Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 150399883

GI number: 150399883

Start: 1148778

End: 1150280

Strand: Reverse

Name: guaB [H]

Synonym: Mevan_1138

Alternate gene names: 150399883

Gene position: 1150280-1148778 (Counterclockwise)

Preceding gene: 150399889

Following gene: 150399878

Centisome position: 66.87

GC content: 37.52

Gene sequence:

>1503_bases
ATGGTGATTCTTTTGTTTTTAGATAAAATTGTTAGTGCTAAAAAAGCATACACTTTTGATGACGTATTATTAATTCCAAA
CAGGTCATACGTTGATCCAAAAACTACAGACGTTTCAGTAGATATTTCTGGAGTAAAGCTTAATATTCCAATTATTTCCG
CTGCAATGGATACGGTTTCTGAAAAAGATATGGCAATAGCCCTTGCAAGAAGGGGTGGAATTGCAGTAATTCATAGAAAT
ATGACCATAGAAGAGCAAGTTAAGCATATAAAAGCCGTAAAAATGGCTGAAAATCTTGTAATAAGGGACGTTGTAACAAT
AGGCCCTTCGAAAACAGTTCTCGAAGCTGAACGCATAATGTATGAATATAACGTTAGTGGACTTCCGGTTGTTGATGAAA
ATAAAAAACTTGTCGGTATTTTAACAACAAGAGATTTAAAATTTATACCAAACAAAGGTGTGGCTGTTGAAACCGTTATG
ACAAAGGAAGTACTCCACTGCCATGAAGATACCCCTTATGAAGAAATTCTAAATAGACTTTATGAAAATAAAATTGAAAG
AGCCCCAATTTTAGATAGGGAATCAAAAGTTCTCCTTGGAATGGTTACATTAAGAGACATACTAAAAAGGAAAAAATACC
CTGAAGCTGCAAGAGATGCCGAAGGAAAATTAATTGTTGCCGCAGCTTGTGGGCCAAATGATTTTGAAAGGGCTGAAGCA
TTGCTTTTAGCAGGTGTTGATGCAATTGCAATTGACTGTGCTCATGCACACAACATGAGCGTTGTTGAAAATGTAAAAAA
GTTAAAAGAAATAACTAAAAAAACTAAAACTAAATTATTTGTTGGAAATATTGCAACAGGTGAGGCTGCTGAAGATTTAA
TTAAAGCCGGAGCAGATGCACTTAAAGTTGGAATCGGGCCAGGTTCCATATGTACTACAAGAGTTGTTGCAGGAGTTGGA
GTTCCCCAACTTAGTGCAATTGCAGAAGTTTCAGATGTGGCTAAAAAGTATGGAATTCCAGTAATTGCAGACGGCGGTTT
AAAATATAGTGGCGACATTGCAAAAGCAATTGCGGCTGGAGCTGATGCAGTTATGATTGGAAGTTTACTTGCAGGTACTG
AAGAAGCCCCAGGTTCACTTTTAACGATTAACGGGAGAAAATATAAACAATATAGGGGCATGGGCTCCCTTGGTGCAATG
TGCGGAAGTTCAGGAAATGTTGCAGATAGATACTTTCAAAGTGGGCATATGCAGCATTCAAAGCTGGTTCCGGAAGGAAT
TGAAGGTGCAGTTCCATTTAAAGGGCCTGCTAGTGATATTGTATTCCAGTTAGTTGGAGGACTTAGGTCTTCAATGGGAT
ACTGCGGCGCACAAAAACTTTCAGATATGCACAAAAAAGCGAAATTTGTAATAATAACTCATAGTGGACAGAAGGAAAGT
CACCCTCATGATGTTTTAATTACGAATGAAGCCCCAAATTACCCGATAAATTCAGAAAGATAA

Upstream 100 bases:

>100_bases
GTAATAGTATTTTCTGATTATATATCATTTAAAAGCGAATTAATTTTTAAAACTACCGCCAAATTTATATATTAATTTAA
ATAATATAGAAAAAAAGGTA

Downstream 100 bases:

>100_bases
ATTTTAAAATATTTATTTTTTAAATTAAAAATAATTTTGTTAAAAAAAACAGATGTTTTGTAAAATTTAAAAATTAGTAA
ACTTTTCTTCCAATTTTGGA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MVILLFLDKIVSAKKAYTFDDVLLIPNRSYVDPKTTDVSVDISGVKLNIPIISAAMDTVSEKDMAIALARRGGIAVIHRN
MTIEEQVKHIKAVKMAENLVIRDVVTIGPSKTVLEAERIMYEYNVSGLPVVDENKKLVGILTTRDLKFIPNKGVAVETVM
TKEVLHCHEDTPYEEILNRLYENKIERAPILDRESKVLLGMVTLRDILKRKKYPEAARDAEGKLIVAAACGPNDFERAEA
LLLAGVDAIAIDCAHAHNMSVVENVKKLKEITKKTKTKLFVGNIATGEAAEDLIKAGADALKVGIGPGSICTTRVVAGVG
VPQLSAIAEVSDVAKKYGIPVIADGGLKYSGDIAKAIAAGADAVMIGSLLAGTEEAPGSLLTINGRKYKQYRGMGSLGAM
CGSSGNVADRYFQSGHMQHSKLVPEGIEGAVPFKGPASDIVFQLVGGLRSSMGYCGAQKLSDMHKKAKFVIITHSGQKES
HPHDVLITNEAPNYPINSER

Sequences:

>Translated_500_residues
MVILLFLDKIVSAKKAYTFDDVLLIPNRSYVDPKTTDVSVDISGVKLNIPIISAAMDTVSEKDMAIALARRGGIAVIHRN
MTIEEQVKHIKAVKMAENLVIRDVVTIGPSKTVLEAERIMYEYNVSGLPVVDENKKLVGILTTRDLKFIPNKGVAVETVM
TKEVLHCHEDTPYEEILNRLYENKIERAPILDRESKVLLGMVTLRDILKRKKYPEAARDAEGKLIVAAACGPNDFERAEA
LLLAGVDAIAIDCAHAHNMSVVENVKKLKEITKKTKTKLFVGNIATGEAAEDLIKAGADALKVGIGPGSICTTRVVAGVG
VPQLSAIAEVSDVAKKYGIPVIADGGLKYSGDIAKAIAAGADAVMIGSLLAGTEEAPGSLLTINGRKYKQYRGMGSLGAM
CGSSGNVADRYFQSGHMQHSKLVPEGIEGAVPFKGPASDIVFQLVGGLRSSMGYCGAQKLSDMHKKAKFVIITHSGQKES
HPHDVLITNEAPNYPINSER
>Mature_500_residues
MVILLFLDKIVSAKKAYTFDDVLLIPNRSYVDPKTTDVSVDISGVKLNIPIISAAMDTVSEKDMAIALARRGGIAVIHRN
MTIEEQVKHIKAVKMAENLVIRDVVTIGPSKTVLEAERIMYEYNVSGLPVVDENKKLVGILTTRDLKFIPNKGVAVETVM
TKEVLHCHEDTPYEEILNRLYENKIERAPILDRESKVLLGMVTLRDILKRKKYPEAARDAEGKLIVAAACGPNDFERAEA
LLLAGVDAIAIDCAHAHNMSVVENVKKLKEITKKTKTKLFVGNIATGEAAEDLIKAGADALKVGIGPGSICTTRVVAGVG
VPQLSAIAEVSDVAKKYGIPVIADGGLKYSGDIAKAIAAGADAVMIGSLLAGTEEAPGSLLTINGRKYKQYRGMGSLGAM
CGSSGNVADRYFQSGHMQHSKLVPEGIEGAVPFKGPASDIVFQLVGGLRSSMGYCGAQKLSDMHKKAKFVIITHSGQKES
HPHDVLITNEAPNYPINSER

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=499, Percent_Identity=35.0701402805611, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI217035146, Length=496, Percent_Identity=34.6774193548387, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI34328930, Length=496, Percent_Identity=34.6774193548387, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI156616279, Length=496, Percent_Identity=34.6774193548387, Blast_Score=254, Evalue=9e-68,
Organism=Homo sapiens, GI34328928, Length=494, Percent_Identity=34.412955465587, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI217035152, Length=480, Percent_Identity=35.4166666666667, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI217035148, Length=494, Percent_Identity=34.2105263157895, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI217035150, Length=496, Percent_Identity=32.4596774193548, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI50541954, Length=270, Percent_Identity=38.8888888888889, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI50541952, Length=270, Percent_Identity=38.8888888888889, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI50541948, Length=270, Percent_Identity=38.8888888888889, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI50541956, Length=270, Percent_Identity=38.8888888888889, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI156104880, Length=264, Percent_Identity=39.3939393939394, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1788855, Length=491, Percent_Identity=47.0468431771894, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1786293, Length=249, Percent_Identity=39.3574297188755, Blast_Score=168, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI71994385, Length=488, Percent_Identity=31.3524590163934, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71994389, Length=436, Percent_Identity=32.5688073394495, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17560440, Length=286, Percent_Identity=37.4125874125874, Blast_Score=179, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6323585, Length=491, Percent_Identity=35.8452138492872, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6322012, Length=485, Percent_Identity=35.8762886597938, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6323464, Length=489, Percent_Identity=35.9918200408998, Blast_Score=273, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=35.1032448377581, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6319353, Length=135, Percent_Identity=39.2592592592593, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24641071, Length=491, Percent_Identity=37.6782077393075, Blast_Score=268, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24641073, Length=491, Percent_Identity=37.6782077393075, Blast_Score=268, Evalue=8e-72,
Organism=Drosophila melanogaster, GI28571163, Length=448, Percent_Identity=38.3928571428571, Blast_Score=252, Evalue=3e-67,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53778; Mature: 53778

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVILLFLDKIVSAKKAYTFDDVLLIPNRSYVDPKTTDVSVDISGVKLNIPIISAAMDTVS
CEEEEEHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCEEEECCCHHHHHHHCC
EKDMAIALARRGGIAVIHRNMTIEEQVKHIKAVKMAENLVIRDVVTIGPSKTVLEAERIM
CCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEHHEECCCCHHHHHHHHEE
YEYNVSGLPVVDENKKLVGILTTRDLKFIPNKGVAVETVMTKEVLHCHEDTPYEEILNRL
EEECCCCCCEECCCCEEEEEEEECCEEECCCCCCEEEHHHHHHHHHHCCCCCHHHHHHHH
YENKIERAPILDRESKVLLGMVTLRDILKRKKYPEAARDAEGKLIVAAACGPNDFERAEA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCCHHHHHHH
LLLAGVDAIAIDCAHAHNMSVVENVKKLKEITKKTKTKLFVGNIATGEAAEDLIKAGADA
HHHCCCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHCCCCE
LKVGIGPGSICTTRVVAGVGVPQLSAIAEVSDVAKKYGIPVIADGGLKYSGDIAKAIAAG
EEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEECCCCEECCHHHHHHHCC
ADAVMIGSLLAGTEEAPGSLLTINGRKYKQYRGMGSLGAMCGSSGNVADRYFQSGHMQHS
CCHHHHHHHHCCCCCCCCCEEEECCCHHHHHCCCCHHHHHCCCCCCHHHHHHHCCCCCHH
KLVPEGIEGAVPFKGPASDIVFQLVGGLRSSMGYCGAQKLSDMHKKAKFVIITHSGQKES
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEECCCCCC
HPHDVLITNEAPNYPINSER
CCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MVILLFLDKIVSAKKAYTFDDVLLIPNRSYVDPKTTDVSVDISGVKLNIPIISAAMDTVS
CEEEEEHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCEEEECCCHHHHHHHCC
EKDMAIALARRGGIAVIHRNMTIEEQVKHIKAVKMAENLVIRDVVTIGPSKTVLEAERIM
CCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEHHEECCCCHHHHHHHHEE
YEYNVSGLPVVDENKKLVGILTTRDLKFIPNKGVAVETVMTKEVLHCHEDTPYEEILNRL
EEECCCCCCEECCCCEEEEEEEECCEEECCCCCCEEEHHHHHHHHHHCCCCCHHHHHHHH
YENKIERAPILDRESKVLLGMVTLRDILKRKKYPEAARDAEGKLIVAAACGPNDFERAEA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCCHHHHHHH
LLLAGVDAIAIDCAHAHNMSVVENVKKLKEITKKTKTKLFVGNIATGEAAEDLIKAGADA
HHHCCCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHCCCCE
LKVGIGPGSICTTRVVAGVGVPQLSAIAEVSDVAKKYGIPVIADGGLKYSGDIAKAIAAG
EEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEECCCCEECCHHHHHHHCC
ADAVMIGSLLAGTEEAPGSLLTINGRKYKQYRGMGSLGAMCGSSGNVADRYFQSGHMQHS
CCHHHHHHHHCCCCCCCCCEEEECCCHHHHHCCCCHHHHHCCCCCCHHHHHHHCCCCCHH
KLVPEGIEGAVPFKGPASDIVFQLVGGLRSSMGYCGAQKLSDMHKKAKFVIITHSGQKES
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEECCCCCC
HPHDVLITNEAPNYPINSER
CCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]