPIVDLKEGIKRTVEWTKNK

Sequences:

>Translated_302_residues
MKVLITGGAGFIGSHIVDKFLENNHEVVVLDNLTTGNLDNIKRNNDNIEFINKSIRDNDLNFEDIDVVIHHAAQINVRTS
VENPVLDGDINILGLINILEKIKKYGVKKIIFASSGGAVYGEPEYMPVDENHVGAPMSPYGVSKFCGEEYIKLYNRLYGI
DYTILRYSNVFGERQDPLGEAGVISIFIDKMVKNEKATIFGDGGQTRDFVYVGDVAEANLKALDWKNEIVNIGTGIETSV
NELYSVIANELNYNDKPIYDKPREGEVYRISLEINKAKKLGWKPIVDLKEGIKRTVEWTKNK
>Mature_302_residues
MKVLITGGAGFIGSHIVDKFLENNHEVVVLDNLTTGNLDNIKRNNDNIEFINKSIRDNDLNFEDIDVVIHHAAQINVRTS
VENPVLDGDINILGLINILEKIKKYGVKKIIFASSGGAVYGEPEYMPVDENHVGAPMSPYGVSKFCGEEYIKLYNRLYGI
DYTILRYSNVFGERQDPLGEAGVISIFIDKMVKNEKATIFGDGGQTRDFVYVGDVAEANLKALDWKNEIVNIGTGIETSV
NELYSVIANELNYNDKPIYDKPREGEVYRISLEINKAKKLGWKPIVDLKEGIKRTVEWTKNK

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=326, Percent_Identity=34.9693251533742, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI42516563, Length=310, Percent_Identity=29.3548387096774, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI56237023, Length=344, Percent_Identity=31.6860465116279, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI56118217, Length=344, Percent_Identity=31.6860465116279, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI189083684, Length=344, Percent_Identity=31.6860465116279, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1786974, Length=334, Percent_Identity=30.8383233532934, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1788353, Length=336, Percent_Identity=29.4642857142857, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI48994969, Length=331, Percent_Identity=29.3051359516616, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788365, Length=322, Percent_Identity=22.9813664596273, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790049, Length=316, Percent_Identity=26.5822784810127, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788589, Length=338, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=309, Percent_Identity=30.7443365695793, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71982035, Length=343, Percent_Identity=28.8629737609329, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71982038, Length=345, Percent_Identity=28.695652173913, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI115532424, Length=326, Percent_Identity=30.6748466257669, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17568069, Length=326, Percent_Identity=30.6748466257669, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319493, Length=339, Percent_Identity=30.6784660766962, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321437, Length=351, Percent_Identity=25.0712250712251, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356223, Length=311, Percent_Identity=32.1543408360129, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19923002, Length=339, Percent_Identity=29.7935103244838, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 33919; Mature: 33919

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLITGGAGFIGSHIVDKFLENNHEVVVLDNLTTGNLDNIKRNNDNIEFINKSIRDNDL
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCC
NFEDIDVVIHHAAQINVRTSVENPVLDGDINILGLINILEKIKKYGVKKIIFASSGGAVY
CHHHHHHEEEHHEEEEEEECCCCCEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEE
GEPEYMPVDENHVGAPMSPYGVSKFCGEEYIKLYNRLYGIDYTILRYSNVFGERQDPLGE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCC
AGVISIFIDKMVKNEKATIFGDGGQTRDFVYVGDVAEANLKALDWKNEIVNIGTGIETSV
CCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCEEEEECCCCEEECCCCCCHHH
NELYSVIANELNYNDKPIYDKPREGEVYRISLEINKAKKLGWKPIVDLKEGIKRTVEWTK
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHCC
NK
CC
>Mature Secondary Structure
MKVLITGGAGFIGSHIVDKFLENNHEVVVLDNLTTGNLDNIKRNNDNIEFINKSIRDNDL
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCC
NFEDIDVVIHHAAQINVRTSVENPVLDGDINILGLINILEKIKKYGVKKIIFASSGGAVY
CHHHHHHEEEHHEEEEEEECCCCCEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEE
GEPEYMPVDENHVGAPMSPYGVSKFCGEEYIKLYNRLYGIDYTILRYSNVFGERQDPLGE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCC
AGVISIFIDKMVKNEKATIFGDGGQTRDFVYVGDVAEANLKALDWKNEIVNIGTGIETSV
CCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCEEEEECCCCEEECCCCCCHHH
NELYSVIANELNYNDKPIYDKPREGEVYRISLEINKAKKLGWKPIVDLKEGIKRTVEWTK
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHCC
NK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]