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The map label for this gene is trpE [H]

Identifier: 150399085

GI number: 150399085

Start: 379590

End: 380909

Strand: Reverse

Name: trpE [H]

Synonym: Mevan_0331

Alternate gene names: 150399085

Gene position: 380909-379590 (Counterclockwise)

Preceding gene: 150399086

Following gene: 150399084

Centisome position: 22.15

GC content: 35.98

Gene sequence:

>1320_bases
ATGTATAAATTGGATTACGTAAACCCGTTAAAACTTTATGGGGTTTTAAGGGATGAAGGAAAGTATCCAGTAATGCTTGA
ATCAAGAGCTAAGGGGCAAATTAATGCAAGGTACACTTACATTTCTTCAAATCCTGAATACATGCTTAGAATTGGAAATA
AAACCAAAATGGATAACGAAACAATTTCAAAAGAAAGCAATCCCTTCAAAGCATTAAAAGAAAACTTTAAAATTACTCAA
AAAGGCGATAGATTTACAGGAGGATATGTTGGATACATTGCTTATGACTGCATACATAACTACATTGGCGGAAAAATCGA
GGAACCTTCGGTATTTGGTTATTACGACCACATGTATGTTTATGACCACGTTACAAGGCAGTTTTACTTTCACTCTGAAA
ATAATTCAGCTGAAGAATTAACGAATGCTAAAAAAACTGTTGAAAAAGCAAAAAACTTCAAAATCGAACAAGAAGACGGG
GGAATTGAAGTATTAGGATGTGACGCTAATTTTGAAGAATACGTGGAAATGGTTGAACGGGCAAAAGAATATATTTACGC
AGGGGATGCATTTCAAGTCGTTCCTTCAAGAGAATATCAATTAAAAAATGAATTTTCTGCATTTCAACTCTACCAAAATC
TCAGAAATATCAATCCAAGCCCTTACATGTTTTTACTTGAATTTGATAAAGATGTAGTTGGAGCATCCCCTGAAACAATG
GCATCAGTTCAAAACAACGTTTTAAAGGTAAATCCGATTGCAGGAACTGCGCCGATTGGAAAAAATGAAAATGAAACTAA
AAAATTGGCGGAAATACTTTTAAAAGACGAGAAAGAGCGAGCAGAACATATGATGCTGGTTGATCTTGCAAGAAACGATG
TTAGAAAAGTTTCAAAATCCGGAAGCATAATTCTTGAAAGATTTTTTGACGTTGTAAGGTACAGCCATGTTCAACACATA
GAAAGCGAGGTTCTTGGAACATTGAAAAACGGTTCAACAATATTTGATGCAATAGAAGCAGCATTTCCGGCAGGAACATT
AACGGGGGCTCCAAAATTTAGGGCAATGGAAATTATCGATGAAATTGAAAAATCGAGAAGAAAAATCTACGGTGGAGCTG
TAGGTTACTTTTCAAACAGTGGAAATGCGGATTTGGCGATCGGAATTAGAATGGCCGAAATTGACAGTGTTTGTAGGGTT
AGGGCAGGTGGTGGAGTAGTTTCTGACTCAGTACCTGAAAATGAATACTACGAAACAGAGCGGAAAATGGCCGCAATGAT
GAAAGCATTGGGTGTTAAAAATGATAGTAATAATCGATAA

Upstream 100 bases:

>100_bases
TATGCATCAGAAATTGTTTCTGACTTTTTAGAAGGTGTTGAAATTGCAAAAAATGCAATAGATTCGGGAAAAGTTCTTAA
AAAGCTTGAGATGATAAAAA

Downstream 100 bases:

>100_bases
CAAAGATTCGTTTGTATGGAATTTGGCCGATTATGCATCGATTTATGATAATGTACGCGTGGTTCCAAATAATATCACGA
TTTTTGAATTAAAAAAATTA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MYKLDYVNPLKLYGVLRDEGKYPVMLESRAKGQINARYTYISSNPEYMLRIGNKTKMDNETISKESNPFKALKENFKITQ
KGDRFTGGYVGYIAYDCIHNYIGGKIEEPSVFGYYDHMYVYDHVTRQFYFHSENNSAEELTNAKKTVEKAKNFKIEQEDG
GIEVLGCDANFEEYVEMVERAKEYIYAGDAFQVVPSREYQLKNEFSAFQLYQNLRNINPSPYMFLLEFDKDVVGASPETM
ASVQNNVLKVNPIAGTAPIGKNENETKKLAEILLKDEKERAEHMMLVDLARNDVRKVSKSGSIILERFFDVVRYSHVQHI
ESEVLGTLKNGSTIFDAIEAAFPAGTLTGAPKFRAMEIIDEIEKSRRKIYGGAVGYFSNSGNADLAIGIRMAEIDSVCRV
RAGGGVVSDSVPENEYYETERKMAAMMKALGVKNDSNNR

Sequences:

>Translated_439_residues
MYKLDYVNPLKLYGVLRDEGKYPVMLESRAKGQINARYTYISSNPEYMLRIGNKTKMDNETISKESNPFKALKENFKITQ
KGDRFTGGYVGYIAYDCIHNYIGGKIEEPSVFGYYDHMYVYDHVTRQFYFHSENNSAEELTNAKKTVEKAKNFKIEQEDG
GIEVLGCDANFEEYVEMVERAKEYIYAGDAFQVVPSREYQLKNEFSAFQLYQNLRNINPSPYMFLLEFDKDVVGASPETM
ASVQNNVLKVNPIAGTAPIGKNENETKKLAEILLKDEKERAEHMMLVDLARNDVRKVSKSGSIILERFFDVVRYSHVQHI
ESEVLGTLKNGSTIFDAIEAAFPAGTLTGAPKFRAMEIIDEIEKSRRKIYGGAVGYFSNSGNADLAIGIRMAEIDSVCRV
RAGGGVVSDSVPENEYYETERKMAAMMKALGVKNDSNNR
>Mature_439_residues
MYKLDYVNPLKLYGVLRDEGKYPVMLESRAKGQINARYTYISSNPEYMLRIGNKTKMDNETISKESNPFKALKENFKITQ
KGDRFTGGYVGYIAYDCIHNYIGGKIEEPSVFGYYDHMYVYDHVTRQFYFHSENNSAEELTNAKKTVEKAKNFKIEQEDG
GIEVLGCDANFEEYVEMVERAKEYIYAGDAFQVVPSREYQLKNEFSAFQLYQNLRNINPSPYMFLLEFDKDVVGASPETM
ASVQNNVLKVNPIAGTAPIGKNENETKKLAEILLKDEKERAEHMMLVDLARNDVRKVSKSGSIILERFFDVVRYSHVQHI
ESEVLGTLKNGSTIFDAIEAAFPAGTLTGAPKFRAMEIIDEIEKSRRKIYGGAVGYFSNSGNADLAIGIRMAEIDSVCRV
RAGGGVVSDSVPENEYYETERKMAAMMKALGVKNDSNNR

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=437, Percent_Identity=29.2906178489703, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787518, Length=279, Percent_Identity=40.1433691756272, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87082077, Length=262, Percent_Identity=25.1908396946565, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786809, Length=264, Percent_Identity=25, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=447, Percent_Identity=34.2281879194631, Blast_Score=223, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6324361, Length=289, Percent_Identity=24.5674740484429, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR010116
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 49735; Mature: 49735

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKLDYVNPLKLYGVLRDEGKYPVMLESRAKGQINARYTYISSNPEYMLRIGNKTKMDNE
CCCCCCCCHHHHEEEEECCCCCCEEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCH
TISKESNPFKALKENFKITQKGDRFTGGYVGYIAYDCIHNYIGGKIEEPSVFGYYDHMYV
HHCCCCCHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHH
YDHVTRQFYFHSENNSAEELTNAKKTVEKAKNFKIEQEDGGIEVLGCDANFEEYVEMVER
HHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCHHHHHHHHHH
AKEYIYAGDAFQVVPSREYQLKNEFSAFQLYQNLRNINPSPYMFLLEFDKDVVGASPETM
HHHHEECCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHCCCCHHHH
ASVQNNVLKVNPIAGTAPIGKNENETKKLAEILLKDEKERAEHMMLVDLARNDVRKVSKS
HHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
GSIILERFFDVVRYSHVQHIESEVLGTLKNGSTIFDAIEAAFPAGTLTGAPKFRAMEIID
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
EIEKSRRKIYGGAVGYFSNSGNADLAIGIRMAEIDSVCRVRAGGGVVSDSVPENEYYETE
HHHHHHHHHCCCEEEEECCCCCCEEEEEEEHHHHHHHHEEECCCCEECCCCCCCHHHHHH
RKMAAMMKALGVKNDSNNR
HHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MYKLDYVNPLKLYGVLRDEGKYPVMLESRAKGQINARYTYISSNPEYMLRIGNKTKMDNE
CCCCCCCCHHHHEEEEECCCCCCEEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCH
TISKESNPFKALKENFKITQKGDRFTGGYVGYIAYDCIHNYIGGKIEEPSVFGYYDHMYV
HHCCCCCHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHH
YDHVTRQFYFHSENNSAEELTNAKKTVEKAKNFKIEQEDGGIEVLGCDANFEEYVEMVER
HHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCHHHHHHHHHH
AKEYIYAGDAFQVVPSREYQLKNEFSAFQLYQNLRNINPSPYMFLLEFDKDVVGASPETM
HHHHEECCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHCCCCHHHH
ASVQNNVLKVNPIAGTAPIGKNENETKKLAEILLKDEKERAEHMMLVDLARNDVRKVSKS
HHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
GSIILERFFDVVRYSHVQHIESEVLGTLKNGSTIFDAIEAAFPAGTLTGAPKFRAMEIID
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
EIEKSRRKIYGGAVGYFSNSGNADLAIGIRMAEIDSVCRVRAGGGVVSDSVPENEYYETE
HHHHHHHHHCCCEEEEECCCCCCEEEEEEEHHHHHHHHEEECCCCEECCCCCCCHHHHHH
RKMAAMMKALGVKNDSNNR
HHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10628865 [H]