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The map label for this gene is coaBC [H]

Identifier: 150398749

GI number: 150398749

Start: 3773197

End: 3774420

Strand: Reverse

Name: coaBC [H]

Synonym: Smed_3566

Alternate gene names: 150398749

Gene position: 3774420-3773197 (Counterclockwise)

Preceding gene: 150398752

Following gene: 150398747

Centisome position: 99.8

GC content: 66.09

Gene sequence:

>1224_bases
ATGACACTGTCGGGAAAGCGTATCCTTCTCATCATCTCCGGCGGCATCGCGGCATATAAAAGCCTCGACCTGATCCGCCG
CCTGCGCGAGCGCGGCGCCGACGTGCGTCCGGTGATGACGGCGGCGGCGCAGCGATTCGTGACGCCGCTCACCGTCGGCG
CACTTTCCGCCTCTCACGTCTTTACGGAGCTTTTTTCGCGCGAGGACGAACAGGATGTCGGCCATATCCGGCTGGCGCGC
CATTGCGATCTCGTCGTGGTGGCGCCGGCAACGGCTGACCTCATGGCGAAGATTGCCAATGGCCATGCCGACGACCTCGC
CTCGACGGTGCTCCTGGCGACCGACCGGCCGGTGCTGCTCGCTCCGGCCATGAACCCGAAGATGTGGATGCATCCGGCCA
CACGCCGCAACCGCGCGACGCTTGCCGGCGACGGCGTCCGCTTTATCGGACCCGGCACAGGTGAAATGGCTGAAAGCGGA
GAGGCAGGTGAAGGCCGCATGGCCGACCCTCTGGAGATCGTCGCGGCGGTAGAGGGAATGCTTGGCGAGACGAGGATCGG
CGGATCGGGGCCGCTCTCCGGCCGTAAGGCGATCGTCACTTCCGGCCCGACGCACGAGCCGATCGATCCGGTTCGATACA
TCGCCAACCGCTCGTCGGGAAAGCAGGGCCACGCGATCGCAGCGGCACTTGCGCGGCTCGGTGCGGATGTCACGCTGATT
TCGGGGCCGGTGACCATCGCGGATCCCGCCGGCGTGCGCGTCGTGCGGATCGAGCGCGCCGAGGAGATGCGCGATGCCGT
GCTGTCTGCTCTGCCCGCCGATGTGGCCGTCATGGTGGCAGCGGTGGCCGACTGGCGCGTCGCATCCACAGCCGGCAACA
AGATCAAGAAGCGGCCGGGCGAGGCCCCGCCTTCACTTCGGCTTGCGGAAAATCCCGACATCCTGAAGACCGTGGGCCAC
CACGCATCTCGGCCCAGGCTCGTGATCGGCTTTGCCGCGGAAACCGAGAACGTCAGCGAGAACGGCCGCGCCAAACTTGA
GAAGAAGGGTGCCGACTACATTCTTGCCAACGACGTCTCGCCCGAAACCGGCATCATGGGCGGCGACCGCAACCGCGTGA
AGCTGATCGGCCGCGACGGAACGGAGGACTGGCCAGAAATGGGCAAGGATGACGTGGCGGAGAAGCTGGCGGCTCTGATC
GAGAAGAAGCTCTCCGCCCAGTAG

Upstream 100 bases:

>100_bases
AAATTTTGGCCAACACACCAACTAGGCCCGCAATTGCGTGCGGCAAGACGGTCGAGTAGGGTCGCCGAAAACGGACGGAG
GCGGCTGAGGCCGAAGCGGA

Downstream 100 bases:

>100_bases
CGCGACACCAACGATCGGTTACGCCTCAACCTCTTCCGGAATGACCAGGACCGGCCGCGGCGGAACGTCGCCGGTCCTGA
AGAGACGAACGTCGACTCCG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTLSGKRILLIISGGIAAYKSLDLIRRLRERGADVRPVMTAAAQRFVTPLTVGALSASHVFTELFSREDEQDVGHIRLAR
HCDLVVVAPATADLMAKIANGHADDLASTVLLATDRPVLLAPAMNPKMWMHPATRRNRATLAGDGVRFIGPGTGEMAESG
EAGEGRMADPLEIVAAVEGMLGETRIGGSGPLSGRKAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALARLGADVTLI
SGPVTIADPAGVRVVRIERAEEMRDAVLSALPADVAVMVAAVADWRVASTAGNKIKKRPGEAPPSLRLAENPDILKTVGH
HASRPRLVIGFAAETENVSENGRAKLEKKGADYILANDVSPETGIMGGDRNRVKLIGRDGTEDWPEMGKDDVAEKLAALI
EKKLSAQ

Sequences:

>Translated_407_residues
MTLSGKRILLIISGGIAAYKSLDLIRRLRERGADVRPVMTAAAQRFVTPLTVGALSASHVFTELFSREDEQDVGHIRLAR
HCDLVVVAPATADLMAKIANGHADDLASTVLLATDRPVLLAPAMNPKMWMHPATRRNRATLAGDGVRFIGPGTGEMAESG
EAGEGRMADPLEIVAAVEGMLGETRIGGSGPLSGRKAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALARLGADVTLI
SGPVTIADPAGVRVVRIERAEEMRDAVLSALPADVAVMVAAVADWRVASTAGNKIKKRPGEAPPSLRLAENPDILKTVGH
HASRPRLVIGFAAETENVSENGRAKLEKKGADYILANDVSPETGIMGGDRNRVKLIGRDGTEDWPEMGKDDVAEKLAALI
EKKLSAQ
>Mature_406_residues
TLSGKRILLIISGGIAAYKSLDLIRRLRERGADVRPVMTAAAQRFVTPLTVGALSASHVFTELFSREDEQDVGHIRLARH
CDLVVVAPATADLMAKIANGHADDLASTVLLATDRPVLLAPAMNPKMWMHPATRRNRATLAGDGVRFIGPGTGEMAESGE
AGEGRMADPLEIVAAVEGMLGETRIGGSGPLSGRKAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALARLGADVTLIS
GPVTIADPAGVRVVRIERAEEMRDAVLSALPADVAVMVAAVADWRVASTAGNKIKKRPGEAPPSLRLAENPDILKTVGHH
ASRPRLVIGFAAETENVSENGRAKLEKKGADYILANDVSPETGIMGGDRNRVKLIGRDGTEDWPEMGKDDVAEKLAALIE
KKLSAQ

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=188, Percent_Identity=32.4468085106383, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI87082301, Length=390, Percent_Identity=45.8974358974359, Blast_Score=285, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17560194, Length=196, Percent_Identity=33.6734693877551, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24657262, Length=180, Percent_Identity=31.1111111111111, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43016; Mature: 42885

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSGKRILLIISGGIAAYKSLDLIRRLRERGADVRPVMTAAAQRFVTPLTVGALSASHV
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
FTELFSREDEQDVGHIRLARHCDLVVVAPATADLMAKIANGHADDLASTVLLATDRPVLL
HHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHCCCHHHHHHEEEEECCCCEEE
APAMNPKMWMHPATRRNRATLAGDGVRFIGPGTGEMAESGEAGEGRMADPLEIVAAVEGM
ECCCCCCEEECCCCCCCCEEEECCCEEEECCCCCCHHCCCCCCCCCCCCHHHHHHHHHHH
LGETRIGGSGPLSGRKAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALARLGADVTLI
HCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEE
SGPVTIADPAGVRVVRIERAEEMRDAVLSALPADVAVMVAAVADWRVASTAGNKIKKRPG
ECCEEEECCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEHHCCCHHHCCCC
EAPPSLRLAENPDILKTVGHHASRPRLVIGFAAETENVSENGRAKLEKKGADYILANDVS
CCCCCCEECCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCEEEECCCC
PETGIMGGDRNRVKLIGRDGTEDWPEMGKDDVAEKLAALIEKKLSAQ
CCCCCCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLSGKRILLIISGGIAAYKSLDLIRRLRERGADVRPVMTAAAQRFVTPLTVGALSASHV
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
FTELFSREDEQDVGHIRLARHCDLVVVAPATADLMAKIANGHADDLASTVLLATDRPVLL
HHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHCCCHHHHHHEEEEECCCCEEE
APAMNPKMWMHPATRRNRATLAGDGVRFIGPGTGEMAESGEAGEGRMADPLEIVAAVEGM
ECCCCCCEEECCCCCCCCEEEECCCEEEECCCCCCHHCCCCCCCCCCCCHHHHHHHHHHH
LGETRIGGSGPLSGRKAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALARLGADVTLI
HCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEE
SGPVTIADPAGVRVVRIERAEEMRDAVLSALPADVAVMVAAVADWRVASTAGNKIKKRPG
ECCEEEECCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEHHCCCHHHCCCC
EAPPSLRLAENPDILKTVGHHASRPRLVIGFAAETENVSENGRAKLEKKGADYILANDVS
CCCCCCEECCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCEEEECCCC
PETGIMGGDRNRVKLIGRDGTEDWPEMGKDDVAEKLAALIEKKLSAQ
CCCCCCCCCCCEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA