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The map label for this gene is mvk [H]

Identifier: 150399397

GI number: 150399397

Start: 696105

End: 697064

Strand: Reverse

Name: mvk [H]

Synonym: Mevan_0646

Alternate gene names: 150399397

Gene position: 697064-696105 (Counterclockwise)

Preceding gene: 150399398

Following gene: 150399394

Centisome position: 40.53

GC content: 29.79

Gene sequence:

>960_bases
ATGACATTAACTGTTAAAACACCTTCAAAAGTCATATTATTTGGGGAACATGCGGTTGTAGATGGATATTCTGCAATTGC
AATGGCAATAGATCTTAAAACAACAGGGGAAATTAAAGGTAATTTTGAAACAATAACAATTGAACTTTCAGATTTAAATG
AAATTTTTGAAATAGCTCCTAAATTAATTAAAGAATTAGATATTTCAAATTTCAGTCCCTCTTTAAAGTATGTATTATGC
GCTACAAAGTATGCAATAAACTACCTAATTGAATTTAAGGGTTTAACGTCAATAACTCCGTTTAAACTTAAAATATTTTC
AGAAATTCCCGTAAGCTGCGGTCTTGGTTCTTCGGCATCAGTTGTTGTAACAACAATTAATTCAATTTCAAATTTTTATG
GAATTTCCCTTAAAAATGAAGAAGTAATTAACATGGCTTATTCGGTTGAAAAGGATATTCAAGGGCGTGCAAGTATAACT
GACACTGCAACAATTACCTTATCTGGAATGATTGAAATTTATGCTGGAAATTATAAAATAATGCCAAAAGAACTCAGTGA
ATTTATAAAAACGTGTAATTTTTTAATTGTTAACGTTGAAGAAAGAACGAGAAAAACAGCAGATTTAGTGTGGGAAGTTT
CAGAACATCCTCAAAAAGAGGAATTATTTAAAAAAATCGGGACGATAATTGAAAAAGTAAAACATAACCGTTCAAAAGAA
GAACTTGGAAAATTAATGGTTGAAAACCATGAAATTTTAAAAAAATTTGGAATTTCAACTGAAAAGCTAGATTTGGTTAT
TGAAGCTTCAAAAAAGTATGCACATGGTGGAAAATTAACCGGTGCAGGAGGGGGCGGTTCTGTAATAATTCTTCTAAAAA
ATGAAAAGGAAGAATTATTAAAAGAACTTAAAAAAATCGGAGTAACAGGAACTTTTGAGTGCAAAATGACAAATTTTTAA

Upstream 100 bases:

>100_bases
TTGGAACAAAAGGACTTTTAATGGCGGACTTTAATGGAAATGTTGAAAATCGTGATAAAATAAATTTAAAACGACTTAGA
AGGTGGGGTTAGGTAAAAAC

Downstream 100 bases:

>100_bases
TAAATTAATCTGCTTTCTGACCTACTCCAATGTAAATTCTATGTTTTCCAATTTTTCCACCGCCAAGTGAATAAATTTCA
ATTTTATTTTCTCTTGCAAG

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MTLTVKTPSKVILFGEHAVVDGYSAIAMAIDLKTTGEIKGNFETITIELSDLNEIFEIAPKLIKELDISNFSPSLKYVLC
ATKYAINYLIEFKGLTSITPFKLKIFSEIPVSCGLGSSASVVVTTINSISNFYGISLKNEEVINMAYSVEKDIQGRASIT
DTATITLSGMIEIYAGNYKIMPKELSEFIKTCNFLIVNVEERTRKTADLVWEVSEHPQKEELFKKIGTIIEKVKHNRSKE
ELGKLMVENHEILKKFGISTEKLDLVIEASKKYAHGGKLTGAGGGGSVIILLKNEKEELLKELKKIGVTGTFECKMTNF

Sequences:

>Translated_319_residues
MTLTVKTPSKVILFGEHAVVDGYSAIAMAIDLKTTGEIKGNFETITIELSDLNEIFEIAPKLIKELDISNFSPSLKYVLC
ATKYAINYLIEFKGLTSITPFKLKIFSEIPVSCGLGSSASVVVTTINSISNFYGISLKNEEVINMAYSVEKDIQGRASIT
DTATITLSGMIEIYAGNYKIMPKELSEFIKTCNFLIVNVEERTRKTADLVWEVSEHPQKEELFKKIGTIIEKVKHNRSKE
ELGKLMVENHEILKKFGISTEKLDLVIEASKKYAHGGKLTGAGGGGSVIILLKNEKEELLKELKKIGVTGTFECKMTNF
>Mature_318_residues
TLTVKTPSKVILFGEHAVVDGYSAIAMAIDLKTTGEIKGNFETITIELSDLNEIFEIAPKLIKELDISNFSPSLKYVLCA
TKYAINYLIEFKGLTSITPFKLKIFSEIPVSCGLGSSASVVVTTINSISNFYGISLKNEEVINMAYSVEKDIQGRASITD
TATITLSGMIEIYAGNYKIMPKELSEFIKTCNFLIVNVEERTRKTADLVWEVSEHPQKEELFKKIGTIIEKVKHNRSKEE
LGKLMVENHEILKKFGISTEKLDLVIEASKKYAHGGKLTGAGGGGSVIILLKNEKEELLKELKKIGVTGTFECKMTNF

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Drosophila melanogaster, GI78707210, Length=359, Percent_Identity=27.8551532033426, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 35337; Mature: 35205

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTVKTPSKVILFGEHAVVDGYSAIAMAIDLKTTGEIKGNFETITIELSDLNEIFEIAP
CEEEEECCCEEEEEECCEEECCCEEEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHH
KLIKELDISNFSPSLKYVLCATKYAINYLIEFKGLTSITPFKLKIFSEIPVSCGLGSSAS
HHHHHCCCCCCCCCCEEEEEHHHHHHEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCE
VVVTTINSISNFYGISLKNEEVINMAYSVEKDIQGRASITDTATITLSGMIEIYAGNYKI
EEEEEEHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEECCEEE
MPKELSEFIKTCNFLIVNVEERTRKTADLVWEVSEHPQKEELFKKIGTIIEKVKHNRSKE
CHHHHHHHHHCCCEEEEEEHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCHH
ELGKLMVENHEILKKFGISTEKLDLVIEASKKYAHGGKLTGAGGGGSVIILLKNEKEELL
HHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCEEEECCCCCEEEEEEECCHHHHH
KELKKIGVTGTFECKMTNF
HHHHHCCCCEEEEEEECCC
>Mature Secondary Structure 
TLTVKTPSKVILFGEHAVVDGYSAIAMAIDLKTTGEIKGNFETITIELSDLNEIFEIAP
EEEEECCCEEEEEECCEEECCCEEEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHH
KLIKELDISNFSPSLKYVLCATKYAINYLIEFKGLTSITPFKLKIFSEIPVSCGLGSSAS
HHHHHCCCCCCCCCCEEEEEHHHHHHEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCE
VVVTTINSISNFYGISLKNEEVINMAYSVEKDIQGRASITDTATITLSGMIEIYAGNYKI
EEEEEEHHHHHHEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEECCEEE
MPKELSEFIKTCNFLIVNVEERTRKTADLVWEVSEHPQKEELFKKIGTIIEKVKHNRSKE
CHHHHHHHHHCCCEEEEEEHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCHH
ELGKLMVENHEILKKFGISTEKLDLVIEASKKYAHGGKLTGAGGGGSVIILLKNEKEELL
HHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCEEEECCCCCEEEEEEECCHHHHH
KELKKIGVTGTFECKMTNF
HHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10497066 [H]