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The map label for this gene is mscS [H]

Identifier: 150399546

GI number: 150399546

Start: 825876

End: 826685

Strand: Reverse

Name: mscS [H]

Synonym: Mevan_0795

Alternate gene names: 150399546

Gene position: 826685-825876 (Counterclockwise)

Preceding gene: 150399549

Following gene: 150399537

Centisome position: 48.06

GC content: 33.7

Gene sequence:

>810_bases
ATGATTCAGACATTATCTTTAATGGGGTACTCACTAAGTTTTGAAATAATGACTTTAGTTAAATTTTTTTTAATACTTAT
TTTTGGGTACATTTCAGTTAGGACAATAAAAACAGTTTTAAAAAGAGGCGTAAAAAAGAGTAAAATTCCAGAATTGGTTT
CTGAATTTGTAATTCATCTTATTAGCTCTTTATTGTACGTTCTGGTACTTTTACTTGCAGTAGGGGTTTTTGGAATAGAA
ACGGGGCCCATAATACTTGGGTTATCTGCTTCAATCGGACTTATTTTGGGTTTTGGATTTCAGGATACTCTTACAAATCT
TACCTCTGGAATATGGATTGCCGTAATGAGGCCCCTTGATAAGGATGAAGTAGTTCAGGTTGGCGGAATAACTGGAAAAG
TTGTTGAATTAGGTATAATGGCAACAAAACTTTTAACGCCAGATAATGTAGTAATTACAATACCAAATAAGCTTGTTTGG
GGAAGTCCAATAACAAACTATACTAGAATGGATTTAAGAAGAGTAGATGTGGCAGTTGGAGTTAGCTACAGTGGAAGTGT
CCAAGATGCAATTTCCTCTGCAATGGAACTTATTTTAAGCCATAATTTGGTTTTGAAAGACCCTACTCCGGCAGTAATTG
TTACTGAACTTGGAAATTCTTCAGTTAATTTACAGCTTAGGGCTTGGACTAAAACAGAGGATTATTGGAAACTTAAAAGT
GAATTGACAAGAGGAATATATGAAAAGTATAAAAAAGAAGGAATAGAAATACCATTTCCGCAGATGGATGTGCATATTCA
TAAATACTAA

Upstream 100 bases:

>100_bases
TATATACACCTTTAATTATAATAAATAGTATATCTAAATCCTGCTATAAATTTTAATGTAAATTTACATTAAACAATTAT
TTATTATGGGGTAAATTATT

Downstream 100 bases:

>100_bases
CTATTTTTTTAATTGAATTATTTTAATAAACATATTTTAAAAAAATATTATTTATTTTAAATGGCCCAAGATATGGCCAG
TTTCTTTTTTAATTATTTGA

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MIQTLSLMGYSLSFEIMTLVKFFLILIFGYISVRTIKTVLKRGVKKSKIPELVSEFVIHLISSLLYVLVLLLAVGVFGIE
TGPIILGLSASIGLILGFGFQDTLTNLTSGIWIAVMRPLDKDEVVQVGGITGKVVELGIMATKLLTPDNVVITIPNKLVW
GSPITNYTRMDLRRVDVAVGVSYSGSVQDAISSAMELILSHNLVLKDPTPAVIVTELGNSSVNLQLRAWTKTEDYWKLKS
ELTRGIYEKYKKEGIEIPFPQMDVHIHKY

Sequences:

>Translated_269_residues
MIQTLSLMGYSLSFEIMTLVKFFLILIFGYISVRTIKTVLKRGVKKSKIPELVSEFVIHLISSLLYVLVLLLAVGVFGIE
TGPIILGLSASIGLILGFGFQDTLTNLTSGIWIAVMRPLDKDEVVQVGGITGKVVELGIMATKLLTPDNVVITIPNKLVW
GSPITNYTRMDLRRVDVAVGVSYSGSVQDAISSAMELILSHNLVLKDPTPAVIVTELGNSSVNLQLRAWTKTEDYWKLKS
ELTRGIYEKYKKEGIEIPFPQMDVHIHKY
>Mature_269_residues
MIQTLSLMGYSLSFEIMTLVKFFLILIFGYISVRTIKTVLKRGVKKSKIPELVSEFVIHLISSLLYVLVLLLAVGVFGIE
TGPIILGLSASIGLILGFGFQDTLTNLTSGIWIAVMRPLDKDEVVQVGGITGKVVELGIMATKLLTPDNVVITIPNKLVW
GSPITNYTRMDLRRVDVAVGVSYSGSVQDAISSAMELILSHNLVLKDPTPAVIVTELGNSSVNLQLRAWTKTEDYWKLKS
ELTRGIYEKYKKEGIEIPFPQMDVHIHKY

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=261, Percent_Identity=31.0344827586207, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786670, Length=214, Percent_Identity=28.0373831775701, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787591, Length=236, Percent_Identity=24.1525423728814, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI2367355, Length=214, Percent_Identity=24.2990654205607, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29784; Mature: 29784

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQTLSLMGYSLSFEIMTLVKFFLILIFGYISVRTIKTVLKRGVKKSKIPELVSEFVIHL
CCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ISSLLYVLVLLLAVGVFGIETGPIILGLSASIGLILGFGFQDTLTNLTSGIWIAVMRPLD
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEHHEECCHHHHHHHHHCCEEEEEECCCC
KDEVVQVGGITGKVVELGIMATKLLTPDNVVITIPNKLVWGSPITNYTRMDLRRVDVAVG
HHHEEEECCCCHHHHHHHHHHHHEECCCCEEEECCCCEEECCCCCCHHHHHHHHHHEEEE
VSYSGSVQDAISSAMELILSHNLVLKDPTPAVIVTELGNSSVNLQLRAWTKTEDYWKLKS
CCCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCEEEEEEEEECCCHHHHHHHH
ELTRGIYEKYKKEGIEIPFPQMDVHIHKY
HHHHHHHHHHHHCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MIQTLSLMGYSLSFEIMTLVKFFLILIFGYISVRTIKTVLKRGVKKSKIPELVSEFVIHL
CCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ISSLLYVLVLLLAVGVFGIETGPIILGLSASIGLILGFGFQDTLTNLTSGIWIAVMRPLD
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEHHEECCHHHHHHHHHCCEEEEEECCCC
KDEVVQVGGITGKVVELGIMATKLLTPDNVVITIPNKLVWGSPITNYTRMDLRRVDVAVG
HHHEEEECCCCHHHHHHHHHHHHEECCCCEEEECCCCEEECCCCCCHHHHHHHHHHEEEE
VSYSGSVQDAISSAMELILSHNLVLKDPTPAVIVTELGNSSVNLQLRAWTKTEDYWKLKS
CCCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCEEEEEEEEECCCHHHHHHHH
ELTRGIYEKYKKEGIEIPFPQMDVHIHKY
HHHHHHHHHHHHCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]