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The map label for this gene is fdhA [H]

Identifier: 150399359

GI number: 150399359

Start: 663600

End: 665624

Strand: Reverse

Name: fdhA [H]

Synonym: Mevan_0608

Alternate gene names: 150399359

Gene position: 665624-663600 (Counterclockwise)

Preceding gene: 150399360

Following gene: 150399358

Centisome position: 38.7

GC content: 37.04

Gene sequence:

>2025_bases
ATGAACGTGGAATTCATTCATACGATATGCCCTTACTGCGGTACAGGCTGCGGTTTGGATCTCGTTGTAAAGGATGGAAA
ACTAGTTGGGACAAATCCATTCAAACGACATCCGGTAAATGAGGGAAAAACCTGTATTAAGGGAAGCTACAGTCACGAGT
TTGTACACTGTGAAGATAGACTAAAAACTCCATTAATTAGAAAAAATGGAGAATTGGTTGAATCATCATGGGAAGAAGCT
CTAAATTTGATTTCAAGTAAATTAAAGGATTATTCTCCAGAAGAAATCGGATTTTTTTCATCTGCAAGATGTAGCAATGA
AGATAATTACGTATTTCAAAAATTTGCAAGAACAGTAATGAAGACCAATAATATTGACCACTGTGCAAGACTTTGACACT
CAGCAACTGTGGTCGGTTTAGGGCAAGCTTTTGGTTCAGGTGCTATGACAAATTCAATTTCTGATATAGAACAAGCAGAT
TGTATATTTATAATAGGTTCAAATACGTTTGAACAACACCCGCTTGTTGCAAGAAGGGTTATTCGTGCAAAAGAAAAAGG
TACAAAGGTCGTTGTAGTTGATCCAAGGTATACTCCAACTGCAAAACAGGCCGATTTATACTTGCAATTACTTCCAGGTA
CAAACGCAGCAGTTTTAAACGGAGTAATGCATGTAATTATAAATGAAAAGCTTACAAATGATGAATTTATAAAAAACAGG
ACAAAAGGGTACGATGAATTGAAGAAAACCCTTGAAAAATATACTCCAGAATACGTATCTAAAATTACCGGTGTAGCTCC
TGAATTAATAATTGAAGCTGCAAAAATGTATGGAAGCGCAGAAAAATCAACAATACTCTACTGTATGGGTATAACTCAGT
TTATTCATGGGGTAGATAACGTAAAATGTTGTTGTAACTTGGCAATGATCACTGGAAACATGGGAAAACCCGGAACAGGT
GTAAACCCGTTAAGGGGGCAAAATAATGTTCAAGGTGCATGTGACATGGGTGCACTTCCAAATGTATTTCCGGGATACCA
ACCTATTCCACTAAATCATGAAAAACTTGCAGAAACTTGGAATACGCCAGTTGATTGCCAAATTGGACTTTCAATTCCAG
ATATGCTCTCTAAGGCGGGTGAACAAGTAAAATGTATATATATTCTTGGTGAAAATCCAATGGTTTCAGATCCAGACCTT
CACCACGTGGAACATGCATTAAATAGCCTTGATTTTTTAATAGTTCAAGATATATTCTTAACTGAAACCGCAAAACTTGC
AGATGTTGTGTTACCTGGAGCTTCCTGGGCAGAAAAAGATGGAACTTTCTCAAATACTGAAAGGAGAATTCAAAGGATAA
GAAAAGCTGTTGACGCACCCGGTGAAGCAATCGAAGACTGGAAGATTGTAAAGATGATTGCTGAAAAGATGGGTCAAGGG
GATTTATTTAACTTCAATACTCCTGAAGAAGTATTTAATGAAATTTCAAAGGTTACTCCACAATATGGTGGCGTTACTTA
CGAAAGACTTGGTGTTGATGGACTACACTGGCCATGTAAAACATTAGATGATCCTGGAACGCCTATACTTCACTGTGAGA
AATATTTAACACCTGATGGTCTTGGGAATATATTTGCAGTCGAATATAAAGATCCAGATGAGATGGCAAATCAAGAATAC
CCGCTTACACTAACGACTGGTAGAATTATTTTCCACTACCACACGGGTACAATGACAAGAAGAAGTAAGCACATGTCTGA
TGAAATAGATGAAGGATTTGTTGAGATTCACCCTGACGATGCAAAGGTTCTAAAGATTAAAAATAAAGAAAAAATTAAAG
TATCTACAAAAAGGGGCGAAGTGGTTGTAAACGCAAAAATTACCCCAAATATTAAGCAAGGTGTTATATTTATGCCATTC
CACTTTGCAGAAACCGCAGCTAACATTTTAACGAACCCTGCACTTGATCCTAACTGTAAAATCCCGGAATATAAAGTATG
TGCTGCGAAAGTGGAGAAATTATAG

Upstream 100 bases:

>100_bases
CAATAATTATAGCACAAATGGATTAGTATGAACTAATTTGGAATACTAATCTTTAACTGAAAACCAAAAGGTGTCACACA
TAATTTAACGGTGATGATTA

Downstream 100 bases:

>100_bases
GCTATTAGGGATTTTAAACGAGGGATACAATGAGCAATGAAATGTACTATGTACAGGCAGCAGATCCTGCAATACTTGAA
AAAGGAGAGTGTGGCGGTGC

Product: formate dehydrogenase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MNVEFIHTICPYCGTGCGLDLVVKDGKLVGTNPFKRHPVNEGKTCIKGSYSHEFVHCEDRLKTPLIRKNGELVESSWEEA
LNLISSKLKDYSPEEIGFFSSARCSNEDNYVFQKFARTVMKTNNIDHCARLUHSATVVGLGQAFGSGAMTNSISDIEQAD
CIFIIGSNTFEQHPLVARRVIRAKEKGTKVVVVDPRYTPTAKQADLYLQLLPGTNAAVLNGVMHVIINEKLTNDEFIKNR
TKGYDELKKTLEKYTPEYVSKITGVAPELIIEAAKMYGSAEKSTILYCMGITQFIHGVDNVKCCCNLAMITGNMGKPGTG
VNPLRGQNNVQGACDMGALPNVFPGYQPIPLNHEKLAETWNTPVDCQIGLSIPDMLSKAGEQVKCIYILGENPMVSDPDL
HHVEHALNSLDFLIVQDIFLTETAKLADVVLPGASWAEKDGTFSNTERRIQRIRKAVDAPGEAIEDWKIVKMIAEKMGQG
DLFNFNTPEEVFNEISKVTPQYGGVTYERLGVDGLHWPCKTLDDPGTPILHCEKYLTPDGLGNIFAVEYKDPDEMANQEY
PLTLTTGRIIFHYHTGTMTRRSKHMSDEIDEGFVEIHPDDAKVLKIKNKEKIKVSTKRGEVVVNAKITPNIKQGVIFMPF
HFAETAANILTNPALDPNCKIPEYKVCAAKVEKL

Sequences:

>Translated_674_residues
MNVEFIHTICPYCGTGCGLDLVVKDGKLVGTNPFKRHPVNEGKTCIKGSYSHEFVHCEDRLKTPLIRKNGELVESSWEEA
LNLISSKLKDYSPEEIGFFSSARCSNEDNYVFQKFARTVMKTNNIDHCARL*HSATVVGLGQAFGSGAMTNSISDIEQAD
CIFIIGSNTFEQHPLVARRVIRAKEKGTKVVVVDPRYTPTAKQADLYLQLLPGTNAAVLNGVMHVIINEKLTNDEFIKNR
TKGYDELKKTLEKYTPEYVSKITGVAPELIIEAAKMYGSAEKSTILYCMGITQFIHGVDNVKCCCNLAMITGNMGKPGTG
VNPLRGQNNVQGACDMGALPNVFPGYQPIPLNHEKLAETWNTPVDCQIGLSIPDMLSKAGEQVKCIYILGENPMVSDPDL
HHVEHALNSLDFLIVQDIFLTETAKLADVVLPGASWAEKDGTFSNTERRIQRIRKAVDAPGEAIEDWKIVKMIAEKMGQG
DLFNFNTPEEVFNEISKVTPQYGGVTYERLGVDGLHWPCKTLDDPGTPILHCEKYLTPDGLGNIFAVEYKDPDEMANQEY
PLTLTTGRIIFHYHTGTMTRRSKHMSDEIDEGFVEIHPDDAKVLKIKNKEKIKVSTKRGEVVVNAKITPNIKQGVIFMPF
HFAETAANILTNPALDPNCKIPEYKVCAAKVEKL
>Mature_674_residues
MNVEFIHTICPYCGTGCGLDLVVKDGKLVGTNPFKRHPVNEGKTCIKGSYSHEFVHCEDRLKTPLIRKNGELVESSWEEA
LNLISSKLKDYSPEEIGFFSSARCSNEDNYVFQKFARTVMKTNNIDHCARL*HSATVVGLGQAFGSGAMTNSISDIEQAD
CIFIIGSNTFEQHPLVARRVIRAKEKGTKVVVVDPRYTPTAKQADLYLQLLPGTNAAVLNGVMHVIINEKLTNDEFIKNR
TKGYDELKKTLEKYTPEYVSKITGVAPELIIEAAKMYGSAEKSTILYCMGITQFIHGVDNVKCCCNLAMITGNMGKPGTG
VNPLRGQNNVQGACDMGALPNVFPGYQPIPLNHEKLAETWNTPVDCQIGLSIPDMLSKAGEQVKCIYILGENPMVSDPDL
HHVEHALNSLDFLIVQDIFLTETAKLADVVLPGASWAEKDGTFSNTERRIQRIRKAVDAPGEAIEDWKIVKMIAEKMGQG
DLFNFNTPEEVFNEISKVTPQYGGVTYERLGVDGLHWPCKTLDDPGTPILHCEKYLTPDGLGNIFAVEYKDPDEMANQEY
PLTLTTGRIIFHYHTGTMTRRSKHMSDEIDEGFVEIHPDDAKVLKIKNKEKIKVSTKRGEVVVNAKITPNIKQGVIFMPF
HFAETAANILTNPALDPNCKIPEYKVCAAKVEKL

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=89, Percent_Identity=40.4494382022472, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI3868721, Length=686, Percent_Identity=41.6909620991254, Blast_Score=560, Evalue=1e-160,
Organism=Escherichia coli, GI1788534, Length=785, Percent_Identity=28.7898089171975, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI3868720, Length=636, Percent_Identity=28.4591194968553, Blast_Score=209, Evalue=6e-55,
Organism=Escherichia coli, GI3868719, Length=612, Percent_Identity=27.9411764705882, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787778, Length=652, Percent_Identity=25.3067484662577, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87081797, Length=483, Percent_Identity=25.2587991718427, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1787870, Length=490, Percent_Identity=25.3061224489796, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI171474008, Length=474, Percent_Identity=25.7383966244726, Blast_Score=113, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17565758, Length=157, Percent_Identity=31.8471337579618, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 74686; Mature: 74686

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVEFIHTICPYCGTGCGLDLVVKDGKLVGTNPFKRHPVNEGKTCIKGSYSHEFVHCEDR
CCCCHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCCCCCCCCCEECCCCCCCEEEEHHH
LKTPLIRKNGELVESSWEEALNLISSKLKDYSPEEIGFFSSARCSNEDNYVFQKFARTVM
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHH
KTNNIDHCARLHSATVVGLGQAFGSGAMTNSISDIEQADCIFIIGSNTFEQHPLVARRVI
HCCCHHHHHHHHHHHEEECHHHHCCCCHHCCHHHHCCCCEEEEECCCCCCCCHHHHHHHH
RAKEKGTKVVVVDPRYTPTAKQADLYLQLLPGTNAAVLNGVMHVIINEKLTNDEFIKNRT
HHHHCCCEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHC
KGYDELKKTLEKYTPEYVSKITGVAPELIIEAAKMYGSAEKSTILYCMGITQFIHGVDNV
CCHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHCCCCCH
KCCCNLAMITGNMGKPGTGVNPLRGQNNVQGACDMGALPNVFPGYQPIPLNHEKLAETWN
HHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
TPVDCQIGLSIPDMLSKAGEQVKCIYILGENPMVSDPDLHHVEHALNSLDFLIVQDIFLT
CCCCEEECCCCHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ETAKLADVVLPGASWAEKDGTFSNTERRIQRIRKAVDAPGEAIEDWKIVKMIAEKMGQGD
HHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
LFNFNTPEEVFNEISKVTPQYGGVTYERLGVDGLHWPCKTLDDPGTPILHCEKYLTPDGL
CCCCCCHHHHHHHHHHCCCCCCCEEHHHCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCC
GNIFAVEYKDPDEMANQEYPLTLTTGRIIFHYHTGTMTRRSKHMSDEIDEGFVEIHPDDA
CCEEEEEECCHHHHCCCCCCEEEEECEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCC
KVLKIKNKEKIKVSTKRGEVVVNAKITPNIKQGVIFMPFHFAETAANILTNPALDPNCKI
EEEEECCCCEEEEEECCCCEEEEEEECCCHHCCEEEEEEHHHHHHHHHHCCCCCCCCCCC
PEYKVCAAKVEKL
CCHHHHHHHHHCC
>Mature Secondary Structure
MNVEFIHTICPYCGTGCGLDLVVKDGKLVGTNPFKRHPVNEGKTCIKGSYSHEFVHCEDR
CCCCHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCCCCCCCCCEECCCCCCCEEEEHHH
LKTPLIRKNGELVESSWEEALNLISSKLKDYSPEEIGFFSSARCSNEDNYVFQKFARTVM
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHH
KTNNIDHCARLHSATVVGLGQAFGSGAMTNSISDIEQADCIFIIGSNTFEQHPLVARRVI
HCCCHHHHHHHHHHHEEECHHHHCCCCHHCCHHHHCCCCEEEEECCCCCCCCHHHHHHHH
RAKEKGTKVVVVDPRYTPTAKQADLYLQLLPGTNAAVLNGVMHVIINEKLTNDEFIKNRT
HHHHCCCEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHC
KGYDELKKTLEKYTPEYVSKITGVAPELIIEAAKMYGSAEKSTILYCMGITQFIHGVDNV
CCHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHCCCCCH
KCCCNLAMITGNMGKPGTGVNPLRGQNNVQGACDMGALPNVFPGYQPIPLNHEKLAETWN
HHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
TPVDCQIGLSIPDMLSKAGEQVKCIYILGENPMVSDPDLHHVEHALNSLDFLIVQDIFLT
CCCCEEECCCCHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ETAKLADVVLPGASWAEKDGTFSNTERRIQRIRKAVDAPGEAIEDWKIVKMIAEKMGQGD
HHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
LFNFNTPEEVFNEISKVTPQYGGVTYERLGVDGLHWPCKTLDDPGTPILHCEKYLTPDGL
CCCCCCHHHHHHHHHHCCCCCCCEEHHHCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCC
GNIFAVEYKDPDEMANQEYPLTLTTGRIIFHYHTGTMTRRSKHMSDEIDEGFVEIHPDDA
CCEEEEEECCHHHHCCCCCCEEEEECEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCC
KVLKIKNKEKIKVSTKRGEVVVNAKITPNIKQGVIFMPFHFAETAANILTNPALDPNCKI
EEEEECCCCEEEEEECCCCEEEEEEECCCHHCCEEEEEEHHHHHHHHHHCCCCCCCCCCC
PEYKVCAAKVEKL
CCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]