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The map label for this gene is ilvD

Identifier: 150400071

GI number: 150400071

Start: 1354729

End: 1356381

Strand: Reverse

Name: ilvD

Synonym: Mevan_1329

Alternate gene names: 150400071

Gene position: 1356381-1354729 (Counterclockwise)

Preceding gene: 150400072

Following gene: 150400069

Centisome position: 78.86

GC content: 37.63

Gene sequence:

>1653_bases
ATGATTAGCGATAATATAAAAAAAGGAGTAATTAGAAGCCCTAATCGGGCTCTTTTAAAGGCTTGCGGATATACGGATGA
AGATATGGAAAAACCGTTTATTGGAGTTGTAAATAGCTTTACAGACGTAGTTCCCGGCCATATTCACTTAAGAACATTGG
CAGAAGCTGTTAAAAATGGAGTTTATGCAAACGGCGGAACCCCCTTTGAATTTAACACTATTGGAATTTGTGATGGCATT
GCAATGGGTCATGAAGGCATGAAGTATTCCTTACCCTCAAGAGAAATTATCGCAGATGCAGTTGAATCAATGGCAAGAGC
CCACGGGTTTGATGGATTAGTATTAATTCCAACGTGCGATAAAATCGTTCCTGGAATGATAATGGGTGCATTAAGATTAA
ATATTCCATTTATTGTAGTTACCGGTGGCCCAATGCTTCCAGGGGAATTCCAAGGAAAAAAATACGAACTTATCAGCCTA
TTTGAAGGTGTAGGTCAGTACCAAGTTGGAAAAATTAGTGAAGAGGAATTAAAATGCATTGAAGACTGTGCATGTTCAGG
TGCCGGAAGTTGTGCAGGGCTATACACTGCAAATAGTATGGCTTGCCTTACAGAAGCATTAGGACTTTCCCTTCCAATGT
GTGCAACAACACATGCAGTTGATGCTCAAAAAGTTAGAATCGCTAAAAAAAGTGGTTCAAAAATAGTAGATTTAGTAAAA
CAAGACATTAAACCAAAAGATATCTTAACAAAAGAAGCTTTTGAAAATGCAATTTTAGTAGACCTTGCATTAGGCGGTTC
CACAAACACAACTCTCCACATTCCTGCAATTGCAAATGAAATCGAAAATAAATTTATAACACTAGATGATTTCGATAGAT
TAAGCGATGAAGTTCCACATATTGCGTCAATTAAGCCCGGTGGAGAACATTTCATGATTGATTTACATAATGCAGGGGGA
ATTCCCGCAGTATTCAATGTTTTAAAAGAAAAAATTAGAGATACAAACACCGTTAGTGGAAAAACCACCTTAGAAATTGC
TAAAGAGGTAAAATACATAAACTATGATGTTATAAGAAAAACTGAAGCACCGGTTCATGAAACTGCAGGTTTAAGGGTTT
TAAAAGGAAATATTGCGCCAAATGGTTGTGTTGTAAAAATTGGGGCAGTGAATCCAAAAATGTATAAACATGAAGGCCCT
GCAAAGGTATTTAATTCAGAAGACGATGCAATTTCTGCAATTCTTGGTGGAAAGATTGTTTCGGGCGACGTTATTGTAAT
AAGATATGAAGGGCCATCCGGGGGCCCCGGAATGAGAGAAATGCTATCCCCAACATCTGCAATTTGCGGAATGGGTCTTG
ATGATAGTGTTGCACTAATAACTGATGGAAGGTTCAGCGGTGGAAGTAGGGGGCCGTGTATTGGACATATTTCTCCAGAA
GCTATGGCTGGAGGACTAATTGCAGTGATTAATGATGGAGACACTATAAAAATCGACATGATTGGAAAAAAAATAAATGT
TGAATTAAATAACAGTGAAATCGAAAATCGGTTAAAATCGCTTAAAATACCTGAACCAAAAGTTAAAACGGGCTACCTTT
CAAGATATTCAAGACTAGTTTCTTCAGCTGATGAAGGTGCAGTTTTAAAATAG

Upstream 100 bases:

>100_bases
TCATTAAATCTTTTTGAAGAACTTATAAAAAATTAAATTTATACGATACTTTTTTATCCAATCTAATTAAATACCAATTG
GACTGTTAATGGTGGTAAAT

Downstream 100 bases:

>100_bases
TTTAAAAGATAGTATATCGATAAAATAATCGATTAAAATAATTATATTTAAGATAATATAATTAACATATATCTTAAAAT
TATATTTTTAAAATTCTAAA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MISDNIKKGVIRSPNRALLKACGYTDEDMEKPFIGVVNSFTDVVPGHIHLRTLAEAVKNGVYANGGTPFEFNTIGICDGI
AMGHEGMKYSLPSREIIADAVESMARAHGFDGLVLIPTCDKIVPGMIMGALRLNIPFIVVTGGPMLPGEFQGKKYELISL
FEGVGQYQVGKISEEELKCIEDCACSGAGSCAGLYTANSMACLTEALGLSLPMCATTHAVDAQKVRIAKKSGSKIVDLVK
QDIKPKDILTKEAFENAILVDLALGGSTNTTLHIPAIANEIENKFITLDDFDRLSDEVPHIASIKPGGEHFMIDLHNAGG
IPAVFNVLKEKIRDTNTVSGKTTLEIAKEVKYINYDVIRKTEAPVHETAGLRVLKGNIAPNGCVVKIGAVNPKMYKHEGP
AKVFNSEDDAISAILGGKIVSGDVIVIRYEGPSGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
AMAGGLIAVINDGDTIKIDMIGKKINVELNNSEIENRLKSLKIPEPKVKTGYLSRYSRLVSSADEGAVLK

Sequences:

>Translated_550_residues
MISDNIKKGVIRSPNRALLKACGYTDEDMEKPFIGVVNSFTDVVPGHIHLRTLAEAVKNGVYANGGTPFEFNTIGICDGI
AMGHEGMKYSLPSREIIADAVESMARAHGFDGLVLIPTCDKIVPGMIMGALRLNIPFIVVTGGPMLPGEFQGKKYELISL
FEGVGQYQVGKISEEELKCIEDCACSGAGSCAGLYTANSMACLTEALGLSLPMCATTHAVDAQKVRIAKKSGSKIVDLVK
QDIKPKDILTKEAFENAILVDLALGGSTNTTLHIPAIANEIENKFITLDDFDRLSDEVPHIASIKPGGEHFMIDLHNAGG
IPAVFNVLKEKIRDTNTVSGKTTLEIAKEVKYINYDVIRKTEAPVHETAGLRVLKGNIAPNGCVVKIGAVNPKMYKHEGP
AKVFNSEDDAISAILGGKIVSGDVIVIRYEGPSGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
AMAGGLIAVINDGDTIKIDMIGKKINVELNNSEIENRLKSLKIPEPKVKTGYLSRYSRLVSSADEGAVLK
>Mature_550_residues
MISDNIKKGVIRSPNRALLKACGYTDEDMEKPFIGVVNSFTDVVPGHIHLRTLAEAVKNGVYANGGTPFEFNTIGICDGI
AMGHEGMKYSLPSREIIADAVESMARAHGFDGLVLIPTCDKIVPGMIMGALRLNIPFIVVTGGPMLPGEFQGKKYELISL
FEGVGQYQVGKISEEELKCIEDCACSGAGSCAGLYTANSMACLTEALGLSLPMCATTHAVDAQKVRIAKKSGSKIVDLVK
QDIKPKDILTKEAFENAILVDLALGGSTNTTLHIPAIANEIENKFITLDDFDRLSDEVPHIASIKPGGEHFMIDLHNAGG
IPAVFNVLKEKIRDTNTVSGKTTLEIAKEVKYINYDVIRKTEAPVHETAGLRVLKGNIAPNGCVVKIGAVNPKMYKHEGP
AKVFNSEDDAISAILGGKIVSGDVIVIRYEGPSGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
AMAGGLIAVINDGDTIKIDMIGKKINVELNNSEIENRLKSLKIPEPKVKTGYLSRYSRLVSSADEGAVLK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=591, Percent_Identity=44.1624365482233, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1786464, Length=488, Percent_Identity=35.2459016393443, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI2367371, Length=506, Percent_Identity=34.5849802371541, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1788157, Length=557, Percent_Identity=29.802513464991, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322476, Length=548, Percent_Identity=42.3357664233577, Blast_Score=401, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_METVS (A6URV4)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323838.1
- STRING:   A6URV4
- GeneID:   5325163
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1329
- eggNOG:   arNOG04340
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK00911
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58608; Mature: 58608

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISDNIKKGVIRSPNRALLKACGYTDEDMEKPFIGVVNSFTDVVPGHIHLRTLAEAVKNG
CCCCCCCCCCCCCCCHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCC
VYANGGTPFEFNTIGICDGIAMGHEGMKYSLPSREIIADAVESMARAHGFDGLVLIPTCD
EEECCCCCEEEEEEEEECCHHCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCH
KIVPGMIMGALRLNIPFIVVTGGPMLPGEFQGKKYELISLFEGVGQYQVGKISEEELKCI
HHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHH
EDCACSGAGSCAGLYTANSMACLTEALGLSLPMCATTHAVDAQKVRIAKKSGSKIVDLVK
HHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCHHCCCCCCHHHEEEEHHCCCHHHHHHH
QDIKPKDILTKEAFENAILVDLALGGSTNTTLHIPAIANEIENKFITLDDFDRLSDEVPH
HCCCCHHHHHHHHHCCEEEEEEEECCCCCCEEECCHHHHHHCCCEEEECCHHHHHHCCCC
IASIKPGGEHFMIDLHNAGGIPAVFNVLKEKIRDTNTVSGKTTLEIAKEVKYINYDVIRK
EEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHEEEC
TEAPVHETAGLRVLKGNIAPNGCVVKIGAVNPKMYKHEGPAKVFNSEDDAISAILGGKIV
CCCCCHHCCCCEEEECCCCCCCEEEEEECCCCHHCCCCCCHHHCCCCCHHHHHHHCCEEE
SGDVIVIRYEGPSGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
ECCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCHH
AMAGGLIAVINDGDTIKIDMIGKKINVELNNSEIENRLKSLKIPEPKVKTGYLSRYSRLV
HHCCCEEEEEECCCEEEEEEECEEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
SSADEGAVLK
HCCCCCCCCC
>Mature Secondary Structure
MISDNIKKGVIRSPNRALLKACGYTDEDMEKPFIGVVNSFTDVVPGHIHLRTLAEAVKNG
CCCCCCCCCCCCCCCHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCC
VYANGGTPFEFNTIGICDGIAMGHEGMKYSLPSREIIADAVESMARAHGFDGLVLIPTCD
EEECCCCCEEEEEEEEECCHHCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCH
KIVPGMIMGALRLNIPFIVVTGGPMLPGEFQGKKYELISLFEGVGQYQVGKISEEELKCI
HHHHHHHHHHHEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHH
EDCACSGAGSCAGLYTANSMACLTEALGLSLPMCATTHAVDAQKVRIAKKSGSKIVDLVK
HHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCHHCCCCCCHHHEEEEHHCCCHHHHHHH
QDIKPKDILTKEAFENAILVDLALGGSTNTTLHIPAIANEIENKFITLDDFDRLSDEVPH
HCCCCHHHHHHHHHCCEEEEEEEECCCCCCEEECCHHHHHHCCCEEEECCHHHHHHCCCC
IASIKPGGEHFMIDLHNAGGIPAVFNVLKEKIRDTNTVSGKTTLEIAKEVKYINYDVIRK
EEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHEEEC
TEAPVHETAGLRVLKGNIAPNGCVVKIGAVNPKMYKHEGPAKVFNSEDDAISAILGGKIV
CCCCCHHCCCCEEEECCCCCCCEEEEEECCCCHHCCCCCCHHHCCCCCHHHHHHHCCEEE
SGDVIVIRYEGPSGGPGMREMLSPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHISPE
ECCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCHH
AMAGGLIAVINDGDTIKIDMIGKKINVELNNSEIENRLKSLKIPEPKVKTGYLSRYSRLV
HHCCCEEEEEECCCEEEEEEECEEEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
SSADEGAVLK
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA