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The map label for this gene is ahcY [H]

Identifier: 150398968

GI number: 150398968

Start: 246884

End: 248131

Strand: Reverse

Name: ahcY [H]

Synonym: Mevan_0213

Alternate gene names: 150398968

Gene position: 248131-246884 (Counterclockwise)

Preceding gene: 150398978

Following gene: 150398967

Centisome position: 14.43

GC content: 35.42

Gene sequence:

>1248_bases
TTGAGTAGAGTTAAAGATATGAATCTTGCTAAGGCAGGTCATTTAAAAATGAACTGGGCAAAACAACACATGCCTGTTTT
AGGACTTATTCAAGAAGAATTTAAGAAAGAAAAACCATTTGAAGGACTTACTATTGGAATGGCACTTCATTTAGAAGCTA
AAACTGCGATTTTGGCAGAAACCTTGATGGAAGGGGGAGCAAAAATTGTAATTACTGGCTGTAACCCCTTATCAACACAA
GATGATGTTGCTGCTGCATGCGTAGAAAAAGGAATGGAAGTTTACGCTTGGAGAGGCGAAACTAATGAAGAATACTACGA
AAACTTAAATTTAGTTCTTGATTCAAACCCTGACATAATAATTGATGATGGTGCAGACCTTATTTTTTTGATACATACAA
AAAGGCCCGAACTTATTGGAAAAATTATTGGGGGATGCGAAGAAACAACAACTGGGGTCATTAGATTAAAAGCAATGGCT
GAAGAAGGGGCTTTAAAGTTTCCCGTAGTTAATGTAAATGATGCATATACAAAACACATGTTTGATAATCGTTACGGAAC
CGGTCAAAGTGCAATTGATGGGATAATTCGGACTACAAATATGCTAATTGCAGGTAAAAATATTGTTGTTGCAGGATATG
GCTGGTGTGGAAGAGGCGTTGCATCAAGAGCATCAGGACATGGGGCAAACGTTATTATTACAGAAATAAATCCTATAAGG
GCCCTTGAAGCTAAAATGGATGGATTTACCGTGTTAAAAATGGAAGAAGCTGCAAAAGTTGGGGATATTTTTGTAACTAC
AACCGGATGTAAAGATATTATCCGGATGGAACACTTCCTTTTAATGAAAGAGGGTGCGGTTTTATCAAATGCTGGACATT
TTGATAATGAAATAAACAAATGCGACCTAAAAGAGCTTTCAAAATCTGTTAAAGAAGTTAGATATAATATTGAAGAATAC
GATTTAAAGAACAAAAAAATCTACTTACTTGGCGAAGGAAGACTTGTAAATTTAGCATGTGCAGATGGTCATCCTTGTGA
AGTTATGGACATGAGTTTTGCAAATCAGGCTTTAAGTGCAAAGTTTATCAAGGAAAACTCTGGAAAACTTAAAAATCAAG
TTTATGAAATTCCTTATGAACAGGATGTAAAAATAGCTTCAATAAAACTAACATCAATGGATACCCAAATAGATGAACTT
TCGCCAGAGCAAAGGAAGTATTTATGTGATTGGAAGGAAGGAACATAA

Upstream 100 bases:

>100_bases
ATATGTTATGATAAATAATGGATTAGGACTAAGATTAAGATTAAGATTAAGTATTCATTTAGCAATAACTTTAGAATAAT
AATTTTTTTATGGTGAAATA

Downstream 100 bases:

>100_bases
TTTTAATACCTTTTAATTTTAAAATATTTTTAATATTTAAAAGCTTACTTTTTTAAAAAAATTTAAAATTCAAGTGATAA
GGATGGAAAAACCCGTGATG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSRVKDMNLAKAGHLKMNWAKQHMPVLGLIQEEFKKEKPFEGLTIGMALHLEAKTAILAETLMEGGAKIVITGCNPLSTQ
DDVAAACVEKGMEVYAWRGETNEEYYENLNLVLDSNPDIIIDDGADLIFLIHTKRPELIGKIIGGCEETTTGVIRLKAMA
EEGALKFPVVNVNDAYTKHMFDNRYGTGQSAIDGIIRTTNMLIAGKNIVVAGYGWCGRGVASRASGHGANVIITEINPIR
ALEAKMDGFTVLKMEEAAKVGDIFVTTTGCKDIIRMEHFLLMKEGAVLSNAGHFDNEINKCDLKELSKSVKEVRYNIEEY
DLKNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALSAKFIKENSGKLKNQVYEIPYEQDVKIASIKLTSMDTQIDEL
SPEQRKYLCDWKEGT

Sequences:

>Translated_415_residues
MSRVKDMNLAKAGHLKMNWAKQHMPVLGLIQEEFKKEKPFEGLTIGMALHLEAKTAILAETLMEGGAKIVITGCNPLSTQ
DDVAAACVEKGMEVYAWRGETNEEYYENLNLVLDSNPDIIIDDGADLIFLIHTKRPELIGKIIGGCEETTTGVIRLKAMA
EEGALKFPVVNVNDAYTKHMFDNRYGTGQSAIDGIIRTTNMLIAGKNIVVAGYGWCGRGVASRASGHGANVIITEINPIR
ALEAKMDGFTVLKMEEAAKVGDIFVTTTGCKDIIRMEHFLLMKEGAVLSNAGHFDNEINKCDLKELSKSVKEVRYNIEEY
DLKNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALSAKFIKENSGKLKNQVYEIPYEQDVKIASIKLTSMDTQIDEL
SPEQRKYLCDWKEGT
>Mature_414_residues
SRVKDMNLAKAGHLKMNWAKQHMPVLGLIQEEFKKEKPFEGLTIGMALHLEAKTAILAETLMEGGAKIVITGCNPLSTQD
DVAAACVEKGMEVYAWRGETNEEYYENLNLVLDSNPDIIIDDGADLIFLIHTKRPELIGKIIGGCEETTTGVIRLKAMAE
EGALKFPVVNVNDAYTKHMFDNRYGTGQSAIDGIIRTTNMLIAGKNIVVAGYGWCGRGVASRASGHGANVIITEINPIRA
LEAKMDGFTVLKMEEAAKVGDIFVTTTGCKDIIRMEHFLLMKEGAVLSNAGHFDNEINKCDLKELSKSVKEVRYNIEEYD
LKNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALSAKFIKENSGKLKNQVYEIPYEQDVKIASIKLTSMDTQIDELS
PEQRKYLCDWKEGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=415, Percent_Identity=45.3012048192771, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI239937451, Length=394, Percent_Identity=46.1928934010152, Blast_Score=317, Evalue=9e-87,
Organism=Homo sapiens, GI195539349, Length=410, Percent_Identity=37.8048780487805, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI298286489, Length=410, Percent_Identity=37.8048780487805, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI24308043, Length=410, Percent_Identity=37.8048780487805, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI195539337, Length=410, Percent_Identity=37.8048780487805, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI21361647, Length=410, Percent_Identity=37.3170731707317, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17506425, Length=416, Percent_Identity=43.0288461538462, Blast_Score=318, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6320882, Length=432, Percent_Identity=41.4351851851852, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24642172, Length=411, Percent_Identity=44.0389294403893, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24656245, Length=401, Percent_Identity=38.4039900249377, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI45553387, Length=409, Percent_Identity=37.1638141809291, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI45553385, Length=409, Percent_Identity=37.1638141809291, Blast_Score=261, Evalue=8e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 45966; Mature: 45834

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVKDMNLAKAGHLKMNWAKQHMPVLGLIQEEFKKEKPFEGLTIGMALHLEAKTAILAE
CCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHH
TLMEGGAKIVITGCNPLSTQDDVAAACVEKGMEVYAWRGETNEEYYENLNLVLDSNPDII
HHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHCCCEEEEECCCCEE
IDDGADLIFLIHTKRPELIGKIIGGCEETTTGVIRLKAMAEEGALKFPVVNVNDAYTKHM
EECCCCEEEEEECCCHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEEEECCCHHHHHH
FDNRYGTGQSAIDGIIRTTNMLIAGKNIVVAGYGWCGRGVASRASGHGANVIITEINPIR
HCCCCCCCHHHHHHHHHHCEEEEECCEEEEEECCCCCCCHHHCCCCCCCEEEEECCCCCE
ALEAKMDGFTVLKMEEAAKVGDIFVTTTGCKDIIRMEHFLLMKEGAVLSNAGHFDNEINK
EHHHCCCCEEEEEEHHCCCCCEEEEEECCHHHHHHHHHHHEEECCCEEECCCCCCCCCCC
CDLKELSKSVKEVRYNIEEYDLKNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALSA
CCHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCEEEEEEECCCCCCEEEECHHHHHHHHH
KFIKENSGKLKNQVYEIPYEQDVKIASIKLTSMDTQIDELSPEQRKYLCDWKEGT
HHHHCCCCCHHHHEEECCCCCCCEEEEEEEEECCCHHHHCCCHHHHEEECCCCCC
>Mature Secondary Structure 
SRVKDMNLAKAGHLKMNWAKQHMPVLGLIQEEFKKEKPFEGLTIGMALHLEAKTAILAE
CCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHH
TLMEGGAKIVITGCNPLSTQDDVAAACVEKGMEVYAWRGETNEEYYENLNLVLDSNPDII
HHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHCCCEEEEECCCCEE
IDDGADLIFLIHTKRPELIGKIIGGCEETTTGVIRLKAMAEEGALKFPVVNVNDAYTKHM
EECCCCEEEEEECCCHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEEEECCCHHHHHH
FDNRYGTGQSAIDGIIRTTNMLIAGKNIVVAGYGWCGRGVASRASGHGANVIITEINPIR
HCCCCCCCHHHHHHHHHHCEEEEECCEEEEEECCCCCCCHHHCCCCCCCEEEEECCCCCE
ALEAKMDGFTVLKMEEAAKVGDIFVTTTGCKDIIRMEHFLLMKEGAVLSNAGHFDNEINK
EHHHCCCCEEEEEEHHCCCCCEEEEEECCHHHHHHHHHHHEEECCCEEECCCCCCCCCCC
CDLKELSKSVKEVRYNIEEYDLKNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALSA
CCHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCEEEEEEECCCCCCEEEECHHHHHHHHH
KFIKENSGKLKNQVYEIPYEQDVKIASIKLTSMDTQIDELSPEQRKYLCDWKEGT
HHHHCCCCCHHHHEEECCCCCCCEEEEEEEEECCCHHHHCCCHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA