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The map label for this gene is serA [H]

Identifier: 150399650

GI number: 150399650

Start: 919553

End: 921124

Strand: Reverse

Name: serA [H]

Synonym: Mevan_0900

Alternate gene names: 150399650

Gene position: 921124-919553 (Counterclockwise)

Preceding gene: 150399653

Following gene: 150399649

Centisome position: 53.55

GC content: 36.32

Gene sequence:

>1572_bases
ATGTTAAAGATACTTATAACCGACCCGTTACACGAAAGTGCTATTGAGATTTTAAAAGAAGCAGGGGAAGTCGAAATTGC
TACCGGAATCAGTATTGAAGAGATAAAACAAAAAATAAAAGATGCTGATGCACTCGTTGTTAGGAGTGGTACAACAGTTA
CAAAAGAGATAATTGATGCATCAGAGAACTTAAAAGTAATTGCGAGAGCAGGTGTTGGCGTTGATAATGTTGATCTAGAT
GCGGCAACGGAAAAAGGAGTAGTTGTTGTAAATGCGCCAGATGCATCATCGATTTCAGTTGCAGAATTAATGTTTGGTTT
AATGCTTTCAGCTGCAAGAAACATTCCTCAAGCAACTGCTTCACTTAAAAAGGGGGAATGGGATAGAAAGTCATTTAAGG
GAATGGAAGTTTACGCAAAGACACTTGGAATTGTAGGCCTTGGACGAATAGGTCAGCAAGTTGCAAAAAGGGCCCAAGCA
TTTGAAATGAATATTGTAGCATATGATCCATACATTCCAGAAAATGTAGCATCAGAATTAGGGATTAAATTACTTTCAGT
TGATGAATTATGTGCAGAAAGTGAATTTATAACTCTTCACGTCCCATTAACTACAAAAACAAAACACATGATTGGAAAAA
CCCAGTTTGACCTTATGAAAAACAACACCATAATTATAAACTGTGCAAGAGGGGGTTTAATCGATGAAAACGCTCTTTAC
GATGCAATAAACTGTGGAAAAGTTAAAGCTGCAGGACTAGATGTCTTTGAAGAAGAGCCGCCTACAAAAAATCCATTAAT
TTCGCTAAATGGGCTTATTGGTACGCCTCATCAAGGTGCATCAACAGAAGAAGCCCAATTAAGTGCAGGAACAATCGTTG
CAGAACAAACTGTTAAAATATTGAAAGGTGAATCTGCAGAAAACGTTGTAAATCTTCCAATGGTGCCGACCGAAAAAATG
AAAAAACTAATGCCTTATCTGGTTTTAGCTGAAAAAATGGGTTCAATGTCAATCCAATACTTGGATAATTCGATAGATAT
CGTAGAAATTACTTACATGGGCGACCTTGCAAAAGAAAAGACTGAAATGCTTAAAAGAGCATTTTTAAAAGGGATATTGT
CTCCCATTTTACTTGCGGGAGTAAACCTTGTAAATGCACCCGTTATTGCTAAAAACAGGAATATTAGACTTGTAGAAGGA
ATAATGGCTGAAAGTGACTATGGAAATTCCATCAAAATTGTTGCAAGAGGTAAAAACGATGAAATATCATTAATTGGAAG
TATCGAACATAAAGAAGTGGTTTTTAGGGAAATTAATGGATATAGGATGGACATAAAACCCGAAGGTACTATTTGCATAA
TAAAACATATTGATAGGCCAGGAATGGTTGGAAAAGTTGGCTTAATTCTTGGCGAACACGGTATAAACATTGCAGGAATG
CAAGTTGGGAGAAAAGAGCCTGGTGGACACAGTATCATGTTTTTAGATATTGATCACATGATTCCCGAAGAAGTAATGGA
CGAAATTAAAAAAATTGAAAATGTTAGGGCTGTAAGGGCAATAAACATTTAA

Upstream 100 bases:

>100_bases
TATTAATTTATGGCCGTAAATATAAAATGGATACGAAAGACTATCATAAAAATAATTAAAAGCGTATTTTAGACGAATGT
CTTTTAAGGTGATTATAGAA

Downstream 100 bases:

>100_bases
TTTTACTTTATTTTACTTAATTTTTTAATATTTTAGGGTGATTTTATCGAAAGCATTCTAATAGGGTTACTTGCTGCACT
TTTGTATGGCGTTGGAACTT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MLKILITDPLHESAIEILKEAGEVEIATGISIEEIKQKIKDADALVVRSGTTVTKEIIDASENLKVIARAGVGVDNVDLD
AATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQATASLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQA
FEMNIVAYDPYIPENVASELGIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENALY
DAINCGKVKAAGLDVFEEEPPTKNPLISLNGLIGTPHQGASTEEAQLSAGTIVAEQTVKILKGESAENVVNLPMVPTEKM
KKLMPYLVLAEKMGSMSIQYLDNSIDIVEITYMGDLAKEKTEMLKRAFLKGILSPILLAGVNLVNAPVIAKNRNIRLVEG
IMAESDYGNSIKIVARGKNDEISLIGSIEHKEVVFREINGYRMDIKPEGTICIIKHIDRPGMVGKVGLILGEHGINIAGM
QVGRKEPGGHSIMFLDIDHMIPEEVMDEIKKIENVRAVRAINI

Sequences:

>Translated_523_residues
MLKILITDPLHESAIEILKEAGEVEIATGISIEEIKQKIKDADALVVRSGTTVTKEIIDASENLKVIARAGVGVDNVDLD
AATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQATASLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQA
FEMNIVAYDPYIPENVASELGIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENALY
DAINCGKVKAAGLDVFEEEPPTKNPLISLNGLIGTPHQGASTEEAQLSAGTIVAEQTVKILKGESAENVVNLPMVPTEKM
KKLMPYLVLAEKMGSMSIQYLDNSIDIVEITYMGDLAKEKTEMLKRAFLKGILSPILLAGVNLVNAPVIAKNRNIRLVEG
IMAESDYGNSIKIVARGKNDEISLIGSIEHKEVVFREINGYRMDIKPEGTICIIKHIDRPGMVGKVGLILGEHGINIAGM
QVGRKEPGGHSIMFLDIDHMIPEEVMDEIKKIENVRAVRAINI
>Mature_523_residues
MLKILITDPLHESAIEILKEAGEVEIATGISIEEIKQKIKDADALVVRSGTTVTKEIIDASENLKVIARAGVGVDNVDLD
AATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQATASLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQA
FEMNIVAYDPYIPENVASELGIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENALY
DAINCGKVKAAGLDVFEEEPPTKNPLISLNGLIGTPHQGASTEEAQLSAGTIVAEQTVKILKGESAENVVNLPMVPTEKM
KKLMPYLVLAEKMGSMSIQYLDNSIDIVEITYMGDLAKEKTEMLKRAFLKGILSPILLAGVNLVNAPVIAKNRNIRLVEG
IMAESDYGNSIKIVARGKNDEISLIGSIEHKEVVFREINGYRMDIKPEGTICIIKHIDRPGMVGKVGLILGEHGINIAGM
QVGRKEPGGHSIMFLDIDHMIPEEVMDEIKKIENVRAVRAINI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=451, Percent_Identity=37.6940133037694, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI6912396, Length=317, Percent_Identity=32.4921135646688, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4557497, Length=311, Percent_Identity=33.1189710610932, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI61743967, Length=311, Percent_Identity=33.1189710610932, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI145580578, Length=311, Percent_Identity=32.7974276527331, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI4557499, Length=311, Percent_Identity=32.7974276527331, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI145580575, Length=311, Percent_Identity=32.7974276527331, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1789279, Length=390, Percent_Identity=32.5641025641026, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI87082289, Length=318, Percent_Identity=32.7044025157233, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=33.2046332046332, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1788660, Length=309, Percent_Identity=29.4498381877023, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=43.5643564356436, Blast_Score=256, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI25147481, Length=320, Percent_Identity=29.6875, Blast_Score=141, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=329, Percent_Identity=36.1702127659575, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322116, Length=334, Percent_Identity=35.3293413173653, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324055, Length=240, Percent_Identity=31.6666666666667, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=27.34375, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=298, Percent_Identity=23.8255033557047, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=308, Percent_Identity=25.3246753246753, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921140, Length=303, Percent_Identity=42.2442244224422, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=30.5993690851735, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=28.7539936102236, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=28.7539936102236, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=28.7539936102236, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=28.7539936102236, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=28.7539936102236, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24646446, Length=296, Percent_Identity=32.7702702702703, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646448, Length=296, Percent_Identity=32.7702702702703, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646452, Length=296, Percent_Identity=32.7702702702703, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646450, Length=296, Percent_Identity=32.7702702702703, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI62472511, Length=298, Percent_Identity=32.5503355704698, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=28.525641025641, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=31.2101910828025, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56763; Mature: 56763

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKILITDPLHESAIEILKEAGEVEIATGISIEEIKQKIKDADALVVRSGTTVTKEIIDA
CEEEEEECCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCEEEEECCCHHHHHHHCC
SENLKVIARAGVGVDNVDLDAATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQATA
CCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHH
SLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQAFEMNIVAYDPYIPENVASEL
HHHCCCCCHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHH
GIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENALY
CEEEEEHHHHHCCCCEEEEEEECCCCHHHHHCCCHHHEECCCEEEEEECCCCCCCCCHHH
DAINCGKVKAAGLDVFEEEPPTKNPLISLNGLIGTPHQGASTEEAQLSAGTIVAEQTVKI
CCCCCCCEEECCCCHHCCCCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCEEEHHHHHHH
LKGESAENVVNLPMVPTEKMKKLMPYLVLAEKMGSMSIQYLDNSIDIVEITYMGDLAKEK
HCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCHHHHHH
TEMLKRAFLKGILSPILLAGVNLVNAPVIAKNRNIRLVEGIMAESDYGNSIKIVARGKND
HHHHHHHHHHHHHHHHHHHCCHHHCCCEEECCCCEEEEEEEECCCCCCCEEEEEEECCCC
EISLIGSIEHKEVVFREINGYRMDIKPEGTICIIKHIDRPGMVGKVGLILGEHGINIAGM
CEEEEECCCHHHHHHEECCCEEEEECCCCCEEEEEECCCCCCEEEEEEEEECCCCEEEEE
QVGRKEPGGHSIMFLDIDHMIPEEVMDEIKKIENVRAVRAINI
ECCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MLKILITDPLHESAIEILKEAGEVEIATGISIEEIKQKIKDADALVVRSGTTVTKEIIDA
CEEEEEECCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCEEEEECCCHHHHHHHCC
SENLKVIARAGVGVDNVDLDAATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQATA
CCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHH
SLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQAFEMNIVAYDPYIPENVASEL
HHHCCCCCHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHH
GIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENALY
CEEEEEHHHHHCCCCEEEEEEECCCCHHHHHCCCHHHEECCCEEEEEECCCCCCCCCHHH
DAINCGKVKAAGLDVFEEEPPTKNPLISLNGLIGTPHQGASTEEAQLSAGTIVAEQTVKI
CCCCCCCEEECCCCHHCCCCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCEEEHHHHHHH
LKGESAENVVNLPMVPTEKMKKLMPYLVLAEKMGSMSIQYLDNSIDIVEITYMGDLAKEK
HCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCHHHHHH
TEMLKRAFLKGILSPILLAGVNLVNAPVIAKNRNIRLVEGIMAESDYGNSIKIVARGKND
HHHHHHHHHHHHHHHHHHHCCHHHCCCEEECCCCEEEEEEEECCCCCCCEEEEEEECCCC
EISLIGSIEHKEVVFREINGYRMDIKPEGTICIIKHIDRPGMVGKVGLILGEHGINIAGM
CEEEEECCCHHHHHHEECCCEEEEECCCCCEEEEEECCCCCCEEEEEEEEECCCCEEEEE
QVGRKEPGGHSIMFLDIDHMIPEEVMDEIKKIENVRAVRAINI
ECCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]