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The map label for this gene is 150399958

Identifier: 150399958

GI number: 150399958

Start: 1238777

End: 1239862

Strand: Reverse

Name: 150399958

Synonym: Mevan_1215

Alternate gene names: NA

Gene position: 1239862-1238777 (Counterclockwise)

Preceding gene: 150399962

Following gene: 150399957

Centisome position: 72.08

GC content: 30.66

Gene sequence:

>1086_bases
ATGAAATTTGGATGGATAATGTCAAGTTCCTCTGACATTGAAGAAAGAAAAGATACAGTTAAAGATTCTCTTGAAAGTTC
AATTCCTGCAATTATTGTTAAAAAAGATGAAATTAGTACAGTAAGGGAATTAGGAAGCATTGAAATAATTTCAGATAGTT
TAGATGCGGATATTGTTTTAGTGACTAAAAAAGATGATTTAGATATTTTAAAATCTGCAAAAGATTCTGGAAAAAAAACT
TGCGTATATATTACAATTGAAACAAAAGAAGATGAAATTTACGCAACTAAAGTAAGCAGACTTGATTTTGTAGATTACAT
AATTTTAGAAGGTAAAGACTGGACAATTATTCCTCTTGAAAATATTATTGCCGACTTATTTAATGAAGATATAAAAATTG
TATCTTTAGTAAATAATGTAAATGATGCAAAAGCTGCTTACGAAATTTTAGAAAAGGGCGTTGATGGAGTAGTGCTTGTA
CCAAAAGATATCAATGAAGTAAAAGAATTTTCAAAATTAATAGATAGTATGAATTTTGAAAATGTAGCTCTTGATTATGC
GGTAATTAAAAAAATTGAACCAGTTGGAAGTGGCGATCGGGTTTGTATTGACACCTGTTCAATTATGGAAATCGGGGAAG
GCATGTTAATTGGGTCATATTCAAGGGGCATGTTTTTAGTACATTCCGAGTCCGTTGAAAACCCTTACGTTGCAACAAGG
CCGTTTAGGGTAAATGCAGGCCCTGTTCATGCGTATATATTATGCCCTGAAAATAAAACTAAATATTTAAGTGATTTAAA
AGCCGGAGATAAAGTACTTATTGTTAATAAAGATGGAAAAACAAGGGAAACTGTTATCGGGCGCATAAAAATAGAAAAAA
GGCCCCTATTTTTAGTTGAAGCAGAATACAATGGAGAAATATTAAGAACTATTCTTCAAAATGCTGAAACTATAAGACTT
GTTTCTGATGAAGGAAAGCCCATTTCAGTTGTTGATTTAAAAGAAGGATTAAAAGTTTTGATAAAACCTGATGAAAATGC
TAGGCATTTTGGAATGGCGATAAATGAATCAATTATTGAAAAATAA

Upstream 100 bases:

>100_bases
TTTTAATATAATATACCAATAATACATAAAAATATATAGATTAACATATATTAAGTCAGTAAACAAAGGACATATTTAAA
ATAAATTCAGTGGTGAATTC

Downstream 100 bases:

>100_bases
CATAATATCTAAATATTTAATTTTATAATTAACTAATGGTGTAGCTATGGTCAAAGGTCAGACTGTTTTTGTCCAAAATC
CGTTTAAAAAAATTGTTAGA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: DHQ synthase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKFGWIMSSSSDIEERKDTVKDSLESSIPAIIVKKDEISTVRELGSIEIISDSLDADIVLVTKKDDLDILKSAKDSGKKT
CVYITIETKEDEIYATKVSRLDFVDYIILEGKDWTIIPLENIIADLFNEDIKIVSLVNNVNDAKAAYEILEKGVDGVVLV
PKDINEVKEFSKLIDSMNFENVALDYAVIKKIEPVGSGDRVCIDTCSIMEIGEGMLIGSYSRGMFLVHSESVENPYVATR
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLIVNKDGKTRETVIGRIKIEKRPLFLVEAEYNGEILRTILQNAETIRL
VSDEGKPISVVDLKEGLKVLIKPDENARHFGMAINESIIEK

Sequences:

>Translated_361_residues
MKFGWIMSSSSDIEERKDTVKDSLESSIPAIIVKKDEISTVRELGSIEIISDSLDADIVLVTKKDDLDILKSAKDSGKKT
CVYITIETKEDEIYATKVSRLDFVDYIILEGKDWTIIPLENIIADLFNEDIKIVSLVNNVNDAKAAYEILEKGVDGVVLV
PKDINEVKEFSKLIDSMNFENVALDYAVIKKIEPVGSGDRVCIDTCSIMEIGEGMLIGSYSRGMFLVHSESVENPYVATR
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLIVNKDGKTRETVIGRIKIEKRPLFLVEAEYNGEILRTILQNAETIRL
VSDEGKPISVVDLKEGLKVLIKPDENARHFGMAINESIIEK
>Mature_361_residues
MKFGWIMSSSSDIEERKDTVKDSLESSIPAIIVKKDEISTVRELGSIEIISDSLDADIVLVTKKDDLDILKSAKDSGKKT
CVYITIETKEDEIYATKVSRLDFVDYIILEGKDWTIIPLENIIADLFNEDIKIVSLVNNVNDAKAAYEILEKGVDGVVLV
PKDINEVKEFSKLIDSMNFENVALDYAVIKKIEPVGSGDRVCIDTCSIMEIGEGMLIGSYSRGMFLVHSESVENPYVATR
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLIVNKDGKTRETVIGRIKIEKRPLFLVEAEYNGEILRTILQNAETIRL
VSDEGKPISVVDLKEGLKVLIKPDENARHFGMAINESIIEK

Specific function: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis

COG id: COG1465

COG function: function code E; Predicted alternative 3-dehydroquinate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type DHQ synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHQS_METVS (A6URJ1)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323725.1
- STRING:   A6URJ1
- GeneID:   5325762
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1215
- eggNOG:   arNOG05006
- HOGENOM:   HBG670179
- OMA:   DRVCIDT
- ProtClustDB:   PRK02290
- HAMAP:   MF_01244
- InterPro:   IPR002812
- PIRSF:   PIRSF006655
- ProDom:   PD017907

Pfam domain/function: PF01959 DHQS

EC number: NA

Molecular weight: Translated: 40291; Mature: 40291

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGWIMSSSSDIEERKDTVKDSLESSIPAIIVKKDEISTVRELGSIEIISDSLDADIVL
CCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEECCCCCCEEE
VTKKDDLDILKSAKDSGKKTCVYITIETKEDEIYATKVSRLDFVDYIILEGKDWTIIPLE
EEECCCHHHHHHCCCCCCEEEEEEEEECCCCEEEEEEHHHCCEEEEEEEECCCEEEEEHH
NIIADLFNEDIKIVSLVNNVNDAKAAYEILEKGVDGVVLVPKDINEVKEFSKLIDSMNFE
HHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCC
NVALDYAVIKKIEPVGSGDRVCIDTCSIMEIGEGMLIGSYSRGMFLVHSESVENPYVATR
CEEEHHHHHHHCCCCCCCCEEEEEEECHHHCCCCEEEEECCCCEEEEECCCCCCCEEEEC
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLIVNKDGKTRETVIGRIKIEKRPLFLVE
CEEECCCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCEEEEE
AEYNGEILRTILQNAETIRLVSDEGKPISVVDLKEGLKVLIKPDENARHFGMAINESIIE
ECCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCEEHHHHHHC
K
C
>Mature Secondary Structure
MKFGWIMSSSSDIEERKDTVKDSLESSIPAIIVKKDEISTVRELGSIEIISDSLDADIVL
CCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEECCCCCCEEE
VTKKDDLDILKSAKDSGKKTCVYITIETKEDEIYATKVSRLDFVDYIILEGKDWTIIPLE
EEECCCHHHHHHCCCCCCEEEEEEEEECCCCEEEEEEHHHCCEEEEEEEECCCEEEEEHH
NIIADLFNEDIKIVSLVNNVNDAKAAYEILEKGVDGVVLVPKDINEVKEFSKLIDSMNFE
HHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCC
NVALDYAVIKKIEPVGSGDRVCIDTCSIMEIGEGMLIGSYSRGMFLVHSESVENPYVATR
CEEEHHHHHHHCCCCCCCCEEEEEEECHHHCCCCEEEEECCCCEEEEECCCCCCCEEEEC
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLIVNKDGKTRETVIGRIKIEKRPLFLVE
CEEECCCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCEEEEE
AEYNGEILRTILQNAETIRLVSDEGKPISVVDLKEGLKVLIKPDENARHFGMAINESIIE
ECCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCEEHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA