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The map label for this gene is asd [H]

Identifier: 150399453

GI number: 150399453

Start: 751352

End: 752398

Strand: Reverse

Name: asd [H]

Synonym: Mevan_0702

Alternate gene names: 150399453

Gene position: 752398-751352 (Counterclockwise)

Preceding gene: 150399454

Following gene: 150399452

Centisome position: 43.74

GC content: 36.1

Gene sequence:

>1047_bases
ATGAAAATTAAAGTAGGAATATTGGGGGCAACTGGAAATGTTGGGCAGAGATTTATACAAATGCTCGAAAACCACCCCAT
ATTTGAACTTGAAGCATTAGGTGCTTCAGAACGAAGTTTGGGAAAAACTTATAAAGAAGCATGTTACTGGTACCAGACTG
AACCAATTCCTGAAGATGTTTCAAAAGCAGTAGTTGTTTCAACAAACCCGGATGATAAAGCATATGAAGATGTTGACATA
GTGTTTTCAGCATTACCCTCTGACTTAGCAAAAAAACTTGAACCCGCATTTGCGAAAGCCGGAAAATATGTATTTTCAAA
TGCGTCCGCAATGAGGATGGAAAAAGATGTACCATTAATCGTTCCAGAGGTAAATTATGAGCATTTTGGAATGATTGAAG
TTCAAAAGAGCAATAATAATACTGACGGTGCAGTGATAACTAACCCAAACTGTTCAACAATTGCAGCAGTACTTTCTTTA
AAACCAATTATGGATAAATTTGGTATAGATTTAGTAAATATAACAACAATGCAAGCCGTAAGTGGTGCAGGATATGACGG
AGTTCCCTCAATGGCAATTTTAGACAATCTTGTTCCCCATATTGGTGGAGAGGAAGAAAAAATGCAGACAGAATCTTTAA
AAATTCTTGGGAATTTTGAAGAAAACGGATTTAAAAATGCCAATTTTAAAATGGGCGTATCTTGTAACCGAGTACCGGTA
ATTGATGGCCATACTGAAAGTATTTTCGTAAAAACAACTGAAGAAACAACTCCTGAAGAAATCATAAACGCAATGAATGA
TTTTGACCCATTAAAAAGGTTTAACCTTCCAAGTTATGCAAAACCTATTGTTATTAGAAGCGAAATTGATAGGCCCCAGC
CAAGACTTGATAGAAATACTGGAAATGGAATGTCTATTGTTGTTGGGAGGGTTAGAAAAGACCCAATATTTACTGTAAAA
TACACTGCACTTGAACATAACACTATAAGGGGAGCTGCAGGAGCAAGCGTTCTAAATGCGGAGTTATTTGTTCAAAAATA
TCTCTAA

Upstream 100 bases:

>100_bases
TAAAATGAGGCCAATGGGTGTAGTAAAAGGATAATTTTATTAATATATAAAAGGAATATTTTACGTAAATTTAAGCTAAA
ATCGTATTGAAGGTGAAACA

Downstream 100 bases:

>100_bases
ATTATTCTTTCTTTTTTAATGCATTAATTTATACTTTTAAATATTTTAATATTTTTTAAATATATTAGAATTAATCGATA
TATTGAAAGGTATAAATATA

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKIKVGILGATGNVGQRFIQMLENHPIFELEALGASERSLGKTYKEACYWYQTEPIPEDVSKAVVVSTNPDDKAYEDVDI
VFSALPSDLAKKLEPAFAKAGKYVFSNASAMRMEKDVPLIVPEVNYEHFGMIEVQKSNNNTDGAVITNPNCSTIAAVLSL
KPIMDKFGIDLVNITTMQAVSGAGYDGVPSMAILDNLVPHIGGEEEKMQTESLKILGNFEENGFKNANFKMGVSCNRVPV
IDGHTESIFVKTTEETTPEEIINAMNDFDPLKRFNLPSYAKPIVIRSEIDRPQPRLDRNTGNGMSIVVGRVRKDPIFTVK
YTALEHNTIRGAAGASVLNAELFVQKYL

Sequences:

>Translated_348_residues
MKIKVGILGATGNVGQRFIQMLENHPIFELEALGASERSLGKTYKEACYWYQTEPIPEDVSKAVVVSTNPDDKAYEDVDI
VFSALPSDLAKKLEPAFAKAGKYVFSNASAMRMEKDVPLIVPEVNYEHFGMIEVQKSNNNTDGAVITNPNCSTIAAVLSL
KPIMDKFGIDLVNITTMQAVSGAGYDGVPSMAILDNLVPHIGGEEEKMQTESLKILGNFEENGFKNANFKMGVSCNRVPV
IDGHTESIFVKTTEETTPEEIINAMNDFDPLKRFNLPSYAKPIVIRSEIDRPQPRLDRNTGNGMSIVVGRVRKDPIFTVK
YTALEHNTIRGAAGASVLNAELFVQKYL
>Mature_348_residues
MKIKVGILGATGNVGQRFIQMLENHPIFELEALGASERSLGKTYKEACYWYQTEPIPEDVSKAVVVSTNPDDKAYEDVDI
VFSALPSDLAKKLEPAFAKAGKYVFSNASAMRMEKDVPLIVPEVNYEHFGMIEVQKSNNNTDGAVITNPNCSTIAAVLSL
KPIMDKFGIDLVNITTMQAVSGAGYDGVPSMAILDNLVPHIGGEEEKMQTESLKILGNFEENGFKNANFKMGVSCNRVPV
IDGHTESIFVKTTEETTPEEIINAMNDFDPLKRFNLPSYAKPIVIRSEIDRPQPRLDRNTGNGMSIVVGRVRKDPIFTVK
YTALEHNTIRGAAGASVLNAELFVQKYL

Specific function: This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp [H]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320362, Length=360, Percent_Identity=43.0555555555556, Blast_Score=278, Evalue=8e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR005676
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 38297; Mature: 38297

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKVGILGATGNVGQRFIQMLENHPIFELEALGASERSLGKTYKEACYWYQTEPIPEDV
CEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHEEEEECCCCCCCC
SKAVVVSTNPDDKAYEDVDIVFSALPSDLAKKLEPAFAKAGKYVFSNASAMRMEKDVPLI
CCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHCHHHHHCCCCEECCCHHHEECCCCCEE
VPEVNYEHFGMIEVQKSNNNTDGAVITNPNCSTIAAVLSLKPIMDKFGIDLVNITTMQAV
EECCCCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEHHHHH
SGAGYDGVPSMAILDNLVPHIGGEEEKMQTESLKILGNFEENGFKNANFKMGVSCNRVPV
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCCCCCCCEEECCCCCCEEE
IDGHTESIFVKTTEETTPEEIINAMNDFDPLKRFNLPSYAKPIVIRSEIDRPQPRLDRNT
ECCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCCCCCCCCC
GNGMSIVVGRVRKDPIFTVKYTALEHNTIRGAAGASVLNAELFVQKYL
CCCEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHEECC
>Mature Secondary Structure
MKIKVGILGATGNVGQRFIQMLENHPIFELEALGASERSLGKTYKEACYWYQTEPIPEDV
CEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHEEEEECCCCCCCC
SKAVVVSTNPDDKAYEDVDIVFSALPSDLAKKLEPAFAKAGKYVFSNASAMRMEKDVPLI
CCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHCHHHHHCCCCEECCCHHHEECCCCCEE
VPEVNYEHFGMIEVQKSNNNTDGAVITNPNCSTIAAVLSLKPIMDKFGIDLVNITTMQAV
EECCCCCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEHHHHH
SGAGYDGVPSMAILDNLVPHIGGEEEKMQTESLKILGNFEENGFKNANFKMGVSCNRVPV
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCCCCCCCEEECCCCCCEEE
IDGHTESIFVKTTEETTPEEIINAMNDFDPLKRFNLPSYAKPIVIRSEIDRPQPRLDRNT
ECCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCCCCCCCCC
GNGMSIVVGRVRKDPIFTVKYTALEHNTIRGAAGASVLNAELFVQKYL
CCCEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]