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The map label for this gene is hisC

Identifier: 150400686

GI number: 150400686

Start: 276693

End: 277808

Strand: Reverse

Name: hisC

Synonym: Maeo_0250

Alternate gene names: 150400686

Gene position: 277808-276693 (Counterclockwise)

Preceding gene: 150400687

Following gene: 150400682

Centisome position: 17.7

GC content: 29.21

Gene sequence:

>1116_bases
ATGACAATAGATAATAAAATAAGACATATTGTAAAGGAATTTAAAGCTTATGTGCCTGGAAAATCTAAGGAAGAAATAGC
ACGAAATTATAATATAAATCCCGACGAAATTATAAAATTAGGCTCTAATGAAAATCCATGGGGGAGCTCCCCGAAAATAA
AAGAGGAAATATTAAAAGAATTACCTAATATACATCAATATCCAGAGCCAGTAAATCCAATACTCATGGAGGAATTAAGT
AAATTTACAAATATTCCAAAGGAAAATATAGTAGTTGGTGGAGATGGTGCTGATGAGATAATAGATACAATGATGAGGAT
TTTAATAGATAAAGATGATGAGGTAATTATTCCAATACCAACTTTTACACAGTATAGAATATCTGCAAAAATATATGGTG
CAAATATAAAATATGCAAAATTTGATAAGGAAAAAGATTTCAAATTAGATGTGGATAGTGTTTTAAACAACATCACAGAT
AAAACAAAAATTATATTCTTATGTACTCCAAACAACCCCACCGGAAATATAATTGATAAAAAAGATATTGAAAAAATCAT
AAATTCAACAGATGCCCTTGTAATGATAGACCATGCATATATTGAATATTCAAAAGAAGAATATGATTTAACAGAATTTG
CATTAAAATATGACAATGTTTTAATTTTAAGAACTTTTTCAAAGGTATTTGGTTTAGCAGGGCAAAGAATTGGCTACGGT
ATCACCAGTAAAAAAATTGTAGATTATATGATGAGAGTTAAACCAATATTCAGCATAACCAGATTAAGCCAAATTTGTGC
CATTACAGCACTAAGGGATAAAGAATTTTTTGAAAAATCAAAAAATGACGGTATAAAAAGCATGGAAATATTATATAATG
GTTTAAAAGAATTTAAGGAGTTAAAAGTTTATCCTTCCGAAGCAAATTATTTACTTGTGGAAGTTAAAAATGGCATGAGC
TCTGGTGAGTTTTGCGTGGAGCTCCTGAAAAGAGGGGTAATTGTAAGAGATTGTAAATCTTTTGAAGGACTTGATGGGGA
ATATGTAAGGGTTGCCATTGGAACATTTGAAGAAGATAGAAGATTTTTAGAGATTTTAAAGGAGATTGTTAATTAA

Upstream 100 bases:

>100_bases
TCTTATTTGCATAATATGGAGTGAAACAGTTCGAAGATTGACTATAAATAAATAACATACACGAACATGAATGATAATAA
TTAGATAAATAGGTGGAATA

Downstream 100 bases:

>100_bases
TTTTTTATTTATTTTACTATTTAAATTTTAGTGTAGTCATAATTTGAGATTATAGTAAGTTCAAAAACTGTCCCTAATAT
GTCCCTATTTTTTTATGTCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTIDNKIRHIVKEFKAYVPGKSKEEIARNYNINPDEIIKLGSNENPWGSSPKIKEEILKELPNIHQYPEPVNPILMEELS
KFTNIPKENIVVGGDGADEIIDTMMRILIDKDDEVIIPIPTFTQYRISAKIYGANIKYAKFDKEKDFKLDVDSVLNNITD
KTKIIFLCTPNNPTGNIIDKKDIEKIINSTDALVMIDHAYIEYSKEEYDLTEFALKYDNVLILRTFSKVFGLAGQRIGYG
ITSKKIVDYMMRVKPIFSITRLSQICAITALRDKEFFEKSKNDGIKSMEILYNGLKEFKELKVYPSEANYLLVEVKNGMS
SGEFCVELLKRGVIVRDCKSFEGLDGEYVRVAIGTFEEDRRFLEILKEIVN

Sequences:

>Translated_371_residues
MTIDNKIRHIVKEFKAYVPGKSKEEIARNYNINPDEIIKLGSNENPWGSSPKIKEEILKELPNIHQYPEPVNPILMEELS
KFTNIPKENIVVGGDGADEIIDTMMRILIDKDDEVIIPIPTFTQYRISAKIYGANIKYAKFDKEKDFKLDVDSVLNNITD
KTKIIFLCTPNNPTGNIIDKKDIEKIINSTDALVMIDHAYIEYSKEEYDLTEFALKYDNVLILRTFSKVFGLAGQRIGYG
ITSKKIVDYMMRVKPIFSITRLSQICAITALRDKEFFEKSKNDGIKSMEILYNGLKEFKELKVYPSEANYLLVEVKNGMS
SGEFCVELLKRGVIVRDCKSFEGLDGEYVRVAIGTFEEDRRFLEILKEIVN
>Mature_370_residues
TIDNKIRHIVKEFKAYVPGKSKEEIARNYNINPDEIIKLGSNENPWGSSPKIKEEILKELPNIHQYPEPVNPILMEELSK
FTNIPKENIVVGGDGADEIIDTMMRILIDKDDEVIIPIPTFTQYRISAKIYGANIKYAKFDKEKDFKLDVDSVLNNITDK
TKIIFLCTPNNPTGNIIDKKDIEKIINSTDALVMIDHAYIEYSKEEYDLTEFALKYDNVLILRTFSKVFGLAGQRIGYGI
TSKKIVDYMMRVKPIFSITRLSQICAITALRDKEFFEKSKNDGIKSMEILYNGLKEFKELKVYPSEANYLLVEVKNGMSS
GEFCVELLKRGVIVRDCKSFEGLDGEYVRVAIGTFEEDRRFLEILKEIVN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=373, Percent_Identity=27.6139410187668, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788722, Length=335, Percent_Identity=24.1791044776119, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788627, Length=151, Percent_Identity=27.8145695364238, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=376, Percent_Identity=26.3297872340426, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6322401, Length=290, Percent_Identity=23.1034482758621, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_META3 (A6UTL8)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324452.1
- ProteinModelPortal:   A6UTL8
- SMR:   A6UTL8
- STRING:   A6UTL8
- GeneID:   5327756
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0250
- eggNOG:   arNOG04897
- HOGENOM:   HBG646350
- OMA:   NADENRR
- ProtClustDB:   PRK00950
- BioCyc:   MAEO419665:MAEO_0250-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 42589; Mature: 42458

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDNKIRHIVKEFKAYVPGKSKEEIARNYNINPDEIIKLGSNENPWGSSPKIKEEILKE
CCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHEEEECCCCCCCCCCCCHHHHHHHH
LPNIHQYPEPVNPILMEELSKFTNIPKENIVVGGDGADEIIDTMMRILIDKDDEVIIPIP
CCCCCCCCCCCCHHHHHHHHHHHCCCHHCEEECCCCHHHHHHHHHHHHCCCCCCEEEECC
TFTQYRISAKIYGANIKYAKFDKEKDFKLDVDSVLNNITDKTKIIFLCTPNNPTGNIIDK
CCCEEEEEEEEEECCEEEEECCCCCCCEECHHHHHHCCCCCEEEEEEECCCCCCCCCCCH
KDIEKIINSTDALVMIDHAYIEYSKEEYDLTEFALKYDNVLILRTFSKVFGLAGQRIGYG
HHHHHHHCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHCCEEEEHHHHHHHCCCCCHHCCC
ITSKKIVDYMMRVKPIFSITRLSQICAITALRDKEFFEKSKNDGIKSMEILYNGLKEFKE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LKVYPSEANYLLVEVKNGMSSGEFCVELLKRGVIVRDCKSFEGLDGEYVRVAIGTFEEDR
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEHHHHCCCCCCCEEEEEECCCHHHH
RFLEILKEIVN
HHHHHHHHHHC
>Mature Secondary Structure 
TIDNKIRHIVKEFKAYVPGKSKEEIARNYNINPDEIIKLGSNENPWGSSPKIKEEILKE
CCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHEEEECCCCCCCCCCCCHHHHHHHH
LPNIHQYPEPVNPILMEELSKFTNIPKENIVVGGDGADEIIDTMMRILIDKDDEVIIPIP
CCCCCCCCCCCCHHHHHHHHHHHCCCHHCEEECCCCHHHHHHHHHHHHCCCCCCEEEECC
TFTQYRISAKIYGANIKYAKFDKEKDFKLDVDSVLNNITDKTKIIFLCTPNNPTGNIIDK
CCCEEEEEEEEEECCEEEEECCCCCCCEECHHHHHHCCCCCEEEEEEECCCCCCCCCCCH
KDIEKIINSTDALVMIDHAYIEYSKEEYDLTEFALKYDNVLILRTFSKVFGLAGQRIGYG
HHHHHHHCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHCCEEEEHHHHHHHCCCCCHHCCC
ITSKKIVDYMMRVKPIFSITRLSQICAITALRDKEFFEKSKNDGIKSMEILYNGLKEFKE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LKVYPSEANYLLVEVKNGMSSGEFCVELLKRGVIVRDCKSFEGLDGEYVRVAIGTFEEDR
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEHHHHCCCCCCCEEEEEECCCHHHH
RFLEILKEIVN
HHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA