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The map label for this gene is hisB

Identifier: 150400579

GI number: 150400579

Start: 159441

End: 160013

Strand: Direct

Name: hisB

Synonym: Maeo_0141

Alternate gene names: 150400579

Gene position: 159441-160013 (Clockwise)

Preceding gene: 150400578

Following gene: 150400580

Centisome position: 10.16

GC content: 33.68

Gene sequence:

>573_bases
TTGCGAGTTTTTGAAGTGGAGAGGACAACAAATGAAACAAATATAAAATTAAGATTAAACATAGATGGGACTGGAAATTA
TGAAATAACTACCAAAATCCCTTTTTTCGACCATATTTTATCCTCATTTGTAAAACATGGTTCTTTTGATTTATCTCTAA
TTGCTGAGGGAGATTTGGAAATTGATGACCATCATACCGTTGAAGATGTTGGTATATGTTTAGGAATGGCAATGAATAAA
ATTGAGAAGAAGAATATAAAGAGATTTGGACATGCCATTGTTCCGATGGACGAAGCAAGAGCTATGGTTTCTATTGATTT
GGGGGGGCGTCCTTTTGTAGTAGGAAATTATATTCCAAAGAGGGATAAAGTTGGAGAACTCTCCACCGAAAATATAGTTC
ATTTCTTTGAGTCAATGGCAAACAATGGAAATATGAATATACATTTTGAAGTAATTGGAGAGAACGAACACCACAAAATA
GAGGCACTTTTTAAGGCTTTTGGGATTGCATTGGATAATGCAACTCAAATTGACGAAAGAAAAGGAATAATTAGCACAAA
AGGAGTTATATAA

Upstream 100 bases:

>100_bases
TAAAGATTCGTGGAAATCATATTTAAATTATAAGGATATAGATGTTATGGAATCAACATGCCCATTTAAATAATTCCCTA
AAATAATAAAAGGTGATACC

Downstream 100 bases:

>100_bases
ATAAAAATCATATAAATAATCATAAATAAGGATTATTTAAATCAAAGGTAAAATTATGAAAGTAATAGGAAAAATGGGAC
CCTCCCAAAAAAATCAAAAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MRVFEVERTTNETNIKLRLNIDGTGNYEITTKIPFFDHILSSFVKHGSFDLSLIAEGDLEIDDHHTVEDVGICLGMAMNK
IEKKNIKRFGHAIVPMDEARAMVSIDLGGRPFVVGNYIPKRDKVGELSTENIVHFFESMANNGNMNIHFEVIGENEHHKI
EALFKAFGIALDNATQIDERKGIISTKGVI

Sequences:

>Translated_190_residues
MRVFEVERTTNETNIKLRLNIDGTGNYEITTKIPFFDHILSSFVKHGSFDLSLIAEGDLEIDDHHTVEDVGICLGMAMNK
IEKKNIKRFGHAIVPMDEARAMVSIDLGGRPFVVGNYIPKRDKVGELSTENIVHFFESMANNGNMNIHFEVIGENEHHKI
EALFKAFGIALDNATQIDERKGIISTKGVI
>Mature_190_residues
MRVFEVERTTNETNIKLRLNIDGTGNYEITTKIPFFDHILSSFVKHGSFDLSLIAEGDLEIDDHHTVEDVGICLGMAMNK
IEKKNIKRFGHAIVPMDEARAMVSIDLGGRPFVVGNYIPKRDKVGELSTENIVHFFESMANNGNMNIHFEVIGENEHHKI
EALFKAFGIALDNATQIDERKGIISTKGVI

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=192, Percent_Identity=42.1875, Blast_Score=147, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324776, Length=212, Percent_Identity=35.377358490566, Blast_Score=133, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_META3 (A6UTB1)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324345.1
- ProteinModelPortal:   A6UTB1
- SMR:   A6UTB1
- STRING:   A6UTB1
- GeneID:   5326922
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0141
- eggNOG:   arNOG05643
- HOGENOM:   HBG289010
- OMA:   FGWAIIP
- ProtClustDB:   PRK00951
- BioCyc:   MAEO419665:MAEO_0141-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21327; Mature: 21327

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFEVERTTNETNIKLRLNIDGTGNYEITTKIPFFDHILSSFVKHGSFDLSLIAEGDLE
CEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCEE
IDDHHTVEDVGICLGMAMNKIEKKNIKRFGHAIVPMDEARAMVSIDLGGRPFVVGNYIPK
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCCEEEECCCCC
RDKVGELSTENIVHFFESMANNGNMNIHFEVIGENEHHKIEALFKAFGIALDNATQIDER
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCEECCCCCCHHHH
KGIISTKGVI
CCEEECCCCC
>Mature Secondary Structure
MRVFEVERTTNETNIKLRLNIDGTGNYEITTKIPFFDHILSSFVKHGSFDLSLIAEGDLE
CEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCEE
IDDHHTVEDVGICLGMAMNKIEKKNIKRFGHAIVPMDEARAMVSIDLGGRPFVVGNYIPK
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCCEEEECCCCC
RDKVGELSTENIVHFFESMANNGNMNIHFEVIGENEHHKIEALFKAFGIALDNATQIDER
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCEECCCCCCHHHH
KGIISTKGVI
CCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA