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The map label for this gene is eIF2G

Identifier: 150400682

GI number: 150400682

Start: 272793

End: 274025

Strand: Reverse

Name: eIF2G

Synonym: Maeo_0246

Alternate gene names: 150400682

Gene position: 274025-272793 (Counterclockwise)

Preceding gene: 150400686

Following gene: 150400681

Centisome position: 17.46

GC content: 37.23

Gene sequence:

>1233_bases
ATGGTAAAAGTAAAACAGTCGGAAATAAATATTGGTATGGTTGGTCATGTTGACCACGGAAAAACCAGTTTAACCAGACA
ACTAACCGGAACATGGACGGACACCCACAGTGAAGAGTTAAAAAGAGGAATCTCCATAAGATTAGGTTATGCAGATTGTG
AGATTATGAAGTGCCCAAAATGTGGAGCTCCCGAAGCATATTCTGTGAGCAAAACCTGTCCAGTATGTGGCACCAAAACA
AAAATGTCAAGAAAAATATCATTTGTAGATGCACCTGGGCACGAAACGCTAATGGCTACAATGTTATCAGGAGCTTCCCT
TATGAATGGGGCAATATTGGTAATAGCTGCAACAGAAAAATGCCCACAACCCCAAACAAAAGAACATTTAATGGCACTTG
ATGCCCTTGGAATTGAAAATATTATTATTGTTCAAAACAAAATTGATTTAGTTGATGAAGAAAGAGCAAAAGAAAGCTAC
AACGAAATAAAAGAATTTGTAAAAGACACAGTAGCAGAAAAAGCCCCAATTATCCCTATTTCAGCACATCACGGAGCAAA
TATTGATATATTATTAAATGCAATTGAGGATTTAATGCCAACCCCTGAAATGGATGAGGGAGCTCCTGCACGATTATATG
TTGCAAGAAGTTTTGACATCAATAAACCAGGATGCGAGATAAGTAAGCTTAAAGGTGGGGTTATCGGAGGGAGCATAATT
CAAGGAACACTTAATTCAGGCGAAAAAATCGAAATTAAACCGGGATTAAAAATCGTAGAAGGAAATAAAATTAGATGGGA
ATCTATAATTACAAAAATCACATCTCTTGGTGTTGGAGGTAAAACTGTTAAAGTGGCTCATCCGGGAGGATTGGTTGGAA
TTGGAACAGAATTAGACCCAGCACTTACAAAATCAGATTCACTAAGTGGATGTGTAGCCGGAGCTCCGGGAACATTGCCT
GAAACTTTATCCGAAATCACAGTTCAAACAAAATTATTGGATAGAATTGTAGGTTCAGACGAAGAATTAATAATAAGCCC
TTTAAAATCAAATGAAGCTTTAATGTTAAATGTGGGAACAGCAACCACAGTTGGAATAATAACCTCCGCAAGAGGAGATA
TGGCTGATATGAAGTTAAAACTTCCTATTTGCGCAGATAAAGGGGACAGAATAGCAATGAGTAGAAGAATAGGTTCAAGA
TGGAGATTAATTGGATATGGAATTATTCAATAA

Upstream 100 bases:

>100_bases
CAACATTAATATATATGTAATAAATATTTTATTATAATAAATATAAACATATAATGATAACAATTAAAATTAAATAATAA
ACGGAATTAGAGGGATATCG

Downstream 100 bases:

>100_bases
ATTAAATACTATTTTTATTTTTTATCTTTTTTATCTTTTTAATTTATAATTAATCTTCGGTCTTTTTCAGTTAAATACGA
TAACAAAGCTAAATTTCACA

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MVKVKQSEINIGMVGHVDHGKTSLTRQLTGTWTDTHSEELKRGISIRLGYADCEIMKCPKCGAPEAYSVSKTCPVCGTKT
KMSRKISFVDAPGHETLMATMLSGASLMNGAILVIAATEKCPQPQTKEHLMALDALGIENIIIVQNKIDLVDEERAKESY
NEIKEFVKDTVAEKAPIIPISAHHGANIDILLNAIEDLMPTPEMDEGAPARLYVARSFDINKPGCEISKLKGGVIGGSII
QGTLNSGEKIEIKPGLKIVEGNKIRWESIITKITSLGVGGKTVKVAHPGGLVGIGTELDPALTKSDSLSGCVAGAPGTLP
ETLSEITVQTKLLDRIVGSDEELIISPLKSNEALMLNVGTATTVGIITSARGDMADMKLKLPICADKGDRIAMSRRIGSR
WRLIGYGIIQ

Sequences:

>Translated_410_residues
MVKVKQSEINIGMVGHVDHGKTSLTRQLTGTWTDTHSEELKRGISIRLGYADCEIMKCPKCGAPEAYSVSKTCPVCGTKT
KMSRKISFVDAPGHETLMATMLSGASLMNGAILVIAATEKCPQPQTKEHLMALDALGIENIIIVQNKIDLVDEERAKESY
NEIKEFVKDTVAEKAPIIPISAHHGANIDILLNAIEDLMPTPEMDEGAPARLYVARSFDINKPGCEISKLKGGVIGGSII
QGTLNSGEKIEIKPGLKIVEGNKIRWESIITKITSLGVGGKTVKVAHPGGLVGIGTELDPALTKSDSLSGCVAGAPGTLP
ETLSEITVQTKLLDRIVGSDEELIISPLKSNEALMLNVGTATTVGIITSARGDMADMKLKLPICADKGDRIAMSRRIGSR
WRLIGYGIIQ
>Mature_410_residues
MVKVKQSEINIGMVGHVDHGKTSLTRQLTGTWTDTHSEELKRGISIRLGYADCEIMKCPKCGAPEAYSVSKTCPVCGTKT
KMSRKISFVDAPGHETLMATMLSGASLMNGAILVIAATEKCPQPQTKEHLMALDALGIENIIIVQNKIDLVDEERAKESY
NEIKEFVKDTVAEKAPIIPISAHHGANIDILLNAIEDLMPTPEMDEGAPARLYVARSFDINKPGCEISKLKGGVIGGSII
QGTLNSGEKIEIKPGLKIVEGNKIRWESIITKITSLGVGGKTVKVAHPGGLVGIGTELDPALTKSDSLSGCVAGAPGTLP
ETLSEITVQTKLLDRIVGSDEELIISPLKSNEALMLNVGTATTVGIITSARGDMADMKLKLPICADKGDRIAMSRRIGSR
WRLIGYGIIQ

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily

Homologues:

Organism=Homo sapiens, GI4503507, Length=424, Percent_Identity=45.2830188679245, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI34147630, Length=438, Percent_Identity=25.5707762557078, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI54607086, Length=383, Percent_Identity=25.5874673629243, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI2367247, Length=401, Percent_Identity=25.1870324189526, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790412, Length=438, Percent_Identity=26.9406392694064, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789737, Length=438, Percent_Identity=26.9406392694064, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17509919, Length=424, Percent_Identity=42.4528301886792, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI25141371, Length=436, Percent_Identity=28.2110091743119, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17556456, Length=361, Percent_Identity=27.7008310249307, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506081, Length=330, Percent_Identity=25.4545454545455, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115532067, Length=201, Percent_Identity=29.8507462686567, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115532065, Length=217, Percent_Identity=26.7281105990783, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32566629, Length=310, Percent_Identity=24.8387096774194, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17552884, Length=333, Percent_Identity=23.7237237237237, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17569207, Length=333, Percent_Identity=23.7237237237237, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320863, Length=422, Percent_Identity=43.3649289099526, Blast_Score=356, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6324761, Length=273, Percent_Identity=31.1355311355311, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24647046, Length=423, Percent_Identity=45.8628841607565, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24647048, Length=423, Percent_Identity=45.8628841607565, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921738, Length=248, Percent_Identity=33.4677419354839, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363316, Length=339, Percent_Identity=27.4336283185841, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17864358, Length=339, Percent_Identity=27.4336283185841, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI19922690, Length=283, Percent_Identity=27.5618374558304, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45553807, Length=376, Percent_Identity=22.6063829787234, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45553816, Length=376, Percent_Identity=22.6063829787234, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24651721, Length=376, Percent_Identity=22.6063829787234, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17864154, Length=376, Percent_Identity=22.6063829787234, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF2G_META3 (A6UTL4)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324448.1
- ProteinModelPortal:   A6UTL4
- SMR:   A6UTL4
- STRING:   A6UTL4
- GeneID:   5327768
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0246
- eggNOG:   arNOG04625
- HOGENOM:   HBG307581
- OMA:   IAANEPC
- ProtClustDB:   PRK04000
- BioCyc:   MAEO419665:MAEO_0246-MONOMER
- HAMAP:   MF_00119
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- PRINTS:   PR00315
- TIGRFAMs:   TIGR03680
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; SSF50465 Elong_init_C; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 43829; Mature: 43829

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVKQSEINIGMVGHVDHGKTSLTRQLTGTWTDTHSEELKRGISIRLGYADCEIMKCPK
CCEEECCCCCEEEEEECCCCCHHHHHEEECCCCCCCHHHHHCCCEEEEECCCCEEEECCC
CGAPEAYSVSKTCPVCGTKTKMSRKISFVDAPGHETLMATMLSGASLMNGAILVIAATEK
CCCCCCCCCCCCCCCCCCCHHHCEEEEEEECCCHHHHHHHHHCCCHHCCCEEEEEEECCC
CPQPQTKEHLMALDALGIENIIIVQNKIDLVDEERAKESYNEIKEFVKDTVAEKAPIIPI
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
SAHHGANIDILLNAIEDLMPTPEMDEGAPARLYVARSFDINKPGCEISKLKGGVIGGSII
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHCCCCEECCCEE
QGTLNSGEKIEIKPGLKIVEGNKIRWESIITKITSLGVGGKTVKVAHPGGLVGIGTELDP
EEECCCCCEEEECCCCEEEECCEEEHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCC
ALTKSDSLSGCVAGAPGTLPETLSEITVQTKLLDRIVGSDEELIISPLKSNEALMLNVGT
CCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCC
ATTVGIITSARGDMADMKLKLPICADKGDRIAMSRRIGSRWRLIGYGIIQ
CEEEEEEECCCCCCCCEEEEEEEECCCCCEEEEHHHCCCCEEEEEEEECC
>Mature Secondary Structure
MVKVKQSEINIGMVGHVDHGKTSLTRQLTGTWTDTHSEELKRGISIRLGYADCEIMKCPK
CCEEECCCCCEEEEEECCCCCHHHHHEEECCCCCCCHHHHHCCCEEEEECCCCEEEECCC
CGAPEAYSVSKTCPVCGTKTKMSRKISFVDAPGHETLMATMLSGASLMNGAILVIAATEK
CCCCCCCCCCCCCCCCCCCHHHCEEEEEEECCCHHHHHHHHHCCCHHCCCEEEEEEECCC
CPQPQTKEHLMALDALGIENIIIVQNKIDLVDEERAKESYNEIKEFVKDTVAEKAPIIPI
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
SAHHGANIDILLNAIEDLMPTPEMDEGAPARLYVARSFDINKPGCEISKLKGGVIGGSII
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHCCCCEECCCEE
QGTLNSGEKIEIKPGLKIVEGNKIRWESIITKITSLGVGGKTVKVAHPGGLVGIGTELDP
EEECCCCCEEEECCCCEEEECCEEEHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCC
ALTKSDSLSGCVAGAPGTLPETLSEITVQTKLLDRIVGSDEELIISPLKSNEALMLNVGT
CCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCC
ATTVGIITSARGDMADMKLKLPICADKGDRIAMSRRIGSRWRLIGYGIIQ
CEEEEEEECCCCCCCCEEEEEEEECCCCCEEEEHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA