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The map label for this gene is trpC [H]

Identifier: 150399087

GI number: 150399087

Start: 381867

End: 382556

Strand: Reverse

Name: trpC [H]

Synonym: Mevan_0333

Alternate gene names: 150399087

Gene position: 382556-381867 (Counterclockwise)

Preceding gene: 150399088

Following gene: 150399086

Centisome position: 22.24

GC content: 34.64

Gene sequence:

>690_bases
ATGACCATAGAGTTTAAAAAACAGGCGAGAGCCATACAAAATTTTGGTAAAAACCCAATAATTGCGGAAATTAAAGTTCA
CTCTCCAAAATACGGTGATTTATTGAACGGGAGATCTGAACTTGATATTTTAAAAATATACGAAGATGCAAACGTAGTCG
GAATTTCATATATTACAGATAAACAGCATTTCAATGGAAATTTTGACGTTTTCAAAAAGATATGCGAAAATACCGACCTT
CCAGTTTTAAGAAAAGATTTTATCACTACAAAAGATGAAATCGAAAAAACTGCGAATGCAGGTGCAAGTACTGTACTGAT
AATTGCAAGGCTTTTGAAAGAAAAAACGGCAGAGTTTGTCGATTTTGCACTTGAATGCGGGCTTGATACCCTTGTTGAAG
TGCACAACACTGAAGAAATCGAAATTGCAAAACATACGAATACAACAATGATCGGGATAAATAATCGGGACATTTCAAAA
CTGGAACTCGATGACGGAACCGTTTCTTTAACCGAAAAACTTGCAGATTTAATTCCAAAGAACAGGATACTCGTTAGTGA
AAGCGGAATTTCAAATCTAGCAGATTTAAAACAGGCACTAAAGCATGCTAATGCTGCACTTATTGGAACATCATTTATGA
CAGCAAAATATCAAGAAGAATTCGTAAAAAGCTTTGTTGAGGGAAAATAA

Upstream 100 bases:

>100_bases
ATTTAATCGATATATTTAAGATAATTAATGTATATTGGACTTTCAAACATTCAAATGATTAAGTTGATGGATTAATCACG
ATTTAATTTTAGGGGATAAT

Downstream 100 bases:

>100_bases
TGCTTAATAAGCTTGTAGAATGTGAAAACCTCACTTTTGAAGAATCATACGAATTATTTAACATGCTTTTAGAGGAAAGT
GAAATACGAATTGCAGCATA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTIEFKKQARAIQNFGKNPIIAEIKVHSPKYGDLLNGRSELDILKIYEDANVVGISYITDKQHFNGNFDVFKKICENTDL
PVLRKDFITTKDEIEKTANAGASTVLIIARLLKEKTAEFVDFALECGLDTLVEVHNTEEIEIAKHTNTTMIGINNRDISK
LELDDGTVSLTEKLADLIPKNRILVSESGISNLADLKQALKHANAALIGTSFMTAKYQEEFVKSFVEGK

Sequences:

>Translated_229_residues
MTIEFKKQARAIQNFGKNPIIAEIKVHSPKYGDLLNGRSELDILKIYEDANVVGISYITDKQHFNGNFDVFKKICENTDL
PVLRKDFITTKDEIEKTANAGASTVLIIARLLKEKTAEFVDFALECGLDTLVEVHNTEEIEIAKHTNTTMIGINNRDISK
LELDDGTVSLTEKLADLIPKNRILVSESGISNLADLKQALKHANAALIGTSFMTAKYQEEFVKSFVEGK
>Mature_228_residues
TIEFKKQARAIQNFGKNPIIAEIKVHSPKYGDLLNGRSELDILKIYEDANVVGISYITDKQHFNGNFDVFKKICENTDLP
VLRKDFITTKDEIEKTANAGASTVLIIARLLKEKTAEFVDFALECGLDTLVEVHNTEEIEIAKHTNTTMIGINNRDISKL
ELDDGTVSLTEKLADLIPKNRILVSESGISNLADLKQALKHANAALIGTSFMTAKYQEEFVKSFVEGK

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=202, Percent_Identity=30.6930693069307, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322638, Length=219, Percent_Identity=29.6803652968037, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 25532; Mature: 25400

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEFKKQARAIQNFGKNPIIAEIKVHSPKYGDLLNGRSELDILKIYEDANVVGISYITD
CCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHCCCCCCEEEEEECCCCEEEEEEEEC
KQHFNGNFDVFKKICENTDLPVLRKDFITTKDEIEKTANAGASTVLIIARLLKEKTAEFV
CCCCCCCHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
DFALECGLDTLVEVHNTEEIEIAKHTNTTMIGINNRDISKLELDDGTVSLTEKLADLIPK
HHHHHCCHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCC
NRILVSESGISNLADLKQALKHANAALIGTSFMTAKYQEEFVKSFVEGK
CEEEEECCCCHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIEFKKQARAIQNFGKNPIIAEIKVHSPKYGDLLNGRSELDILKIYEDANVVGISYITD
CCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHCCCCCCEEEEEECCCCEEEEEEEEC
KQHFNGNFDVFKKICENTDLPVLRKDFITTKDEIEKTANAGASTVLIIARLLKEKTAEFV
CCCCCCCHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
DFALECGLDTLVEVHNTEEIEIAKHTNTTMIGINNRDISKLELDDGTVSLTEKLADLIPK
HHHHHCCHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCC
NRILVSESGISNLADLKQALKHANAALIGTSFMTAKYQEEFVKSFVEGK
CEEEEECCCCHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]