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The map label for this gene is mtaD [H]

Identifier: 150400108

GI number: 150400108

Start: 1393508

End: 1394887

Strand: Reverse

Name: mtaD [H]

Synonym: Mevan_1366

Alternate gene names: 150400108

Gene position: 1394887-1393508 (Counterclockwise)

Preceding gene: 150400109

Following gene: 150400107

Centisome position: 81.1

GC content: 29.86

Gene sequence:

>1380_bases
ATGGAAAATGGGCTTAAAAATATATTAATAAAAAATGTATCCTATTACATTGACGGTAATTTAAATATTCATCAAAACTG
CGACATTTTAATTGAGCAGAAAACAAAAATATTAAAAGATGAAGAAATTAATTTAAAAAAAAATAATTTAAAAGAAAGTA
TGGCTGACGAAAGTATAGCTAATGAAAGTAACGTCAATATAACTTTTGGAAAATCACTTATAGAGAAAAAAAACCTAAAT
AAATCAGACATTAAAATAATAGATGGCAAAAGAAAGTGTGCTATTCCCGGATTATACAATGCACACACCCATATTCCAAT
GACATTACTTAGGGGAATTTCTGATGATATGGCATTAAATGACTGGCTAAATAAAAAAATATGGCCTAATGAAGCAAAAT
TAACTAAGGAAGATGTGTACACCGGTTCATTAATAGGTTGTCTTGAGATGCTTCGTTTTGGAGTTACCACGTTTAACGAA
ATGTACTTTTTTTCAGAAGAAATTGTAACGGCTACAAAGGAAGTAGGATTAAAAGCACAGGTTTCATACCCAATAATGGA
TTTTGGAACGCCTGACGAAAAAAATCTTGATAGACTTTTAAATTCTGCAAAAAAGTTTGTAAAAAATAATATTAATGAAA
AAAATATATTGCCCGGAATCGCACCTCATGCACCATATACTTGTTCAGAAGAAACATATATTGAATGTAAGGAAATTTCA
ATTGAAAATAACATAAATTTACATACCCATGTTTCTGAAACTCGATATGAAGTTGTGGAACTAGAAAATAAGATAAATAT
GCGACCAATTGACTACCTTGAAAAAATAGGTGTTTTAAACGAAAAATTAAATGCTGCACACTGCGTCTGGATTACAAAAG
ATGAAGCAAAAAAACTTTCAAAAAATAATGTGAAAATACTCCACTGTCCAACAAGTAATATGAAACTTGCAAGTGGCGGA
GTAATGCCTGCAATGGAACTTTTAAACAATGGTGCAAACATTTCGCTTGGAACGGATGGCCCTGCAAGTAATAATAACTT
AGATATTATTCGAGAAATGAAAACAGCATCTTTACTCCATAAATCCCACAGGTGGGATCCAACTGTCCTAAATATTGATA
CAGCTTTAAAAATGGGTATTAACAGCGAAAGCATAGGTTTTAAAAACAATGATATTGTTTTATTAGATTTAAATTCCCCA
CATTTTATTCCAATAAATAATATAAAATCTAATATCGTTTATTGTGCAAATGGAAACGATGTGGATACAGTAATTGTTGA
TGGAAAAATACTACTTGAAAACAAAACATATAAATTACGAGAAGCGTTTATTAATACTACTTACAAAAAAGCATGCAAAA
TTACGGAAAAATTCAACTAA

Upstream 100 bases:

>100_bases
TATTTCATACAAAAATTTATAAAAAGTTATCAAAACTAAATAAAAATCAAAAATAACGAAAAATAAGTAACAAAAAGTAA
TTCAAAACGGGTTGAATATA

Downstream 100 bases:

>100_bases
TTAGTTATTAAATAGAGTAAATAATTAAAAAATAGCAAAATGCTATGAAATAATTTTTAAATAATATTTAAATGATTTTT
AAAGAATTTTTAAATAATGT

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MENGLKNILIKNVSYYIDGNLNIHQNCDILIEQKTKILKDEEINLKKNNLKESMADESIANESNVNITFGKSLIEKKNLN
KSDIKIIDGKRKCAIPGLYNAHTHIPMTLLRGISDDMALNDWLNKKIWPNEAKLTKEDVYTGSLIGCLEMLRFGVTTFNE
MYFFSEEIVTATKEVGLKAQVSYPIMDFGTPDEKNLDRLLNSAKKFVKNNINEKNILPGIAPHAPYTCSEETYIECKEIS
IENNINLHTHVSETRYEVVELENKINMRPIDYLEKIGVLNEKLNAAHCVWITKDEAKKLSKNNVKILHCPTSNMKLASGG
VMPAMELLNNGANISLGTDGPASNNNLDIIREMKTASLLHKSHRWDPTVLNIDTALKMGINSESIGFKNNDIVLLDLNSP
HFIPINNIKSNIVYCANGNDVDTVIVDGKILLENKTYKLREAFINTTYKKACKITEKFN

Sequences:

>Translated_459_residues
MENGLKNILIKNVSYYIDGNLNIHQNCDILIEQKTKILKDEEINLKKNNLKESMADESIANESNVNITFGKSLIEKKNLN
KSDIKIIDGKRKCAIPGLYNAHTHIPMTLLRGISDDMALNDWLNKKIWPNEAKLTKEDVYTGSLIGCLEMLRFGVTTFNE
MYFFSEEIVTATKEVGLKAQVSYPIMDFGTPDEKNLDRLLNSAKKFVKNNINEKNILPGIAPHAPYTCSEETYIECKEIS
IENNINLHTHVSETRYEVVELENKINMRPIDYLEKIGVLNEKLNAAHCVWITKDEAKKLSKNNVKILHCPTSNMKLASGG
VMPAMELLNNGANISLGTDGPASNNNLDIIREMKTASLLHKSHRWDPTVLNIDTALKMGINSESIGFKNNDIVLLDLNSP
HFIPINNIKSNIVYCANGNDVDTVIVDGKILLENKTYKLREAFINTTYKKACKITEKFN
>Mature_459_residues
MENGLKNILIKNVSYYIDGNLNIHQNCDILIEQKTKILKDEEINLKKNNLKESMADESIANESNVNITFGKSLIEKKNLN
KSDIKIIDGKRKCAIPGLYNAHTHIPMTLLRGISDDMALNDWLNKKIWPNEAKLTKEDVYTGSLIGCLEMLRFGVTTFNE
MYFFSEEIVTATKEVGLKAQVSYPIMDFGTPDEKNLDRLLNSAKKFVKNNINEKNILPGIAPHAPYTCSEETYIECKEIS
IENNINLHTHVSETRYEVVELENKINMRPIDYLEKIGVLNEKLNAAHCVWITKDEAKKLSKNNVKILHCPTSNMKLASGG
VMPAMELLNNGANISLGTDGPASNNNLDIIREMKTASLLHKSHRWDPTVLNIDTALKMGINSESIGFKNNDIVLLDLNSP
HFIPINNIKSNIVYCANGNDVDTVIVDGKILLENKTYKLREAFINTTYKKACKITEKFN

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=285, Percent_Identity=28.4210526315789, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI87082177, Length=425, Percent_Identity=23.7647058823529, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789249, Length=280, Percent_Identity=23.9285714285714, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540282, Length=289, Percent_Identity=24.5674740484429, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319963, Length=290, Percent_Identity=26.8965517241379, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24643849, Length=262, Percent_Identity=26.3358778625954, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 51789; Mature: 51789

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENGLKNILIKNVSYYIDGNLNIHQNCDILIEQKTKILKDEEINLKKNNLKESMADESIA
CCCCHHHHHEECEEEEECCCEEEECCCCEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHC
NESNVNITFGKSLIEKKNLNKSDIKIIDGKRKCAIPGLYNAHTHIPMTLLRGISDDMALN
CCCCEEEEECHHHHHHCCCCCCCEEEECCCCEEECCCCCCCCCCCHHHHHHCCCCCHHHH
DWLNKKIWPNEAKLTKEDVYTGSLIGCLEMLRFGVTTFNEMYFFSEEIVTATKEVGLKAQ
HHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEE
VSYPIMDFGTPDEKNLDRLLNSAKKFVKNNINEKNILPGIAPHAPYTCSEETYIECKEIS
ECCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
IENNINLHTHVSETRYEVVELENKINMRPIDYLEKIGVLNEKLNAAHCVWITKDEAKKLS
ECCCCEEEEECCHHHEEEEEHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHC
KNNVKILHCPTSNMKLASGGVMPAMELLNNGANISLGTDGPASNNNLDIIREMKTASLLH
CCCEEEEECCCCCCEEECCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
KSHRWDPTVLNIDTALKMGINSESIGFKNNDIVLLDLNSPHFIPINNIKSNIVYCANGND
HHCCCCCEEEEECHHHEECCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCC
VDTVIVDGKILLENKTYKLREAFINTTYKKACKITEKFN
EEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENGLKNILIKNVSYYIDGNLNIHQNCDILIEQKTKILKDEEINLKKNNLKESMADESIA
CCCCHHHHHEECEEEEECCCEEEECCCCEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHC
NESNVNITFGKSLIEKKNLNKSDIKIIDGKRKCAIPGLYNAHTHIPMTLLRGISDDMALN
CCCCEEEEECHHHHHHCCCCCCCEEEECCCCEEECCCCCCCCCCCHHHHHHCCCCCHHHH
DWLNKKIWPNEAKLTKEDVYTGSLIGCLEMLRFGVTTFNEMYFFSEEIVTATKEVGLKAQ
HHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEE
VSYPIMDFGTPDEKNLDRLLNSAKKFVKNNINEKNILPGIAPHAPYTCSEETYIECKEIS
ECCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
IENNINLHTHVSETRYEVVELENKINMRPIDYLEKIGVLNEKLNAAHCVWITKDEAKKLS
ECCCCEEEEECCHHHEEEEEHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHC
KNNVKILHCPTSNMKLASGGVMPAMELLNNGANISLGTDGPASNNNLDIIREMKTASLLH
CCCEEEEECCCCCCEEECCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
KSHRWDPTVLNIDTALKMGINSESIGFKNNDIVLLDLNSPHFIPINNIKSNIVYCANGND
HHCCCCCEEEEECHHHEECCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCC
VDTVIVDGKILLENKTYKLREAFINTTYKKACKITEKFN
EEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]