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The map label for this gene is yccK [H]

Identifier: 150398675

GI number: 150398675

Start: 3696726

End: 3697721

Strand: Reverse

Name: yccK [H]

Synonym: Smed_3489

Alternate gene names: 150398675

Gene position: 3697721-3696726 (Counterclockwise)

Preceding gene: 150398677

Following gene: 150398674

Centisome position: 97.77

GC content: 62.95

Gene sequence:

>996_bases
ATGAAATACCGCAAGCTTGGCAACGAACTCACCGTTTCGACCGTCGGCCTCGGTTGCATGGGAATGAGCTTCGCCTATGG
CGAAGCAGACGAAAACCAATCGATCCGCACGCTTCATCGCGCCGTTGAACTCGGCGTCAACTTCTTCGACACGGCGGAGG
TCTACGGCCCCTACGAGAACGAGAAGCTGATCGGCAAAGCGCTGAAAGACCGGCGCGATCAGGTCGTAATCGCCACCAAA
TTCGGCTTTCGAATCGAACCGGGCAAGCCCGCCACTCGAGCGATCAGGGGCGTCGACGGCCGGCCGGAAAATGCGAAAGC
CGTTGCAGAGGCATCCCTTGGGAGACTCGGCATCGATATCATCGATCTCTATTACCAACACCGCGTCGACCCGGCCGTAC
CGATCGAGGAAACGGTCGGCGCAATGGCCGAGCTGGTGAAAGAAGGCAAGGTGCGCGCCCTCGGACTTTCCGAGGCGAGC
GCCGCCACCATCCGCCGCGCCCATTCCGTGCACCCGATCGCGGCCGTACAGAGCGAGTACTCACTCTGGTCGCGTGATCC
GGAACAGGAGGTTCTCGCCACCTGCCGCGAGCTCGGCATCGGCTTCGTTCCTTACAGCCCGCTGGGGCGCGGCATGCTGA
CGGGTGCGATCCGCAGGCTCGAGGATCTCGCTGCCGACGATTTCCGGCGATCTCTGCCGCGCTTTCAGCAGGAGAATTTC
GAGGCCAATGCGGCGCTAATCGGCACGCTCGAAAGGCTCGCCTCGGCAAGAGAGGTGACCGCTGCCCAGCTTGCACTCGC
CTGGGTCGTCAATCAGGGCGAGGACATCGTGCCGATTCCCGGGGCGCGCAGGATCGAGCATCTGGAGCAGAACGTGGCCG
CCGCCGGGATCGTCCTCACAGAAGGCGAACGCGCAGAAATCGGCGAAGCGCTTTCTCCGGAACGCGTCGCCGGCCGACGC
TACACGGACGCATCGCTTGCCCTGACGAACAGGTAA

Upstream 100 bases:

>100_bases
CGCAGCGCCCTCATCGGGCGACGTTTTCATTACGCCCAATATCTTCGTGGAACGCCGTGCGTGATCCGCAGGCCGCGCGT
TCAGCCCGAAAGGAAATCCG

Downstream 100 bases:

>100_bases
GCGGCGGCAAGCGGAGCTCAGGGAGCTGGAGGGCATCGCAATTCCGTTGCGATGCCCTAAGTTTATCGCGATGTCCGTCT
CGGCCGTAATCGGAGCGGCA

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKYRKLGNELTVSTVGLGCMGMSFAYGEADENQSIRTLHRAVELGVNFFDTAEVYGPYENEKLIGKALKDRRDQVVIATK
FGFRIEPGKPATRAIRGVDGRPENAKAVAEASLGRLGIDIIDLYYQHRVDPAVPIEETVGAMAELVKEGKVRALGLSEAS
AATIRRAHSVHPIAAVQSEYSLWSRDPEQEVLATCRELGIGFVPYSPLGRGMLTGAIRRLEDLAADDFRRSLPRFQQENF
EANAALIGTLERLASAREVTAAQLALAWVVNQGEDIVPIPGARRIEHLEQNVAAAGIVLTEGERAEIGEALSPERVAGRR
YTDASLALTNR

Sequences:

>Translated_331_residues
MKYRKLGNELTVSTVGLGCMGMSFAYGEADENQSIRTLHRAVELGVNFFDTAEVYGPYENEKLIGKALKDRRDQVVIATK
FGFRIEPGKPATRAIRGVDGRPENAKAVAEASLGRLGIDIIDLYYQHRVDPAVPIEETVGAMAELVKEGKVRALGLSEAS
AATIRRAHSVHPIAAVQSEYSLWSRDPEQEVLATCRELGIGFVPYSPLGRGMLTGAIRRLEDLAADDFRRSLPRFQQENF
EANAALIGTLERLASAREVTAAQLALAWVVNQGEDIVPIPGARRIEHLEQNVAAAGIVLTEGERAEIGEALSPERVAGRR
YTDASLALTNR
>Mature_331_residues
MKYRKLGNELTVSTVGLGCMGMSFAYGEADENQSIRTLHRAVELGVNFFDTAEVYGPYENEKLIGKALKDRRDQVVIATK
FGFRIEPGKPATRAIRGVDGRPENAKAVAEASLGRLGIDIIDLYYQHRVDPAVPIEETVGAMAELVKEGKVRALGLSEAS
AATIRRAHSVHPIAAVQSEYSLWSRDPEQEVLATCRELGIGFVPYSPLGRGMLTGAIRRLEDLAADDFRRSLPRFQQENF
EANAALIGTLERLASAREVTAAQLALAWVVNQGEDIVPIPGARRIEHLEQNVAAAGIVLTEGERAEIGEALSPERVAGRR
YTDASLALTNR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=321, Percent_Identity=30.5295950155763, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI27436971, Length=292, Percent_Identity=31.8493150684932, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI27436969, Length=320, Percent_Identity=30.625, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4504825, Length=318, Percent_Identity=30.5031446540881, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI27436962, Length=321, Percent_Identity=30.2180685358255, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI27436966, Length=321, Percent_Identity=29.9065420560748, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI223718702, Length=283, Percent_Identity=28.9752650176678, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI41327764, Length=234, Percent_Identity=31.6239316239316, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI41152114, Length=230, Percent_Identity=28.695652173913, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI87081735, Length=342, Percent_Identity=34.5029239766082, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1788070, Length=327, Percent_Identity=36.085626911315, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789375, Length=334, Percent_Identity=29.6407185628743, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788081, Length=302, Percent_Identity=29.4701986754967, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787674, Length=307, Percent_Identity=27.6872964169381, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1789199, Length=348, Percent_Identity=29.0229885057471, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17564128, Length=207, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325384, Length=351, Percent_Identity=29.9145299145299, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6325169, Length=350, Percent_Identity=27.4285714285714, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319958, Length=304, Percent_Identity=29.6052631578947, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323998, Length=304, Percent_Identity=29.9342105263158, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322615, Length=258, Percent_Identity=29.8449612403101, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319951, Length=296, Percent_Identity=26.3513513513513, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646155, Length=172, Percent_Identity=34.3023255813954, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24640980, Length=327, Percent_Identity=24.7706422018349, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45549126, Length=323, Percent_Identity=25.077399380805, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646159, Length=228, Percent_Identity=28.5087719298246, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36121; Mature: 36121

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYRKLGNELTVSTVGLGCMGMSFAYGEADENQSIRTLHRAVELGVNFFDTAEVYGPYEN
CCHHHCCCEEEEHHHCHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCC
EKLIGKALKDRRDQVVIATKFGFRIEPGKPATRAIRGVDGRPENAKAVAEASLGRLGIDI
HHHHHHHHHCCCCCEEEEEECCEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
IDLYYQHRVDPAVPIEETVGAMAELVKEGKVRALGLSEASAATIRRAHSVHPIAAVQSEY
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHH
SLWSRDPEQEVLATCRELGIGFVPYSPLGRGMLTGAIRRLEDLAADDFRRSLPRFQQENF
HHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EANAALIGTLERLASAREVTAAQLALAWVVNQGEDIVPIPGARRIEHLEQNVAAAGIVLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCEEEE
EGERAEIGEALSPERVAGRRYTDASLALTNR
CCCHHHHCCCCCCHHHCCCCCCCCCEEECCC
>Mature Secondary Structure
MKYRKLGNELTVSTVGLGCMGMSFAYGEADENQSIRTLHRAVELGVNFFDTAEVYGPYEN
CCHHHCCCEEEEHHHCHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCC
EKLIGKALKDRRDQVVIATKFGFRIEPGKPATRAIRGVDGRPENAKAVAEASLGRLGIDI
HHHHHHHHHCCCCCEEEEEECCEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
IDLYYQHRVDPAVPIEETVGAMAELVKEGKVRALGLSEASAATIRRAHSVHPIAAVQSEY
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHH
SLWSRDPEQEVLATCRELGIGFVPYSPLGRGMLTGAIRRLEDLAADDFRRSLPRFQQENF
HHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EANAALIGTLERLASAREVTAAQLALAWVVNQGEDIVPIPGARRIEHLEQNVAAAGIVLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCEEEE
EGERAEIGEALSPERVAGRRYTDASLALTNR
CCCHHHHCCCCCCHHHCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]