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The map label for this gene is purE [H]

Identifier: 150400541

GI number: 150400541

Start: 110238

End: 110708

Strand: Direct

Name: purE [H]

Synonym: Maeo_0103

Alternate gene names: 150400541

Gene position: 110238-110708 (Clockwise)

Preceding gene: 150400532

Following gene: 150400542

Centisome position: 7.02

GC content: 35.67

Gene sequence:

>471_bases
ATGATTACAATAATTATGGGTAGTGAAAGCGATTTAAAAATAGCAGAAAAGGGAGCTCCCCTATTAAAAGAATTTGGAAT
TCCATTTGAAGTGAGAGTGGCGTCAGCACATAGAACACCAGAATTAGTTGAAGAAATTATGAAAAATAGCCAGGCAAAAG
TATTTATAGCAATTGCAGGACTTGCAGCACATCTCCCCGGAGTTGTAGCGGCTTTAACAACAAAACCAGTAATAGCTGTT
CCAGTTGAAAGTAAATTGGATGGAATGGATGCTCTTTTAAGTTGCGTTCAAATGCCACCAGGAATACCAACAGCAACCGT
TGGAATCGATAGAGGAGACAATGCAGCAATATTGGCAGCTGAAATAATTGCCATAAGTGATGAGGAAGTAAGTAAAAAAT
TAGTAGAATTTAGAGAAAAACAGAAAGAAAAAGTTATTAAATCAGACGAAAAAGTAAGAAATTTGTTTTAA

Upstream 100 bases:

>100_bases
TTTTTATATTATATATGGGTATCAGTTTATCAAACATTTATATATTAAAAAAGTATATATTATGAATTAATATGGTAAAA
AAATATGGAGTCGTGATAAT

Downstream 100 bases:

>100_bases
AGAATATATTAATAATTGATATATACGAATATATTCAATTTATTTTTTAATAATCTAATAACTTTTTATAGGATATATTT
TTTAAATATTAGTATGATGG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MITIIMGSESDLKIAEKGAPLLKEFGIPFEVRVASAHRTPELVEEIMKNSQAKVFIAIAGLAAHLPGVVAALTTKPVIAV
PVESKLDGMDALLSCVQMPPGIPTATVGIDRGDNAAILAAEIIAISDEEVSKKLVEFREKQKEKVIKSDEKVRNLF

Sequences:

>Translated_156_residues
MITIIMGSESDLKIAEKGAPLLKEFGIPFEVRVASAHRTPELVEEIMKNSQAKVFIAIAGLAAHLPGVVAALTTKPVIAV
PVESKLDGMDALLSCVQMPPGIPTATVGIDRGDNAAILAAEIIAISDEEVSKKLVEFREKQKEKVIKSDEKVRNLF
>Mature_156_residues
MITIIMGSESDLKIAEKGAPLLKEFGIPFEVRVASAHRTPELVEEIMKNSQAKVFIAIAGLAAHLPGVVAALTTKPVIAV
PVESKLDGMDALLSCVQMPPGIPTATVGIDRGDNAAILAAEIIAISDEEVSKKLVEFREKQKEKVIKSDEKVRNLF

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Homo sapiens, GI119220559, Length=137, Percent_Identity=34.3065693430657, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI119220557, Length=137, Percent_Identity=34.3065693430657, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI5453539, Length=137, Percent_Identity=34.3065693430657, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1786734, Length=153, Percent_Identity=41.8300653594771, Blast_Score=93, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=156, Percent_Identity=46.7948717948718, Blast_Score=134, Evalue=6e-33,
Organism=Drosophila melanogaster, GI18860083, Length=139, Percent_Identity=34.5323741007194, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16729; Mature: 16729

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIIMGSESDLKIAEKGAPLLKEFGIPFEVRVASAHRTPELVEEIMKNSQAKVFIAIAG
CEEEEECCCCCCEEHHCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEEEEEH
LAAHLPGVVAALTTKPVIAVPVESKLDGMDALLSCVQMPPGIPTATVGIDRGDNAAILAA
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEE
EIIAISDEEVSKKLVEFREKQKEKVIKSDEKVRNLF
EEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MITIIMGSESDLKIAEKGAPLLKEFGIPFEVRVASAHRTPELVEEIMKNSQAKVFIAIAG
CEEEEECCCCCCEEHHCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEEEEEH
LAAHLPGVVAALTTKPVIAVPVESKLDGMDALLSCVQMPPGIPTATVGIDRGDNAAILAA
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEE
EIIAISDEEVSKKLVEFREKQKEKVIKSDEKVRNLF
EEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]