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The map label for this gene is fabA [H]

Identifier: 150398636

GI number: 150398636

Start: 3659342

End: 3659857

Strand: Reverse

Name: fabA [H]

Synonym: Smed_3450

Alternate gene names: 150398636

Gene position: 3659857-3659342 (Counterclockwise)

Preceding gene: 150398638

Following gene: 150398635

Centisome position: 96.77

GC content: 62.02

Gene sequence:

>516_bases
ATGACCACCAGACAATCCAGCTTCAGCTACGAGGAAATCCTGATCTGCGGCCGAGGCGAAATGTTTGGCCCCGGCAACGC
GCAGCTGCCGCTGCCGCCGATGCTGATGTTCAATCGCATCACCGACATTTCGGAAACAGGCGGGCCCCACGACAAGGGTT
ACGTTCGCGCCGAGTTCGACATTACGCCGGACCTGTGGTTCTTTCCGTGTCACTTCATGGGCGATCCGGTCATGCCCGGC
TGCCTCGGCCTCGACGCCATGTGGCAATTGACCGGCTTCTTCCTGGGTTGGCTTGGGGAGGCCGGCAAGGGCCGCGCCAT
CTCCACGGGCGAGGTGAAGTTCACCGGCATGGTGACGCCGAAGACCAAGCTGGTAGAATACGGCATCGACTTCAAGCGCG
TCATGCGCGGCCGCCTGGTCCTCGGCATTGCCGACGGCTGGATGAAGGCCGATGGCGAAACCATCTATAAGGCCACCGAC
CTCAGGGTCGGCCTCTTCCAGGAAAAGGCCGGCTGA

Upstream 100 bases:

>100_bases
CCGGCACCGCAGCCGCGGATGACAGCTGCGCTTCAAATCAGACCGGACTTGCACTAAAGCAGGTCGGAGAACACAATATA
GACTCGGGAAGCAACCATCC

Downstream 100 bases:

>100_bases
ACTGCGGGCGATCCCGCACGGTTCCAATCGAAGAAAAGGTCATCTGACATGAGACGGGTTGTTGTAACGGGCCTCGGGAT
CGTTTCCTCGATCGGCAGCG

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTTRQSSFSYEEILICGRGEMFGPGNAQLPLPPMLMFNRITDISETGGPHDKGYVRAEFDITPDLWFFPCHFMGDPVMPG
CLGLDAMWQLTGFFLGWLGEAGKGRAISTGEVKFTGMVTPKTKLVEYGIDFKRVMRGRLVLGIADGWMKADGETIYKATD
LRVGLFQEKAG

Sequences:

>Translated_171_residues
MTTRQSSFSYEEILICGRGEMFGPGNAQLPLPPMLMFNRITDISETGGPHDKGYVRAEFDITPDLWFFPCHFMGDPVMPG
CLGLDAMWQLTGFFLGWLGEAGKGRAISTGEVKFTGMVTPKTKLVEYGIDFKRVMRGRLVLGIADGWMKADGETIYKATD
LRVGLFQEKAG
>Mature_170_residues
TTRQSSFSYEEILICGRGEMFGPGNAQLPLPPMLMFNRITDISETGGPHDKGYVRAEFDITPDLWFFPCHFMGDPVMPGC
LGLDAMWQLTGFFLGWLGEAGKGRAISTGEVKFTGMVTPKTKLVEYGIDFKRVMRGRLVLGIADGWMKADGETIYKATDL
RVGLFQEKAG

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP [H]

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787187, Length=170, Percent_Identity=60.5882352941176, Blast_Score=222, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114 [H]

Pfam domain/function: PF07977 FabA [H]

EC number: =4.2.1.60 [H]

Molecular weight: Translated: 18957; Mature: 18826

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRQSSFSYEEILICGRGEMFGPGNAQLPLPPMLMFNRITDISETGGPHDKGYVRAEFD
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHCCCCCCCCEEEEEEE
ITPDLWFFPCHFMGDPVMPGCLGLDAMWQLTGFFLGWLGEAGKGRAISTGEVKFTGMVTP
CCCCCEEEEHHHCCCCCCCCHHCHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEEECC
KTKLVEYGIDFKRVMRGRLVLGIADGWMKADGETIYKATDLRVGLFQEKAG
CHHEECCCCCHHHHHCCEEEEEEECCEEECCCCEEEEECCEEEEEEECCCC
>Mature Secondary Structure 
TTRQSSFSYEEILICGRGEMFGPGNAQLPLPPMLMFNRITDISETGGPHDKGYVRAEFD
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHCCCCCCCCEEEEEEE
ITPDLWFFPCHFMGDPVMPGCLGLDAMWQLTGFFLGWLGEAGKGRAISTGEVKFTGMVTP
CCCCCEEEEHHHCCCCCCCCHHCHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEEECC
KTKLVEYGIDFKRVMRGRLVLGIADGWMKADGETIYKATDLRVGLFQEKAG
CHHEECCCCCHHHHHCCEEEEEEECCEEECCCCEEEEECCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]