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The map label for this gene is pcn

Identifier: 150399761

GI number: 150399761

Start: 1025479

End: 1026228

Strand: Reverse

Name: pcn

Synonym: Mevan_1013

Alternate gene names: 150399761

Gene position: 1026228-1025479 (Counterclockwise)

Preceding gene: 150399762

Following gene: 150399760

Centisome position: 59.66

GC content: 30.13

Gene sequence:

>750_bases
ATGTTTAAAGCTACATGTAATTCAAGGGATTTTAAAAAAGTTATAAATGCGACAAGCAACCTAGTAGACGAAATTTGTTT
TGAAGTAGATGAAACCGGAATTAAAGCAAGTGCAATGGATCCATCACACGTTGCCCTCGTAAGTATGGGGATGCCAAAAG
AAGTTTTTGAGAGTTATGAGGGAGATATTCATGATATTGGTATTGATTTAGAAGCATTAAAAAAGATAATTGCAAGAAGT
AAGGGGGATGAAAAGCTAATTTTGGAGCTTGATGATGAAAAAAATAAATTAAATGTTACTTTTAAAAGTAATGTTACAAG
AAAGTTTTCAATTGCATTATATGATGTTTCATCAAGTAATTTAAAAGTTCCAGATATATCCTATCCAAATCAGGTTTCAA
TTAAGGCAGGGGCATTTGTTGAAGCATTAAAAGATGCGGAGCTAGTAAACGATCACATAACTCTTAAAGTAGATGAAGAT
AAATTTGTAATCTATTCAAAAGGTGATTTAAACCAGAGTGAAACTGTATTTGAAAATAACAATGACGAATATGAAACTTT
AACTGAATTTAAAATGTCAGAACCTTCGAAAAGCACATTTAATTTAGCCTATTTAAAAGATTTAACAAAATCAACTTCAG
CAGAAGATATTCTTAAAATATACTTAGGTTCAGACATGCCTGTAAAAATTGAATATGAAGTTAGCGGTTCTAAACTTGTA
TTTTTACTTGCACCAAGAATTGAATCTTAA

Upstream 100 bases:

>100_bases
TAATTTTGAATTTTTATAAAAATCACTTAAAAAACCATATATATTTTTGTACAAAATAGGTTTGTAATAATTCATACAGA
TAAAACTAACTGGTGAATAG

Downstream 100 bases:

>100_bases
TTTAACTTTATTACTTTGATTTTTAAAAAGTGAAAGACATGTATAAAAAAATAAGGGATGCATTTTTTAACGAATTTTTA
AAAGAGGGTTTAGGGGAATT

Product: proliferating cell nuclear antigen PcnA

Products: NA

Alternate protein names: Proliferating cell nuclear antigen homolog; PCNA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MFKATCNSRDFKKVINATSNLVDEICFEVDETGIKASAMDPSHVALVSMGMPKEVFESYEGDIHDIGIDLEALKKIIARS
KGDEKLILELDDEKNKLNVTFKSNVTRKFSIALYDVSSSNLKVPDISYPNQVSIKAGAFVEALKDAELVNDHITLKVDED
KFVIYSKGDLNQSETVFENNNDEYETLTEFKMSEPSKSTFNLAYLKDLTKSTSAEDILKIYLGSDMPVKIEYEVSGSKLV
FLLAPRIES

Sequences:

>Translated_249_residues
MFKATCNSRDFKKVINATSNLVDEICFEVDETGIKASAMDPSHVALVSMGMPKEVFESYEGDIHDIGIDLEALKKIIARS
KGDEKLILELDDEKNKLNVTFKSNVTRKFSIALYDVSSSNLKVPDISYPNQVSIKAGAFVEALKDAELVNDHITLKVDED
KFVIYSKGDLNQSETVFENNNDEYETLTEFKMSEPSKSTFNLAYLKDLTKSTSAEDILKIYLGSDMPVKIEYEVSGSKLV
FLLAPRIES
>Mature_249_residues
MFKATCNSRDFKKVINATSNLVDEICFEVDETGIKASAMDPSHVALVSMGMPKEVFESYEGDIHDIGIDLEALKKIIARS
KGDEKLILELDDEKNKLNVTFKSNVTRKFSIALYDVSSSNLKVPDISYPNQVSIKAGAFVEALKDAELVNDHITLKVDED
KFVIYSKGDLNQSETVFENNNDEYETLTEFKMSEPSKSTFNLAYLKDLTKSTSAEDILKIYLGSDMPVKIEYEVSGSKLV
FLLAPRIES

Specific function: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication

COG id: COG0592

COG function: function code L; DNA polymerase sliding clamp subunit (PCNA homolog)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PCNA family

Homologues:

Organism=Homo sapiens, GI33239451, Length=245, Percent_Identity=26.9387755102041, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI4505641, Length=245, Percent_Identity=26.9387755102041, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71995072, Length=220, Percent_Identity=29.0909090909091, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319564, Length=243, Percent_Identity=27.1604938271605, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585303, Length=242, Percent_Identity=22.3140495867769, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136790, Length=245, Percent_Identity=23.6734693877551, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45552759, Length=245, Percent_Identity=23.6734693877551, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCNA_METVS (A6UQZ4)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323528.1
- ProteinModelPortal:   A6UQZ4
- SMR:   A6UQZ4
- STRING:   A6UQZ4
- GeneID:   5325624
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1013
- eggNOG:   arNOG05779
- HOGENOM:   HBG553564
- OMA:   ICRDLSQ
- ProtClustDB:   PRK01115
- HAMAP:   MF_00317
- InterPro:   IPR000730
- InterPro:   IPR022649
- InterPro:   IPR022659
- InterPro:   IPR022648
- PANTHER:   PTHR11352
- PRINTS:   PR00339
- TIGRFAMs:   TIGR00590

Pfam domain/function: PF02747 PCNA_C; PF00705 PCNA_N

EC number: NA

Molecular weight: Translated: 27865; Mature: 27865

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS01251 PCNA_1; PS00293 PCNA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKATCNSRDFKKVINATSNLVDEICFEVDETGIKASAMDPSHVALVSMGMPKEVFESYE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCHHHHHHHC
GDIHDIGIDLEALKKIIARSKGDEKLILELDDEKNKLNVTFKSNVTRKFSIALYDVSSSN
CCEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEEEEECCCC
LKVPDISYPNQVSIKAGAFVEALKDAELVNDHITLKVDEDKFVIYSKGDLNQSETVFENN
EECCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCEEECCC
NDEYETLTEFKMSEPSKSTFNLAYLKDLTKSTSAEDILKIYLGSDMPVKIEYEVSGSKLV
CCCHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCHHHHHEEEECCCCCEEEEEEECCCEEE
FLLAPRIES
EEECCCCCC
>Mature Secondary Structure
MFKATCNSRDFKKVINATSNLVDEICFEVDETGIKASAMDPSHVALVSMGMPKEVFESYE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCHHHHHHHC
GDIHDIGIDLEALKKIIARSKGDEKLILELDDEKNKLNVTFKSNVTRKFSIALYDVSSSN
CCEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEEEEECCCC
LKVPDISYPNQVSIKAGAFVEALKDAELVNDHITLKVDEDKFVIYSKGDLNQSETVFENN
EECCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCEEECCC
NDEYETLTEFKMSEPSKSTFNLAYLKDLTKSTSAEDILKIYLGSDMPVKIEYEVSGSKLV
CCCHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCHHHHHEEEECCCCCEEEEEEECCCEEE
FLLAPRIES
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA