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The map label for this gene is birA [C]

Identifier: 150399869

GI number: 150399869

Start: 1135745

End: 1136440

Strand: Reverse

Name: birA [C]

Synonym: Mevan_1124

Alternate gene names: 150399869

Gene position: 1136440-1135745 (Counterclockwise)

Preceding gene: 150399870

Following gene: 150399868

Centisome position: 66.07

GC content: 26.58

Gene sequence:

>696_bases
TTGGATTTTGAGTATATTTATCTTGAAGAAATAGATTCCACAAATAAATTTGCATATGATCTTGGAAAACAGTGTAAAAG
AAATTTAGTGATTGTTTCAAAAATTCAAACTAGTGGAAAAGGTAGGATGGATAGAACATGGATTTCTAAAGAAGGGGGGC
TTTATTTTTCGATTTTAATGGATATTTCAAGAGTAAACCCGATTGAAAAAATTAATTTTTTGGCATCAGTTAGCGTACTT
GAAACTTTAAAATATTTTTCAAATGAAAATTTCCAAATAAAGTGGCCAAACGACATCCTATGTAATGATAAAAAAATTTG
CGGAATTTTAACTGAATTAAATGTTTTAAAGGGCTATTTTGTACTTGGAATTGGACTAAACATAAATAATAAAATTGAAA
GTAGCATTAAAAACGTTGGAACTTCATTATACTGCCTTGAAAAAGAAAATTTTGACATTAAACAGATATTTGAGGAATTT
ATTAAAAATTTTAAAGTCAATCTTTATATGGATAATAATGCCATTTTAGAAAAGTATAAGACATATTCTAAAACGATTAA
TAGTAATGTAAATTTAATACTACCAAATAAAACTGTTTTTGGAAGAGTTGTCGAAATTGATTTTAACGGGATATACCTTC
TAAATGAAAAAGAAATTTCAATATATGATGTTGGAGACTGCATTCACCTGAGGTAG

Upstream 100 bases:

>100_bases
AGATTTAAAAGACAGTATATATATATTTCCGGAAGTTGTAAAAAAAGTTGAACCTGAAATGTACCTTTTAAATGTTTTTG
AAAATTATTAGTGGGATATT

Downstream 100 bases:

>100_bases
TCCTGAAAAAAAGTTGGTGAAAGAATGATTTATAAATTAAATGGTATAGGATATGATTCTAATTCTTACCTGATAGTTGG
TAAAAAAACTGTTTTAATTG

Product: biotin--acetyl-CoA-carboxylase ligase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MDFEYIYLEEIDSTNKFAYDLGKQCKRNLVIVSKIQTSGKGRMDRTWISKEGGLYFSILMDISRVNPIEKINFLASVSVL
ETLKYFSNENFQIKWPNDILCNDKKICGILTELNVLKGYFVLGIGLNINNKIESSIKNVGTSLYCLEKENFDIKQIFEEF
IKNFKVNLYMDNNAILEKYKTYSKTINSNVNLILPNKTVFGRVVEIDFNGIYLLNEKEISIYDVGDCIHLR

Sequences:

>Translated_231_residues
MDFEYIYLEEIDSTNKFAYDLGKQCKRNLVIVSKIQTSGKGRMDRTWISKEGGLYFSILMDISRVNPIEKINFLASVSVL
ETLKYFSNENFQIKWPNDILCNDKKICGILTELNVLKGYFVLGIGLNINNKIESSIKNVGTSLYCLEKENFDIKQIFEEF
IKNFKVNLYMDNNAILEKYKTYSKTINSNVNLILPNKTVFGRVVEIDFNGIYLLNEKEISIYDVGDCIHLR
>Mature_231_residues
MDFEYIYLEEIDSTNKFAYDLGKQCKRNLVIVSKIQTSGKGRMDRTWISKEGGLYFSILMDISRVNPIEKINFLASVSVL
ETLKYFSNENFQIKWPNDILCNDKKICGILTELNVLKGYFVLGIGLNINNKIESSIKNVGTSLYCLEKENFDIKQIFEEF
IKNFKVNLYMDNNAILEKYKTYSKTINSNVNLILPNKTVFGRVVEIDFNGIYLLNEKEISIYDVGDCIHLR

Specific function: Bira Acts Both As A Biotin-Operon Repressor And As The Enzyme That Synthesizes The Corepressor, Acetyl-CoA:Carbon- Dioxide Ligase. This Protein Also Activates Biotin To Form Biotinyl-5'-Adenylate And Transfers The Biotin Moiety To Biotin-Accepting Protei

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Escherichia coli, GI1790408, Length=235, Percent_Identity=28.5106382978723, Blast_Score=89, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004408
- InterPro:   IPR003142
- InterPro:   IPR004143 [H]

Pfam domain/function: PF02237 BPL_C; PF03099 BPL_LipA_LipB [H]

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 26773; Mature: 26773

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFEYIYLEEIDSTNKFAYDLGKQCKRNLVIVSKIQTSGKGRMDRTWISKEGGLYFSILM
CCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEECCCCCEEEEEEE
DISRVNPIEKINFLASVSVLETLKYFSNENFQIKWPNDILCNDKKICGILTELNVLKGYF
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCHHHHHHHHHHHHCCEE
VLGIGLNINNKIESSIKNVGTSLYCLEKENFDIKQIFEEFIKNFKVNLYMDNNAILEKYK
EEEEECCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHH
TYSKTINSNVNLILPNKTVFGRVVEIDFNGIYLLNEKEISIYDVGDCIHLR
HHHHHHCCCCEEEECCCCEEEEEEEEECCCEEEEECCCEEEEECCCEEECC
>Mature Secondary Structure
MDFEYIYLEEIDSTNKFAYDLGKQCKRNLVIVSKIQTSGKGRMDRTWISKEGGLYFSILM
CCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEECCCCCEEEEEEE
DISRVNPIEKINFLASVSVLETLKYFSNENFQIKWPNDILCNDKKICGILTELNVLKGYF
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCHHHHHHHHHHHHCCEE
VLGIGLNINNKIESSIKNVGTSLYCLEKENFDIKQIFEEFIKNFKVNLYMDNNAILEKYK
EEEEECCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHH
TYSKTINSNVNLILPNKTVFGRVVEIDFNGIYLLNEKEISIYDVGDCIHLR
HHHHHHCCCCEEEECCCCEEEEEEEEECCCEEEEECCCEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]