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The map label for this gene is tbp [H]

Identifier: 150400012

GI number: 150400012

Start: 1297918

End: 1298463

Strand: Reverse

Name: tbp [H]

Synonym: Mevan_1270

Alternate gene names: 150400012

Gene position: 1298463-1297918 (Counterclockwise)

Preceding gene: 150400013

Following gene: 150400011

Centisome position: 75.49

GC content: 33.52

Gene sequence:

>546_bases
ATGGAGCCTGAAATTAAGATTGTAAACGTGGTTGTATCCACCCAGATAGGTACTGATATCGATTTAGAATATGCTGCGGA
CATTTTAGATAACGCAGAATATGAACCAGAACAATTTCCAGGATTAGTTTGTAGATTGAGTGATCCTAAGGTTGCACTTT
TAATATTTAGAAGTGGCAAATTAAATTGTACGGGTGCAAAAAGTAAAGAAGATGCGGAAATTGCAATTAAAAAAATAATA
AAAGAACTAAAGGAAGCTGGAATGGAAATTATAGATAATCCCGTAGTAAGTGTACAAAACATGGTTGCAACAACAGAACT
TGGTATGGAACCAAATTTAGATGATATTTCAACCTTAGAATGCACCGAATACGAACCTGAGCAGTTCCCAGGTCTTGTTT
ATAGATTAAGCGACCCTAAAGTAGTAGTACTAATATTTGGCAGTGGAAAAGTCGTAATTACGGGTTTAAAAGTAATTGAA
GATGCATATATTGCATTTGACAAAATATCTGCAACATTAAAAGAATTAGAACAGGAATTATATTAA

Upstream 100 bases:

>100_bases
TACCAAAATTAATTTATATATTTAAATGTATAAACTATATATAAATATTTATATACTATATAAATAGAAAAATATAGCAT
ATATATAAACTGGTGAAAGA

Downstream 100 bases:

>100_bases
AACGGGATATTCGTGATTGCAATAATTGACTACAATGCGGGAAACTTAAGAAGTATTGAAAAGGCTTTTGAACTTTACAC
TAAAGATATAATTGTTACAA

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein; BAP; TATA sequence-binding protein; TBP; TATA-box factor [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MEPEIKIVNVVVSTQIGTDIDLEYAADILDNAEYEPEQFPGLVCRLSDPKVALLIFRSGKLNCTGAKSKEDAEIAIKKII
KELKEAGMEIIDNPVVSVQNMVATTELGMEPNLDDISTLECTEYEPEQFPGLVYRLSDPKVVVLIFGSGKVVITGLKVIE
DAYIAFDKISATLKELEQELY

Sequences:

>Translated_181_residues
MEPEIKIVNVVVSTQIGTDIDLEYAADILDNAEYEPEQFPGLVCRLSDPKVALLIFRSGKLNCTGAKSKEDAEIAIKKII
KELKEAGMEIIDNPVVSVQNMVATTELGMEPNLDDISTLECTEYEPEQFPGLVYRLSDPKVVVLIFGSGKVVITGLKVIE
DAYIAFDKISATLKELEQELY
>Mature_181_residues
MEPEIKIVNVVVSTQIGTDIDLEYAADILDNAEYEPEQFPGLVCRLSDPKVALLIFRSGKLNCTGAKSKEDAEIAIKKII
KELKEAGMEIIDNPVVSVQNMVATTELGMEPNLDDISTLECTEYEPEQFPGLVYRLSDPKVVVLIFGSGKVVITGLKVIE
DAYIAFDKISATLKELEQELY

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation [H]

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family [H]

Homologues:

Organism=Homo sapiens, GI285026520, Length=177, Percent_Identity=37.2881355932203, Blast_Score=127, Evalue=4e-30,
Organism=Homo sapiens, GI4507379, Length=177, Percent_Identity=37.2881355932203, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI39930602, Length=177, Percent_Identity=36.1581920903955, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4759234, Length=154, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17555358, Length=178, Percent_Identity=38.7640449438202, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320996, Length=174, Percent_Identity=37.9310344827586, Blast_Score=123, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17647997, Length=178, Percent_Identity=38.2022471910112, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17136834, Length=178, Percent_Identity=35.9550561797753, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294 [H]

Pfam domain/function: PF00352 TBP [H]

EC number: NA

Molecular weight: Translated: 19998; Mature: 19998

Theoretical pI: Translated: 4.07; Mature: 4.07

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPEIKIVNVVVSTQIGTDIDLEYAADILDNAEYEPEQFPGLVCRLSDPKVALLIFRSGK
CCCCEEEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEECCC
LNCTGAKSKEDAEIAIKKIIKELKEAGMEIIDNPVVSVQNMVATTELGMEPNLDDISTLE
EEECCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEE
CTEYEPEQFPGLVYRLSDPKVVVLIFGSGKVVITGLKVIEDAYIAFDKISATLKELEQEL
ECCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHC
Y
C
>Mature Secondary Structure
MEPEIKIVNVVVSTQIGTDIDLEYAADILDNAEYEPEQFPGLVCRLSDPKVALLIFRSGK
CCCCEEEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEECCC
LNCTGAKSKEDAEIAIKKIIKELKEAGMEIIDNPVVSVQNMVATTELGMEPNLDDISTLE
EEECCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEE
CTEYEPEQFPGLVYRLSDPKVVVLIFGSGKVVITGLKVIEDAYIAFDKISATLKELEQEL
ECCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA