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The map label for this gene is cya1 [H]

Identifier: 150398648

GI number: 150398648

Start: 3670822

End: 3672777

Strand: Reverse

Name: cya1 [H]

Synonym: Smed_3462

Alternate gene names: 150398648

Gene position: 3672777-3670822 (Counterclockwise)

Preceding gene: 150398649

Following gene: 150398647

Centisome position: 97.11

GC content: 63.65

Gene sequence:

>1956_bases
ATGCACATTGCCGACGGGGACAAGCCTTCTGGGACCTGGACCAGCTCACTGCGATCGCTGCTCGGTCTCGTGATGGTTGC
GATGCTCATCGTCGTGTCCGCGACGCTGGTGGGGCTTGACTATCGCCGCGCGCGCGTTGCCGCCATCGCAGGCGCCGAAG
ACAATATGAGCGCCTTCGTCGGCCGTCTGGTCGATCGCCTGGGGATGCTTTCCGGCGATACCTCCGCACTTGTCAACCTC
GTCGCATCGGTCGCCAATTCCTTTCTGGTCCCGCCGCCGGAGCGGATGCATGACAAAGTAGCGGTCCTGCGCGAAGGCAT
CGCCCGCTCGCCGCATATCGACGGCGTCTATGTCGGTTATCCGAGCGGCGCATTTTTTCATGTGGTTGATCTGGACTCGG
CCGCCTGGCGCATGGCGCTGGACGCGCCGCGGGGCGCGGCCATCGCTGTGCGTTCGATGGAACGGGACGACCAGGGCAAG
CCCTTCGACCGGATCCTGTTCCTGGACGCGAGCGGTTTGCAGTTCGCCGAACGCCGCGCTGCTTCGAACGGATTCGATCC
CAGAACGCGGCCCTGGTACCGCGCCGCCGTCAACGGCCAGGCGCCGGTGGCGATAGGCCCCTATGAGATGGCCACGACAC
GCAATCTGGGGATGACGATATCGCAGGCTCACAGCGGCAATCCCAAGATCGTTATCGGCGCCGATGTCGTGCTCGACACG
ATCACCGATTTTCTGTCCCGCGAGCGGCTGACCGACGACTCGGTTTCGTTCGTTCTCGACGCGGTCGGACGGCCGATCAT
CCACTCCGACACCGTAATGATGCGGCGCATCATGGCATCGAAAGGGCGGGACCAACCGGTGGTCACGCCGCAGGAAGACG
GGCTGATCGAGAGGATTCGGCGCAACCCGCCACCGGCCGGAAAGGCAACCCTCGTCGAGGTCGGAGATCGCACCTATCTC
GTGACCGTGGCACCGCTCGAATCGGCATTGCTCCTATCCGGACACAGGGTCGTCGTCGCCGCCCCGCTCGACGAACTGCT
GGCGGCGGCCAACGAAACCCTTGTTCAGGGACTTGCCGTCTCCGGAGCCGTGGTGGTGGTGGCCGTTCTCCTGGCGCTCG
TGCTTGCGCATCTGATCACGAAATCGCTCAACCAGCTCACCGACAGCGCCAACCGCCTTCAAGACCTGGATTTTTCCACG
CCCATCGAGGTTTCCTCGCATGTGGCCGAAATCTCGATGCTCAACGGCGCGATGAACAAGGCCCGTGACGCGATCTTCAC
CTTTGCGCTCTATGTGCCGAAGGAACTGGTGCGCAAGGGCATCGAATCCGGCCACTTCGGCGGCCGCGCCGCCTGGCGGC
AGGAAGTGACGGCGCTGTTCACCGACATCTACGACTTCACCACCATCAGCGAAGGACGCTCGCCGGAAGAAGTGGTGGCG
ATGCTCTCGGAATATTTTGACCTTTTCAGCGAGATCGTCGACGCGCATGACGGAACCATCATCCAGTTCCATGGAGACTC
GGTCTTCGCCATGTGGAACGCGCCGGTCGCCGATGTCAGACATGCCGAGAATGCCTGTCGTTGCGCACTCGCCGTCGAGG
AGAGGCTTCGGGCCTTCAACGCTGCGCAACGCGCCAGGGGATTGCCGGAATTCCGCACCCGCTTCGGTATCCACACCGGC
ACGGCCGTCGTCGGCAGCGTCGGTGCCAAGGAACGGCTGCAATACACCGCCATGGGCGATACCGTGAACGTCGCCTCGCG
GCTCGAGGGCATGAACAAGGATTATGGCACGACAGTTCTGGCAAGCGGTGCGGTGGTGGCGCAATGCAAGGACATGGTGA
AATTCCGCCCGCTCGGCACCGCCAGGGCCAAGGGCCGCTCGACGGCGCTCGACATTTACGAAGTCGTGGGCGTGGCCCGC
GCGGTGGATACTGCCGAGACAGGAACGGCCGCCTGA

Upstream 100 bases:

>100_bases
TTCATGATTTTAGGTCCATCCGACTAAAATCGTCGTGATCTATGCAAATCCGGAGCAATATTGCAAAACTCCGGAATCGG
GATGCAAGGACATCGAAAGC

Downstream 100 bases:

>100_bases
CCGAGATCTCAGAAGATGCTGCACGAATTGCAGGGCCGCTGAGATCGCTTCGGCGCCTGAAAACAAGAAAAGCCCGGAAA
TCCGGGCTTTTCTTGTTATC

Product: putative adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1 [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MHIADGDKPSGTWTSSLRSLLGLVMVAMLIVVSATLVGLDYRRARVAAIAGAEDNMSAFVGRLVDRLGMLSGDTSALVNL
VASVANSFLVPPPERMHDKVAVLREGIARSPHIDGVYVGYPSGAFFHVVDLDSAAWRMALDAPRGAAIAVRSMERDDQGK
PFDRILFLDASGLQFAERRAASNGFDPRTRPWYRAAVNGQAPVAIGPYEMATTRNLGMTISQAHSGNPKIVIGADVVLDT
ITDFLSRERLTDDSVSFVLDAVGRPIIHSDTVMMRRIMASKGRDQPVVTPQEDGLIERIRRNPPPAGKATLVEVGDRTYL
VTVAPLESALLLSGHRVVVAAPLDELLAAANETLVQGLAVSGAVVVVAVLLALVLAHLITKSLNQLTDSANRLQDLDFST
PIEVSSHVAEISMLNGAMNKARDAIFTFALYVPKELVRKGIESGHFGGRAAWRQEVTALFTDIYDFTTISEGRSPEEVVA
MLSEYFDLFSEIVDAHDGTIIQFHGDSVFAMWNAPVADVRHAENACRCALAVEERLRAFNAAQRARGLPEFRTRFGIHTG
TAVVGSVGAKERLQYTAMGDTVNVASRLEGMNKDYGTTVLASGAVVAQCKDMVKFRPLGTARAKGRSTALDIYEVVGVAR
AVDTAETGTAA

Sequences:

>Translated_651_residues
MHIADGDKPSGTWTSSLRSLLGLVMVAMLIVVSATLVGLDYRRARVAAIAGAEDNMSAFVGRLVDRLGMLSGDTSALVNL
VASVANSFLVPPPERMHDKVAVLREGIARSPHIDGVYVGYPSGAFFHVVDLDSAAWRMALDAPRGAAIAVRSMERDDQGK
PFDRILFLDASGLQFAERRAASNGFDPRTRPWYRAAVNGQAPVAIGPYEMATTRNLGMTISQAHSGNPKIVIGADVVLDT
ITDFLSRERLTDDSVSFVLDAVGRPIIHSDTVMMRRIMASKGRDQPVVTPQEDGLIERIRRNPPPAGKATLVEVGDRTYL
VTVAPLESALLLSGHRVVVAAPLDELLAAANETLVQGLAVSGAVVVVAVLLALVLAHLITKSLNQLTDSANRLQDLDFST
PIEVSSHVAEISMLNGAMNKARDAIFTFALYVPKELVRKGIESGHFGGRAAWRQEVTALFTDIYDFTTISEGRSPEEVVA
MLSEYFDLFSEIVDAHDGTIIQFHGDSVFAMWNAPVADVRHAENACRCALAVEERLRAFNAAQRARGLPEFRTRFGIHTG
TAVVGSVGAKERLQYTAMGDTVNVASRLEGMNKDYGTTVLASGAVVAQCKDMVKFRPLGTARAKGRSTALDIYEVVGVAR
AVDTAETGTAA
>Mature_651_residues
MHIADGDKPSGTWTSSLRSLLGLVMVAMLIVVSATLVGLDYRRARVAAIAGAEDNMSAFVGRLVDRLGMLSGDTSALVNL
VASVANSFLVPPPERMHDKVAVLREGIARSPHIDGVYVGYPSGAFFHVVDLDSAAWRMALDAPRGAAIAVRSMERDDQGK
PFDRILFLDASGLQFAERRAASNGFDPRTRPWYRAAVNGQAPVAIGPYEMATTRNLGMTISQAHSGNPKIVIGADVVLDT
ITDFLSRERLTDDSVSFVLDAVGRPIIHSDTVMMRRIMASKGRDQPVVTPQEDGLIERIRRNPPPAGKATLVEVGDRTYL
VTVAPLESALLLSGHRVVVAAPLDELLAAANETLVQGLAVSGAVVVVAVLLALVLAHLITKSLNQLTDSANRLQDLDFST
PIEVSSHVAEISMLNGAMNKARDAIFTFALYVPKELVRKGIESGHFGGRAAWRQEVTALFTDIYDFTTISEGRSPEEVVA
MLSEYFDLFSEIVDAHDGTIIQFHGDSVFAMWNAPVADVRHAENACRCALAVEERLRAFNAAQRARGLPEFRTRFGIHTG
TAVVGSVGAKERLQYTAMGDTVNVASRLEGMNKDYGTTVLASGAVVAQCKDMVKFRPLGTARAKGRSTALDIYEVVGVAR
AVDTAETGTAA

Specific function: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Homo sapiens, GI167830411, Length=135, Percent_Identity=37.7777777777778, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI4504217, Length=190, Percent_Identity=33.6842105263158, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI222080083, Length=179, Percent_Identity=34.0782122905028, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI4580422, Length=135, Percent_Identity=36.2962962962963, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI134152694, Length=177, Percent_Identity=32.2033898305085, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4557255, Length=137, Percent_Identity=30.6569343065693, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI24497587, Length=137, Percent_Identity=29.9270072992701, Blast_Score=71, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193206632, Length=134, Percent_Identity=35.8208955223881, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17534659, Length=137, Percent_Identity=36.4963503649635, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212659371, Length=134, Percent_Identity=34.3283582089552, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71989805, Length=134, Percent_Identity=31.3432835820896, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989822, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI86564713, Length=173, Percent_Identity=28.9017341040462, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508769, Length=135, Percent_Identity=31.1111111111111, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561804, Length=226, Percent_Identity=26.5486725663717, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193207841, Length=143, Percent_Identity=30.0699300699301, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193206054, Length=149, Percent_Identity=32.8859060402685, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71985505, Length=138, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62484298, Length=135, Percent_Identity=34.8148148148148, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI62484477, Length=135, Percent_Identity=34.8148148148148, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI116008008, Length=135, Percent_Identity=34.8148148148148, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161078020, Length=141, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574512, Length=135, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076872, Length=135, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI62473752, Length=140, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137448, Length=140, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330470, Length=176, Percent_Identity=27.8409090909091, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330468, Length=176, Percent_Identity=27.8409090909091, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85725044, Length=143, Percent_Identity=34.965034965035, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24647268, Length=138, Percent_Identity=36.9565217391304, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281366459, Length=135, Percent_Identity=32.5925925925926, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281366457, Length=135, Percent_Identity=32.5925925925926, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281366455, Length=135, Percent_Identity=32.5925925925926, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI56292422, Length=135, Percent_Identity=32.5925925925926, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI56292424, Length=135, Percent_Identity=32.5925925925926, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24666940, Length=135, Percent_Identity=32.5925925925926, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 69965; Mature: 69965

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIADGDKPSGTWTSSLRSLLGLVMVAMLIVVSATLVGLDYRRARVAAIAGAEDNMSAFV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCHHHHH
GRLVDRLGMLSGDTSALVNLVASVANSFLVPPPERMHDKVAVLREGIARSPHIDGVYVGY
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEC
PSGAFFHVVDLDSAAWRMALDAPRGAAIAVRSMERDDQGKPFDRILFLDASGLQFAERRA
CCCCEEEEEECCCHHHHEEECCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHH
ASNGFDPRTRPWYRAAVNGQAPVAIGPYEMATTRNLGMTISQAHSGNPKIVIGADVVLDT
HCCCCCCCCCCCEEEECCCCCCEEECCCHHHCCCCCCCEEECCCCCCCCEEEEHHHHHHH
ITDFLSRERLTDDSVSFVLDAVGRPIIHSDTVMMRRIMASKGRDQPVVTPQEDGLIERIR
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
RNPPPAGKATLVEVGDRTYLVTVAPLESALLLSGHRVVVAAPLDELLAAANETLVQGLAV
CCCCCCCCEEEEEECCCEEEEEECCCCCHHEECCCEEEEECCHHHHHHHHHHHHHHHHHH
SGAVVVVAVLLALVLAHLITKSLNQLTDSANRLQDLDFSTPIEVSSHVAEISMLNGAMNK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ARDAIFTFALYVPKELVRKGIESGHFGGRAAWRQEVTALFTDIYDFTTISEGRSPEEVVA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
MLSEYFDLFSEIVDAHDGTIIQFHGDSVFAMWNAPVADVRHAENACRCALAVEERLRAFN
HHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAQRARGLPEFRTRFGIHTGTAVVGSVGAKERLQYTAMGDTVNVASRLEGMNKDYGTTVL
HHHHHCCCHHHHHHHCCCCCCHHHHCCCHHHHEEEEECCCHHHHHHHHCCCCCCCCCCHH
ASGAVVAQCKDMVKFRPLGTARAKGRSTALDIYEVVGVARAVDTAETGTAA
CCCHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHIADGDKPSGTWTSSLRSLLGLVMVAMLIVVSATLVGLDYRRARVAAIAGAEDNMSAFV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCHHHHH
GRLVDRLGMLSGDTSALVNLVASVANSFLVPPPERMHDKVAVLREGIARSPHIDGVYVGY
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEC
PSGAFFHVVDLDSAAWRMALDAPRGAAIAVRSMERDDQGKPFDRILFLDASGLQFAERRA
CCCCEEEEEECCCHHHHEEECCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHH
ASNGFDPRTRPWYRAAVNGQAPVAIGPYEMATTRNLGMTISQAHSGNPKIVIGADVVLDT
HCCCCCCCCCCCEEEECCCCCCEEECCCHHHCCCCCCCEEECCCCCCCCEEEEHHHHHHH
ITDFLSRERLTDDSVSFVLDAVGRPIIHSDTVMMRRIMASKGRDQPVVTPQEDGLIERIR
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
RNPPPAGKATLVEVGDRTYLVTVAPLESALLLSGHRVVVAAPLDELLAAANETLVQGLAV
CCCCCCCCEEEEEECCCEEEEEECCCCCHHEECCCEEEEECCHHHHHHHHHHHHHHHHHH
SGAVVVVAVLLALVLAHLITKSLNQLTDSANRLQDLDFSTPIEVSSHVAEISMLNGAMNK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ARDAIFTFALYVPKELVRKGIESGHFGGRAAWRQEVTALFTDIYDFTTISEGRSPEEVVA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
MLSEYFDLFSEIVDAHDGTIIQFHGDSVFAMWNAPVADVRHAENACRCALAVEERLRAFN
HHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAQRARGLPEFRTRFGIHTGTAVVGSVGAKERLQYTAMGDTVNVASRLEGMNKDYGTTVL
HHHHHCCCHHHHHHHCCCCCCHHHHCCCHHHHEEEEECCCHHHHHHHHCCCCCCCCCCHH
ASGAVVAQCKDMVKFRPLGTARAKGRSTALDIYEVVGVARAVDTAETGTAA
CCCHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 1970565 [H]