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The map label for this gene is 150399676

Identifier: 150399676

GI number: 150399676

Start: 945500

End: 946471

Strand: Reverse

Name: 150399676

Synonym: Mevan_0927

Alternate gene names: NA

Gene position: 946471-945500 (Counterclockwise)

Preceding gene: 150399679

Following gene: 150399675

Centisome position: 55.03

GC content: 33.02

Gene sequence:

>972_bases
ATGGATAGAGATTTGAGGCCTATTTTTTGGAATGATGAAGAAAAAAAACTTATACTAGTAGATCAGCGAAAACTTCCAAA
TAAGCTTGAGTATTTTGAATGTAAAACTTATACTGATGTATGTTATGCAATAAAAGATATGGTTGTAAGAGGGGCTCCTG
CAATTGGTGTTTCCGCAGCATATGGGTTGGCATTAGCGGAATTAAACGGAAATAACATTGAAAATGCATATATGGAATTG
AAAGAAACAAGGCCAACTGCGGTAAATTTATTTTGGGCCCTTGATAAGGCTATGAATGCAAAAATAAATGGAAAATCGAT
TTTAGATGAAGCTAAACTAATCCATGACGAAGATGTTGAATTATGCAAAAAAATTGGAAAAATCGGTGAAACGTTAATTA
AAGACGGCGATACAATTTTAACACATTGCAATGCGGGAGCACTAGCAACATCAGCATACGGAACTGCATTAAGTATTATT
AGATTTGCACATTATTCCGGTAAAAAAATAAATGTTATATCTGATGAAACAAGACCAAGATTACAGGGTGCGAAATTGAC
CTGTTTTGAACTAAATTATGAAAAAATCCCTGTAAAAGCAATATGTGATAATACTGCAGGATATTTGATGAGTAAAGGTA
TGATTGATAAAATAATTGTTGGTGCAGACCGGATTCTTTCTGACTATCATGTTTTTAACAAAATTGGAACTTATTCGCTA
GCAATACTTGCAAAATATCACAATGTTCCATTTTATGTTGCAGCACCCTATTCTACGTTTGACTTTAAAAGTAAGCTTGT
AGATATTGTAGTTGAAGAACGAGATGATGTAGAAGTAACCTATATTGATGGCGTAAGAGTTGTTTCAGAAGGAGTTTCTG
CATACAACTTTGCATTTGACTGTACGCCTCCAGAATTAATTACTGGAATAATTACTGAAAAAGAGATAATTTATCCAAAT
TTGGGAAAATAA

Upstream 100 bases:

>100_bases
TATTAATACAAATCGTTTGATTGTACCGTATAAATTAAATACTGTTTTTACAGTTACTTATTTTTAGTACCTTCGATTTA
TGTTGGAGTTGGTGAGATAT

Downstream 100 bases:

>100_bases
TTAGTAAATATTTTGTAAATATGCTAATTCATAAATAAATTTATAAATTTATGGACAGGATTTCTCCTGTCCGAATGGAT
TTTTGAATGTTTTCAGCTTT

Product: aIF-2BI family translation initiation factor

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MDRDLRPIFWNDEEKKLILVDQRKLPNKLEYFECKTYTDVCYAIKDMVVRGAPAIGVSAAYGLALAELNGNNIENAYMEL
KETRPTAVNLFWALDKAMNAKINGKSILDEAKLIHDEDVELCKKIGKIGETLIKDGDTILTHCNAGALATSAYGTALSII
RFAHYSGKKINVISDETRPRLQGAKLTCFELNYEKIPVKAICDNTAGYLMSKGMIDKIIVGADRILSDYHVFNKIGTYSL
AILAKYHNVPFYVAAPYSTFDFKSKLVDIVVEERDDVEVTYIDGVRVVSEGVSAYNFAFDCTPPELITGIITEKEIIYPN
LGK

Sequences:

>Translated_323_residues
MDRDLRPIFWNDEEKKLILVDQRKLPNKLEYFECKTYTDVCYAIKDMVVRGAPAIGVSAAYGLALAELNGNNIENAYMEL
KETRPTAVNLFWALDKAMNAKINGKSILDEAKLIHDEDVELCKKIGKIGETLIKDGDTILTHCNAGALATSAYGTALSII
RFAHYSGKKINVISDETRPRLQGAKLTCFELNYEKIPVKAICDNTAGYLMSKGMIDKIIVGADRILSDYHVFNKIGTYSL
AILAKYHNVPFYVAAPYSTFDFKSKLVDIVVEERDDVEVTYIDGVRVVSEGVSAYNFAFDCTPPELITGIITEKEIIYPN
LGK
>Mature_323_residues
MDRDLRPIFWNDEEKKLILVDQRKLPNKLEYFECKTYTDVCYAIKDMVVRGAPAIGVSAAYGLALAELNGNNIENAYMEL
KETRPTAVNLFWALDKAMNAKINGKSILDEAKLIHDEDVELCKKIGKIGETLIKDGDTILTHCNAGALATSAYGTALSII
RFAHYSGKKINVISDETRPRLQGAKLTCFELNYEKIPVKAICDNTAGYLMSKGMIDKIIVGADRILSDYHVFNKIGTYSL
AILAKYHNVPFYVAAPYSTFDFKSKLVDIVVEERDDVEVTYIDGVRVVSEGVSAYNFAFDCTPPELITGIITEKEIIYPN
LGK

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=336, Percent_Identity=37.5, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI23943880, Length=323, Percent_Identity=34.3653250773994, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4503503, Length=200, Percent_Identity=32.5, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI78000158, Length=263, Percent_Identity=24.7148288973384, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI187607323, Length=263, Percent_Identity=24.7148288973384, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI78000156, Length=263, Percent_Identity=24.7148288973384, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=318, Percent_Identity=33.9622641509434, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17557123, Length=206, Percent_Identity=30.0970873786408, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=381, Percent_Identity=32.8083989501312, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322878, Length=264, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357667, Length=340, Percent_Identity=36.4705882352941, Blast_Score=200, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24651647, Length=340, Percent_Identity=36.4705882352941, Blast_Score=200, Evalue=9e-52,
Organism=Drosophila melanogaster, GI281364091, Length=258, Percent_Identity=26.7441860465116, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24659399, Length=258, Percent_Identity=26.7441860465116, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24659407, Length=258, Percent_Identity=26.7441860465116, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922816, Length=258, Percent_Identity=26.7441860465116, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 36049; Mature: 36049

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRDLRPIFWNDEEKKLILVDQRKLPNKLEYFECKTYTDVCYAIKDMVVRGAPAIGVSAA
CCCCCCCEEECCCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCHHH
YGLALAELNGNNIENAYMELKETRPTAVNLFWALDKAMNAKINGKSILDEAKLIHDEDVE
HCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHCCCCCCHHHHHHHHHCCCCHHH
LCKKIGKIGETLIKDGDTILTHCNAGALATSAYGTALSIIRFAHYSGKKINVISDETRPR
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
LQGAKLTCFELNYEKIPVKAICDNTAGYLMSKGMIDKIIVGADRILSDYHVFNKIGTYSL
CCCCEEEEEECCCCCCCHHEECCCCHHHHHHCCCHHHHHHCHHHHHHHHHHHHHCCHHEE
AILAKYHNVPFYVAAPYSTFDFKSKLVDIVVEERDDVEVTYIDGVRVVSEGVSAYNFAFD
EEEEEECCCCEEEECCCCCHHHHHHHHHHEEECCCCEEEEEECCCHHHHCCCCCEEEEEE
CTPPELITGIITEKEIIYPNLGK
CCCHHHHHHHHCCCEEECCCCCC
>Mature Secondary Structure
MDRDLRPIFWNDEEKKLILVDQRKLPNKLEYFECKTYTDVCYAIKDMVVRGAPAIGVSAA
CCCCCCCEEECCCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCHHH
YGLALAELNGNNIENAYMELKETRPTAVNLFWALDKAMNAKINGKSILDEAKLIHDEDVE
HCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHCCCCCCHHHHHHHHHCCCCHHH
LCKKIGKIGETLIKDGDTILTHCNAGALATSAYGTALSIIRFAHYSGKKINVISDETRPR
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
LQGAKLTCFELNYEKIPVKAICDNTAGYLMSKGMIDKIIVGADRILSDYHVFNKIGTYSL
CCCCEEEEEECCCCCCCHHEECCCCHHHHHHCCCHHHHHHCHHHHHHHHHHHHHCCHHEE
AILAKYHNVPFYVAAPYSTFDFKSKLVDIVVEERDDVEVTYIDGVRVVSEGVSAYNFAFD
EEEEEECCCCEEEECCCCCHHHHHHHHHHEEECCCCEEEEEECCCHHHHCCCCCEEEEEE
CTPPELITGIITEKEIIYPNLGK
CCCHHHHHHHHCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]